• Asian Pacific Journal of Cancer Prevention
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• v.13 no.11
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• pp.5773-5775
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• 2012

Objective: To assess the diagnostic and prognostic value of AFP and des-gamma-carboxyprothrombin (DCP) in combination and alone for hepatocellular carcinoma. Materials and Methods: A case control study carried out in the Department of Biochemistry of Manipal College of Medical Sciences, Pokhara, Nepal between $1^{st}$ January 2010 and $31^{st}$ December 2011. The variables collected were age, gender, BMI, total proteins, albumin, AST, ALT, total bilirubin, DCP, AFP. Approval for the study was obtained from the institutional research ethical committee. Estimation of AFP was performed by ELISA reader for all cases. Analysis was done using descriptive statistics and confidence interval (CI). The data was analyzed using Excel 2003, R 2.8.0 Statistical Package for the Social Sciences (SPSS) for Windows Version 16.0 (SPSS Inc; Chicago, IL, USA) and the EPI Info 3.5.1 Windows Version. Results:The mean age of HCC cases was $53.6{\pm}14.93$ yrs. The percentage of females was less than males in both cases (23%) and controls (29%). The specificity of DCP reached 100% when its values was equal or greater than 150 (MAU/ml) for 0, 3, 6, 9, 12 months preceding the diagnosis of HCC. Similarly, the specificity for AFP was also nearly 100% when its value was equal or greater than 200 ng/ml 0, 3, 6, 9, 12 months earlier to the finding of HCC. The specificity of DCP (${\geq}40MAU/mL$) and AFP(${\geq}20$ ng/mL) in combination was 93%, 97%, 95%, 96%, 97% in respect to 0, 3, 6, 9, 12 months prior to the diagnosis of HCC. Conclusion: The combination of both DCP and AFP will improve the finding of initial HCC and the sensitivity of these markers was utmost at the time of HCC identification and noticeably lesser at former time points.

• The Journal of Korean Obstetrics and Gynecology
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• v.30 no.1
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• pp.29-41
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• 2017

Objectives: We analyzed chief complaints of patients visiting Korean Gynecology clinic to figure out their characteristics and expand medical fields of Korean Gynecology. Methods: We analyzed chief complaints of 1,690 female patients who visited Korean Gynecology clinic of ${\bigcirc}{\bigcirc}$ University Hospital from 2013 to 2015. Results: 1. Average age of outpatients were $38.68{\pm}12.4$ and the age group distribution showed 30s were most (41.4%), followed by 40s, 20s, and 50s. 2. The season distribution showed patients were most in winter (28.0%), and least in summer (22.7%). 3. The disease distribution showed patients of puerperal disease were most (18.9%). 4. Patients of menstruation-associated disease were most in 20s and less, puerperal disease in 30s, supplemental and postoperative care in 40s, reproductive and endocrine disease in 50s, abnormal sense disease in 60s, and supplemental and postoperative in 70s and more. 5. The age group distribution of chief complaints showed cold hypersensitivity in hands and feet in 20s, and the season distribution showed puerperal winds in summer and cold hypersensitivity in hands and feet in winter. 6. The distribution of all chief complaints showed puerperal care were most (10.1%), and the percentage of all-kind care were high (29.9%). Conclusions: The clinical fields of Korean Gynecology can be expanded in general health care of women as well as treatment of diseases.

• Korean Journal of Agricultural Science
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• v.44 no.4
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• pp.525-530
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• 2017

Weaning is the most stressful event for nursery pigs because they are moved from familiar to unfamiliar environments. In addition, weaned pigs have immature digestive and immune systems. This situation makes weaned pigs susceptible to diseases and makes the absorption of nutrients from diets difficult. A feed approach, such as dietary enzyme supplementation, can be considered a solution. This study investigated the effects of dietary enzyme cocktail on diarrhea and immune responses of weaned pigs. A total 36 weaned pigs ($5.92{\pm}0.48kg\;BW$; 28 d old) were randomly allotted to 2 dietary treatments (3 pigs/pen, 6 replicates/treatment) in a randomized complete block design. The dietary treatments were a typical diet based on corn and soybean meal (CON) and CON with 0.05% enzyme cocktail (Cocktail; combination of xylanase, ${\alpha}-amylase$, protease, ${\beta}-glucanase$, and pectinase). Pigs were fed their respective diets for 6 wk. Incidence of diarrhea, packed cell volume (PCV), white blood cells (WBC) count, and immunoglobulin content were measured. A significantly lower incidence of diarrhea (p < 0.05) was observed in the Cocktail group as compared with the CON group. The Cocktail group also showed a decreased PCV (p < 0.1) on d 3 after weaning than the CON group. However, no differences were observed for number of WBC and contents of immunoglobulin G, M, and A between the Cocktail and CON groups. Consequently, inclusion of an enzyme cocktail in diets for weaned pigs had a positive influence on gut health by reducing the incidence of diarrhea in the present study.

• Korean Journal of Agricultural Science
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• v.44 no.4
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• pp.513-518
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• 2017

Soybean, one of most widely used swine feed component in the world, contains non-starch polysaccharides (NSP). The digestive system of weaned pigs is not yet fully developed, and thus weaned pigs cannot easily digest diets based on corn and soybean meal. Dietary exogenous enzymes supplementation has been intensively investigated to assist digestion of anti-nutritional factors, such as NSP. This experiment was conducted to investigate the effects of dietary enzyme cocktail on growth performance, intestinal morphology, and nutrient digestibility of weaned pigs. A total 36 weaned pigs ($5.92{\pm}0.48kg\;BW$; 28 d old) were randomly allotted to 2 dietary treatments (3 pigs/pen, 6 replicates/treatment) in a randomized complete block design. The dietary treatments were a typical diet based on corn and soybean meal (CON) and CON with 0.05% enzyme cocktail (Cocktail; mixture of xylanase, ${\alpha}-amylase$, protease, ${\beta}-glucanase$, and pectinase). Pigs were fed their respective diets for 6 wk. Growth performance, morphology of ileum, apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of dry matter, crude protein, and energy of weaned pigs were measured. No significant differences (p > 0.05) were observed for growth performance for the duration of the experimental period, and morphology of ileum, and nutrient digestibility between CON and Cocktail treatment groups. Therefore, the results from the current study indicated that enzyme cocktail supplementation in diets had no influence on growth performance, intestinal morphology, and nutrient digestibility of weaned pigs.

• The Korea Journal of Herbology
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• v.22 no.2
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• pp.45-50
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• 2007

objectives: We investigated the moisturizing and cooling effects of the cosmetic product with Scrophularia Buergeriana, Poria Cocos, Lonicera Japonica, Portulaca Oleracea and Ginko Biloba extract on human skin by using non-invasive instrument. Methods: We measured physiological effects after volunteers(female, n=5) applied the cosmetic product containing the extract of oriental herbs. The forearm skin moisturization was measured with $Corneometer^{\circledR}$ CM825 after 15min, 3hr, and 6hr. The forearm skin surface roughness was with Scanning electron microscopy after 15min, and 6hr. The face skin temperatures cooling and microcirculation effects were measured with ThermaCAMTM PM525 and LDl-Periscan PlM II after 15min, and 30min. Results: The forearm skin moisturization was imcreased 108% after 15min. The forearm skin surface roughness was decreased significantly after 15min. The face skin temperatures were cooling down to $30.7^{\circ}C$. The face skin microcirculation effect was normalized time-dependently. Conclusions: We concluded that cosmetic product containing the extract of Scrophularia Buergeriana, Poria Cocos, Lonicera Japonica, Portulaca Oleracea and Ginko Biloba had a moisturization effect and improving the surface roughness, temperature and microcirculation on the human skin.

• Asian-Australasian Journal of Animal Sciences
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• v.30 no.2
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• pp.236-245
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• 2017

Objective: The study was to investigate the effects of alanyl-glutamine (Ala-Gln) and glutamine (Gln) supplementation on the intestinal mucosa barrier in piglets. Methods: A total of 180 barrows with initial weight $10.01{\pm}0.03kg$ were randomly allocated to three treatments, and each treatment consisted of three pens and twenty pigs per pen. The piglets of three groups were fed with control diet [0.62% alanine (Ala)], Ala-Gln diet (0.5% Ala-Gln), Gln diet (0.34% Gln and 0.21% Ala), respectively. Results: The results showed that in comparison with control diet, dietary Ala-Gln supplementation increased the height of villi in duodenum and jejunum (p<0.05), Gln supplementation increased the villi height of jejunum (p<0.05), Ala-Gln supplementation up-regulated the mRNA expressions of epidermal growth factor receptor and insulin-like growth factor 1 receptor in jejunal mucosa (p<0.05), raised the mRNA expressions of Claudin-1, Occludin, zonula occludens protein-1 (ZO-1) and the protein levels of Occludin, ZO-1 in jejunal mucosa (p<0.05), Ala-Gln supplementation enlarged the number of goblet cells in duodenal and ileal epithelium (p<0.05), Gln increased the number of goblet cells in duodenal epithelium (p<0.05) and Ala-Gln supplementation improved the concentrations of secretory immunoglobulin A and immunoglobulin G in the jejunal mucosa (p<0.05). Conclusion: These results demonstrated that dietary Ala-Gln supplementation could maintain the integrity of small intestine and promote the functions of intestinal mucosa barriers in piglets.

• Journal of Mushroom
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• v.13 no.1
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• pp.50-55
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• 2015

Glucan has been shown to have a significant role in the activation of the immune system, including increased activity of macrophages and so on. Sparassis latifolia (formerly S. crispa) is an edible mushroom abundant in dietary fiber and widely known to contain high levels of ${\beta}$-glucan. In the present study, fermentation broths containing soluble ${\beta}$-glucan were prepared by fermentation with mushrooms with four Lactobacillus species (L. plantarum subsp. Plantarum, L. acidophilus, L. helveticus, and L. delbrueckii subsp. Bulgaricus). After culturing four Lactobacillus spp. in MRS broth, each Lactobacillus was inoculated into MRS broth containing S. latifolia powder 5% (w/v) at $37^{\circ}C$ in an anaerobic incubator for five days. It showed that the ${\beta}$-glucan contents were different in each fermentation sample. The suitable conditions for the preparation of mushroom fermentation broths were investigated and discussed.

• 한국공간정보시스템학회:학술대회논문집
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• 2007.06a
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• pp.268-272
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• 2007

현재 시행되고 있는 하천정비와 하도정비는 하천 흐름의 특성을 간과한 채 일괄적으로 진행되어 왔으며 그 결과로 하천의 인공화는 지금까지 계속되고 있다. 이에 따라 하천 및 하도의 물리, 화학, 생물에 미치는 영향은 심각하며, 그 동안 인위적인 하천교란의 요인과 하천교란에 따른 영향, 즉 하상변동, 외래종 식생 침입, 생태서식처 변화 등의 정량적 평가 기술의 수립은 매우 미흡한 상태이다. 뿐만 아니라 하천 교란 극복을 위한 저감기술, 복원기술 및 적응관리 기술 또한 체계적으로 정리되지 못하여 하천과 댐 관리당국이 어려움을 겪고 있다. 이러한 상황을 극복하기 위해서는 하천 교란에 대항하는 회복관리 기술 개발을 위한 교란 평가 기술이 필요하다. 따라서 본 연구에서는 항공사진 및 GIS기법을 이용하여 국내 주요하천의 원인별 교란실태를 조사하고 분석함으로써 하천교란 조사기술 개발에 응용할 수 있는 방안을 제시하고자 하였다. 분석을 위하여 댐 하류의 하천교란 및 적응현장 시범지역을 선정한 후 대상 지역의 항공사진을 GIS화하여 하천 교란 실태를 분석하는 데에 필요한 자료를 생성하였으며 생성된 자료를 바탕으로 하천의 평면 및 단면의 변화특성을 조사할 수 있었다. 또한 경년별 저수로 형태와 하천 중심선 비교 분석을 통하여 저수로의 이동 및 변화 양상을 규명해 낼 수 있었으며 그 결과 댐 하류지역에서 하도안정문제가 발생하였음을 확인할 수 있었다. 본 연구 결과를 바탕으로 보다 효율적인 하도안정문제에 관한 대책수립이 가능하리라 보며, 이를 위해서는 하천 교란 조사기술 개발에 대한 연구가 뒤따라야 할 것이다.과적임을 알 수 있었다. 실험 결과 본 기법으로 유휴시간에 프로세서를 저전력모드로 바꾸는 기존의 고전적인 전력 관리 기법보다 전체 시스템 전력 소모를 9% 더 절약할 수 있었다. 위성영상과 DEM 개발기술이 87% 이상의 점수를 받아 가장 시장성 및 활용성이 높은 기술로 평가되었으며, 초다분광영상에 대한 기술은 70%를 겨우 넘는 수준에서 평가가 되었다. 멀티센서 공간영상정보 통합처리 기술 개발은 다목적 실용위성의 보유, 국가 NGIS 사업의 결과물이 상당히 축척이 되어 있고, 라이다(LiDAR) 기술의 도입을 위한 환경이 조성되었기에 다른 국가에 비해 멀티센서 기술의 적용과 산업화가 가시화 될 수 있을 것으로 기대된다. 그러나 멀티센서 자료의 수급이 용이하지 못하고, 법 제도적인 한계, 시장의 성숙도가 기대이하라는 점 등의 한계를 노정하고 있다.a var. sieboldii 3. Pinus densiflora, Q. aliena, Q. acutissima, P. thunbergii, Q. acuta 4. Carpinus laxiflora, Camellia japonicas. C. tschonoskii community의 5개 그룹으로 나타났다. 하류의 부착돌말류는 상대적으로 양호한 수질을 가지고 있는 정점 1에서 다양한 생물상을, 탄천의 영향을 받는 정점 2는 상대적으로 수질이 악화되어 호오염성 종들이 높은 분포를 나타내고 있었다. 또한 부착돌말류 중 Cymbella minuta는 다른 부착돌말류에 비해 강한 오염지표성을 나타내고 있었다.p=0.000, $4.76{\pm}3.31$

• Korean Journal of Food Science and Technology
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• v.29 no.1
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• pp.77-81
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• 1997

In order to develop a new type of natural seasoning material combining fish meat with seaweed, a processing method of the mixture of enzyme treated mackerel meat and Laminaria powder was studied. Mackerel meat previously boiled and deboned was treated with proteolytic enzyme to enhance taste of meat by proper hydrolysis. The enzyme-treated meat was dried at $100{\pm}2^{\circ}C$ for 4 hrs, and finally mixed with kelp power, moistened in advance, plus binding agents (0.02% calcium carbonate) to aid the formation of pellets by extrusion. Boiled mackerel meat of enzyme treated (0.03% Protease-A) at $50^{\circ}C$ for 90 min was adequate to result an increase in 6 times of total free amino acid content and about 10% increase of taste-enhancing amino acids such as glutamic acid, glycine, arginine, lysine.

• Journal of Korean Society for Atmospheric Environment
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• v.30 no.6
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• pp.555-568
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• 2014

The construction equipment is one of the major sources for hazardous air pollutants in Korea, and the its management has been of great concern recently. The objective of this study was to estimate each contribution of emission of construction equipments according to their production year, electric power consumption and type. To achieve this goal, we developed pollutant emission factors for the machineries manufactured after 2009, which are excluded from the present framework of Korean air pollutants inventory, CAPSS. More than 800 data obtained from emission investigations were utilized for the estimation. Compared with the previous estimation, the scheme used this study was modified to incorporate new emission factors as well as to include the corresponding activity data. Such improvement allow us to gain more detailed emission informations which are better characterized by specifications of construction equipments. The total amount of pollutants emitted from construction equipments in 2011 were estimated as 126.8, 7.0, 58.3, and 17.0 kton for $NO_x$, PM, CO, and VOC, respectively. The estimation results indicate that the increase in the emission of equipments is significantly related to their age and power consumption. The emissions of the older ones manufactured from 1992~1996 were estimated to be the contribution ranged from 23.7% to 26.8%, whereas the newer ones (2009~2011) showed the attributions of 11.3~21.5%. In addition, the results show that the emission of each equipment was increased with the increase in the electric power consumption of engine, probably due to their average output power. Among the nine types of machinery compared, excavators and forklifts were investigated to contribute relatively higher emissions in the level of 39.8~44.0% and 32.0~34.2%, respectively.