• Safety and Health at Work
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• 제12권2호
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• pp.184-191
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• 2021

Background: Hearing protection devices (HPDs) are often used in the workplace to prevent hearing damage caused by noise. However, a factor that can lead to hearing loss in the workplace is improper HPD fitting, and the previous literature has shown that instructing workers on how to properly insert their HPDs can make a significant difference in the degree of attenuation. Methods: Two studies were completed on a total of 33 Hydro One workers. A FitCheck Solo field attenuation estimation system was used to measure the personal attenuation rating (PAR) before and after providing one-on-one fitting instructions. In addition, external ear canal diameters were measured, and a questionnaire with items related to frequency of use, confidence, and discomfort was administered. Results: Training led to an improvement in HPD attenuation, particularly for participants with poorer PARs before training. The questionnaire results indicated that much HPD discomfort is caused by heat, humidity, and communication difficulties. External ear canal asymmetry did not appear to significantly influence the measured PAR. Conclusion: In accordance with the previous literature, our studies suggest that one-on-one instruction is an effective training method for HPD use. Addressing discomfort issues from heat, humidity, and communication issues could help to improve the use of HPDs in the workplace. Further research into the effects of canal asymmetry on the PAR is needed.

• 한국정보과학회 언어공학연구회:학술대회논문집(한글 및 한국어 정보처리)
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• 한국정보과학회언어공학연구회 2020년도 제32회 한글 및 한국어 정보처리 학술대회
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• pp.321-326
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• 2020

본 연구에서는 한국어 감성분석 성능 향상을 위한 DECO(Dictionnaire Electronique du COreen) 한국어 전자사전과 LGG(Local-Grammar Graph) 패턴문법 기술 프레임에 의존파서 및 LSTM을 적용하는 하이브리드 방법론을 제안하였다. 본 연구에 사용된 DECO-LGG 언어자원을 소개하고, 이에 기반하여 의미 정보를 의존파서(D-PARS)와 페어링하는 한편 OOV(Out Of Vocabulary)의 문제를 LSTM을 통해 해결하여 자질기반 감성분석 결과를 제시하였다. 부트스트랩 방식으로 반복 확장될 수 있는 LGG 언어자원 및 알고리즘을 통해 수행되는 자질기반 감성분석 프로세스는 전용 플랫폼 DecoFESA를 통해 그 범용성을 확장하였다. 실험을 위해서 네이버 쇼핑몰의 '화장품 구매 후기글'을 크롤링하였으며, DecoFESA 플랫폼을 통해 현재 구축된 DECO-LGG 언어자원 기반의 감성분석 성능을 평가하였다. 이를 통해 대용량 언어자원의 구축과 이를 활용하기 위한 어휘 시퀀스 처리 알고리즘의 구현이 보다 정확한 자질기반 감성분석 결과를 제공할 수 있음을 확인하였다.

• The Korean Journal of Physiology and Pharmacology
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• 제8권5호
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• pp.245-251
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• 2004

The effects of fetal mesencephalic cell grafts on the restoration of nigrostriatal dopaminergic function were studied in the intrastriatal 6-hydroxydopamine-lesioned rats. Four weeks after lesioning, transplantation of ventral mesencephalic cells from embryonic day 14 fetuses showed the number of tyrosine hydroxylase (TH) positive cells and fiber outgrowth in the grafted striatum, and significantly ameliorated symptomatic motor behavior of the animals, as determined by apomorphine-induced rotation. Furthermore, in substantia nigra pars compacta (SNc), the numbers of TH + cells and fibers were markedly restored. Dopamine content of ipsilateral SNc was close to that of contralateral SNc $(91.9{\pm}9.8%)$ in the transplanted animals, while the ratio was approximately 32% in sham-grafted animals. These results indicate that grafted cells restored the activity for the dopaminergic neurons located in SNc, although they were transplanted into striatum. In addition, we showed that the implanted fetal cells expressed high level of glial cell line-derived neurotrophic factor (GDNF), suggesting that the transplanted fetal cells might serve as a dopamine producer and a reservoir of neurotrophic factors. These results may be helpful in consideration of the therapeutic transplantation at early stage of PD.

• 생물정신의학
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• 제24권4호
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• pp.225-234
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• 2017

Objectives Local gyrification reflects the early neural development of cortical connectivity, and is regarded as a potential neural endophenotype in psychiatric disorders. Several studies have suggested altered local gyrification in patients with bipolar I disorder (BD-I). The purpose of the present study was to investigate the alterations in the cortical gyrification of whole brain cortices in patients with BD-I. Methods Twenty-two patients with BD-I and age and sex-matched 22 healthy controls (HC) were included in this study. All participants underwent T1-weighted structural magnetic resonance imaging (MRI). The local gyrification index (LGI) of 66 cortical regions were analyzed using the FreeSurfer (Athinoula A. Martinos Center for Biomedical Imaging). One-way analysis of covariance (ANCOVA) was used to analyze the difference of LGI values between two groups adjusting for age and sex as covariates. Results The patients with BD-I showed significant hypogyria in the left pars opercularis (uncorrected-p = 0.049), the left rostral anterior cingulate gyrus (uncorrected-p = 0.012), the left caudal anterior cingulate gyrus (uncorrected-p = 0.033). However, these findings were not significant after applying the multiple comparison correction. Severity or duration of illness were not significantly correlated with LGI in the patients with BD-I. Conclusions Our results of lower LGI in the anterior cingulate cortex and the ventrolateral prefrontal cortex in the BD-I group implicate that altered cortical gyrification in neural circuits involved in emotion-processing may contribute to pathophysiology of BD-I.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2005년도 춘계학술대회
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• pp.53-60
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• 2005

Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting $1\%$ of the population above the age of 65 and is characterized by a selective loss of dopaminergic neurons in the substantia nigra pars compacta. Although the underlying cause of dopaminergic cell death or the mechanism by which these cells degenerate is still not clearly understood, oxidative stress, mitochondrial dysfunction, and protein misfolding are thought to play important roles in the dopaminergic degeneration in PD. Tetrahydrobiopterin (BH4) is synthesized exclusively in the monoaminergic, including dopaminergic, cells and serves as an endogenous and obligatory cofactor for syntheses of the potential oxidative stressors dopamine and nitric oxide. In addition to its contribution toward the syntheses of these two potentially toxic molecules, BH4 itself can directly generate oxidative stress. BH4 undergoes oxidation during the hydroxylation reaction as well as nonenzymatic autooxidation to produce hydrogen peroxide and superoxide radical. We have previously suggested BH4 as an endogenous molecule responsible for the dopaminergic neurodegeneration. BH4 exerts selective toxicity to dopamine-producing cells via generation of oxidative stress, mitochondrial dysfunction, and apoptosis. BH4 also induces morphological, biochemical, and behavioral characteristics associated with PD in vivo. BH4 as well as enzyme activity and gene expression of GTP cyclohydrolase I, the rate-limiting enzyme in BH4 synthesis pathway, are readily upregulated by cellular changes such as calcium influx and by various stimuli including stress situations. This points to the possibility that cellular availability of BH4 might be increased in aberrant conditions, leading to increased extracellular BH4 subsequent degeneration. The fact that BH4 is specifically and endogenously synthesized in dopaminergic cells, Is readily upregulated, and generates oxidative stress-related cell death provides physical relevance of this molecule as an attractive candidate with which to explain the mechanism of pathogenesis of PD.

• 한국분말재료학회지
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• 제10권6호
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• pp.383-389
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• 2003

As in other areas of materials technology, the tendency towards light weight constructions becomes more and more important also for powder metallurgy. The development is mainly driven by the automotive industry looking for mass reduction of vehicles as a major factor for fuel economy. Powder metallurgy has to offer a number of interesting areas including the development of sintered materials of light metals. PM aluminium alloys with improved properties are on the way to replace ferrous pars. For high temperature applications in the engine, titanium aluminide based materials offer a great potential, e.g. for exhaust valves. The PM route using elemental powders and reactions sintering is considered to be a cost effective way for net shape parts production. Furthermore it is expected that lower costs for titanium raw materials coming from metallurgical activities will offer new chances for sintered parts with titanium alloys. The field of cellular metals expands with the hollow sphere technique, that can provide materials of many metals and alloys with a great flexibility in structure modifications. These structures are expected to be used in improving the safety (crash absoption) and noise reduction in cars in the near future and offer great potential for many other applications.

• 대한한의학회지
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• 제29권4호
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• pp.94-103
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• 2008

Objectives: The aim of this study was to determine whether celastrol, the triterpenoid component of Celastrus orbiculatus, offers neuroprotection against Parkinson's disease (PD) in mice administered 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine(MPTP). Methods: We examined how celastrol affected MPTP-induced neuronal loss of tyrosine hydroxylase (TH)-positive dopaminergic neurons in substantia nigra pars compacta (SNpc) in the midbrain of mice. C57BL/6J mice were divided into four groups: (1) saline-saline, (2) saline-celastrol, (3) MPTP-saline, and (4) MPTP-celastrol. The mice were injected intraperitoneally (i.p.) with four administrations of MPTP (18mg/kg) at 2 h intervals and then i.p. administered celastrol (3mg/kg) two times at 12 h after last celastrol administration. Expression of TH on the SNpc of brain tissues were analyzed at 7 days after the treatments by immunohistochemistry and Western blot. Results: Immunohistochemical analysis using TH antibody showed that celastrol provided significantly protective effects against MPTP-induced loss of TH-positive dopaminergic neurons in the SNpc region of the midbrain of mice. Our Western blot study also showed that celastrol significantly inhibits the MPTP-induced neuronal damage via the up-regulation of TH protein levels in MPTP mice. Conclusions: The present results suggest that it may be possible to use celastrol for the prevention of nigral degenerative disorders including PD, caused by exposure to toxic substances.

• Journal of Korean Neurosurgical Society
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• 제50권4호
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• pp.341-347
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• 2011

Objective : The purpose of this retrospective study was to evaluate the efficacy and safety of atlantoaxial stabilization using a new entry point for C2 pedicle screw fixation. Methods : Data were collected from 44 patients undergoing posterior C1 lateral mass screw and C2 screw fixation. The 20 cases were approached by the Harms entry point, 21 by the inferolateral point, and three by pars screw. The new inferolateral entry point of the C2 pedicle was located about 3-5 mm medial to the lateral border of the C2 lateral mass and 5-7 mm superior to the inferior border of the C2-3 facet joint. The screw was inserted at an angle $30^{\circ}$ to $45^{\circ}$ toward the midline in the transverse plane and $40^{\circ}$ to $50^{\circ}$ cephalad in the sagittal plane. Patients received followed-up with clinical examinations, radiographs and/or CT scans. Results : There were 28 males and 16 females. No neurological deterioration or vertebral artery injuries were observed. Five cases showed malpositioned screws (2.84%), with four of the screws showing cortical breaches of the transverse foramen. There were no clinical consequences for these five patients. One screw in the C1 lateral mass had a medial cortical breach. None of the screws were malpositioned in patients treated using the new entry point. There was a significant relationship between two group (p=0.036). Conclusion : Posterior C1-2 screw fixation can be performed safely using the new inferolateral entry point for C2 pedicle screw fixation for the treatment of high cervical lesions.

• 한국정보통신학회논문지
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• 제13권2호
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• pp.431-436
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• 2009

홈 네트워크 분야는 최근에 급격히 발달하고 있는 분야로서 그 성장 범위를 점차 확대해 나가고 있으며, 홈 네트 워크 분야의 기술 발달은 가전기기와 주변기기의 제어 및 관리를 위한 홈 네트워크 관리 기술의 발전을 가져오고 있다. 이러한 홈 네트워크의 구현은 기술의 발달에 따라 그 기능 또한 점점 복잡하고 다양한 프로세서의 처리를 필요로 하는 경향이 두드러지고 있다. 홈 네트워크 시스템은 여러 가지 요소에 의해 영향을 받기 때문에 시스템의 설계 상당히 중요한 과정에 해당된다. 이에 본 논문에서는 임베디드 개발 장비, STR710F Chip, CC2420 RF Module-Chip을 이용 소형화된 모듈을 설계하고 확장성을 고려하여 RS232C와 USB를 인터페이스로 한 홈 네트워크 시스템 모듈을 설계하였다.

• 복식
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• 제34권
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• pp.135-150
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• 1997

The purpose of this study was to inves-tigate the economic performance of the textile industry for the Korean traditional clothes. The content of this paper had two pars; The first part was for the macroeconomic aspects such as location production employments and the produc-tion facilities of the textile industries. The second part was for the microeconomic aspects such as business type branding method fabric type R&D efforts sourc-ing and the distributional channel The major results were as follows: 1.) Most textile firms for the korean traditional clothes were located in Gongju for man-made fibers and in Jinju for silk fabrics. 2) The size of the textile industry in terms of the number of business produc-tion amount the number of employee de-creased during 1994 and 1995 due to the decreasing demand. 3) Over the half of the textile firms produced raw fabric products while only 20% of them were involved in additional dyeing and /or printing finish which re-sulted in low value added production 4) The R&D effort of the textile indus-try for the Korean traditional clothes was very low due to the market uncertainty lack of technological knowledge and most of all small size of the firms 5) Most raw materials for the textile in -dustry were imported with high(25%) tariff rates resulting in price increase and thus low competitiveness in the market. 6) The textile producers sole about the 70% of their products to the wholesalers while selling the rest to the retailers di-rectly. This showed the dual structure of the distribution channel in the textile products. These results suggested some implica-tions for the firms the policy makers and the researchers. The firms should develop new and improved products to increase and create consumer demand by intensive R&D efforts. The government policy ma-kers should give financial supports the firms with R&D investment and legal help such as lowing tariff rate for the raw ma-terials. The researchers from the academy could help the textile industry with the advanced technological knowledge and up-date information for the consumer fashion demand.