Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.10a
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- Pages.114-114
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- 2001
OXIDATIVE DNA DAMAGE AND APOPTOSIS INDUCED BY TETRAHYDROPAPAVEROLINE IN PC12 CELLS
- Shin, Mi-Hyun (College of Pharmacy, Seoul National University) ;
- Jang, Jung-Hee (College of Pharmacy, Seoul National University) ;
- Lee, Jeong-Sang (College of Pharmacy, Seoul National University) ;
- Surh, Young-Joan (College of Pharmacy, Seoul National University)
- Published : 2001.10.01
Abstract
Tetrahydropapaveroline (THP), a dopamine-derived 6, 7-dihydroxy-1-(3' ,4'-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline, has been suspected as a possible dopaminergic neurotoxin to elicit Parkinsonism. Autooxidation or enzymatic oxidation of THP and subsequent generation of reactive oxygen species (ROS) may contribute to the degeneration of dopaminergic neurons induced by this isoquinoline alkaloid.(omitted)
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