• Journal of Preventive Medicine and Public Health
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• v.27 no.4 s.48
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• pp.793-805
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• 1994

Investigating the existence of volume-outcome relationships for specific disease groups relates directly to the policy issue of whether, and how, specific inpatient services should be regionalized. This study examined whether medical costs and lengths of stay as outcomes were affected by changes in volume within hospitals. Based on the claims data obtained from National Federation of Medical Associations, each six disease categories from medical and surgical conditions were selected and 29,720 cases from 1,266 hospitals were analyzed. Main findings of the research can be summarized as follows: 1. Analyzing volume and cost per case relationship, tonsillectomy class 1, hernia procedure class 0, appendectomy and cesarean section class 0,1 in surgical conditions showed negative relationship significantly. In cases of medical conditions, costs per case in respiratory neoplasm class 2, COPD class 1, 2, digestive malignancy were also related to volume negtively. 2. Comparing volume with length of stay per case, lens procedure class 0, hernia procedure class 0, appendectomy class 0,1, cesarean section class 1 in surgical conditions showed negative relationships significantly. In medical conditions, volume of respiratory neoplasm class 2, COPD class 1,2, digestive malignancy class 0 were associated with negatively. 3. Within same disease categories, changes in cost and length of stay per case to volume were more remarkable in severe cases. These results suggested a significant inverse relationship between disease cases and cost, length of stay per case as outcome variables.

• Journal of The Korean Society of Grassland and Forage Science
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• v.14 no.1
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• pp.1-6
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• 1994

This experiment was carried out to study the effect of cutting frequencies(2, 3: one time grazed after 2 cuts, 3, 4, 6 cuts per year) and nitrogen fertilization(0 and 120 kg per ha and year) on botanical composition of permanent grassland at the "Federal Research Institute for Agriculture in Alpine Regions(Gumpenstein)," Austria The results are summarized as follows: 1. With only fertilizing phosphorus(P) and potassium(K),mean annual dry matter yields were 6.9 - 8.4 ton per ha and highest when only one time grazed after 2 cuts, but fell progressively with increase in cutting frequency and additonal fertilization of nitrogen. The average nitrogen efficiences expensed as dry matter yieldsfig) per feltilized nitrogenfig per ha) were 10.3 kg. 2. When N fertilizer was applied, the proportion of tall and medium grasses in the mixed swards increased by 30 - 50% compared with only fertilizing PK. Whereas swards with fertilizing only PK generally stimulated composition of the legumes at the expense of the grasses(30 - 50%). 3. Although the proportion of tall and medium grasses(Trisetum flavescens and Dachlis glomerara) and tall herbs(hntodon hispidus, Taraxacum oflcinale and Aegopodium podagraria) increased by infrequent cutting, frequently cutting plots helped increase the proportion of short grasses(Poa pratensis and Poa trivialis), especially where plots both had been applied with nitrogen fertilizer. 4. Nitrogen fertilization resulted in higher existence of herbs and weeds such as Taramcum oficinale. Aegopodium podagraria, Galium mllugo, Anthriscus silvestris and Lamium album. 5. Due to unusually high or low cutting frequencies such as 4 cuts or 2 cuts per year increased botanical compostion of Heracleum sphondylium.hondylium.

• BMB Reports
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• v.46 no.12
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• pp.600-605
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• 2013

Interplay between calcium ions ($Ca^{2+}$) and reactive oxygen species (ROS) delicately controls diverse pathophysiological functions of vascular smooth muscle cells (VSMCs). However, details of the $Ca^{2+}$ and ROS signaling network have been hindered by the absence of a method for dual measurement of $Ca^{2+}$ and ROS. Here, a real-time monitoring system for $Ca^{2+}$ and ROS was established using a genetically encoded hydrogen peroxide indicator, HyPer, and a ratiometric $Ca^{2+}$ indicator, fura-2. For the simultaneous detection of fura-2 and HyPer signals, 540 nm emission filter and 500 nm~ dichroic beamsplitter were combined with conventional exciters. The wide excitation spectrum of HyPer resulted in marginal cross-contamination with fura-2 signal. However, physiological $Ca^{2+}$ transient and hydrogen peroxide were practically measurable in HyPer-expressing, fura-2-loaded VSMCs. Indeed, distinct $Ca^{2+}$ and ROS signals could be successfully detected in serotonin-stimulated VSMCs. The system established in this study is applicable to studies of crosstalk between $Ca^{2+}$ and ROS.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.28 no.2
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• pp.216-226
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• 1983

Genetic studies on the $F_2$ generation of a set of half diallel crosses involving six cowpea varieties were conducted. by the randomized block design with three replications to determine combining ability, gene action and the relationships between parents and their $F_2$ hybrids. The 12 agronomic characters namely, days to flowering, days from flowering to maturity, days to maturity, diameter of stem, length of internode, number of branches per plant, length of pod, number of pods per plant, number of grains per pod, number of grains per plant, 100 grain weight and grain weight per plot were observed, and the $F_2$ generation of this diallel set of crosses was analysed for each character according to the method by Jinks and Hayman. The results obtained are summarized as follows: 1. Vr-Wr graphical analyses; The following seven characters, days to flowering, number of branches per plant, length of pod, number of pods per plant, number of grains per plant, 100 grain weight and grain weight per plot appeared to be partially dominant, and over dominance was found for days from flowering to maturity, days to maturity, length of internode and number of grains per pod. But diameter of stem indicated partial dominance near complete dominance. 2. Estimates of genetic variance components; In the degree of dominance,. eight characters, that is, days to flowering, days from flowering to maturity, days to maturity, length of internode, number of pods per plant, number of grains per pod, number of grains per plant and grain weight per plot were expressed larger than 1. And the characters, days from flowering to maturity, number of branches per plant and number of grains per plant as the degree of mean dominance ($H_1$/D) were found to be negative value over other characters. On the other hand, apprent asymmetry of dominance-recessive allele ($H_2$ /$4H_1$) produced comparatively estimates with lower value on days from flowering to maturity, length of internode, number of branches per plant and number of grains per pod. 3. Analyses of combining ability; Mean square value of GCA(general combining ability) appeared to be more important than those of SCA (specific combining ability) for most characters, and among them, grain weight per plot showed the highest mean square value in GCA and SCA. 4. Effect of combining ability; Variety 178 was expressed as the highest GCA effects in five characters (days to flowering days to maturity, number of pods per plant, number of grains per plant and grain weight per plot). SCA effects were differed from parents, characters and crosses, but crosses between TVu 1857 $\times$ TVu 2885 and TVu 2702 $\times$ J78 were shown to be highly with SCA effects on yield.

• Journal of Bio-Environment Control
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• v.16 no.1
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• pp.62-66
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• 2007

This study was carried out to develop the stable plug seedling production for hydroponics of spinaches by various nursery media, plug tray size and seed number per plug tray cell. When plant grown in various nursery media, the seeding stand rate was shown in order of granular rockwool with good water retention, granular rockwool>granular rockwool mixed with pearlite>cocopeat>pearlite>poly urethane foame. Thus, poly urethane foame indicated the lower seedling stand rate. There was no difference in growth of the seedlings md the seeding stand rate by the plug tray size, and no significant difference in the plant height and the number of leaves among the seed number per plug tray cell. But, leaf area of plant in 2 grains seeding per cell was $113.0cm^2$, was wider in compared with 5 grains seeding of which leaf area was $88.0cm^2$. Accordingly, the leaf area per plant decreased as more and more the number of seeds per plug tray cell increased. The fresh weight of a plant per plug tray cell was the heaviest with 12.5g in the 2 grains, and the total fresh weight of plants per cell was 33.9g in 4 grains seeding, thus it tended to was bigger compared with other treatments. Consequently, given that the number of seeds per cell was decreased, the fresh weight of a plant increased. On the other hand, the total fresh weight per cell showed a tendency to be reducing as more and more the number of seeds per plug tray cell decreased. The yield in the 4 grains seeding was increased by 46% as $14,910kg{\cdot}ha^{-1}$ in compared with the yield in 2 grains seeding as $10,200kg{\cdot}ha^{-1}$.

• Development and Reproduction
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• v.8 no.1
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• pp.57-64
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• 2004

This study was carried out to examine the expression of the circadian clock genes in the mouse ovary and testis at different developmental stages. Expression of Period1(Per 1), Period2(Per2), Period3(Per3), Cryptochrome1(Cry1), Cyptochrome2(Cry2), Clock Small and Prokineticin1 and Prokineticin2 receptor(Prok1r, Prok2r) genes in mouse ovary was explored by semiquantitative reverse transcription Polymerase chain reaction(RT-PCR) according to the developmental stage(post partum day; ppd 1, 7, 10, 21 and 35). Immunohistochemistry using PER1 antibody was also analyzed. The differential expression pattern of clock genes was presented according to stages of the mouse ovarian development (ppd 1, 7, 10, 21 and 35). In the cases of ovaries, at the starting point of follicle growth at ppd 7 and 10, the clock gene expression patterns were changed vastly. According to the developmental stages, the clock genes were highly expressed at ppd 7 and 10 in mouse testis also. Receptors for Prok2, the circadian output molecule of SCN, were also expressed in ovary at ppd 7 and in testis at ppd 1 and 7, respectively. Immnunohistochemical analysis of PER1 showed positive signals in the cytoplasm of oocytes and granulosa cells. The level or PER1 expression was increased in cells at the spermatogonia and the condensing spermatids. The expression pattern of Perl and localization of PER1 were showed similar patterns according to the developmental stages in ovary and testis. Taken together, it could be observed that the expression of clock genes was highly correlated with gonadal development and germ cell differentiation in mice. Therefore, in this study, circadian programming of the genes in the ovary and testis is strongly imposed across a wide range of core reproductive cycles and normal development of gametes. Although the existence of circadian genes is clearly investigated, further studies on the direct evidence is required for the understanding of the relationship between circadian genes and regulation of gonadal differentiation and germ cell development.

• Journal of Plant Biology
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• v.12 no.2
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• pp.28-42
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• 1969

Field studies were conducted with the split plot design of 20 treatment with a combination of 4 levels of 3, 5, 7 and 9 plants per hill and 5 levels of 60, 80, 100, 120 and 140 hills per 3.3$m^2$ on non-, low- and high-salty areas. Rice variety, Kusabue was grown under jthe standard fertilization and cultivating. Investigation was made on the productive structure of plant population, leaf-area index, light intensity curve by stratum of crop population at the panicle differentiation stage. The competition density effect on the photosynthetic capacity was low as the salt concentration became higher. This seemed to suggest the possiblity of an increased yielding capacity by closer planting in the salty areas. The effect of an increased number of hills per unit area was greater than that of an increased unmber of plants per hill due to the total leaf area and space distribution of the actie assimilation parts of rice plants. The number of ppanicle per unit area in the salty areas were increased when the number of hill per 3.3$m^2$ increased over an increased number of plants per hill, and the panicle weight was reduced by close planting in the non-lalty area, while it was not reduced so much in the salty areas. The number of grains per panicle was significantly decreased by close planting in the salty areas as in the non-salty area, and ratio of matured grain was not decreased even by close planting in the salty areas, while it was significantly decreased by close planting in the non-salty area. An increase in the rice yield was possible by close planting and greatly related to leaf area index in the salty areas but not in the non-salty area. Increasing the number of hills per unit area showed greater effect on the increase of the rice yield than an increased number of plants per hill in the salty areas. Relationships between the growth characteristics and the rice population affected by plant spacing mode for maximum production were discussed.

• The Korean Journal of Emergency Medical Services
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• v.8 no.1
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• pp.199-210
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• 2004

Since the 119 fire department was legally permitted to serve in Emergency Medical Service(EMS)Operation of emergency patients in 1983, 119 EMS operation in general has made a big progress in serving the needs for emergency patients. Currently EMS operation is carried out by 119 EMS unit, private ambulance Co.,etc. But due to the public recognition and volunteers, 119 EMS operation carries the major share of the service. This observation is not surprising in that such a trends occured in Japan 20 years ago. This paper compared the 119 EMS operation conducted by the fire department in Korea with that of Japan in order to draw some inferences from the comparison. The results of the study compared to Japan were as follows: 1. Japan was higher 1.5 times in the number of EMS units per population(100,000), 1.1 times in the number of patient transports per unit. 2. Japan was higher 4.54 times in the number of the 119 EMS personnel per population(100,000), 30.6 times in that per square killometers, 30.6 times per 119 EMS unit, in per ambulance 2.48times. 3. Japan was higher 1.83 times in the number of ambulance per population(100,000), 1.26 times in that per square killo meters. 4. Japan was higher 1.7 times in the number of transport patients per population (100,000), but Korea was higher 2.68 times in the transport patients per EMS personal. 5. Compared to Japan, there was no emergency care related to ALS, for example, such as administering dugs orally and intravenously, interpreting elctrocardiograms, performing endotracheal tube or LMA insertion, using monitors and other complex equipments in Korea.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.14 no.1
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• pp.111-120
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• 1984

The author analyzed clinically and radiologically 319 radicular cysts which were proven histologically in Infirmary College of Dentistry Yonsei University and Seoul National University Hospital from 1965 to 1983, and which occurred in 167 males and 139 females between the ages of 6 and 70. This analysis was undertaken to discover the frequency and distribution of the radicular cysts with regard to the age and sex, the chief complaints of the patients, the regions, the radiographical appearances, the tooth changes, and the anatomical structures involved by the lesions. The obtained results were as follows: 1. The most frequently involved age group for the radicular cysts was the third decade of the patients, and the greatest number 69.9 per cent occurred between the ages of 11 and 40 years. The statistical analysis did not show any significant difference between male and female (P>0.05) 2. The frequently involved region for the radicular cysts was orderly the maxillary anterior region (44.9 per cent), the mandibular anterior region (15.9 per cent), the maxillary premolar region (14.8 per cent), and the mandibular premolar region (11.0 per cent). The maxillo-mandibular ratio of the radicular cysts was about 7:3. The statistical analysis did not show any significant difference between right and left sides (P>0.05). 3. The greatest number was 92.2 per cent, which were involved in apical portions of the radicular cysts, 88.7 per cent of the radicular cysts were found in the round shapes which were oval and elliptical, and 66.8 per cent of the radicular cysts were observed with the completely hyperostotic borders. 4. The radicular cysts caused the root resorption in 55.2 per cent and the migration of the involved tooth or teeth in 23.5 per cent respectively.

• Korea Journal of Hospital Management
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• v.7 no.2
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• pp.24-36
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• 2002

The purpose of this paper is to find the factors affecting the number of patients per physician for a day at hospital and compare them with the results of previous studies. We used data of Korean national patients survey that had been carried out by central government and local health centers from October 27th to November 11th in 1999. Descriptive analyses were performed to overview the general characteristics of our study subject. Also, we tried to find the factors affecting the number of patients per physician for a day at hospital through t test and correlation analysis. Factors affecting the number of outpatients per physician for a day at hospital are location, training type, ownership, No. of physicians, No. of beds per physician, No. of physicists per physician, No. of nursing aids per physician and No. of medical technicians per physician. While factors affecting the number of inpatients per physician for a day at hospital are location, ownership, No. of physicians, No. of beds per physician, No. of pharmacists per physician, No. of nurses per physician, No. of nursing aids per physician and No. of administrative auxiliary personnels per physician. The most correlated variable with outpatients per physician for a day at hospital is No. of medical technicians per physician while the most correlated variable with inpatients per physician for a day at hospital is No. of beds per physician. A more detailed investigation is needed for verifying factors affecting the number of patients per physician for a day at hospital and other medical institutions.