• 한국환경보건학회지
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• 제34권1호
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• pp.20-26
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• 2008

The objective of the study which utilised population based data was to determine the respiratory condition of elementary school children in Gangneung. From October 9th to December 14th, 2006, Pulmonary Function Tests (PFT) including Forced Vital Capacity (FVC) and Forced Expiratoy Volume in I Second $(FEV_1)$ were conducted on the target group of children using a spirometer. The prevalence of asthmatic symptoms was 29.8% among boys and 39.6% among girls. By using logistic regression, we found that family history of allergic rhinitis (OR=3.90, CI=1.05-14.51), experience of allergic conjunctivitis (OR=4.67, CI=1.54-14.16) and atopic dermatitis (OR=2.86, CI=1.17-7.05) significantly increased the asthmatic symptoms. Also, a family history of asthma and food allergy were associated with asthmatic symptoms. In relation to housing and environmental risk factors, residences under the ground (OR=3.59, CI=1.35-9.51) and big-size dolls (OR=2.71, CI=0.86-8.53) significantly increased the prevalence of asthmatic symptoms. For PFT, above four families, exposure of passive smoking and pets significantly reduced FVC in both groups (p<0.05). In girls, a big-size doll was significantly associated with decreased lung function (FVC and $FEV_1$). In boys, using bed significantly reduced $FEV_1$. Also, the risk of asthmatic symptoms was found to increase when the house has been built for 5 years or more, the house is close to a road $({\leq}100m)$, a gas/Kerosene heater or carpet is utilized within the house. However, their differences were not significant. It is concluded that genetic factor such as a family history of respiratory disease, allergic symptoms and housing risk factor are related to asthmatic symptoms. These results were worth noting because the findings will help address risk factors related respiratory symptoms especially in relation to housing and environment.

• 한국환경과학회지
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• 제20권7호
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• pp.799-809
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• 2011

Objectives: This study is aimed at identifying the influential factors on the pulmonary function of ordinary residents in the surrounding areas of Yeosu Industrial Complex. Methods: The PFT (Pulmonary Function Test) was conducted on the target residents numbering 989 people (male 361, female 628). The exposed group (813 people) resided within the radius of 5km from Yeosu Industrial Complex and the control group (176 people) resided in the radius of more than 15 km from May 2007 to November 2007. The survey also took into account other factors including personal characteristics, life habits, respiratory diseases and allergic symptoms, medical histories, and the living environments of the residents in order to further identify influential factors on pulmonary function. Result: When comparing the PFT values of the exposure groups to the control group of the same city, values of the exposure groups were meaningfully lower with an %$FEV_1$ of 107.05% and %FVC of 100.28%. Conversely, the control group reported an %$FEV_1$ and %FVC of 107.26% and 102.85% respectively, indicating that ambient air pollutants reduce lung function. The odds ratio of asthma diagnosis history increased when a subjects residence was close to a heavily trafficked road, traffic amount was huge, a bed was used, and the family had less than four members. However the results were not statistically meaningful. The odds ratios of abnormal pulmonary function were statistically higher among those with asthma(OR=4.29, CI=1.75-10.56), wheezing (OR=2.59, CI=1.24-5.41), and nasal congestion (OR=2.87, CI=1.36-6.08) (p<0.01). The factors affecting $FEV_1$ were symptoms including asthma, passive smoking and allergic eye disease ($R^2$=0.049, p<0.001). For the FVC symptoms including asthma ($R^2$=0.014, p<0.001) were measured. The analysis showed that FVC decreased with increases in $O_3$ and CO(p<0.01). Furthermore, $FEV_1$ decreased with increases in $O_3$(p<0.01). Conclusions: These results will provide preliminary data for establishing responsive measures to protect the health of residents in industrial complexes from air pollution, and to develop lasting environmental health policies.

• Toxicological Research
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• 제24권4호
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• pp.273-280
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• 2008

The single intratracheal instillation (ITI) of bleomycin (BLM) is a widely used method for inducing experimental pulmonary fibrosis in rat model. In the present study, pulmonary function tests (PFTs) of tidal volume ($V_T$), minute volume ($V_M$), and respiratory frequency ($F_R$) have been applied to study their possibility as a tool to monitor the progress of BLM-induced lung injury in rat model. Rats were treated with a single ITI of BLM (2.5 mg/kg) or saline (control). Animals were euthanized at 3, 7, 14, 21, and 28 days post-ITI. Lung toxicity effects were evaluated by inflammatory cell count, lactate dehydrogenase (LDH) activity in the bronchoalveolar lavage fluid (BALF), and light microscopic examination of lung injury. The PFT parameters were measured immediately before the animals were sacrificed. BLM treatment induced significant cellular changes in BALF-increase in number of total cells, neutrophils, and lymphocytes along with sustained increase in number of macrophages compared to the controls at days 3, 7, and 14. BALF LDH level was significantly increased compared to that in the controls up to day 14. On day 3, infiltration of neutrophils was observed in the alveolar spaces. These changes developed into marked peribronchiolar and interstitial infiltration by inflammatory cells, and extensive thickening of the interalveolar septa on day 7. At 14, 21, and 28 days, mild peribronchiolar fibrosis was observed along with inflammatory cell infiltration. The results of PFT show significant consistencies compared to the results of other toxicity tests. These data demonstrate that the most suitable time point for assessing lung fibrosis in this model is 14 days post-ITI of BLM based on the observation of fibrosis at 14, 21, and 28 days. Further, the progress of lung injury can be traced by monitoring the PFT parameters of $F_R$, $V_T$, and $V_M$.

• 디지털융복합연구
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• 제15권5호
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• pp.263-269
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• 2017

폐기능검사는 호흡기 질환을 진단하는 검사방법으로 정확한 검사 결과를 얻기 위해서는 환자의 이해와 협조가 절대적으로 필요하다. 본 연구는 폐활량검사에서 환자의 이해도와 자세의 중요성에 대하여 실험하였다. 2016년 110명의 건강한 사람을 대상으로 1) 검사자의 설명만으로, 2) 동영상 상영과 검사자의 시연 후, 3) 자세에 제한을 주기 위하여 다리를 꼰 후 어깨를 구부린 상태로 측정하였다. 폐활량 검사기기를 이용하여 FVC, $FEV_1$, $FEV_1/FVC$, $FEF_{25-75%}$, PEF를 측정하였다. 대상자가 검사방법을 이해하기 전과 후의 FVC, $FEV_1$, $FEV_1/FVC$, $FEF_{25-75%}$, PEF가 유의적으로 증가하였다. 잘못된 자세에서 검사 시 FVC, $FEV_1$, PEF의 유의적으로 차이가 있었다. 재현성은 대상자의 이해도와 자세이상에서, 적합성은 자세이상에서 유의적인 차이를 보였다. 폐기능 검사의 정확한 결과를 도출해 내기 위해서는 검사 시 환자의 정확한 이해와 올바른 자세를 유지하여야 신뢰할 수 있는 결과를 얻을 수 있을 것이다.

• 대한한방내과학회지
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• 제24권1호
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• pp.1-10
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• 2003

Background : In recent years, the glucocorticoid hormone has become a fundamental medication for asthma. However, a long period of hormone administration will result. in general. side effects on many body parts as well as hormone dependence, which has become a serious problem for western physicians. Objectives : We aimed to identify the clinical effects of Cheongsanghoha-tang and the steroid sparing effects of Cheongsanghoha-tang on. Materials and Methods : A subject group consists of 36 asthmatics who had been treated with Cheongsanghoha-tang for four weeks. Cheongsanghoha-tang is a herbal decoction, which has been used of the traditional therapeutic agent of asthma. PFT, QLQAKA, blood eosinophil, serum IgE, Serum IL-4. IL-5, IFN-${\gamma}$ were checked before and 4weeks after the treatment. Results : The only FVC% in ICSG among asthmatic patients was increased significantly compared to NICSG. Treatment of Cheongsanghoha-tang for four weeks resulted in significant increase in QLQAKA. The NICSG treated with Cheongsangboha-tang for four weeks were no significant difference in the blood eosinophil, serum IgE, IL-4 and IL-5. The PFT and QLQAKA in NICSG were increased significantly after 4 weeks treatment. But the serum IFN-${\gamma}$ in NICSG was decreased significantly after 4 weeks treatment. Discontinuation of treatment with inhaled corticosteroid in ICSG resulted in insignificant changes in PFT, the blood eosinophil, the serum IgE, IL-4, IL-5 and IFN-${\gamma}$ and significant increase in QLQAKA. As a result. 8 of 13 cases were cured with hormones completely and the rest of ICSG reduced the dose of ICS. Conclusions : This study shows that Cheongsanghoha-tang has the effects on the improvement of pulmonary function and cures asthmatic patients. These findings demonstrate that Cheongsanghoha-tang has the steroid sparing effect. Some satisfactory therapeutic results have been obtained in treating hormone-dependent asthma by Cheongsanghoha-tang. However. the concept and mechanism of hormone-dependent asthma have not been fully defined yet, and the standard for judging therapeutic effects have not been established. Obviously further researches concerning all these are still necessary.

• 대한한의학회지
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• 제23권3호
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• pp.96-103
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• 2002

Objectives : Dyspnea is one of the most common symptoms that we meet, but so far there has been no research about the effects of acupuncture therapy on it. This study was performed in order to evaluate the effect of acupuncture therapy on dyspnea by means of using objective indexes. Methods : The effect of acupuncture therapy was assessed by analyzing the pulmonary function test (PFT) in 10 patients, who had suffered from dyspnea and had pain at the acupuncture point Tian-zong (SI11) when it was compressed by a finger, at our outpatient department. Each patient was treated with acupuncture therapy at both sides of Tian-zong. We compared the results of pre-treatment and post-treatment PFTs, including forced vital capacity (FVC), forced expiratory volume in one second (FEV 1.0), and peak expiratory flow rate (PEFR). Results : FVCs of pre-treatment and post-treatment PFTs were $2.23{\pm}0.34(L)$ and $2.40{\pm}0.36(L)$ respectively (P<0.01). FEV1.0s of pre-treatment and post-treatment PFTs were $1.54{\pm}0.37(L)$ and $1.65{\pm}0.41(L)$ respectively (p<0.05). PEFRs of pre-treatment and post-treatment PFTs were $3.41{\pm}1.26(L)$ and $3.93{\pm}1.42(L)$ respectively (p<0.05). Conclusions From the above data, we conclude that FVC, FEV1.0, and PEFR in dyspneic patients have been improved after acupuncture therapy of Tian-zong, so acupuncture therapy of Tian-zong may relieve the dyspnea symptom.

• 대한한의학회지
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• 제25권2호
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• pp.110-118
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• 2004

Objectives : Based on the changes of quality of life and pulmonary function test, we aimed to identify the effects and side-effects of Gamichuongsangboha-tang and in asthmatic patients. Methods : The subjects consisted of 30 patients with asthma who were treated with Gamichuongsangboha-tang extract for four weeks. Gamichuongsangboha-tang extract is the extracted powder form of the modified herbal decoction Chuongsangboha-whan, which has been used as the traditional therapeutic agent for asthma. Pulmonary function test (PFT) was checked before and after 4 weeks of treatment. Quality of Life QuestionnaireQ for Adult Korean Asthmatics (QLQAKA) was checked before and after 2 and 4 weeks of treatment. Unpleasant symptoms were checked in all patients at 2 weeks and 4 weeks from the beginning of treatment. Results : Treatment with Gamichuongsangboha-tang extract for four weeks resulted in significant increase in $FEV_{1.0}%$, PEFR%, and QLQAKA. The total efficacy rate of QLQAKA in the patient group was 53.3% after 4 weeks. The QLQAKA of the step 2, step 3, and step 4 groups (n=18, 55.6%) classified by global initiative for asthma (GINA) consistently increased, and significant improvement of QLQAKA occurred in the step3 group. In the step 4 group, FEV1.0%, and PEFR% were significantly increased. A total of 15 patients experienced unpleasant symptoms during the first 2 weeks of treatment, but these symptoms disappeared in all but 2 cases with no need of further treatment during the 2nd 2-week period. Conclusions : This study shows that Gamichuongsangboha-tang extract has effects on improvement of pulmonary function and quality of life, especially in persistent symptomatic asthmatics. Obviously further study concerning all these is still necessary.

• 대한한의학회지
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• 제41권3호
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• pp.162-172
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• 2020

Objectives: The purpose of study was to report the clinical improvement of Chronic Obstructive Pulmonary Disease (COPD) patients treated with Korean medicine pulmonary rehabilitation. Methods: The patients were treated with Lung-conduction exercise, Chuna manual therapy, Exercise therapy. To assess the treatment outcomes, we used the pulmonary function test (PFT), modified medical research council scale (mMRC), 6-minute walk distance (6MWD), peak expiratory flow rate (PEFR), COPD assessment test (CAT), St. George respiratory questionnaire (SGRQ). Results: After treatments, the patient's clinical symptoms were improved with CAT, SGRQ's significant decrease and PFT, mMRC, 6MWD and PEFR were maintained or improved slightly. Conclusions: The Korean medicine pulmonary rehabilitation was effective in the treatment of COPD patients. This study suggested the possibility of Korean Medicine pulmonary rehabilitation program in the clinic.

• 동의생리병리학회지
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• 제23권2호
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• pp.505-511
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• 2009

The purpose of this study is to evaluate the difference about pathogenesis of smoker and non-smoker. Author used DSOM to investigate oriental pathogenesis. Smoke group is consisted of people who have history of smoke, and they don't have history of lung disease(Athma, tuberculosis, COPD, suchlike). Non-smoke group is consisted of people who have no history of smoke and they also don't have history of lung disease. Author carried out each group's PFT(Pulmonary Function Test) by AST(American Thoracic Society) method. DSOM was used for pathogenesis investigation of two groups. There was significant difference between smoke group and non-smoke group in FVC (p<0.05), and In non-smoke group, there was significant difference between male and famale in FVC, FVC%, FEV1, FEV1%. There was significant difference between smoke group and non-smoke group in Heat(熱), Cold(寒)(p<0.05). In Male grouop there was significant difference between smoker and non-smoker in deficiency of Deficiency of Yin(陰虛), Heat(熱). In non-smoke group comparison of sex, there was significant difference between male and female in Deficiency of blood(血虛), dampness(濕)(p<0.05). This result showed that the difference of pathogenesis between smoke group and non-smoke group.

• 동의생리병리학회지
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• 제23권3호
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• pp.723-733
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• 2009

The purpose of this study is to evaluate the difference about pathogenesis of normal group and depression group(who' pulmonary function is below expected value). Author used DSOM to investigate oriental pathogenesis. Depression group is consisted of people who's FVC%(forced vital capacity)is below 80% or $FEV_1$/FVC%(Forced Expiratory Volume in 1sec/FVC) is below 70%, and they don't have history of lung disease(Athma, tuberculosis, COPD, suchlike). Normal group is consisted of people who's FVC%(Forced Vital Capacity) is in 80-120% and $FEV_1$/FVC%(Forced Expiratory Volume in 1sec/FVC) is above 70%. they also don't have history of lung disease. Author carried out each group's PFT(pulmonary function test) by ATS(American Thoracic Society) method. DSOM was used for oriental pathogenesis investigation of two groups. There was significant difference between normal group and depression group in Kidney(p<0.05). In depression group comparison of sex, there was significant difference between male and female in stagnation of qi, cold, heat, spleen, phlegm(p<0.05). In Normal group there was significant difference between male and female in stagnation of qi, blood stasis, cold, heat, spleen(p<0.05). In depression group comparison of smoke, there was no significant difference between smoker and non-smoker(p<0.05). In Normal group comparison of smoke, there was significant difference between smoker and non-smoker in heat(p<0.05). This result showed difference of the pathogenesis between Depression group and Normal group.