• 제목/요약/키워드: PAI-I

검색결과 119건 처리시간 0.027초

Effects of High Relative Humidity on Weight Loss, Color Change, and Microbial Activity of Tomatoes during Refrigerated Storage

  • Pai, Tongkun
    • Journal of Applied Biological Chemistry
    • /
    • 제43권4호
    • /
    • pp.250-253
    • /
    • 2000
  • The effects of high relative humidity (RH) on the physicochemical properties and microbial activity of mature green tomatoes ('Dombito') during refrigerated storage were determined at three temperatures (5, 10, and $15^{\circ}C$) and four different RH levels (91, 94, 97, and 99%). At each temperature, the weight loss rates of tomatoes at different levels of RH were significantly (p<0.05) different from each other. For the samples stored at $10^{\circ}C$, the weight losses were generally higher than those for the samples at $15^{\circ}C$ within the same RH level (i.e., greater vapor pressure deficit). The color change rates ('a' value) showed positive slopes, indicating that the tomato color was changing from green to red. Neither bacteria nor fungi caused visible damages to the samples, and the microbial counts were below 650 colony forming units/$cm^2$ during the test period.

  • PDF

Facilitation of AMPA receptor-mediated steady-state current by extrasynaptic NMDA receptors in supraoptic magnocellular neurosecretory cells

  • Pai, Yoon Hyoung;Lim, Chae Seong;Park, Kyung-Ah;Cho, Hyun Sil;Lee, Gyu-Seung;Shin, Yong Sup;Kim, Hyun-Woo;Jeon, Byeong Hwa;Yoon, Seok Hwa;Park, Jin Bong
    • The Korean Journal of Physiology and Pharmacology
    • /
    • 제20권4호
    • /
    • pp.425-432
    • /
    • 2016
  • In addition to classical synaptic transmission, information is transmitted between cells via the activation of extrasynaptic receptors that generate persistent tonic current in the brain. While growing evidence supports the presence of tonic NMDA current ($I_{NMDA}$) generated by extrasynaptic NMDA receptors (eNMDARs), the functional significance of tonic $I_{NMDA}$ in various brain regions remains poorly understood. Here, we demonstrate that activation of eNMDARs that generate INMDA facilitates the ${\alpha}$-amino-3-hydroxy-5-methylisoxazole-4-proprionate receptor (AMPAR)-mediated steady-state current in supraoptic nucleus (SON) magnocellular neurosecretory cells (MNCs). In $low-Mg^{2+}$ artificial cerebrospinal fluid (aCSF), glutamate induced an inward shift in $I_{holding}$ ($I_{GLU}$) at a holding potential ($V_{holding}$) of -70 mV which was partly blocked by an AMPAR antagonist, NBQX. NBQX-sensitive $I_{GLU}$ was observed even in normal aCSF at $V_{holding}$ of -40 mV or -20 mV. $I_{GLU}$ was completely abolished by pretreatment with an NMDAR blocker, AP5, under all tested conditions. AMPA induced a reproducible inward shift in $I_{holding}$ ($I_{AMPA}$) in SON MNCs. Pretreatment with AP5 attenuated $I_{AMPA}$ amplitudes to ~60% of the control levels in $low-Mg^{2+}$ aCSF, but not in normal aCSF at $V_{holding}$ of -70 mV. $I_{AMPA}$ attenuation by AP5 was also prominent in normal aCSF at depolarized holding potentials. Memantine, an eNMDAR blocker, mimicked the AP5-induced $I_{AMPA}$ attenuation in SON MNCs. Finally, chronic dehydration did not affect $I_{AMPA}$ attenuation by AP5 in the neurons. These results suggest that tonic $I_{NMDA}$, mediated by eNMDAR, facilitates AMPAR function, changing the postsynaptic response to its agonists in normal and osmotically challenged SON MNCs.

화침요법(火鍼療法)의 연구동향(硏究動向)과 D.I.T.I를 활용(活用)한 임상적(臨床的) 고찰(考察) (A Literature Review and A Clinical Examination of Burning Acupuncture Therapy of using D.I.T.I.)

  • 박상준;안수기
    • Journal of Acupuncture Research
    • /
    • 제15권2호
    • /
    • pp.407-425
    • /
    • 1998
  • We have studied the clinical application of burning acupuncture by examining 18recent-published papers in the journal 'ZHONGGUO ZHENJIU(中國鍼灸)' for the bibliographical study and clinical study and have given medical treatment of burning acupuncture on 21 Patients who suffered 'the body chill symptoms(冷症)' at the oriental hospital of Won-Kwang University, Kwang-Ju. As a result, we have come to some conclusions as below. 1. The diseases for which the modern borning acupuncture is efficacious are widely extended to various kinds of field such as surgery, internal medicine, gynecology, ophthalmology, otolaryngology. etc. as well as numbness, meridian muscle disease(經筋病) mentioned in 'Neijing(內徑)' . 2. The effects of burning acupuncture therapy are wen zhuang yang qi(溫壯陽氣), sheng ji lian chuang(生肌斂瘡), san han chu shi(散寒除濕), qu fens zhi yang(祛風止痒), qu yu chu fu pai nong(祛瘀除腐排膿), san jie xiao zhong(散結消腫), zhi tong huan ji chu ma mu(止痛緩急除麻木), qing re xie hue jie du(淸熱瀉火解毒). 3. The recently reported diseases for which burning acupuncture is good are internal and external humeral epicondylitis, atheroma, menorrhalgia, thecal cyst, tragomaschalia, pruritus, traumatic onychophemia, gout of feet, prostatomegaly, aacne, supprative infection of body surface, snapping finger, backache, numbness, pyocyst etc. 4. The subjective symptoms of 'the body chill symptoms(冷症)' were, most of all, feeling cold accompanied by pain(16 case), while just 4 cases were feeling cold only. 5. In the related diseases of the body chill symptoms(冷症), feeling pain like arthralgia was the most case, and then dysmenorrhea, menorralgia, depression, anemia in order. 6. In the D.I.T.I before and after burning acupuncture treatment, 6 patients had shown 'excellent' effects and 8 patients had turned out 'good', while 7 patients had become'fair'. 7. In the degree of patient-satisfaction, 5 patients announced 'excellence' and 6 patients expressed 'good', 4 expressed 'fair', while the other 6 showed no change. 8. In the correlation of D.I.T.I and patient-satisfaction, the better the result of clinical treatment was, the more satisfied the patient was, however, in the case 'fair', we saw the degree of patient-satisfaction was relatively low, so we could admit the judging significance of D.I.T.I.

  • PDF

남성 사무직 관리자의 생활습관, 스트레스 수준과 과민성 대장증후군 (Relationship between Life Style, the Level of Stress and Irritable Bowel Syndrome on 1498 Male White Collars)

  • 김종렬;엄상화;전진호;정수진;이창희;정귀원;최순석;배기택
    • Journal of Preventive Medicine and Public Health
    • /
    • 제30권4호
    • /
    • pp.791-804
    • /
    • 1997
  • Irritable bowel syndrome(IBS) is one of the common health problem that has been considered as stress-induced. This study was conducted to investigate the relationship between life style and the level of stress and IBS by structured questionnaire which included questions on life style, the self-esteemed gastrointestinal symptoms, and Psychosocial Well-being Index(PWI). Subjects were 1,498 male white collars who get the regular health check and participated in survey at Inje University Health Promotion Center from January to ,December, 1996. The overall prevalence of IBS was 37.5%(561 cases), and the level of stress by PWI score was higher in IBS group$(41.8{\pm}14.2)$ than symptom-free group$(34.6{\pm}12.6)$. As the result of comparison between the two groups, heavier smoking (adjusted O.R=2.48, 95% C.I 1.81-3.41), longer daily working time (adjusted O.R=5.19, 95% C.I 3.59-7.56), stimulatory food materials-mainly hot or salty (adjusted O.R=1.87, 95% C.I 1.44-2.45), higher body mass index (adjusted O.R=1.80, 95% C.I 1.27-2.57), and higher level of stress (adjusted O.R=2.81, 95% C.I 1.80-4.43) were estimated as risk factors of IBS. On the contrary, 6-8 hours sleeping per day (adjusted O.R=0.38 95% C.I 0.21-0.70), 3-4 times exercise per week (adjusted O.R=0.57 95% C.I 0.39-0.83), and tenure more than 20 years (adjusted O.R=0.25 95% C.I 0.16-0.35) were considered as protective factors to IBS. In summary, the assessment of the stress level might be placed in the first priority to control IBS, at least by some degree, which suggested that IBS could be controlled by avoiding such risk factors and by encouraging such protective factors.

  • PDF

등록문화재 제도에 있어서 경제적 관점을 통한 근대건축물의 보존 및 활용에 관한 연구 (The Preservation and Utilization of Modern Building of the Registered Cultural Properties System through Economical Approach)

  • 김종헌
    • 공학논문집
    • /
    • 제8권1호
    • /
    • pp.13-22
    • /
    • 2006
  • 문화재 등록은 소유주에게 피해만 입히는 행위인가? 문화재의 보존은 경제적 가치가 없는 일인가? 보존과 개발은 반드시 갈등구조 속에서 존재할 수 밖에 없는가? 상호보완관계에서 풀 수는 없는 것인가? 이러한 관점에서 보존과 개발이 첨예하게 대립하고 있는 등록문화재를 중심으로 그에 대한 경제적 해결방안을 살펴보고자 한 이 논문은 1) 등록문화재를 환경조형물로 인정하는 방안과 2) 등록문화재의 랜드마크적 기능을 인정하여 이로 인하여 얻는 이익금의 일부를 보상받는 방안 3) 건축법에서의 높이제한에 대한 완화규정 적용 4) 건축법에서의 건폐율과 용적율 완화규정 적용하는 방안 등을 제안하고 있다. 우리가 근대건축을 보존하고 가치를 부여하는 것은 과거의 향수를 달래기 위한 감상적인 접근이 아니라 현재 우리의 삶을 풍요롭게 만들 수 있는 기반이며, 앞으로 새로운 삶을 충족시킬 수 있는 수준 높은 새로운 건축을 위한 창조적 행위이다.

  • PDF

경량기포콘크리트의 제조 및 기포제의 특성분석 (Preparation of Lightweight Aerated Concrete and Characteristic Analysis of Foaming Agent)

  • 임굉;임재석
    • 공학논문집
    • /
    • 제8권1호
    • /
    • pp.31-50
    • /
    • 2006
  • 수축은 콘크리트에 균열을 발생시키는 경우도 있다. 일반적 조건하에서는 콘크리트의 건조를 피할 수 없으며 건조가 일어나면 수축이 생기므로 대부분의 콘크리트 적용분야에서는 실제로 이와 같이 균열발생을 고려하여야 한다. 균열이 발생한 콘크리트는 균열이 없는 콘크리트에 비하여 강도가 약하고 투과성이 크며 화학적 침식의 영향을 받기 쉽다. 또 재령의 경과에 따라 경량기포콘크리트의 강도발현은 기포제의 종류, 물과 시멘트와의 비, 양생조건 및 기간 등과 같은 인자에 의존하고 있다. 경량기포콘크리트의 강도가 높으면 높을수록 수축에 의하여 균열이 발생할 가능성이 감소한다. 그러므로 온돌구조용으로의 경량기포콘크리트의 강도는 소포율과 시멘트의 건조수축과의 균열저감효과에 크게 의존된다.

  • PDF

Hypoglycemic Effect and Hepatic Detoxification Activity of Extracts from Crataegus fructus and Morus alba L. in Alcohol-treated Rats

  • Kim, Ji-Su
    • 대한의생명과학회지
    • /
    • 제13권1호
    • /
    • pp.17-23
    • /
    • 2007
  • To consider potentially new sources which have hypoglycemic effect and accelerating alcohol detoxification, this study was designed to investigate the effect of Crataegus fructus and Morns alba L. in alcohol-treated rats. I compared the body weight, glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alcohol dehydrogenase (ADH), and aldehyde dehydrogenase (ALDH) of rats administered both alcohol and extract of experimental plants to rats treated with alcohol alone. Administration of extracts of C. fructus and M alba, respectively, resulted in a significant reduction in the blood glucose level and the activities of ADH of liver compared to the control rats, and administration of extract of M. alba showed significantly lower on bodyweight gain in the rats than in other treated rats. In contrast, the activities of ALDH of liver were increased. The activities of AST and ALT between the only alcohol-treated rats and the alcohol and experimental plants-treated rats were no significant difference. The results suggest that C. fructus and M alba have a hypoglycemic effect, and reduce liver damage by accelerating acetaldehyde metabolism in alcoholic rats, so the combined effect of C. fructus and M alba may be considered as an alternative remedy for hangovers, alcohol-induced overweight and alcohol-induced diabetes.

  • PDF

비틀림 하중을 받는 얇은 빔의 동적 불안정성에 관한 연구 (Study on the Dynamic Torsional Instability of a Thin Beam)

  • 박진선;주재만;박철희
    • 한국소음진동공학회:학술대회논문집
    • /
    • 한국소음진동공학회 1995년도 추계학술대회논문집; 한국종합전시장, 24 Nov. 1995
    • /
    • pp.185-190
    • /
    • 1995
  • In recent years, many researcher have been interested in the stability of a thin beam. Among them, Pai and Nayfeh[1] had investigated the nonplanar motion of the cantilever beam under lateral base excitation and chaotic motion, but this study is associated with internal resonance, i.e. one to one resonance. Also Cusumano[2] had made an experiment on a thin beam, called Elastica, under bending loads. In this experiment, he had shown that there exists out-of-plane motion, involving the bending and the torsional mode. Pak et al.[3] verified the validity of Cusumano's experimental works theoretically and defined the existence of Non-Local Mode(NLM), which is came out due to the instability of torsional mode and the corresponding aspect of motions by using the Normal Modes. Lee[4] studied on a thin beam under bending loads and investigated the routes to chaos by using forcing amplitude as a control parameter. In this paper, we are interested in the motion of a thin beam under torsional loads. Here the form of force based on the natural forcing function is used. Consequently, it is found that small torsional loads result in instability and in case that the forcing amplitude is increasing gradually, the motion appears in the form of dynamic double potential well, finally leads to complex motion. This phenomenon is investigated through the poincare map and time response. We also check that Harmonic Balance Method(H.B.M.) is a suitable tool to calculate the bifurcated modes.

  • PDF

판매원의 자기효능감 및 직무과부하가 감정노동에 미치는 영향과 감정의 매개효과 (The Effect of Salesperson's Self Efficacy and Work Overload on Emotional Labor and the Mediating Role of Emotion)

  • 김현숙;전대근;추호정
    • 한국의류학회지
    • /
    • 제35권10호
    • /
    • pp.1150-1160
    • /
    • 2011
  • This study investigates i) the effect of salesperson's self efficacy and work overload on emotional labor and ii) the mediating role of emotion. A survey questionnaire is developed and implemented on salespersons working in the fashion retail stores of department stores. The measurement scales are composed of emotional labor, self efficacy, work overload and emotion. A total of 112 responses are analyzed by confirmatory factor analysis and a structural equation model with AMOS18.0. The results are as follows. Firstly, self efficacy has direct effect on both deep acting and surface acting of emotional labor without the mediating effect of emotion. Self efficacy has a positive effect on deep acting. Secondly, work overload has a negative effect on emotion. Job emotion has positive effect on deep acting and it has a negative effect on surface acting. Thirdly, emotion has a significant mediating effect between work overload and emotional labor. Finally, implications for personal management and job design in the fashion retail organizations are suggested.

Superb Mechanical Stability of n-Octadecyltriethoxysilane Monolayer Due to Direct Chemical Bonds between Silane Headgroups and Mica Surface: Part I

  • 김성수
    • 통합자연과학논문집
    • /
    • 제3권2호
    • /
    • pp.89-95
    • /
    • 2010
  • It is still controversial where the improved stability of n-octadecyltriethoxysilane self-assembled monolayer (OTE SAM) on plasma-pretreated mica surface exactly originates from. To date, it has been well known that the extensive cross-polymerization between silane head-groups is a crucial factor for the outstanding mechanical strength of the monolayer. However, this study clearly showed that the stability comes not only from the cross-links but also, far more importantly, from the direct chemical bonds between silane headgroups and mica surface. To examine this phenomenon, n-octadecyltrichlorosilane monolayers were self-assembled on both untreated and plasma treated mica surfaces, and their adhesion properties at various physical conditions (relative humidity, high stress, and contact repetition) were investigated and compared through the use of the surface forces apparatus technique. It revealed that, in highly humid conditions (>90%RH), there is a substantial difference of stability between untreated and plasma treated cases and the plasma treated surface is mechanically much more stable. It obviously proves that the extensive chemical bonds indeed exist between silane head-groups and plasma treated mica surface and dramatically improve the mechanical stability of the OTE monolayer-coated mica substrate.