• 대한약침학회지
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• 제26권1호
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• pp.38-43
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• 2023

Objectives: Psychiatric symptoms in epilepsy are very common, and the most common symptoms are depression, insomnia, and anxiety. These symptoms not only lower the quality of life of epilepsy patients, but also elevate the risk of epileptic seizures. There are no specific criteria for the available antiepileptic drugs to ameliorate these symptoms in patients with epilepsy, and there is a lack of evidence to support the efficacy and safety of existing drugs. The Shugan Jieyu capsule (SJC) is a traditional herbal medicine composed of Acanthopanax senticosus and Hypericum perforatum and is reported to be effective in relieving psychiatric symptoms. The purpose of this study was to assess the efficacy of SJC as a treatment for psychiatric symptoms in epilepsy patients. Methods: Electronic databases will be investigated for publications in English, Korean, Japanese, and Chinese. The participants of the study are epilepsy patients with psychiatric symptoms diagnosed using any validated criteria. All types of controls will be compared-placebo, conventional treatments, and no treatment-to groups treated with SJC or modified SJC. We will measure the degree of improvement in psychiatric symptoms and check epileptic symptoms, such as the frequency of seizures. The study selection and data extraction will be performed by two independent reviewers, who will also assess methodological quality using the risk-of-bias tool by Cochrane. We will use Review Manager software (RevMan) to carry out all statistical analyses. Results: This systematic review and meta-analysis will be performed in accordance with the PRISMA-P statement. Conclusion: This systematic review is the first study to assess the efficacy and safety of SJC for the treatment of psychiatric symptoms in epilepsy. We expect that this study will provide clinically applicable evidence for patients with epilepsy when selecting drug treatments.

• Restorative Dentistry and Endodontics
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• 제46권2호
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• pp.26.1-26.15
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• 2021

Objectives: The aim of the present systematic review was to investigate the cryopreservation process of dental pulp mesenchymal stromal cells and whether cryopreservation is effective in promoting cell viability and recovery. Materials and Methods: This systematic review was developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and the research question was determined using the population, exposure, comparison, and outcomes strategy. Electronic searches were conducted in the PubMed, Cochrane Library, Science Direct, LILACS, and SciELO databases and in the gray literature (dissertations and thesis databases and Google Scholar) for relevant articles published up to March 2019. Clinical trial studies performed with dental pulp of human permanent or primary teeth, containing concrete information regarding the cryopreservation stages, and with cryopreservation performed for a period of at least 1 week were included in this study. Results: The search strategy resulted in the retrieval of 185 publications. After the application of the eligibility criteria, 21 articles were selected for a qualitative analysis. Conclusions: The cryopreservation process must be carried out in 6 stages: tooth disinfection, pulp extraction, cell isolation, cell proliferation, cryopreservation, and thawing. In addition, it can be inferred that the use of dimethyl sulfoxide, programmable freezing, and storage in liquid nitrogen are associated with a high rate of cell viability after thawing and a high rate of cell proliferation in both primary and permanent teeth.

• 한국콘텐츠학회논문지
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• 제14권10호
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• pp.850-861
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• 2014

본 연구는 국내 고충실도 시뮬레이터를 이용한 시뮬레이션 기반 교육 관련 선행연구들을 체계적으로 고찰하여 간호학생의 임상수행능력과 간호수행 자신감에 대한 효과를 분석하고, 이를 이용해 근거중심의 가이드라인 제공 및 향후 연구방향을 제시하고자 시도되었다. 데이터베이스인 한국교육학술정보원(RISS), 한국학술정보(KISS)와 Google Scholar에서 2005년부터 2014년까지의 문헌을 대상으로 키워드 '간호와 시뮬레이션' 또는 '간호와 시뮬레이터'로 검색하였다. 총 183편의 연구 중 16편의 논문이 최종 선정되었고, Quality Assessment Tool for Quantitative Studies를 이용해 문헌의 질을 확인하였다. 연구결과, 시뮬레이션 기반 교육은 간호학생의 임상수행능력과 자신감 증진에 긍정적인 효과가 있었고, 간호학생들의 직접 간호수행이 힘든 중환자와 분만간호 분야에서 임상실습 교육의 효과적인 교수-학습전략이 될 수 있음을 확인하였다. 시뮬레이션 기반 교육의 효과를 극대화하기 위해 교육자와 시설 등의 적절한 지원이 필요하다. 향후 결과의 일반화를 높이기 위해 충분한 표본수를 고려한 무작위대조연구, 교육효과 평가를 위한 표준화된 도구 개발 및 시뮬레이션이후 제공되는 디브리핑의 효과를 분석하는 연구를 고려해 볼 것을 제언한다.

• 대한약침학회지
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• 제27권1호
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• pp.14-20
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• 2024

Objectives: Frozen shoulder (FS) is one of the most challenging shoulder disorders for patients and clinicians. Its symptoms mainly include any combination of stiffness, nocturnal pain, and limitation of active and passive glenohumeral joint movement. Conventional treatment options for FS are physical therapy, nonsteroidal anti-inflammatory drugs, injection therapy, and arthroscopic capsular release, but adverse and limited effects continue to present problems. As a result, pharmacoacupuncture (PA) is getting attention as an alternative therapy for patients with FS. PA is a new form of acupuncture treatment in traditional Korean medicine (TKM) that is mainly used for musculoskeletal diseases. It has similarity and specificity compared to corticosteroid injection and hydrodilatation, making it a potential alternative injection therapy for FS. However, no systematic reviews investigating the utilization of PA for FS have been published. Therefore, this review aims to standardize the clinical use of PA for FS and validate its therapeutic effect. Methods: The protocol was registered in Prospero (CRD42023445708) on 18 July 2023. Until Aug. 31, 2023, seven electronic databases will be searched for randomized controlled trials of PA for FS. Authors will be contacted, and manual searches will also be performed. Two reviewers will independently screen and collect data from retrieved articles according to predefined criteria. The primary outcome will be pain intensity, and secondary outcomes will be effective rate, Constant-Murley Score, Shoulder Pain and Disability Index, range of motion, quality of life, and adverse events. Bias and quality of the included trials will be assessed using the Cochrane handbook's risk-of-bias tool for randomized trials. Meta analyses will be conducted using Review Manager V.5.3 software. GRADE will be used to evaluate the level of evidence for each outcome. Results: This systematic review and meta-analysis will be conducted following PRISMA statement. The results will be published in a peer-reviewed journal. Conclusion: This review will provide scientific evidence to support health insurance policy as well as the standardization of PA in clinical practice.

• 대한소아치과학회지
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• 제42권4호
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• pp.331-339
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• 2015

소아치과에서 협조가 되지 않는 어린이의 치과치료 시 사용하는 진정법은 환자안전을 최우선으로 고려하여야 하며, 의료사고예방을 위한 evidence-based 진료가 필요하다. 근거중심의학의 부상에 따라 치의학계에도 근거중심치의학(Evidence-Based Dentistry)에 대한 관심이 점차 증가하고 있으나 한국의 진정법에 대한 근거중심의 체계적인 연구는 거의 이루어지지 않고 있다. 이 연구의 목적은 체계적인 문헌고찰법을 이용하여 지금까지 국내에 보고된 소아치과진정(요)법을 검토하고, 향후 국내의 근거중심 소아치과 진정법의 발전 방향을 모색하는 것이다. 본 연구는 "한국보건의료연구원의 체계적인 문헌고찰 지침"을 참고하여 국내 5개 데이터베이스 1) Core 검색 데이터베이스- KM base, KISS 2) 학술정보 및 포털 -국회도서관, DBpia, RISS를 검색하였다. "치과진정법" 및 "치과진정요법"으로 검색어를 제안한 총 470편의 논문 중 문헌선택과정의 흐름도를 따라 중복제거 하고 남은 31개의 논문 중 원문이 제공되는 문헌을 모두 취합한 총 20개 문헌을 분석대상으로 삼았다. 이번 체계적 문헌고찰은 한국 소아치과 영역에서 지난 25년간 시행된 치과진정법에 관한 일관된 근거(evidence)를 확인하기 위하여 GRADE 과정에 정의된 객관적인 기준에 기초하여 진행된 결과, 전체적인 근거는 보통(moderate)의 질로 평가되었다. 그러나, 특히 약물의 추가 투여 부분에 대해서는 매우 낮은(very low)의 질로 평가되었다. 그러므로 향후 안전한 약물의 사용 부분에 대해 보다 체계적으로 잘 고안된 임상 실험이 필요하다.