• Archives of Plastic Surgery
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• 제41권5호
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• pp.466-471
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• 2014

Background Bleeding can be a problem in wound debridement. In search for an effective hemostatic agent, we experimented with a chitosan film combined with the recombinant human epidermal growth factor (rh-EGF), hypothesizing that it would achieve effective hemostasis and simultaneously enhance arterial healing. Methods Forty-eight Sprague-Dawley rats were used, and 96 puncture wounds were made. The wounds were divided into the following four groups: treated with sterile gauze, treated with gelatin sponge, treated with chitosan, and treated with chitosan combined with rh-EGF. Immediate hemostasis was evaluated, and arterial healing was observed histologically. Results Groups B, C, and D showed a significant rate of immediate hemostasis as compared to group A (P<0.05), but there were no significant differences among groups B, C, and D. Histologically, only group D showed good continuity of the vessel wall after 1 week. It was the only group to show smooth muscle cell nuclei of the vessel wall. Conclusions We observed that chitosan has an effective hemostatic potential and the mix of rh-EGF and chitosan does not interfere with chitosan's hemostatic capabilities. We also identified enhanced healing of vessel walls when rh-EGF was added to chitosan. Further research based on these positive findings is needed to evaluate the potential use of this combination on difficult wounds like chronic diabetic ulcerations.

• Archives of Reconstructive Microsurgery
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• 제18권1호
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• pp.31-34
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• 2009

Purpose: Merkel cell carcinoma, also called neuroendocrine carcinoma, is a very rare type of skin cancer that develops as Merkel cells grow out of control. Merkel cell carcinoma is reported below 1% of whole skin neoplasms in the United States and is known that the 2-year survival rate is about 50~70%. The principles of treatment are wide excision of primary lesion with radiotherapy and/or chemotherapy that decrease the local recurrent rate. There has been no report of reconstruction with free flap after resection of Merkel cell carcinoma in Korea. Methods: We reconstructed the skin and soft tissue defect after wide excision of Merkel cell carcinoma with anterolateral thigh perforator free flap in two cases. No distant metastasis was found at the preoperative imaging work-up. In one case, preoperative chemotherapy was performed and the size of lesion was decreased. Results: There were no recurrence and significant complications. Functionally and aesthetically satisfactory results were obtained with reconstruction. Conclusion: Wide excision and reconstruction with anterolateral thigh perforator free flap for Merkel cell carcinoma patient is the first report in Korea. We regard this method as the treatment of choice in Merkel cell carcinoma.

• 인터넷정보학회논문지
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• 제15권5호
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• pp.9-16
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• 2014

최근 정보통신 기술과 다양한 스마트 디바이스들의 성능이 빠르게 발전하고 실생활에 적용됨에 따라, 사물인터넷(Internet of things, IoT)의 중요성이 강조되고 있다. 본 논문에서는 IoT 서비스를 프로세스 기반으로 명세하고 이를 실행하기 위한 프로세스 기반 사물인터넷 객체 협업 모델을 제안한다. 즉, 본 논문의 목적은 프로세스 개념을 적용하여 IoT 서비스를 일련의 실행 순서를 가지는 태스크들과 이의 실행을 담당하는 IoT 객체간의 협업으로 정형적으로 명세하기 위한 방법을 제안하는 것이다. 결론적으로 제안 모델을 통해 IoT 서비스는 프로세스 기반 사물인터넷 컴퓨팅 환경에서 자동적으로 실행되며, 이에 대한 분석, 모니터링, 재사용이 가능할 것으로 기대된다.

• 인터넷정보학회논문지
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• 제19권3호
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• pp.25-33
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• 2018

본 논문에서는 클라우드 컴퓨팅 환경을 기반으로 하는 실시간 엔터프라이즈 워크플로우 관리 시스템을 구현하는데 있어서 반드시 수반되어야 하는 워크플로우 모델링 방법론으로서 정보제어넷 기반 클라우드 워크플로우 모델을 제안한다. 본 논문에서 제안하는 모델은 클라우드 서비스 배치모델을 기반으로 하는 클라우드 워크플로우 아키텍처, 즉 조직 수준 클라우드 배치모델, 커뮤니티 수준 클라우드 배치모델, 공적 수준 클라우드 배치모델, 혼합형 클라우드 배치모델 등으로 분류되는 클라우드 배치모델에 따른 클라우드 워크플로우 아키텍처를 지원하는 것을 목적으로 한다. 이 모델은 전통적으로 엔터프라이즈 워크플로우의 대표적인 정형적 모델링 기법인 정보제어넷 모델링 방법론을 클라우드 배치모델과 연계할 수 있도록 확장시킨 수학적 그래프 모델이다. 결론적으로, 본 논문에서는 제안된 정보제어넷 기반 클라우드 워크플로우 모델을 적용할 수 있는 클라우드 워크플로우 아키텍처와 그에 따른 클라우드 워크플로우 서비스를 설계함으로써 제안된 모델의 적용가능성을 검증한다.

• Archives of Reconstructive Microsurgery
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• 제22권1호
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• pp.18-23
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• 2013

Purpose: For reconstruction of lower extremity defects, various flaps can be used and the appropriate flap must be selected and applied according to the size of the defect. In particular, in cases where the defect size is small to moderate, thinner or smaller volume flaps are useful. The authors performed reconstruction of small to moderate defects on the lower extremities using superficial circumflex iliac artery perforator free flaps and are reporting the results. Materials and Methods: Fifteen patients underwent reconstruction of defects on lower extremity areas using superficial circumflex iliac artery perforator free flaps from July 2011 to July 2012 at this hospital. The flaps were elevated from above the deep fat layer, and, in all cases, the vessel diameter of the flaps was less than 1mm, with the exception of superficial vein that accompanied it. Results: The mean follow up period was 4.46 months, and, despite a partial loss in the flap in two cases, there were no total losses. All donor sites were closed with primary closure, and there was no occurrence of complications, such as hematomas, seromas, or lymphorrheas. The patients were highly satisfied with the donor site scar since it could be masked by underwear. Conclusion: Compared to other flaps, superficial circumflex iliac artery perforator free flaps are thinner in thickness and smaller in volume, which results in a more natural contour of the recipient site after the operation. In addition, since the flap can be elevated from supra-deep fat layer, the operation time can be shortened, and lymphorrhea can be prevented, which in turn lessens donor-site morbidity.

• Archives of Reconstructive Microsurgery
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• 제22권1호
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• pp.33-37
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• 2013

Purpose: The concept and development of perforator free flaps have led to significant advances in microsurgery. Ongoing developments in perforator free flap surgery are aimed at reducing complications and improving surgical outcomes. The aim of this study was to evaluate the effectiveness and application of supermicrosurgery in free flap surgery. Materials and Methods: A total of 267 patients with soft tissue defects of the lower extremity due to various etiologies from January, 2007 to January, 2013. The patients received either an anterolateral thigh free flap (n=83), a superficial circumflex iliac artery free flap (n=152), an upper medial thigh free flap (n=19), or a superior gluteal artery perforator free flap (n=13). Microanastomosis was performed using a perforator-to-perforator technique, either end-to-end or end-to-side. Results: The mean postoperative follow up period was eight months (range: one to 16 months) and flap loss occurred in 11 cases out of 267. All cases of flap loss occurred within two weeks of surgery due to either arterial insufficiency (n=5) or venous congestion (n=6). Conclusion: Supermicrosurgery enables the selection of the most efficient perforator for microanastomosis at the defect site. It also reduces the time required for dissection of recipient vessels, and reduces the possibility of injury to major vessels. Microsurgery using a vessel of less than 1 mm has been reported to increase the risk of flap failure; however, using the most advanced surgical tools and developing experience in the technique can produce success rates similar to those found in the literature.

• 약학회지
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• 제52권5호
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• pp.345-354
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• 2008

This study was designed to investigate the anti-diabetic effect and mechanism of Korean red ginseng extract through transcriptomics in C57BL/KsJ db/db mice. The db/db mice were randomly divided into six groups: diabetic control group (DC), red ginseng extract low dose group (RGL, 100 mg/kg), red ginseng extract high dose group (RGH, 200 mg/kg), metformin group (MET, 300 mg/kg), glipizide group (GPZ, 15 mg/kg) and pioglitazone group (PIO, 30 mg/kg), and treated with drugs once per day for 10 weeks. At the end of treatment, we measured blood glucose, insulin, hemoglobin A1c (HbA1c), triglyceride (TG), adiponectin, leptin, non-esterified fatty acid (NEFA). RGL-treated group lowered the blood glucose and HbA1c levels by 19.6% and 11.4% compared to those in diabetic control group. In addition, plasma adiponectin and leptin levels in RGL-treated groups were increased by 20% and 12%, respectively, compared to those in diabetic control. Morphological analyses of liver, pancreas and epidydimal adipose tissue were done by hematoxylin-eosin staining, and pancreatic islet insulin and glucagon levels were detected by double-immunofluorescence staining. RGL-treated group revealed higher insulin contents and lower glucagon contents compared to diabetic control. To elucidate an action mechanism of Korean red ginseng, DNA microarray analyses were performed in liver and fat tissues, and western blot and RT-PCR were conducted in liver for validation. According to hierarchical clustering and principal component analysis of gene expression Korean red ginseng treated groups were close to metformin treated group. In summary, Korean red ginseng lowered the blood glucose level through protecting destruction of islet cells and shifting glucose metabolism from hepatic glucose production to glucose utilization and improving insulin sensitivity through enhancing plasma adiponectin and leptin levels.

• 한국식품과학회지
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• 제19권1호
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• pp.1-4
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• 1987

1984년(年) 5월(月)부터 1985뚜 4월(月)까지 1년간(年間) 천연산(天然産) 잉어 및 붕장어의 계절에 따른 어묵 원료적성(原料適性)을 실험한 결과. 잉어는 일반성분(一般成分)의 계절변화가 거의 없었으며 년중(年中) 어묵의 품질이 모두 양호하였다. 붕장어는 수분과 조지방의 년중(年中) 변화복(變化福)이 각각 $61.0{\sim}76.6%$, $5.4{\sim}20.8%$로써 변화가 컸고 $9{\sim}2$월(月)의 것은 $3{\sim}8$월(月)의 것보다 수분은 적고 지방함량은 많았으며 이 시기(時期)에 어획(漁獲)한것으로 만든 어묵 가공제품(加工製品)은 다른 때의 것보다 품질이 우수하였다. 단백질, 회 및 탄수욕물 함량은 년중(年中)거의 변화가 없었다.

• 한국통신학회논문지
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• 제36권8B호
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• pp.939-946
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• 2011

인터넷 뱅킹 서비스는 기존의 오프라인 서비스에 비해 편리성을 제공하지만, 해킹 등에 보안에 대한 많은 문제점을 가지고 있다. 이에 대해 금융기관은 보안을 강화하기 위해서 공인인증서, 보안토큰, 보안카드 OTP와 같은 인증 방법들을 제공하여 취약점을 보완토록 하였지만, 해킹 사건이 끊이지 않고 발생하고 있다. 특히 기존 인증방법들은 메모리해킹이나 중간자 공격과 같은 해킹에 대해서 취약점이 제기되고 있어, 새로운 인증방법이 필요하게 되었다. 본 논문에서는 인터넷 뱅킹에서 전자금융거래를 할 때 사용자의 PC와 Mobile 기기에서 이중으로 인증을 받는 Two Channel 인증 방식을 제안하고, 기존의 방식들과 비교분석을 통하여 안전성 및 신뢰성 측면이 강화되는 것은 확인할 수 있다.

• 대한두개안면성형외과학회지
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• 제19권3호
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• pp.168-174
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• 2018

Background: Safety, efficacy, and time to onset of effect of botulinum toxin type A is of importance to persons who seek improvement in glabellar frown lines, but this has not been well studied. The aim of this study was to determine the safety, efficacy, and onset of action of a newly developed botulinum toxin type A (Nabota) for the treatment of glabellar frown lines. Methods: This was a single-arm, open-label, and phase 4 clinical study. Forty-two subjects with glabellar lines were treated with five times of intramuscular injection of 0.1 mL (4 U/0.1 mL) for a total of 20 U of Nabota. Efficacy and safety were assessed at 2, 3, 4, 5, and 14 days. Efficacy was assessed by the investigator and it was defined as a 1-point change on a 4-point scale. Results: Improvement in glabellar frown lines at maximum frown was observed in 85.4% of subjects 2 days after administration. Improvement in glabellar lines at rest was observed in 51.2% of subjects 2 days after administration, and the proportion of subjects showing improvement increased with time. No severe adverse events were recorded. Conclusion: Onset of action was observed in the majority of subjects by 2 days after administration of Nabota. In addition, Nabota was found to be safe and effective for the treatment of glabellar frown lines.