• Korean Journal of Remote Sensing
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• v.12 no.2
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• pp.126-138
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• 1996

The characteristics of rapid development of the low pressure system over the East Sea from 06 to 08 Nov., 1995 has been analyzed in detail by the synoptic numerical products and satellite observations. The Low system was initially triggered the development of the baroclinic leaf cloud over the border of the northern part of Korea and China and moved eastward and then developed explosively com-ma or lambda type cloud system over the East Sea. To forecast well the general development and movement of the coastal winter cyclone over the East Sea popularly in a numerical simulation by several scientists, the large baroclinicity, continuous support of water vapor, and sequential cold outbreak over the warm sea surface have been more commonly concerned about. The cyclone which the central surface pressure was dropped 40hPa within 24 hours has often accompanied strong wind and heavy snow- or rain-fall in the winter season. In all successive observations with 12-hourly satellite imagery and analyzed meteorological variables in this period, the centers of the sea-level pressure and 500hPa geopotential height associated with this cyclone were typically illustrated by moving farther eastward using GMS combined enhanced IR images. The maxi-mum wind sustained by this system with the intensity and central pressure of tropical storm was about 60 knots with the center pressure drop of 44hPa/day similar to the North American cyclonic bomb and Atlantic storm.

• Tuberculosis and Respiratory Diseases
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• v.60 no.2
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• pp.180-186
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• 2006

Background : Para-aminosalicylic acid(PAS) is a 2nd-line drug that can cause severe adverse reactions leading to poor patient compliance. This study evaluated the relapse rate according to the discontinuance of PAS at a certain point after bacteriological conversion during the course of chemotherapy for multidrug-resistant tuberculosis(MDR-TB). Methods : 42 out of 452 MDR-TB patients were enrolled in this study. All subjects were receiving chemotherapy including PAS at National Masan TB Hospital between Jan. 1, 2000 and Dec. 31, 2001. The relapse rate was evaluated after the discontinuance of PAS from their initial regimen as a result of the severe adverse reactions at a certain point after the bacteriological conversion during the course of chemotherapy for MDR-TB. Results : The male to female ratio was 2.5:1, and the mean age was 47.2 years old. The average number of past histories, used drugs and resistant drugs was 1.2, 3.9 and 4.3. The mean number of sensitive drugs included in the inirial regimen was 3.9. The mean time for bacteriological conversion and discontinuance of the PAS was 2.3 months after initiating treatment and 6 months after bacteriological conversion, respectively. There was no relapse after discontinuing PAS during a mean follow up period of 31.6 months. Conclusion : PAS may be discontinued in the cases of serious gastrointestinal problems approximately 6 months after bacteriological conversion without concern about relapse.

• Geomechanics and Engineering
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• v.12 no.1
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• pp.85-109
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• 2017

The paper presents the laboratory study of clayey soil stabilized with Pond ash (PA), Rice husk ash (RHA), cement and their combination used as stabilizers to develop and evaluate the performance of clayey soil. The effect of stabilizer types and dosage on fresh and mechanical properties is evaluated through compaction tests, unconfined compressive strength tests (UCS) and Split tensile strength tests (STS) performed on raw and stabilized soil. In addition SEM (scanning electron microscopy) and XRD (X-ray diffraction) tests were carried out on certain samples in order to study the surface morphological characteristics and hydraulic compounds, which were formed. Specimens were cured for 7, 14 and 28 days after which they were tested for unconfined compression tests and split tensile strength tests. The moisture and density curves indicate that addition of RHA and pond ash results in an increase in optimum moisture content (OMC) and decrease in maximum dry density (MDD). The replacement of clay with 40% PA, 10% RHA and 4% cement increased the strength (UCS and STS) of overall mix in comparison to the mixes where PA and RHA were used individually with cement. The improvement of 336% and 303% in UCS and STS respectively has been achieved with reference to clay only. Developed stabilized soil mixtures have shown satisfactory strength and can be used for low-cost construction to build road infrastructures.

• BMB Reports
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• v.47 no.12
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• pp.691-696
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• 2014

${\alpha}$-Enolase is a glycolytic enzyme and a surface receptor for plasminogen. ${\alpha}$-Enolase-bound plasminogen promotes tumor cell invasion and cancer metastasis by activating plasmin and consequently degrading the extracellular matrix degradation. Therefore, ${\alpha}$-enolase and plasminogen are novel targets for cancer therapy. We found that the amino acid sequence of a peptide purified from enzymatic hydrolysates of seahorse has striking similarities to that of ${\alpha}$-enolase. In this study, we report that this peptide competes with cellular ${\alpha}$-enolase for plasminogen binding and suppresses urokinase plasminogen activator (uPA)-mediated activation of plasminogen, which results in decreased invasive migration of HT1080 fibrosarcoma cells. In addition, the peptide treatment decreased the expression levels of uPA compared to that of untreated controls. These results provide new insight into the mechanism by which the seahorse-derived peptide suppresses invasive properties of human cancer cells. Our findings suggest that this peptide could emerge as a potential therapeutic agent for cancer.

• Journal of Chest Surgery
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• v.21 no.6
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• pp.970-978
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• 1988

There is tendency of increasing number and decreasing age of patients who are indicated for Rastelli operation for their cyanotic congenital heart disease. So there is the need to find the criterion which saves the patients from early postoperative hemodynamic disturbances. We reviewed the 26 patients who had been performed Rastelli operation at Seoul national University Hospital from January 1981 to June 1988. mean age of the patients was 7.8*3.4 years[range 2.5-15years], mean body surface area[BSA] 0.79*0.25m2[range 0.49-1.51m2] and mean hematocrit 57.95*12%[range 48-80%]. We divided these patients into survived group and died group before postoperative 72 hours, and analyzed preoperative arterial oxygen saturation[SaO2], the ratio of diameter of right pulmonary artery to ascending aorta[RPA/AA], the ratio of both right and left pulmonary artery diameter to descending thoracic aorta[RPA+LPA/DTA], pulmonary artery index[PA index], cardiopulmonary bypass time, aorta cross-clamping time, postoperative perfusion state and total amount of dopamine infused postoperatively. The results showed that RPA+LPA/DTA and PA index were statistically significant factors to influence early postoperative cardiac death rate[P< 0.05]. Especially there were good linear correlations between PA index[X] and peripheral perfusion index[Y][Y= - 1.15+0.02 X, r=0.86, P<0.01]and between PA index[X] and total amount of dopamine infused before postoperative 72 hours[mg/kg, Y][Y=61.94 - 0.15 X, r=-0.80, P < 0.01]. Also there were tendencies that the higher RPA+LPA/DTA[Y], the better peripheral perfusion [X] and the lower need of dopamine[X], but no statistical significance.[Y=0.78+1.60 X, r =0. 49, P >0.05] And the discriminate analysis showed that patients with PA index over 221 mm2/BSA could undergo correction with 25 per cent of error rate. In conclusion, early postoperative hemodynamic states could be predicted by preoperatively measured PA index, and which can be used as a criterion for Rastelli operation performed on cyanotic congenital heart disease.

• Atmosphere
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• v.20 no.3
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• pp.229-238
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• 2010

The 1,000~500 hPa thickness and the $0^{\circ}C$ isotherm at 850 hPa have been used as the traditional predictors for wintertime precipitation-type forecasts. New approaches are taking on added significance as preexistence method of determination for wintertime precipitation-type exhibits more or less prevalent false alarms. Moreover thicknesses and thermodynamic profiles from ordinary upper-air observation were not adequate to monitor the atmospheric structure. In this regard, Microwave radiometric profiler microwave radiometer is useful in wintertime precipitation-type forecasts because radiometric measurements provide soundings at high temporal resolution. In this study, the determination and the predictability of wintertime precipitation-type were examined by using the calculated thicknesses, temperature of 850 hPa (T850) from a microwave radiometer, and surface observation at National Center for Intensive Observation of severe weather (NCIO) located at Haenam, Korea. The critical values for traditional predictors (thickness of 1000~500 hPa and T850) were evaluated and adjusted to Haenam region because snow rarely occurred with a 1000-500 hPa thickness > 5,300 m and T850 > $-10^{\circ}C$. Three thicknesses (e.g., 1,000~850, 1000~700, and 850~700 hPa thickness), T850, surface air temperature, and wet-bulb temperature were also evaluated as the additional predictors. A simple nomogram and a flow chart were finally designed to determine the wintertime precipitation-type using the microwave radiometer. The skill scores for the predictability of precipitation-type determination are considerably improved and the predictors showed the temporal variations in 12 hours before precipitation. We can monitor the hit and run snowfall in winter successful by realtime watch of the predictors, especially in commutes of big cities.

• Korean Journal of Clinical Pharmacy
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• v.33 no.2
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• pp.113-121
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• 2023

Background: Globally, the number of patients with aspergillosis is increasing, and the mortality rate remains high. This study aimed to investigate prescribing patterns of antifungal drugs for patients with aspergillosis in South Korea using real-world data. Methods: This retrospective cross-sectional study was performed using National Patient Sample (NPS) data collected by the Health Insurance Review and Assessment Service (HIRA) during 2011-2020. The use of antifungal drugs in patients with aspergillosis was investigated. Results:A total of 1374 patients were identified: 333 patients with invasive pulmonary aspergillosis (IPA) (24.2%), 436 patients with other PA (31.7%), 73 patients with other forms of aspergillosis (5.3%), and 532 patients with unspecified aspergillosis (38.7%). The odds of receiving an antifungal prescription were higher for IPA than for other PA (aOR, 0.233; p<0.001), and higher for hematologic malignancies than for respiratory disorders other than cancer or infections (aOR, 10.018; p<0.001). During each hospitalization period, 56.1% (97/173) and 6.4% (11/173) of IPA hospitalizations received voriconazole and itraconazole monotherapy, respectively, whereas 44.3% (27/61) and 27.9% (17/61) of other PA hospitalizations received itraconazole and voriconazole monotherapy, respectively. Among outpatients with IPA, 67.5% (85/126) and 26.2% (33/126) received voriconazole and itraconazole alone, respectively, whereas among outpatients with other PA, 86.1% (68/79) and 12.7% (10/79) received itraconazole and voriconazole alone, respectively, during the year. Conclusion: In Korea, voriconazole monotherapy was preferred in IPA inpatients, and itraconazole monotherapy was preferred in other PA inpatients. In the ambulatory care settings for IPA and other PA, itraconazole monotherapy was preferred.

• Korean Journal of Radiology
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• v.20 no.5
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• pp.773-780
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• 2019

Objective: To assess segmental liver stiffness (LS) with MRI before and after endovascular intervention in patients with Budd-Chiari syndrome (BCS). Materials and Methods: Twenty-three patients (13 males and 10 females; mean age, 42.6 ± 12.6 years; age range, 31-56 years) with BCS as a primary liver disease were recruited for this study. Two consecutive magnetic resonance elastography (MRE) examinations were performed before the endovascular treatment. Fifteen patients who underwent endovascular intervention treatment also had follow-up MRE scans within three days after the procedure. LS was measured in three liver segments: the right posterior, right anterior, and left medial segments. Inter-reader and inter-exam repeatability were analyzed with intraclass correlation coefficients (ICCs) and Bland-Altman analysis. Segmental LS and clinical characteristics before and after the intervention were also compared. Results: Within three days of the endovascular intervention, all three segmental LS values decreased: LS of the right posterior segment = 7.23 ± 0.88 kPa (before) vs. 4.94 ± 0.84 kPa (after), LS of the right anterior segment = 7.30 ± 1.06 kPa (before) vs. 4.77 ± 0.85 kPa (after), and LS of the left medial segment = 7.22 ± 0.87 kPa (before) vs. 4.87 ± 0.72 kPa (after) (all p = 0.001). There was a significant correlation between LS changes and venous pressure gradient changes before and after treatments (r = 0.651, p = 0.009). The clinical manifestations of all 15 patients significantly improved after therapy. The MRE repeatability was excellent, with insignificant variations (inter-reader, ICC = 0.839-0.943: inter-examination, ICC = 0.765-0.869). Bland-Altman analysis confirmed excellent agreement (limits of agreement, 13.4-19.4%). Conclusion: Segmental LS measured by MRE is a promising repeatable quantitative biomarker for monitoring the treatment response to minimally invasive endovascular intervention in patients with BCS.

• Journal of Biosystems Engineering
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• v.23 no.1
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• pp.1-12
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• 1998

This study was intended to investigate experimentally the effect of inflation pressure on tractive performance of bias-ply tires for agricultural tractors. Traction tests were conducted at the three velocities of 3, 4, and 5.5km/h under few different surface conditions using a 13.6-28 6PR bias-ply tire as driving wheel of the test tractor. When the inflation pressure was reduced from 250kPa to 40kPa by a decrement of either 30 or 50kPa depending upon the test surface conditions, some of the test results showed that the tractive coefficient and efficiency were increased maximally by 40% and 17％, respectively, at 20% slippage. However, it was failed to derive any consistent rules depicting the effect of inflation pressure of bias ply tires on the tractive performance of tractors.

• Journal of Biosystems Engineering
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• v.26 no.2
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• pp.123-130
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• 2001

The research described in this paper was aimed toward improving the understanding of the interaction of tire inflation pressure and the soil-tire interface stresses. A three-directional stress transducer was developed to measure stress distribution on undertread for a tractor tire. The transducer can directly measure three-directional stresses (normal stress, tangental stress and lateral stress and lateral stress) simultaneously and has both strong structure and high sensitivity, which is not changed by the abrasion of the detecting plate. Measurements of soil-undertread interface stresses were made at tire center on undertread on a 12.4-R24 radial tractor tire opeated at three combinations of a dynamic load (11.8kN) and three inflation pressures (59kPa, 108kPa and 157kPa). These measurements showed that as inflation pressure increased, the soil-undertread interface stresses increased. The results of three stresses comparisons were shown that the peak normal stresses were considerably higher than the tangential peak stresses and the peak lateral stresses.