• Title/Summary/Keyword: PCI 2.2

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Fission yeast Pci2 has function in mRNA export as a component of TREX-2 (분열효모 Pci2가 TREX-2 구성요소로서 mRNA 방출에 미치는 영향)

  • Park, Jin Hee;Yoon, Jin Ho
    • Korean Journal of Microbiology
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    • v.54 no.4
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    • pp.325-329
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    • 2018
  • Thp1/PCID2, PCI domain-containing protein, is a component of the evolutionally conserved TREX-2 complex linking mRNA transcription and export. In fission yeast, Schizosaccharomyces pombe, the pci2 (SPBC1105.07c) gene encodes a PCI domain-containing protein that is predicted as a fission yeast orthologue of Thp1 (in budding yeast)/PCID2 (in human). Repression of pci2 expression inhibited both growth and mRNA export. And over-expression of pci2 also exhibited growth retardation with slight accumulation of $poly(A)^+$ RNA in the nucleus. Moreover, yeast two-hybrid and co-immunoprecipitation analysis showed that the Pci2 protein physically interacted with Sac3 and Dss1, which are members of TREX-2 complex. These observations support that the S. pombe Pci2 protein, as a component of TREX-2 complex, is implicated in mRNA export.

Design and Verification of PCI 2.2 Target Controller to support Prefetch Request (프리페치 요구를 지원하는 PCI 2.2 타겟 컨트롤러 설계 및 검증)

  • Hyun Eugin;Seong Kwang-Su
    • The KIPS Transactions:PartA
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    • v.12A no.6 s.96
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    • pp.523-530
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    • 2005
  • When a PCI 2.2 bus master requests data using Memory Read command, a target device may hold PCI bus without data to be transferred for long time because a target device needs time to prepare data infernally. Because the usage efficiency of the PCI bus and the data transfer efficiency are decreased due to this situation, the PCI specification recommends to use the Delayed Transaction mechanism to improve the system performance. But the mechanism cann't fully improve performance because a target device doesn't know the exact size of prefetched data. In the previous work, we propose a new method called Prefetch Request when a bus master intends to read data from the target device. In this paper, we design PCI 2.2 controller and local device that support the proposed method. The designed PCI 2.2 controller has simple local interface and it is used to convert the PCI protocol into the local protocol. So the typical users, who don't know the PCI protocol, can easily design the PCI target device using the proposed PCI controller. We propose the basic behavioral verification, hardware design verification, and random test verification to verify the designed hardware. We also build the test bench and define assembler instructions. And we propose random testing environment, which consist of reference model, random generator ,and compare engine, to efficiently verify corner case. This verification environment is excellent to find error which is not detected by general test vector. Also, the simulation under the proposed test environment shows that the proposed method has the higher data transfer efficiency than the Delayed Transaction about $9\%$.

Design and Verification of PCI 2.2 Target Controller (PCI 2.2 타겟 컨트롤러 설계 및 검증)

  • Seo, Kyung-Ho;Choi, Eun-Ju;Seo, Kwang-Duck;Hyun, Eu-Gin;Seong, Kwang-Su
    • Proceedings of the Korea Information Processing Society Conference
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    • 2005.05a
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    • pp.1671-1674
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    • 2005
  • PCI 2.2 마스터 디바이스가 타겟 디바이스로부터 데이터를 읽어 오고자 할 때 타겟 장치는 내부적으로 데이터를 준비해야 함으로 인해 PCI 버스가 데이터 전송 없이 점유되는 상황이 발생한다. 이를 위해 PCI 2.2 사양에서는 지연전송을 제안하여 전송 효율을 향상시켰지만 이 역시 타겟 디바이스가 얼마의 데이터를 미리 준비 해둘지를 알 수 없어 인해 버스 사용 및 데이터 전송 효율을 떨어뜨리는 원인을 제공한다. 본 논문에서는 먼저 이를 해결하기 위한 새로운 방법을 제안한다. 그리고 이 방법을 지원하는 PCI 타겟 컨트롤러와 로컬 디바이스를 설계하였다. 설계되어진 PCI 타겟 컨트롤러는 PCI 2.2를 전혀 모르는 사용자도 쉽게 PCI 인터페이스를 지원할 수 있도록 한 프로토콜 변환기로 사용될 수 있다. PCI 타겟 컨트롤러와 로컬 디바이스는 먼저 행위 모델로 설계하였으며 또한 이들을 검증하기 위한 테스트벤치를 설계 하였다. 이를 통해 제안되어진 방법의 성능을 측정하였으며 후에 다시 실제 하드웨어로 설계하였다. 설계되어진 하드웨어를 효과적으로 검증하기 위해 참조모델, 랜덤발생기, 비교엔진으로 구성된 랜덤 테스트 환경을 제안하였다. 이 검증 환경에서 수행된 결과를 비교함으로써 일반적인 테스트 벡터에서 발견하기 어려운 에러들을 발견할 수 있었다.

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Method to improve the Data Transfer Efficiency in the PCI 2.2 using Prefetch Request (PCI 2.2에서 프리페치 요구를 이용해서 데이터 전송 효율을 향상시키는 효과적인 방법)

  • 현유진;성광수
    • Journal of the Institute of Electronics Engineers of Korea CI
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    • v.41 no.4
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    • pp.1-8
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    • 2004
  • When the PCI 2.2 bus master requests data using Memory Read command, the target device my hold PCI bus without data transfer for a long time because the target device requires time to prefetch data internally. Because the PCI bus usage efficiency and the data transfer efficiency are decreased due to this situation, the PCI specification recommends to use the Delayed Transaction mechanism to improve the performance. But the mechanism doesn't fully improve performance because the target device doesn't blow prefetch data size exactly. In this paper, we propose a new method to transfer data efficiently when the bus master reads data from the target device. The bus master informs the target device the exact read data size using prefetch request using Memory Write command. The simulation result shows that the proposed method has the higher data transfer efficiency than the Delayed Transaction about 10%.

System Software Design and Simulation for LEON2-FT Processor based on PCI (PCI 기반 LEON2-FT 프로세서를 위한 시스템 소프트웨어 설계 및 시뮬레이션)

  • Choi, Jong-Wook;Nam, Byeong-Gyu
    • Journal of Satellite, Information and Communications
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    • v.8 no.1
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    • pp.54-60
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    • 2013
  • The need for high performance of on-board computer (OBC) is essential due to the growing requirements and diversified missions, and so OBC has been developed on the basis of the standard design and reconfigurable modularization in order to improve the utilization of OBC for different missions. The processor in OBC of next generation satellite which is currently developed by KARI is adopted the LEON2-FT/AT697F processor based SPARC v8 as main processor and controls various devices such as SpaceWire, MIL-STD-1553B and CAN through PCI on the standardized communication chips. This paper presents the architecture and design of system software for LEON2-FT processor based on PCI, and development of PCI software component. Also it describes the porting of VxWorks 6.5 for LEON2-FT and the test under the simulation environment for LEON2-FT and PCI with communication chips.

Clinical outcomes and characteristics of acute myocardial infarction patients with developing fever after percutaneous coronary intervention

  • Jae-Geun Lee;Yeekyoung Ko;Joon Hyouk Choi;Jeong Rae Yoo;Misun Kim;Ki Yung Boo;Jong Wook Beom;Song-Yi Kim;Seung-Jae Joo
    • Journal of Medicine and Life Science
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    • v.19 no.2
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    • pp.46-56
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    • 2022
  • The incidence of fever complicating percutaneous coronary intervention (PCI) is rare. However, little is known regarding the cause of fever after PCI. Therefore, this study aimed to determine the clinical characteristics of patients with acute myocardial infarction (AMI), with or without fever, after PCI. We enrolled a total of 926 AMI patients who underwent PCI. Body temperature (BT) was measured every 4 hours or 8 hours for 5 days after PCI. Patients were divided into two groups according to BT as follows: BT<37.7℃ (no-fever group) and BT ≥37.7℃ (fever group). The 2 years clinical outcomes were compared subsequently. Fever after PCI was associated with higher incidence of major adverse cardiac events (MACE) (hazard ratio [HR], 1.56; 95% confidence interval [CI], 1.07-2.28; P=0.021), all-cause death (HR, 2.32; 95% CI, 1.18-4.45; P=0.014), cardiac death (CD) (HR, 2.57; 95% CI, 1.02-6.76; P=0.049), and any revascularization (HR, 1.69; 95% CI, 1.02-2.81; P=0.044) than without fever. In women, prior chronic kidney disease, lower left ventricular (LV) ejection fraction, higher LV wall motion score index, white blood cell count, peak creatine kinase-myocardial band level, and longer PCI duration were associated with fever after PCI. Procedures such as an intra-aortic balloon pump, extracorporeal membrane oxygenation, continuous renal replacement therapy, central and arterial line insertion, and cardiopulmonary resuscitation were related to fever after PCI. Fever after PCI in patients with AMI was associated with a higher incidence of MACE, all-cause death, CD, and any revascularization at the 2 years mark than in those without fever.

Mechanism for Improving Data Rate on PCI 2.2 Interface (PCI 2.2 Data 전송 효율을 향상시키기 위한 메커니즘)

  • 현유진;성광수
    • Proceedings of the IEEK Conference
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    • 2003.07b
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    • pp.807-810
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    • 2003
  • The PCI 2.2 spec introduces Delayed Transaction mechanism to improve system performance for target device with slow local bus. But this mechanism has some restriction since target device doesn't know prefetch data size. So, we propose a new mechanism, which target device prefetch exact data on local bus, to improve data rate on PCI or local interface. The simulation results showed that the proposed mechanism more improves system performance than the Delayed Transaction mechanism.

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Change of energy consumption according to loading on the ankle of normal adults during gait (정상 성인의 발목에 부가된 하중에 의한 보행 중 에너지 소모도 변화)

  • Kim Bong-Ok;Chae Su-Sung;Kim Yong-Gun;Han Dong-Uck
    • The Journal of Korean Physical Therapy
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    • v.11 no.2
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    • pp.43-50
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    • 1999
  • The purpose of this study was to evaluate the change of the energy consumption when loading to leg of the 60persons who don't have past history of cardiopulmonary and neuromuscular disease, To evaluate the change or energy consumption, heart rate was measured in sitting position for 5minute, during walking for 3minute at for 4.8km on treadmill, and during resting state after walking with 1Kg loading to right ankle, and the other 1Kg loading was added to left ankle and then heart rates were measured in the The results were as follow; 1. PCI value without loading to Ankle were significantly increased compared to 1Kg, and 2Kg. (p<0.05) 2. Female Subjects showed mon increased PCI value in without leading and 2Kg loading compared to male subjects. ( p<0.05) 3. When 1Kg ana 2Ka loading to ankle significantly differences were showed between them. (p<0.05) 4. In the case of 1Kg and 2Kg loading, the difference among age groups was observed and the significant difference among PCI, PCI 1kg, PCI 2kg was showed in the only group that is less than 30 years old. 5. In every PCI condition the difference among height groups was observed and the significant difference among PCI conditions was showed in the only group that is less than 165cm. 6. The difference among weight groups in each PCI condition was not observed, but the significant differences among PCI conditions was showed in every group except the group that h from 60kg to 69kg. These results showed that energy consumption was increased according to loading on the ankle during Sate so weight of orthosis or prosthesis met be considered when choosing them and during gait training with these ones.

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The Analysis of the Effects of the Problem Centered Instruction and Explanatory Instruction (문제 중심 수업과 설명식 수업의 효과 분석)

  • 백선수;김원경
    • Education of Primary School Mathematics
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    • v.2 no.2
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    • pp.103-112
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    • 1998
  • The purpose of this study is to analyze the effects of the Problem Centered Instruction(PCI) and the Explanatory Instruction(El). Two classes of third grade children(69 children) were sampled from an elementary school in Chung-Buk and given a treatment. The results of this study as follows: (1) There was no significant difference between the PCI group and the El group. This means that the PCI doesn't decrease the computational ability, even though the ordinary calculation methods are not taught in the PCI group. (2) The PCI group got scores significantly higher than the El group on application problems. It may be interpreted that the PCI is more effective than the El in problem solving.

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The Association of Hospital Volume of Percutaneous Coronary Intervention with Cardiac Mortality

  • Kim, Jae-Hyun;Kim, Jang-Mook;Park, Eun-Cheol
    • Health Policy and Management
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    • v.28 no.2
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    • pp.168-177
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    • 2018
  • Background: This study investigates the potential volume and outcome association of coronary heart disease (CHD) patients who have undergone percutaneous coronary intervention (PCI) using a large and representative sample. Methods: We used a National Health Insurance Service-Cohort Sample Database from 2002 to 2013 released by the Korean National Health Insurance Service. A total of 8,908 subjects were analyzed. The primary analysis was based on Cox proportional hazards models to examine our hypothesis. Results: After adjusting for confounders, the hazard ratio of thirty-day and 1-year mortality in hospitals with a low volume of CHD patients with PCI was 2.8 and 2.2 times higher (p=0.00) compared to hospitals with a high volume of CHD patients with PCI, respectively. Thirty-day and 1-year mortality of CHD patients with PCI in low-volume hospitals admitted through the emergency room were 3.101 (p=0.00) and 2.8 times higher (p=0.01) than those in high-volume hospitals, respectively. Only 30-day mortality in low-volume hospitals of angina pectoris and myocardial infarction patients with PCI was 5.3 and 2.4 times those in high-volume hospitals with PCI, respectively. Conclusion: Mortality was significantly lower when PCI was performed in a high-volume hospital than in a low-volume hospital. Among patients admitted through the emergency room and diagnosed with angina pectoris, total PCI volume (low vs. high) was associated with significantly greater cardiac mortality risk of CHD patients. Thus, There is a need for better strategic approaches from both clinical and health policy standpoints for treatment of CHD patients.