• The Journal of Pediatrics of Korean Medicine
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• v.26 no.1
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• pp.36-45
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• 2012

Objectives Perillae Folium (PF) has been widely used in Korean herbal medicines used for treatment of acute and chronic inflammatory diseases, such as rhinitis, asthma, and enteritis. In this study, to investigate the protective effect of PF on type 1 allergic response, we determined whether PF inhibits early or late allergic responses. Methods The effect of PF was analyzed by ELISA,. RT-PCR and Western blot in RBL-2H3 cells. Levels of ${\beta}$-hexosaminidase, interleukin (IL)-4 and TNF-${\alpha}$ were measured using enzyme-linked immunosorbent assays (ELISAs). mRNA levels of cytokines and enzymes were analyzed with RT-PCR. Signal transduction was analyzed with Western blot. Results We found that PF suppressed ${\beta}$-hexosaminidase release in RBL-2H3 by the IgE-DNP-HSA stimulation. PF also significantly inhibited enzymes level, such as COX-1, COX-2, iNOS, and HDC2, along with reduced cytokine levels, such as IL-2, IL-3, IL-4, IL-6, IL-13, and TNF-${\alpha}$ in RBL-2H3. In addition, PF suppressed the phospholyation of ERK1/2, JNK1/2, and $I{\kappa}B{\alpha}$. Conclusions Our results indicate that PF protects against type 1 allergic response and exert an anti-inflammatory effect through the inhibition of degranulation and expression of cytokines and enzymes via the suppression of signal transduction.

• Asian-Australasian Journal of Animal Sciences
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• v.11 no.3
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• pp.234-238
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• 1998

Two experiments were conducted with broiler chickens to determine cage floor preferences, the strength of preference for a particular floor type and to evaluate the effect of rearing broilers on the preferred cage floor on productivity. In experiment 1, chicks when offered free access to either wire (WF) or plastic (PF) mesh flooring, preferred the former. However, when the perferred floor type (WF) was illuminated at 800 lux, birds spent longer time on PF. Also provision of incandescent lamps at PF resulted in broilers spending significantly longer period on WF. In experiment 2, while floor type had no effect on growth of female chicks throughout the duration of study, male chicks grown on PF were heavier than their WF counterparts on Days 21, 28, 35 and 42. Neither livability, nor incidence of breast blisters and leg deformities was affected by floor type.

• Proceedings of the SAREK Conference
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• 2008.11a
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• pp.525-530
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• 2008

In the present study, the cooling performances of the air-conditioner applied the fin-tube and aluminum PF heat exchangers have been experimentally investigated by using the calorimeter. The experiment is carried out in the conditions of the standard temperature and the low temperature. Fin type of PF heat exchanger is a triangler and squarer form. PF heat exchanger has smaller refrigerant weight and larger capacity and COP han the fin-tube heat exchanger. The performance of PF-2 heat exchanger with the squarer in is more excellent than that of PF-1 heat exchanger with the triangler fin. The high pressure of PF heat exchanger decreases about 7%, compared to the fin-tube heat exchanger. Also, CSPF of the fin-tube and PF heat exchanger is evaluated.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.25 no.9
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• pp.516-521
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• 2013

In the present study, the performances of a fin-tube evaporator and three PF evaporators for a heat pump dryer were experimentally investigated. Among the tested evaporators, the PF3 type evaporator showed the highest values of heat transfer capacity and dehumidification performance, while the fin-tube evaporator had the lowest values. PF3 showed better performance compared to PF1 and PF2, due to the large pin pitch, which leads to more draining for dehumidified water. Also, the $45^{\circ}$ inclined PF evaporator presented better performance than that of the $90^{\circ}$ inclined PF evaporator, owing to its easier draining characteristics. The effect of air velocity was revealed to be quite large. When the air velocity increased by 20%, the heat transfer capacity and dehumidification performance increased 43%/11%, 48%/13% and 54%/23% for PF1, PF2 and PF3, respectively.

• Clinical and Experimental Reproductive Medicine
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• v.26 no.3
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• pp.331-338
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• 1999

The purposes of this study were to evaluate the effects of insulin-like growth factor (IGF)s in peritoneal fluid (PF) from patients with and without endometriosis on the proliferation of endometrial stromal cells and to investigate the effects of type I IGF receptor antibody on the response of endometrial stromal cells to PF from patients with endometriosis. IGFs in PF from patients with endometriosis (n=14) and without endometriosis (n=10) were measured by immunoradiometric assay and PF samples were divided into low IGF-I PF group (less than 85 ng/ml) and high IGF-I PF group (more than 85 ng/ml). Endometrial stromal cells from patients without endometriosis were cultured in serum free media in the presence or absence of 1 % PF and thymidine incorporation test were used to evaluate the proliferation of endometrial stromal cells. Also cultures were incubated with type I IGF receptor monoclonal antibody (${\alpha}IR_3$) before adding PF. PF from patients with endometriosis and without endometriosis increased thymidine incorporation in endometrial stromal cells. In patients with endometriosis, high IGF-I PF group had high IGF-II levels and resulted in higher thymidine incorporation than low IGF-I PF group but no significant difference in increase in thymidine incorporation between high IGF-I and low IGF-I PF group was noted in patients without endometriosis. There was not a significant correlation between increase in thymidine incorporation and IGF-I levels in PF from patients without endometriosis but in PF from patients with endometriosis. Preincubation with ${\alpha}IR_3$ significantly inhibited the mitogenic response of endometrial stromal cells to PF. Our data indicate that IGF-I in PF may be involved in the growth of ectopic endometrium in patients with endometriosis.

• Applied Chemistry for Engineering
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• v.17 no.4
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• pp.357-360
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• 2006

In this study, we studied the physical properties and application of PF foam as heat insulating materials. In the experimental results, the density of PF foam showed $0.030g/cm^3$ and the thermal conductivity showed $0.026kcal/m.h.^{\circ}C$. Also, thermal resistance of the prepared PF foam was volatilized about 71.7 wt% when the temperature was $500^{\circ}C$ (1 h). And the chemical structure of PF foam have a closed cell type in the important properties as heat insulating materials. Therefore, it was confirmed that the prepared PF foam had excellent performance as heat insulating materials.

• Applied Chemistry for Engineering
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• v.16 no.2
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• pp.288-291
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• 2005

Resol type phenol-formaldehyde (PF) resin was synthesized by addition reaction of formaldehyde (F) and phenol (P). And the PF resin was synthesized by condensation reaction in which water was removed. In this work, we studied the influence of experimental parameters in the addition reaction, such as F/P mole ratio, amount of catalyst, reaction temperature, reaction time, and so on. Also, we studied the influence of molecular weight and viscosity of PE resin as a function of condensation time. As a result, in addition reaction, the reaction time decreased remarkably as the catalyst concentration increased, and the time decreased with increasing reaction temperature at a constant catalyst concentration. Also, in condensation reaction, the viscosity of resol type PF resin increased from 1500 to 9000 cps as a function of condensation time; molecular weight showed from 500 to 1100 g/mol.

• Korean Journal of Construction Engineering and Management
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• v.15 no.5
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• pp.127-137
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• 2014

Project Financing (PF) development project is the type which influences national economy and building industry largely because it is exerted by using borrowed money from many kinds of investors and huge amount of financial raising. Many domestic PF projects are focused mainly on the profit maximization lacking in a sufficient feasibility study. Nowadays many projects are suspending due to the global finance debacle and stagnation of real estate industry. Therefore, in this paper, risk factors of PF project are deducted and Key Success Factors (KSFs) are derived through Factor-Analysis and qualified using Fuzzy-AHP method. And through the evaluation of the derived success factors in real projects, a strong correlationship has been identified between the score of each PF success factor and the level of success and/or expected rate of return (ROR). So, the result of this paper can help decision makers of the PF projects make a better decision and give a meaningful guidance in achieving successful PF projects.

• Journal of Radiation Industry
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• v.6 no.2
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• pp.181-188
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• 2012

A mushroom mutant with increased cellulolytic activity was developed through radiation mutagenesis. The homogenized hypha suspension of Pleurotus florida was exposed to gamma radiation ($^{60}Co$, AECL) at the dose of $LD_{99}$ (0.51 kGy, $D_{10}$; 0.26 kGy). Among 16 mutants, Pf CM4 showed 17.24% more cellulolytic activity than the wild type (p<0.05). It was observed that Pf CM4 can utilize all kinds of carbon sources tested for their mycelia growth. Starch, xylan, and glucose favourably supported the radial mycelia extension. Yeast extract and $NH_4NO_3$ have been recorded as the best organic and inorganic nitrogen sources, respectively. Pf CM4 was found to grow significantly faster, even at high temperature ($30^{\circ}C$), than wild type (p<0.05), and the optimal pH was 5.5~6.5. This study reveals that the mutant Pf CM4 could be employed for the effective recycling of cellulosic wastes, in addition to mushroom farming.

• Nutrition Research and Practice
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• v.12 no.1
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• pp.20-28
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• 2018

BACKGROUND/OBJECTIVES: Perilla frutescens (L.) Britton var. (PF) sprout is a plant of the labiate family. We have previously reported the protective effects of PF sprout extract on cytokine-induced ${\beta}-cell$ damage. However, the mechanism of action of the PF sprout extract in type 2 diabetes (T2DM) has not been investigated. The present study was designed to study the effects of PF sprout extract and signaling mechanisms in the T2DM mice model using C57BL/KsJ-db/db (db/db) mice. MATERIALS/METHODS: Male db/db mice were orally administered PF sprout extract (100, 300, and 1,000 mg/kg of body weight) or rosiglitazone (RGZ, positive drug, 1 mg/kg of body weight) for 4 weeks. Signaling mechanisms were analyzed using liver tissues and HepG2 cells. RESULTS: The PF sprout extract (300 and 1,000 mg/kg) significantly reduced the fasting blood glucose, serum insulin, triglyceride and total cholesterol levels in db/db mice. PF sprout extract also significantly improved glucose intolerance and insulin sensitivity, decreased hepatic gluconeogenic protein expression, and ameliorated histological alterations of the pancreas and liver. Levels of phosphorylated AMP-activated protein kinase (AMPK) protein expression also increased in the liver after treatment with the extract. In addition, an increase in the phosphorylation of AMPK and decrease in the phosphoenolpyruvate carboxykinase and glucose 6-phosphatase proteins in HepG2 cells were also observed. CONCLUSIONS: Our results sugges that PF sprout displays beneficial effects in the prevention and treatment of type 2 diabetes via modulation of the AMPK pathway and inhibition of gluconeogenesis in the liver.