• Title/Summary/Keyword: PC-12

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MODULATION OF ATP-GATED CHANNEL BY ADENOSINE RECEPTOR

  • Park, Tae-Ju;Kim, Kyong-Tai
    • Proceedings of the Korean Biophysical Society Conference
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    • 1996.07a
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    • pp.8-8
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    • 1996
  • The regulatory role of A$\_$2A/ adenosine receptors on the P purinoceptor-mediated calcium signaling was investigated in rat pheochromocytoma (PC 12) cells. When PC 12 cells were treated with 2-p-(2-carboxyethyl) phenethylamino- 5' - N -ethylcarboxamido-adenosine (CGS21680), a specific agonist of the A$\_$2A/ adenosine receptor, extracellular ATP-evoked [Ca$\^$2+/]$\_$I/ rise was inhibited by -20%. (omitted)

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Chlorpromazine Inhibits Store-operated Calcium Entry and Subsequent Norepinephrine Secretion in PC12 Cells

  • Park, Se-Young;Kim, Yong-Hyun;Lee, Yong-Kyu;Kim, Kyong-Tai
    • Proceedings of the Korean Biophysical Society Conference
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    • 1999.06a
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    • pp.67-67
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    • 1999
  • The effect of chlorpromazine on the store-operated Ca$\^$2+/ entry subsequently activated via the phospholipase C signaling pathway was investigated in PC12 cells. Chlorpromazine caused a rapid decline of the bradykinin-induced Ca$\^$2+/ increase to basal level without attenuating the peak level.(omitted)

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Voltage-sensitive Calcium Channels Are Linked to P2X Purinoceptors in PC12 Cells

  • Hur, Eun-Mi;Park, Tae-Ju;Kim, Kyong-Tai
    • Proceedings of the Korean Biophysical Society Conference
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    • 1999.06a
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    • pp.68-68
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    • 1999
  • Extracellular A TP is known to function as a neurotransmitter and as a modulator in the variety of cell types. In PC12 cells, extracellular A TP elevates [Ca$\^$2+/]j through receptor-operated Ca$\^$2+/ channels and through the activation of phospholipase C, thereby facilitating the secretion of neurotransmitters.(omitted)

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Augmentation of constitutive nf-$textsc{k}$b activation by bcl-2 in pc12 cells: implications for protection against oxidative stress

  • Jang, Jung-Hee;Surh, Young-Joon
    • Proceedings of the PSK Conference
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    • 2003.10b
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    • pp.69.3-70
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    • 2003
  • A substantial body of evidence indicates that reactive oxygen intermediates (ROIs) are implicated in pathogenesis of diverse human diseases, including cancer, diabetes and neurodegenerative disorders. Oxidative stress induced by ROIs often causes cell death via apoptosis that is regulated by a plenty of functional genes and their protein products. In the present work, we have investigated the role of bcl-2 in protecting against oxidative death induced by hydrogen peroxide in cultured rat pheochromocytoma (PC12) cells. (omitted)

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Minocycline Directly Blocks Activation of Caspases After Oxidative Stress in PC12 Cells

  • Choi, Yu-Keum;Kim, Gab-Seok;Han, Byung-Hee
    • Proceedings of the PSK Conference
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    • 2003.10b
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    • pp.79.2-79.2
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    • 2003
  • Minocycline is known to protect neurons from microglia-mediated cell death in many experimental models of brain diseases including ischemic stroke, Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), traumatic brain injury, multiple sclerosis, and Parkinson's disease. Activation of caspase-2, 3, 8, and 9 was evident within 2-8 hr following oxidative insult with 0.5 mM hydrogen peroxide in PC12 cells. Minocycline significantly attenuated activation of these caspases up to 18 hr, resulting a significant increase in cell viability as assessed by MTT assay. (omitted)

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A Study on the Policy Agenda for Activating PC Apartment using Focus Group Interview(FGI) (FGI를 사용한 PC공동주택 활성화 정책과제 모색)

  • Bae, Byung-Yun;Kang, Tai-Kyung;Shin, Eun-Young;Kim, Kyong-Hoon
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.12
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    • pp.888-895
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    • 2020
  • In the construction industry, off-site construction (OSC) is drawing attention as a production method due to changes in working hours and the supply and demand of manpower. In 1991, there was a policy of spreading and expanding the use of precast concrete (PC) apartment homes, but they have not been actively used so far since they were discontinued due to quality problems. In this study, policy tasks were analyzed to motivate the application of OSC-based PCs in the apartment housing sector, and policy directions were derived by conducting focus group interviews (FGI). Nine policies are suggested regarding the following topics: PC apartment supply quantity provision, priority application of public housing, priority supply of public housing, preferential floor area ratio, funding, tax support, improvement of business area structure, improvement of delivery method, factory certification system, and training of experts. The results of the FGIs are as follows. First, in order to revitalize PC apartment homes, leading efforts from the public sector are required. Second, rather than reorganizing the business sector or introducing a new delivery method, a policy direction that induces the strengthening of cooperation is desirable. Third, PC activation should be promoted on an institutional basis for securing appropriate construction costs and quality.

Association Between Pancreatitis and Subsequent Risk of Pancreatic Cancer: a Systematic Review of Epidemiological Studies

  • Tong, Gui-Xian;Geng, Qing-Qing;Chai, Jing;Cheng, Jing;Chen, Peng-Lai;Liang, Han;Shen, Xing-Rong;Wang, De-Bin
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.12
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    • pp.5029-5034
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    • 2014
  • This study aimed to summarize published epidemiological evidence for the relationship between pancreatitis and subsequent risk of pancreatic cancer (PC). We searched Medline and Embase for epidemiological studies published by February $5^{th}$, 2014 examining the risk of PC in pancreatitis patients using highly inclusive algorithms. Information about first author, year of publication, country of study, recruitment period, type of pancreatitis, study design, sample size, source of controls and attained age of subjects were extracted by two researchers and Stata 11.0 was used to perform the statistical analyses and examine publication bias. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated with the random effects model. A total of 17 articles documenting 3 cohort and 14 case-control studies containing 14,667 PC cases and 17,587 pancreatitis cases were included in this study. The pooled OR between pancreatitis and PC risk was 7.05 (95%CI: 6.42-7.75). Howeever, the pooled ORs of case-control and cohort studies were 4.62 (95%CI: 4.08-5.22) and 16.3 (95%CI: 14.3-18.6) respectively. The risk of PC was the highest in patients with chronic pancreatitis (pooled OR=10.35; 95%CI: 9.13-11.75), followed by unspecified type of pancreatitis (pooled OR=6.41; 95%CI: 4.93-8.34), both acute and chronic pancreatitis (pooled OR=6.13; 95%CI: 5.00-7.52), and acute pancreatitis (pooled OR=2.12; 95%CI: 1.59-2.83). The pooled OR of PC in pancreatitis cases diagnosed within 1 year was the highest (pooled OR=23.3; 95%CI: 14.0-38.9); and the risk in subjects diagnosed with pancreatitis for no less than 2, 5 and 10 years were 3.03 (95%CI: 2.41-3.81), 2.82 (95%CI: 2.12-3.76) and 2.25 (95%CI: 1.59-3.19) respectively. Pancreatitis, especially chronic pancreatitis, was associated with a significantly increased risk of PC; and the risk decreased with increasing duration since diagnosis of pancreatitis.

OnExpo HOT&COOL / COOL COMPANY 어뮤즈텍

  • O, Suk-Hyeon
    • Digital Contents
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    • no.12 s.127
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    • pp.78-79
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    • 2003
  • 음악을 더 재미있게! 더 편리하게! 종이악보에도 디지털 바람이 불었다. 그리고 그 바람의 선두에는 뮤즈북 스코어(www.musebook.co.kr)가 있다. 뮤즈북 스코어는 최근 개발 된 태블릿 PC를 이용해 수만 장의 악보를 저장해 연주할 수 있는 프로그램으로 음악인식기술을 이용한‘음악인식 전자악보’이다. 피아노 악보대에 종이악보 대신 태블릿 PC를 올려놓고 하드디스크에 저장된 MusicXLM 전자악보들을 마음대로 불러서 사용하는 뮤즈북 스코어는 피아노를 연주 하면 태블릿 PC의 마이크로 소리를 듣고 분석해 자동으로 페이지를 넘겨준다. 사용자의 연주속도 가 빨라지거나 느려지더라도 현재 연주위치를 계 속 추적하기 때문에 사용자는 연주에만 집중할 수 있다.

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Implementation of Mobile Internet E-mail & Chatting Program using WIPI Platform

  • Hwang, Byung-Kon
    • Proceedings of the Korea Society of Information Technology Applications Conference
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    • 2005.11a
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    • pp.7-12
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    • 2005
  • In this paper, we implemented an e-mail and chat program (client) for communication between mobile devices and PCs based on WIPI a South Korea's open wireless platform form developing device and content independent software to break from the way of developing contents that is dependent on different wireless platforms to each mobile communications company. While traditional e-mail and chat programs are written for PC-to-PC communication, we develop them for mobile-to-PC and mobile-to-mobile communications, and we expect to see various mobile contents in the future.

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