• Title/Summary/Keyword: PC12 cells

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Effect of Cynanchum wilfordii Hemeseley Extract on antioxidative enzyme in rat PC 12 pheochromocytoma.

  • Sung, Mi-Kyung;Kwon, Hye-Soon;Lee, Eun-Ju
    • Proceedings of the KSCN Conference
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    • 2003.05a
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    • pp.143-143
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    • 2003
  • Reactive oxygen species are highly reactive oxidant molecules and react with cellular components, causing oxidative damages. These damages may play a significant role in the causation of several chronic diseases. Antioxidative defence systems are present in the body to protect cells from oxidative damages. The first line of defence include dietary antioxidants and enzymes such as superoxide dismutase. Cynanchum wilfordii Hemeseley has been used for centuries as a tonic nutraceutical in China and Korea. (omitted)

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Involvement of Proinflammatory Cascades in Nitrosative Damage in PC12 Cells

  • Um, So-Young;Jang, Jung-Hee;Na, Hye-Kyung;Surh, Young-Joon
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.324.2-325
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    • 2002
  • Recent studies suggest that inflammatory events are implicated in a variety of human diseases including cancer and neurodegenerative diseases. and non-steroidal anti-inflammatory drugs have beneficial effects in treatment or prevention of these disorders. It has been reported that expression of cyclooxygenase (COX)-2 and nitric oxide synthase and subsequent production of prostaglandin (PG) and nitric oxide (NO). respectively are elevated in many inflammatory disorders. (omitted)

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OXIDATIVE DNA DAMAGE AND APOPTOSIS INDUCED BY TETRAHYDROPAPAVEROLINE IN PC12 CELLS

  • Shin, Mi-Hyun;Jang, Jung-Hee;Lee, Jeong-Sang;Surh, Young-Joan
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2001.10a
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    • pp.114-114
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    • 2001
  • Tetrahydropapaveroline (THP), a dopamine-derived 6, 7-dihydroxy-1-(3' ,4'-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline, has been suspected as a possible dopaminergic neurotoxin to elicit Parkinsonism. Autooxidation or enzymatic oxidation of THP and subsequent generation of reactive oxygen species (ROS) may contribute to the degeneration of dopaminergic neurons induced by this isoquinoline alkaloid.(omitted)

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