• Asian-Australasian Journal of Animal Sciences
• /
• v.31 no.1
• /
• pp.3-12
• /
• 2018

Objective: DNA methylation plays a major role in regulating the expression of genes related to traits of economic interest (e.g., weight gain) in livestock animals. This study characterized and investigated the functional inferences of genome-wide DNA methylome in the loin (longissimus dorsi) muscle (LDM) of swine. Methods: A total of 8.99 Gb methylated DNA immunoprecipitation sequence data were obtained from LDM samples of eight Duroc pigs (four pairs of littermates). The reference pig genome was annotated with 78.5% of the raw reads. A total of 33,506 putative methylated regions (PMR) were identified from methylated regions that overlapped at least two samples. Results: Of these, only 3.1% were commonly observed in all eight samples. DNA methylation patterns between two littermates were as diverse as between unrelated individuals (p = 0.47), indicating that maternal genetic effects have little influence on the variation in DNA methylation of porcine LDM. The highest density of PMR was observed on chromosome 10. A major proportion (47.7%) of PMR was present in the repeat regions, followed by introns (21.5%). The highest conservation of PMR was found in CpG islands (12.1%). These results show an important role for DNA methylation in species- and tissue-specific regulation of gene expression. PMR were also significantly related to muscular cell development, cell-cell communication, cellular integrity and transport, and nutrient metabolism. Conclusion: This study indicated the biased distribution and functional role of DNA methylation in gene expression of porcine LDM. DNA methylation was related to cell development, cell-cell communication, cellular integrity and transport, and nutrient metabolism (e.g., insulin signaling pathways). Nutritional and environmental management may have a significant impact on the variation in DNA methylation of porcine LDM.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.40 no.8
• /
• pp.1086-1091
• /
• 2011

Anti-oxidative activity and tyrosinase inhibitory activity of various ethanol extracts of Polygoni multiflori radix (PMR) and Cynanchi wilfordii radix (CWR) were compared to identify an anti-oxidant and whitening agent source from nature. We conducted an investigation into the anti-oxidant activities of PMR and CWR ethanol extracts by measuring total polyphenol content, total flavonoid content, and ABTS radical capacity. The total polyphenol contents of PMR and CWR were 17.31${\pm}$0.54 mg GA/eq g, and 2.75${\pm}$0.22 mg GA/eq g, respectively. The total flavonoid contents of PMR and CWR were 6.38${\pm}$0.39 mg naringine/eq g, and 1.34${\pm}$0.09 mg naringine/eq g, respectively. The 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) radical decolorization of PMR and CWR were 96.89${\pm}$0.21% at 1 mg/mL and 93.49${\pm}$0.76% at 50 mg/mL. Melanoma cells were cultured with the PMR and CWR ethanol extracts for 48 hr, and total melanin content as a final product and the activity of tyrosinase, a key enzyme, in melanogenesis, were estimated. The PMR and CWR ethanol extracts increased melanin content and tyrosinase activity in a dose-dependent manner. These results suggest that PMR and CWR ethanol extracts could be useful as a skin whitening agent.

• Journal of Magnetics
• /
• v.11 no.2
• /
• pp.83-86
• /
• 2006

Controlling magnetic domains in soft underlayer (SUL) of perpendicular magnetic recording (PMR) is an important issue for the application of PMR in HDD. We studied the magnetic domain structures in SUL using the finite element based micromagnetic simulation (FEMM) for the SUL models with different thicknesses. The purpose is to simulate the magnetic domain wall noise when the SUL thickness and saturation magnetization are changed. The simulation results show that a 15 nm SUL forms simpler Neel wall domain wall pattern and 40 nm SUL forms complex Bloch wall. To visualize the effect of these domain walls stray field at a read sensor position, the magnetic stray field of the domain walls at air bearing surface (ABS) which is 50 nm above the SUL was simulated and the results imply that Bloch walls have stronger stray field with more complicated field patterns than Neel walls and this becomes a significant noise source. Therefore, the thickness of the SUL should be controlled to avoid the formation of Bloch walls.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.33 no.10C
• /
• pp.758-763
• /
• 2008

We introduce a noise-predictive turbo equalization using noise filter in perpendicular magnetic recording(PMR) channel. The noise filter mitigates the colored noise in high-density PMR channel. In this paper, the channel detectors used are SOVA (Soft Output Viterbi Algorithm) and BCJR algorithm which proposed by Bahl et al., and the outer decoder used is LDPC (Low Density Parity Check) code that is implemented by sum-product algorithm. Two kinds of LDPC codes are experimented. One is the 0.5Kbyte (4336,4096) LDPC code with the code rate of 0.94, and the other is 1Kbyte (8432,8192) LDPC code with the code rate of 0.97.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.34 no.1C
• /
• pp.15-20
• /
• 2009

For perpendicular magnetic recording (PMR) channels, noise-predictive maximum likelihood (NPML) detection method has been used. But, it is hard to expect improving the performance when the bit density is increased. Hence, we exploit the coding methods which has good performance. In this paper, we show the performance of the recursive systematic convolutional (RSC) codes with turbo-equalization method with different channel bit densities. The noise model is 80% jitter noise and 20% AWGN.

• Molecules and Cells
• /
• v.39 no.7
• /
• pp.573-579
• /
• 2016

During copulation, male Drosophila transfers Sex Peptide (SP) to females where it acts on internal sensory neurons expressing pickpocket (ppk). These neurons induce a post-mating response (PMR) that includes elevated egg-laying and refractoriness to re-mating. Exactly how ppk neurons regulate the different aspects of the PMR, however, remains unclear. Here, we identify a small subset of the ppk neurons which requires expression of a pre-mRNA splicing factor CG3542 for egg-laying, but not refractoriness to mating. We identify two CG3542-ppk expressing neurons that innervate the upper oviduct and appear to be responsible for normal egg-laying. Our results suggest specific subsets of the ppk neurons are responsible for each PMR component.

• Proceedings of the Korea Information Processing Society Conference
• /
• 2009.11a
• /
• pp.771-772
• /
• 2009

최근 대표적인 공간 인덱스 구조인 R-tree를 기반으로 KD-tree나 Quad-tree와 같은 공간 분할 특성을 이용하여 인덱싱 성능을 향상시키기 위한 연구가 활발하다. 본 논문에서는 기존에 제시된 R-tree 기반 인덱스 구조인 SQR-tree와 PMR-tree의 특성을 결합하여 대용량 공간 데이타를 보다 효율적으로 처리하는 인덱스 구조인 MSQR-tree(Mapping-based SQR-tree)를 제시한다. SQR-tree는 Quad-tree를 확장한 SQ-tree와 각 SQ-tree 리프 노드마다 실제로 공간 객체를 저장하는 R-tree가 연계되어 있는 인덱스 구조이고, PMR-tree는 R-tree에 R-tree 리프 노드를 직접 접근할 수 있는 매핑 트리를 적용한 인덱스 구조이다. 본 논문에서 제시하는 MSQR-tree는 SQR-tree를 기본 구조로 가지고 R-tree마다 매핑 트리가 적용된 구조를 갖는다. 따라서, MSQR-tree에서는 SQR-tree와 같이 질의가 여러 R-tree에서 분산 처리되고, PMR-tree와 같이 매핑 트리를 통해 R-tree 리프 노드를 빠르게 접근할 수 있다. 마지막으로 성능 실험을 통해 MSQR-tree의 우수성을 입증하였다.

• Archives of Plastic Surgery
• /
• v.49 no.3
• /
• pp.346-351
• /
• 2022

Background Postmastectomy breast reconstruction (PMR) increases patient satisfaction, quality of life, and psychosocial well-being. There is scarce data regarding the safety of PMR in chronic anticoagulated patients. Perioperative complications can reduce patient satisfaction; therefore, it is important to elucidate the safety of PMR in these patients. Methods A retrospective case-control study of patients who underwent PMR with implants and were on chronic anticoagulation was performed at our institution. Inclusion criteria were women ≥ 18 years old. Exclusion criteria included autologous reconstructions, lumpectomy, and oncoplastic procedures. Two controls for every one patient on anticoagulation were matched by age, body mass index, radiotherapy, smoking history, type of reconstruction, time of reconstruction, and laterality. Results From 2009 to 2020, 37 breasts (20 patients) underwent PMR with implant-based reconstruction and were on chronic anticoagulation. A total of 74 breasts (40 patients) who had similar demographic characteristics to the cases were defined as the control group. Mean age for the case group was 53.6 years (standard deviation [SD] = 16.1), mean body mass index was 28.6 kg/m² (SD = 5.1), and 2.7% of breasts had radiotherapy before reconstruction and 5.4% after reconstruction. Nine patients were on long-term warfarin, six on apixaban, three on rivaroxaban, one on low-molecular-weight heparin, and one on dabigatran. The indications for anticoagulation were prior thromboembolic events in 50%. Anticoagulated patients had a higher risk of capsular contracture (10.8% vs. 0%, p = 0.005). There were no differences regarding incidence of hematoma (2.7% vs. 1.4%, p = 0.63), thromboembolism (5% vs. 0%, p = 0.16), reconstructive-related complications, or length of hospitalization (1.6 days [SD = 24.2] vs. 1.4 days [SD = 24.2], p = 0.85). Conclusion Postmastectomy implant-based breast reconstruction can be safely performed in patients on chronic anticoagulation with appropriate perioperative management of anticoagulation. This information can be useful for preoperative counseling on these patients.

• Journal of Korean Medicine Rehabilitation
• /
• v.18 no.1
• /
• pp.125-140
• /
• 2008

Objectives : The purpose of this study was to investigate the effect of Progressive Muscle Relaxation(PMR) on stress and muscle relaxation in healthy people. Methods : Sample group of 14 healthy subjects had been treated by progressive muscle relaxation for 10 days. Control group of 14 healthy subjects were not treated during the same period. Outcomes were assessed by Meridian-Electromyograph(MEMG), Heart Rate Variability(HRV), Stress Reaction Inventory(SRI). Results : The contraction and fatigue of erector spinae muscle by MEMG had decreased significantly in Sample group. There was no significant difference between two groups in the HRV and SRI. Conclusions : Further studies analysing PMR effect on stress and muscle relaxation are needed.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.33 no.11C
• /
• pp.868-873
• /
• 2008

In this paper, we analyze the burst error performance of LDPC codes on perpendicular magnetic recording(PMR) channel. When burst error is generated on PMR channel, we use channel state information(CSI) to set the LLR information of channel detector zero. We consider the rate 0.94 LDPC codes and use SOVA as channel detector with low complexity.