• The Journal of Korean Medicine
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• v.44 no.4
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• pp.170-181
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• 2023

Objectives: This study aimed to report the efficacy of Korean medicine with Jeongri-tang Gagam-bang for treating psoriasis. Methods: A patient with psoriasis was treated with Jeongri-tang Gagam-bang (正理湯加減方). Moreover, acupuncture was performed on CV12 (中脘) and both sides of ST25 (天樞), GV20 (百會), LI4 (合谷), and LR3 (太衝) for 15 minutes. Psoriasis severity was assessed using the Psoriasis Area and Severity Index (PASI). Pruritis and dyspepsia intensities were ranked on a Visual Analog Scale (VAS) of 0–10. Results: After treatment, the PASI changed from 21.6 to 1.6. Patient's pruritus had almost disappeared and dyspepsia had improved. Conclusions: This study shows that Jeongri-tang Gagam-bang (正理湯加減方) and acupuncture on CV12 (中脘), ST25 (天樞), GV20 (百會), LI4 (合谷), and LR3 (太衝) might be helpful to treat psoriasis symptoms by improving digestive function.

• CELLMED
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• v.9 no.4
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• pp.8.1-8.5
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• 2019

Introduction: Psoriasis is a major health concern around the world. Physicians of the Unani system of medicine have been treating psoriasis for centuries. Aim: The purpose of our study was to assess the effect of Majoon Mundi (a semisolid Unani medication intended for oral intake used as blood purifier) and Qairooti Karnab (a Unani medication in paste form intended for topical application used as emollient) in the treatment $na{\ddot{i}}ve$ psoriasis cases and to collect data to warrant further clinical trials. Material and Methods: Psoriasis cases were diagnosed clinically. Data were collected during treatment of five patients of psoriasis treated with the Majoon Mundi (oral intake of 5 gm twice daily with 200 ml of water for 12 weeks) and Qairooti Karnab (topical application on affected sites twice a day for 12 weeks). Patients were treated for 12 weeks. Treatment response was seen with clinical improvement in skin lesions and measurement of Psoriasis Area and Severity Index (PASI Scoring) before and after treatment. Results: Reduced PASI Score was observed in all five patients after 12 weeks of treatment [PASI before and after treatment was (mean${\pm}$SD) $20.7{\pm}4.6$ vs. $3.2{\pm}1.8$; p-value <0.05.]. Clinical improvement was noticed within an average of 4 weeks of treatment. Conclusion: Preliminary findings indicate the potential therapeutic role of Majoon Mundi and Qairooti Karnab in the treatment of psoriasis. Clinical trials based on this Unani pharmacopeial formulation should be conducted to explore the therapeutic potential of this formulation in psoriasis

• The Journal of Korean Medicine
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• v.37 no.1
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• pp.34-40
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• 2016

Objectives: To observe safety and efficacy of herbal medicine for psoriasis patients. Methods: We did retrospective chart review for 107 psoriasis patients who had been treated by herbal medicine for 2 months, and we analyzed the liver function test (LFT) results and Psoriasis Area and Severity Index (PASI) scores of before and after the treatment. Results: The mean LFT and the number of patients with abnormal LFT decreased after the treatments. More than 95% of patients with normal LFT maintained normal results at after the treatment, and only 2.1% and 4.6% patients with normal LFT showed abnormal Glutamic Oxaloacetic Transaminase (GOT) and Glutamic Pyruvic Transaminase (GPT) results at after the treatment. Also, both mean PASI scores for all patients and patients with abnormal LFT before the treatment decreased significantly. Conclusions: This study suggest that herbal medicine may be safe and effective treatment for psoriasis.

• Journal of Physiology & Pathology in Korean Medicine
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• v.32 no.1
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• pp.80-87
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• 2018

This report describes the effectiveness of mahaenggamseog-tang(麻杏甘石湯) on the patients who suffered from atopic dermatitis and psoriasis. We administered mahaenggamseog-tang with heat-clearing and lung-dispersing(淸熱宣肺) effect to two dermatitis patients who showed sweating with panting(汗出而喘), vexation and thirst(煩渴), aversion to heat(惡熱), agitation(煩燥), swelling of the face and eyes(面目浮腫). The severity of dermatitis was evaluated by visual analogue scale(VAS), pictures, SCORAD index(case 1), PASI(case 2). After the treatment, VAS/SCORAD index of case 1 changed from 9/71.5 to 0/6.1; VAS/PASI of case 2 from 8/36.8 to 1/6.8. Mahaenggamseog-tang could improved the symptoms of atopic dermatitis and psoriasis in this study. This study offers an approach to managing chronic dermatitis more effectively using Mahaenggamseog-tang which used mainly for bronchial diseases and obesity.

• Journal of Sasang Constitutional Medicine
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• v.27 no.1
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• pp.171-177
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• 2015

Objectives The purpose of this study is to give an account of the effects of the Traditional Korean herbal medicine therapy which is based on the Sasang constitutional medicine on psoriasis Methods We diagnosed her as Soyangin(少陽人) based on her nature and emotion, physical chracteristics, symptoms. We thought Leaky Gut Syndrome is related to Soyangin Food Stagnation, stuffiness and fullness(食滯痞滿). So we applied Dokhwaljihwang-tang(獨活地黃湯) which is used to Soyangin Food Stagnation, stuffiness and fullness because her symptoms recurred as a result of Food Stagnation(食滯) after eating meat. The improvement of the skin condition was observed by Psoriasis Area and Severity Index (PASI) score Results Psoriasis patient who was treated with Soyangin Dokhwaljihwang-tang showed improvement in Psoriasis symptom. This case study describes the effectivenss on psoriasis symptoms by using Soyangin Dokhwaljihwang-tang. Conclusions The PASI score of the patient reduced from 10.8 to 1.2 after three months of treatment. According to the result, we concluded that Dokhwaljihwang-tang had a good effect on psoriasis.

• The Korean Journal of Physiology and Pharmacology
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• v.24 no.3
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• pp.213-221
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• 2020

Salvianolic acid B (SAB) is an active phytocomponent of a popular Chinese herb called Radix Salvia militiorrhiza with numerous biological properties. The anti-psoriasis activity of SAB was examined by evaluating various psoriasis inflammatory and keratin markers against imiquimod (IMQ)-induced psoriasis on BALB/c mice. Totally 50 healthy BALB/c mice were evenly divided into 5 groups including control, drug control (SAB; 40 mg/kg), IMQ-induced psoriasis (5%), IMQ exposure and treated with SAB (40 mg/kg), or standard methotrexate (MTX; 1 mg/kg). Mice supplemented with either SAB or MTX significantly lowered the values of psoriasis area severity index (PASI), erythema, scaling, skin thickness, inflammatory markers (interleukin [IL]-22/23/17A/1β/6) and lipid peroxidation product (malondialdehyde). Also, IMQ exposed BALB/c mice treated with SAB or MTX display lesser histopathological changes with enhanced antioxidant activities (catalase, superoxide dismutase). Moreover, the protein expression of keratin markers (K16 and K17) and phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) signaling proteins (pAkt/Akt and pPI3K/PI3K) were significantly downregulated after administration with SAB and MTX as compared with IMQ induced mice. Taking together, SAB and MTX significantly ameliorate psoriatic changes by inhibiting psoriatic inflammatory and keratin markers through abolishing PI3K/Akt signaling pathway. However, further studies (clinical trials) are needed to confirm the anti-psoriatic property of SAB before recommending to psoriasis patients.

• Journal of Physiology & Pathology in Korean Medicine
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• v.33 no.1
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• pp.68-74
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• 2019

This paper confirmed the effect of Baekho-tang(白虎湯) on psoriasis patient diagnosed with Yangmyung-Yeoljeung(陽明熱證). We treated patients with psoriasis classified as Yangmyung-Yeoljeung(陽明熱證) according to Shanghanlun(傷寒論) with Baekho-tang(白虎湯). Two patients was treated with Baekho-tang(白虎湯) for 18 days and 75 days, respectively. Baekho-tang(白虎湯) used in the treatment consisted of Gypsum Fibrosum 16g, Oryza semen 12.5g, Anemarrhena Rhizoma 6g and Glycyrrhizae Radix 2g. The severity of psoriasis was evaluated by PASI(psoriasis area severity index) and pictures. Also we checked the change in Pruritus by VAS(visual analogue scale). After the Baekho-tang(白虎湯) treatment, the PASI of 2 patients decreased from 13 to 2.8 and from 10.8 to 0.8 respectively. In addition, VAS of 2 patients diminished from 10 to 3 and from 8 to 1 respectively. Moreover, no side effects were observed. We received effective results by giving Baekho-tang to Psoriasis patients with sweaty, dry mouth, and heating sensation. Anti-inflammatory, antipyretic effects and immunomodulatory functions of Baekho-tang(白虎湯) could lead to improvement of psoriasis.

• Herbal Formula Science
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• v.30 no.4
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• pp.351-361
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• 2022

Objectives : The purpose of this study is to report the clinical effect of herbal medicine decoction on COVID-19 symptoms remaining after administering Western medicine and worsening eczema during the COVID-19 prevalence period in patients with chronic eczema. Methods : The two chronic eczema patients suffering from COVID-19 symptoms and worsening eczema received a series of herbal medicine decoction for treatment. The effectiveness of treatment was evaluated by VAS, NRS, EASI, PASI, DLQI, photography and subjective evaluation of the patient's improvement of symptoms. Results : After treatment, all symptoms of COVID-19 disappered and aggravated eczema lesions were remarkably improved in both cases. Compared to its peak, the first case shows that PASI improved by 88% and DLQI by 44%. According to photo and symptom changes, the size of the affected area of facial acne and lip eczema was decreased. The second case shows that EASI improved by 43% and DLQI by 65%. According to photo and symptom changes, redness, rash were stopped and pruritus was decreased. Conclusion : This study suggests that herbal medicine could induce effectiveness on both COVID-19 symptoms as well as chronic eczema.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.11 no.4
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• pp.176-179
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• 2001

Iron oxide powders were prepared under high temperature (up to $175^{\circ}C$) and pressure conditions( up to 129 pasi) by precipitation from metal nitrates with aqueous potassium hydroxide. Various types of iron oxide powders were obtained at different conditions. The size and the shape of the particles can be controlled as afunction of starting solution pH. The average particles size of the synthesized iron oxide powders increased, the particle shapes of the powders became fibrous, and the crystalline phase of the powder changes from iron oxide to iron hydroxide with increasing solution pH. The effects of synthesis parameters are discussed.

• Journal of the Korean Society of Food Science and Nutrition
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• v.4 no.1
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• pp.19-23
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• 1975

From a study of the nutrient and gelation substances in Korean persimmon such as Jangdongsi, Pasi, Teabongsi, Kurigam, Nabjackgam, Gamsi and Hucks: The results obtained are summerized as follows: 1. According as persimmon changes into mellowed persimmon in the same kind the ammounts of sugar was increased, while the ammounts of fiber was decreased, but there was little difference in the other nutrient contents. 2. The ratio of 'Ca' and 'P' in persimmons in generally balanced at 1 : 2.5 3. Compared to the standard combination ratio of gelation substance, pectin in the persimmons was over but acid and sugars were very low.