• Journal of Life Science
• /
• v.16 no.5
• /
• pp.759-766
• /
• 2006

Acute promyelocytic leukemia (APL) is a myeloid leukemia caused by over-expression of fusion protein, PML/RAR$({\alpha})$, which was the result of chromosomal translocation and induces the blockage of differentiation of affected promyelocytes. Pharmacological dose of retinoic acid induces the activation of and subsequent degradation of PML/RAR$({\alpha})$ fusion protein, and then APL cells undergo through the normal differentiation pathway. Arsenic trioxide has proved effective in causing remission of acute promyelocytic leukemia by inducing apoptosis of this tumor cells, whereas the heterogeneity of cellular susceptibility to this cytotoxic agent limited its usage on more types of tumors in clinic. This work showed that arsenic trioxide could induce apoptosis of a panel of acute promyelocytic leukemic cell lines, all-trans-retinoic acid (ATRA) sensitive NB4 cells and ATRA resistant UF-1 cell. They were investigated with regard to the correlation between the inherent or intrinsic cellular level of GSH and the apoptotic susceptibility of the cells to arsenic trioxide. We manifested, in two cell types, the inherently existed difference in intracellular GSH level reactive to the arsenic trioxide, and a positive correlation between the GSH level and their apoptotic sensitivity to arsenic trioxide. And it showed that arsenic trioxide could differentiate promyelocytic cancer cells to the cells possessed of dendritic cell surface markers. Unravelling the cause of the different susceptibility between leukemic cells and proving that promyelocyte could be differentiated to dendritic cells by arsenic trioxide will help not only to understand the mechanism underlying the complete remission of acute promyelocytic leukemia induced by arsenic trioxide, but also to expand its clinical usage.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.20 no.7
• /
• pp.380-386
• /
• 2019

Shoulder joint pain is a very common musculoskeletal disorder, in which about 20 percent of adults experience it more than once in their lives. In this study, an objective assessment was made that subacromial space was increased by pectoralis minor stretching exercise, which has a positive effect on impingement syndrome and shoulder pain. Also, This study examined the effects on pectoralis minor length(PML) and acromio-humeral distance(AHD) following pectoralis minor self-stretching exercise in normal adults. In this study, a total of 30 subjects were recruited and randomly divided into a self-stretching exercise group(n=15) and manual stretching exercise group(n=15) to compare the immediate effects of treatment. Studies have shown that both groups have significantly increased both PML and AHD within the group(p<.05). There was no statistically significant difference in the comparison between the groups(p>.05). The results suggest that self-stretching exercise can be recommended as a treatment method for impingement syndrome and prevention of shoulder disease.

• Proceedings of the Korean Society of Surveying, Geodesy, Photogrammetry, and Cartography Conference
• /
• 2004.04a
• /
• pp.209-214
• /
• 2004

This paper presents a RFM-based image matching algorithm which put constraints on the search space through the object-space approach. Also, the detail procedure of generating 3-D surface models from the RFM is introduced as an end-user point of view. The proposed algorithm provides the PML (Piecewise Matching Line) for image matching and reduces the search space to within the confined line-shape area.

• Proceedings of the IEEK Conference
• /
• 2001.06b
• /
• pp.357-360
• /
• 2001

As SOC design methodology becomes popular, processors, the essential core in embedded system are required to be designed fast and supported to customers with expansive behavior description. This paper presents new methodology to meet such goals with designer configurable instruction set simulator for processors. This paper proposes new language called PML(Processor Modeling Language), which is based on microprogramming scheme and is also successful in most behavior of processors. By using this, we can describe scalar processor very efficiently with by-far faster simulation speed in compared with HDL model.

• Proceedings of the IEEK Conference
• /
• 1999.06a
• /
• pp.869-872
• /
• 1999

As integrated circuits are developed, the crosstalk and the pulse distortion have been major problems in the design. In this paper. the PML and one-point resistive source are applied. This paper deal with the microstripline circuit which has the gap and three microstripline. Obtaining the Propagation pulse shape in microstripline, we prove that the use of the FDTD in the microstripline is valid.

• Proceedings of the KIEE Conference
• /
• 2000.11c
• /
• pp.600-602
• /
• 2000

In this paper, channel dropping filters made of microring structure are analyzed by using a finite difference time domain(FDTD) method with Berenger's perfectly matched layer(PML) absorbing boundary condition.

• Annals of Clinical Neurophysiology
• /
• v.6 no.1
• /
• pp.20-25
• /
• 2004

Background and Objectives: The proximal and distal nerve segments are preferentially involved in acquired demyelinating polyneuropathies (ADP). This study was undertaken in order to assess the usefulness of motor evoked potential (MEP) and somatosensory evoked potential (SSEP) in the detection of the proximal nerve lesion in ADP. Methods: MEP, SSEP and conventional NCS were performed in 6 consecutive patients with ADP (3 AIDP, 3 CIDP). MEP was recorded from abductor pollicis brevis and abductor hallucis using magnetic stimulation of the cortex and the cervical/lumbar spinal roots. SSEP were elicited by stimulating the median and posterior tibial nerves. Latency from cortex and cervical/lumbar roots, central motor conduction time (CMCT), EN1-CN2 interpeak latency were measured for comparison. Results: MEP was recorded in 24 limbs (12 upper and 12 lower limbs) and SSEP in 24 limbs (12 median nerve, 12 posterior tibial nerve). F-wave latency was prolonged in 25 motor nerves (25/34, 73.5%). Prolonged CML and PML were found in 41.7% (10/24) and 45.8% (11/24), respectively. Interside difference (ISD) of CMCT was abnormally increased in the upper extremity, 66.7% (4/6 pairs) in case of CML-PML. EN1-CN2 interpeak latency was abnormally prolonged in one median nerve (1/10) and LN1-P1 interpeak latency was normal in all posterior tibial nerves. Conclusions: MEP and SSEP may provide useful information for the proximal nerve and root lesion in ADP. MEP and SSEP is supplemental examination as well as complementary to conventional NCS.

• Korean Journal of Organic Agriculture
• /
• v.24 no.4
• /
• pp.957-967
• /
• 2016

The present study was conducted to investigate effect of dietary protected amino acid on milk yield and composition in dairy cow using meta-analysis. Total 21 research papers were employed in analysis, and mixed model was used for the analysis of effects. Effect of protected methionine (PM) and combination of protected methionine and lysine (PML) were investigated under two different levels of dietary crude protein (CP, <18% and >18%). For performance of dairy cow, milk yield, milk composition including milk fat and protein content and yield and 4% FCM (fat corrected milk) production were used for analysis. In case of milk yield, a trend of increment was found at PM supplementation at low CP (P=0.055). However, the effect of PM at high CP was detected as not significant (P>0.05). In case of milk protein, inclusion of PM at low CP showed significant decrement (P<0.05). However, there was no significant effect of MP on milk protein at high CP (P>0.05). Supplementation of MP at high CP level showed significant increment of milk fat (P<0.05). MP supplementation represented significant increment of 4% FCM production (P<0.05) regardless of dietary CP levels. Effects of PML on milk yield and composition at both of low and high dietary CP were not significant in this study. However, it seem to be that there was a possible positive effect of MPL application at high dietary CP on performance of dairy cow.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.21 no.11
• /
• pp.19-27
• /
• 2020

On an offshore plant topside, various types of offshore facilities for processing energy resources, such as oil and gas, and equipment and outfitting for connecting these facilities are installed in a limited space. An offshore plant superstructure is composed of numerous supporting rack structures and reinforcements for securing and supporting offshore installations and the related equipment. This paper describes the development of design support software to support this superstructure design efficiently. The developed design support software, which was based on AVEVA Marine's PML(Programmable Macro Language), supports the parametric method for superstructure design. A method of batch 3D modeling from 2D drawings for supporting rack structure produced in the basic and detailed design was also developed using AutoLisp. In addition, through the application example of superstructure module design, the design support software introduced in this paper can be expected to reduce the design time by more than 90% compared to the use of only basic functions of AVEVA PDMS.

• Asian Pacific Journal of Cancer Prevention
• /
• v.17 no.11
• /
• pp.4899-4906
• /
• 2016

Aim: To assess the diagnostic utility of serum and salivary interleukin 6 (IL-6) levels in the differential diagnosis of potentially malignant lesions and conditions (PMLs/PMCs) and oral squamous cell carcinoma (OSCC) in a high oral cancer prevalence region. Methods: After appropriate ethical clearance and informed consent, salivary and blood samples were collected from 100 participants in each group (OSCC, PMLs, and healthy controls). Serum and salivary IL-6 levels were measured by enzyme-linked immunosorbent assay and data were subjected to appropriate statistical analysis. Results: Significant differences in IL-6 concentration were noted between OSCC and PML/C patients in both serum and saliva, with salivary levels being 2 to 3 fold higher than serum values in all the groups. Receiver operating characteristic curve analysis demonstrated 96% specificity and 99% sensitivity for salivary IL-6 in differentiating PML from OSCC. Conclusions: The results of the present study suggest that the pro-inflammatory cytokine, IL-6, is elevated in the saliva of patients with OSSC compared to PMD and controls, and thus may prove to have diagnostic and/or prognostic significance.