• Title/Summary/Keyword: PARASITE

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Prevalence of Toxoplasma gondii Antibodies in Stray Dogs from Various Locations in West and East Malaysia

  • Watanabe, Malaika;Sadiq, Mohammed Babatunde;Mulop, Nazrul Iqbal Abdul;Mohammed, Konto;Rani, Puteri Azaziah Megat;Fong, Lau Seng;Aziz, Nor Azlina;Kamaludeen, Juriah;Ramanoon, Siti Zubaidah;Mansor, Rozaihan;Ping, Tan Li;Syed-Hussain, Sharifah Salmah
    • Parasites, Hosts and Diseases
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    • v.58 no.5
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    • pp.487-492
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    • 2020
  • Toxoplasmosis is caused by an obligate intracellular protozoan parasite; Toxoplasma gondii, which is one of the most important zoonotic parasite worldwide. In dogs, the sexual reproductive cycle of T. gondii is lacking, and the animals are not widely consumed as food, but they are vital in the mechanical transmission of the parasite. However, there is no present data on the exposure of stray dogs to T. gondii in Malaysia. The objective of this serological survey was to determine the prevalence of T. gondii antibodies (IgG) and associated factors in stray dogs in East and West Malaysia. Antibodies to T. gondii were determined in serum samples from 222 stray dogs from 6 different states in East and West Malaysia (Peninsular Malaysia) using an Indirect ELISA. The seroprevalence for T. gondii was 23.4% (Confidence interval: CI 17.8-29.2%). Stray dogs from Selangor and Kuala Lumpur had the highest seroprevalence (32.4%; CI 13.2-45.5%) and lowest in those from Penang and Kedah (12.5%; CI 1.3-23.5%). Gender and breed were not associated with T. gondii seropositivity. However, adult dogs were more likely to be seropositive for T. gondii (OR=2.89; CI 1.1-7.7) compared with younger dogs. These results revealed that T. gondii is prevalent in stray dogs in the studied areas in Malaysia, and indicative of the level of environmental contamination of this parasite especially in urban areas.

New Aspect of Patriarch as a Male Abject and Gender Politics of Class Representation - Focusing on (남성 아브젝트라는 새로운 가부장의 형상과 계급 재현의 젠더 정치 -영화 <기생충>을 중심으로)

  • Kim, Keon-Hyung
    • Journal of Popular Narrative
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    • v.27 no.3
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    • pp.53-94
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    • 2021
  • This article pays attention to the gender representation of an abominable male abject that reveal class polarization in the movie Parasite. I seeks to read a new aspect of emotional politics in which a precariat man becomes a male patriarch while representing himself with an abhorrent position. Parasite shows a reversal of daughter and son responsible for parents, contrary to the existing family narrative. They teaches the parents' generation how to survive neoliberal that their place is created only when they take away others' place. However, after losing this prospect, Ki-woo confesses to his father that he is sorry first. Ki-taek also attempted to identify Dong-ik with the patriarch, but this male solidarity collapsed by class and committed murder in sudden anger. As a result, Gi-taek goes down to the hateful status of a stinking underground life, and Ki-woo receives a message of ethical reflection from his isolated father. The film gives the father and son the noble status of ethical fighter who fought against the structure of class polarization, especially the ending epilogue and narration emphasizing the ethical responsibility and mutual solidarity between father and son. In this process, the voices of female characters are gradually omitted, blurring gender screening for male characters. Parasite reveals the political reenactment strategy of precariat men in the age of neoliberalism, which is ethical subject by claiming to be a class abject himself. And representing the hate with gender-selecting, it is beautifying the responsible ethics of the patriarch.

Evaluating the activity of N-89 as an oral antimalarial drug

  • Nagwa S. M. Aly;Hiroaki Matsumori;Thi Quyen Dinh;Akira Sato;Shin-ichi Miyoshi;Kyung-Soo Chang;Hak Sun Yu;Takaaki Kubota;Yuji Kurosaki;Duc Tuan Cao;Gehan A. Rashed;Hye-Sook Kim
    • Parasites, Hosts and Diseases
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    • v.61 no.3
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    • pp.282-291
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    • 2023
  • Despite the recent progress in public health measures, malaria remains a troublesome disease that needs to be eradicated. It is essential to develop new antimalarial medications that are reliable and secure. This report evaluated the pharmacokinetics and antimalarial activity of 1,2,6,7-tetraoxaspiro[7.11]nonadecane (N-89) using the rodent malaria parasite Plasmodium berghei in vivo. After a single oral dose (75 mg /kg) of N-89, its pharmacokinetic parameters were measured, and t1/2 was 0.97 h, Tmax was 0.75 h, and bioavailability was 7.01%. A plasma concentration of 8.1 ng/ml of N-89 was maintained for 8 h but could not be detected at 10 h. The dose inhibiting 50% of parasite growth (ED50) and ED90 values of oral N-89 obtained following a 4-day suppressive test were 20 and 40 mg/kg, respectively. Based on the plasma concentration of N-89, we evaluated the antimalarial activity and cure effects of oral N-89 at a dose of 75 mg/kg 3 times daily for 3 consecutive days in mice harboring more than 0.5% parasitemia. In all the N-89-treated groups, the parasites were eliminated on day 5 post-treatment, and all mice recovered without a parasite recurrence for 30 days. Additionally, administering oral N-89 at a low dose of 50 mg/kg was sufficient to cure mice from day 6 without parasite recurrence. This work was the first to investigate the pharmacokinetic characteristics and antimalarial activity of N-89 as an oral drug. In the future, the following steps should be focused on developing N-89 for malaria treatments; its administration schedule and metabolic pathways should be investigated.

소 내부기생충 감염과 젖소 산유량과의 상관관계

  • 양홍지;윤여백;서준석;노영선;정재명;서창섭
    • Journal of the korean veterinary medical association
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    • v.28 no.12
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    • pp.736-739
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    • 1992
  • This report was undertaken to examine the correlationship between internal parasite infection and amount of milk production before and after vermicidal administration on F. hepatica and gastrointestinal nematoda infected cattle. The obtained results were

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Isolation of Ectroparasitic Bdellovibrio sp. from Several Soils (토괴중에서의 bdellovibrio sp.의 분리시도)

  • 고춘명;이봉기;등영건
    • Korean Journal of Microbiology
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    • v.15 no.1
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    • pp.42-45
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    • 1977
  • Bdellovibrio sp. is an ectoparasitic bacteria which is predatory and parasitic upon other bacteria. This study was carried out the isolation of Bdellovibrio sp. from several soil smaples and observation of this organisms by means of electron microscope. The results are as follows ; The primary isolated Bdellovibrio sp. from soil is an obligate intracellular rod form parasite and possess a monoflagella.

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