• 대한간호학회지
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• 제35권2호
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• pp.239-251
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• 2005

Purpose: This study was designed to construct a structural model for explaining mental health status in middle - aged women. Methods: The data was collected by self - reported questionnaires from 206 middle - aged women in Seoul. Data analysis was done with the SAS pc program for descriptive statistics and a PC - LISREL Program for finding the best fit model which assumes causal relationships among variables. Results: The overall fit of the hypothetical model to the data was good, but paths and variables of the model were modified by considering theoretical implications and statistical significances of parameter estimates. Thus it was modified by excluding 3 paths, The modified model showed was good fit to the data($x^2=177.55$, p=.00), GFI=0.908, AGFI=0.860, RMR=0.013, NFI=0.972, NNFI=0.982). Perceived stress, anger expression method, and self -esteem were found to have direct effects on mental health status in middle - aged women. These predictive variables of mental health status explained $66.6\%$ of the model. Conclusion: Programs to enhance mental health status in middle - aged women should include stress management skill, anger expression skill, and self -esteem enhancement skills to be effective.

• Journal of Microbiology and Biotechnology
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• 제12권5호
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• pp.716-721
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• 2002

The ldhL gene encoding the $_L$-(+) lactate dehydrogenase was cloned from Lactobacillus reuteri ATCC 55739 chromosomal DNA and characterized. An internal 750-bp fiagment of ldhL gene was amplified by PCR using primers based on the conserved region of lactobacilli ldhL genes. A genomic library off. reuteri ATCC 55739 was constructed using pBR322, and colony hybridization experiments were performed using the 750-bp fragment as aprobe. One clone harboring a 4.0-kb PstI fragment was identified, and nucleotide sequencing confirmed it as an open reading frame of 972 bp in size in the middle. In addition to IdhL gene, an ORF homologous to Streptococcus pneumoniae TIGR4 hydrolase gene and 3' part of phosphomevalonate kinase gene (mvaK2) were also found on the 4 kb fragment. $_L$-LDH of L. reuteri ATCC 55739 showed the highest degree of homology with the $_L$-LDH of Pediococcus acidilactici (62.4%), fullowed by the $_L$-LDH of Lactobacillus pentosus (58.7%). The size of IdhL transcript determined by Northern blot was 1 kb, indicating the monocistronic nature of IdhL.

• Bulletin of the Korean Chemical Society
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• 제15권6호
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• pp.460-465
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• 1994

New silicon-monosubstituted (${\eta}^4$-2,3,4,5-tetraphenyl-l-silacyclopentadiene)transi tion metal complexes are described. (7-Alkyl-7-silanorbornadienyl)MLn(Alkyl=Methyl: MLn=CpRu$(CO)_2$: Alkyl=Methyl: MLn=CpNi(CO): Alkyl=Ethyl: MLn=CpNi(CO)) complexes were prepared from the corresponding silole-transition metal complexes with dimethylacetylenedicarboxylate. Cycloaddition products were obtained with 2,3-dimethyl-1,3-butadiene, 2,3-butanedione, and 1,4-benzoquinone through the ruthenium-substituted silylene. We have determined the crystal structure of (1-methyl-2,3,4,5-tetraphenyl-l-silacyclopentadien yl)cyclopentadienyldicarbonylruthenium by using graphite monochromated Mo-Ka radiation. The compound was crystallized in the monoclinic space group $P2_{1/c}$ with a = 9.838(l), b = 15.972(3), c = 18.327(3) ${\AA}$, and ${\beta}= 94.28(l)^{circ}$. The ruthenium moiety CpRu$(CO)_2$ on silicon is in an axial position.

• 한국산학기술학회논문지
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• 제17권9호
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• pp.472-482
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• 2016

본 연구는 노인 손상의 발생이 특정 지역 내 공간의 안전성과 통계적으로 유의한 관계에 있는지를 실증하는 데 목적이 있다. 이러한 연구 목적 수행을 위해 퇴원손상심층조사와 지역안전지수 자료를 결합해 6,572명의 노인 손상환자를 대상으로 손상의도성, 손상발생장소, 손상 시 활동, 손상기전에 따라 지역안전등급의 평균 차이가 있는지를 독립표본 t-검정과 일원배치 분산분석을 통해 검증하였다. 통계 검증 결과 손상의도성의 하위집단별 지역안전등급의 평균 차이는 유의하지 않았으나, 손상발생장소는 화재(t=-2.513, p<.05), 교통(t=-2.387, p<.05), 안전사고(t=-3.627, p<.001), 자살(t=-3.364, p<.01)의 4개 분야에서 집단 간 평균 차이가 있었다. 손상 시 활동은 화재(F=5.972, p<.01), 자연재해(F=6.454, p<.01), 안전사고(F=11.726, p<.001)의 3개 분야에서 집단 간 평균 차이가 있었다. 손상기전은 화재(F=9.267, p<.001), 교통(F=7.759, p<.001), 안전사고(F=3.285, p<.05), 자살(F=8.973, p<.001), 감염병(F=3.109, p<.05)의 5개 분야에서 집단 간 평균 차이가 있었다. 이러한 분석 결과를 토대로 지역안전지수의 개별 분야를 연구 소재로 삼은 선행연구의 보고 내용과 비교해 논의한 후 공간의 안전성 차원에서 노인 손상의 발생을 사전에 예방하고 발생률을 억제하기 위한 3가지의 정책적 실천적 함의를 도출해 제시하였다.

• 영재교육연구
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• 제22권3호
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• pp.779-800
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• 2012

이 연구는 영재의 부적응적 완벽주의가 자살생각에 어떠한 영향을 미치는지 살펴보고 부적응적 완벽주의와 자살생각 간의 관계에서 우울과 학업스트레스의 관계를 검증해봄으로써 영재의 정서적인 특징을 파악하고 자살생각의 위험성에 노출된 영재들에게 도움을 줄 수 있는 방법을 모색하는 데 목적이 있다. 이를 위해 수도권의 한 대학부설 과학영재교육원에 재학중인 중학생 1~3학년 320명을 대상으로 연구를 실시하였다. 연구결과, 첫째, 과학영재의 자살생각에 대한 최종 모형의 적합도는 CFI=.972, TLI=.966, RMSEA=.058로 나타나 적합한 모형임을 확인하였다. 둘째, 자살생각은 부적응적 완벽주의와 우울, 학업스트레스와 모두 정적인 상관관계를 보였다. 셋째, 부적응적 완벽주의에서 우울과 학업스트레스의 경로와 우울에서 자살 생각, 학업스트레스에서 자살생각의 경로는 모두 통계적으로 유의한 것으로 나타났다. 하지만 부적응적 완벽주의에서 자살생각의 경로는 유의하지 않은 것으로 나타났다. 넷째, 우울과 학업스트레스는 부적응적 완벽주의와 자살생각 간의 관계를 완전 매개하는 것으로 나타났다. 이 연구결과는 영재 청소년의 정의적 특성에 대한 이해의 폭을 넓히고, 완벽주의적인 특성을 지닌 영재에게 적절한 상담 및 교육 프로그램을 고안하기 위한 기초자료로 제공될 수 있을 것으로 사료된다.

• 생명과학회지
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• 제15권6호
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• pp.972-978
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• 2005

제주말의 혈통보존을 위한 기초자료를 마련할 목적으로 국내에서 사육중인 제주말 102두를 대상으로 적혈구항원형 및 혈액단백질형의 유전적 다형성을 조사한 결과는 다음과 같다. 적혈구항원형의 표현형 빈도는 $A^{af}$28두($27.45\%),\;C^{a}$ 101두 ($99.02\%),\;K^{-}$ 99두 ($97.06\%),\;U^{a}$ 64두 ($62.75\%),\;P^{b}$ 37두 ($36.27\%),\;Q^{c}$ 48두 ($47.06\%$)에서 높은 빈도를 나타냈으며, D시스템의 31개의 대립유전자 중 $D^{cgm/dghm}$ 14두($13.73\%),\;D^{adn/cgm}$ 10두($9.80\%),\;D^{ad/cgm}$ 9두($8.82\%),\;D^{dghm/dghm}$ 8두($7.84\%),\;D^{cgm/cgm}$ 8두($7.84\%$)에서 높은 빈도의 유전자형이 관찰되었다. 또한 null allele로 추정되는 $D^{ad/c(e)fgm}\;D^{adn/c(e)fgm}\;D^{c(d)fgm/dghm}$대립유전자가 4두에서 관찰되었다. 혈액단백질형은 $AL^{B}$ 49두($48.04\%),\;GC^{F}$ 101두($99.02\%),\;AlB^{K}$ 99두($97.06\%),\;ES^{FI}$ 37두($36.27\%),\;TF^{F2}$ 26두($25.49\%),\;HB^{B1}$ 46두($45.10\%$), and $PGD^{F}$ 88두($86.27\%$)로 높은 빈도를 보였으며, $HB^{A2B1}$ 4두($3.92\%),\;HB^{AB1}$ 2두($1.96\%),\;HB^{AB2}$ 1두($0.98\%),\;PGD^{D}$ 1두($0.98\%$가 특이하게 관찰되었다. 유전자 빈도는 $A^{af}$ (0.3726), $A^{C}$ (0.2647), $C^{-}$ (0.5050), $K^{-}$ (0.9853), $U^{-}$ (0.6863), $P^{b}$ (0.4657), $Q^{c}$ (0.5294), $D^{cgm}$ (0.3039), $HB^{B1}$(0.6863), $PGD^{F}$ (0.9265), $AL^{B}$ (0.6912), $ALB^{K}$ (0.9852), $GC^{F}$ (0.9950), $ES^{I}$ (0.5000) and $TF^{F2}$ (0.4950) 대립유전자가 가장 높은 빈도를 나타내었고 $D^{cgm(f)}$ (0.0196), $HB^{A}$ (0.0147), $HB^{A2}$ (0.0196), $ES^{G}$ (0.0441), $ES^{H}$ (0.0098), $TF^{E}$TF'(0.0246), $TF^{H2}$ (0.0049) and $PGD^{D}$ (0.0098)의 대립유전자가 제주말 에서 특이하게 관찰되었다. 결론적으로 혈액형에 의한 제주말의 유전적 다형은 $A^{af},\;A^{c},\;C^{-},\;K^{-},\;U^{-},\;P^{b},\;Q^{c},\;D^{cgm},\;D^{dghm},\;D^{adn},\;HB^{B1}$, $PGD^{F},\;AL^{B},\;A1B^{K},\;GC^{F},\;ES^{I},\;TF^{F2},\;AL^{B}$, 대립유전자의 빈도가 비교적 높은 것으로 관찰되었고 $A^{ab},\;A^{abf},\;D^{cgm(f)},\;(D^{cfg(k)m}$ 혹은$D^{c(e)fgm}),\;HB^{A},\;HB^{A2},\;ES^{H},\;TF^{E},\;TF^{H2},\;PGD^{D},\;AL^{B}$의 대립유전자가 제주말에서 특이하게 관찰되었다.

• 생명과학회지
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• 제20권5호
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• pp.799-804
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• 2010

혈관 수축력 및 혈압 조절에 관여하는 것으로 알려진 아라키돈산을 물질 대사시키는 CYP2C19 유전자는 최근 심혈관 질환 관련 연구의 새로운 유전자로 제시되고 있다. 본 연구에서는 CYP2C19 유전자의 2 종류 다형성 ($CYP2C19^*2$와 $CYP2C19^*3$)과 고혈압 간의 연관성을 조사하고자 하였다. 연세대학교 의료원 심장혈관병원에서 수집한 1,241명(환자군: 537명, 대조군: 704명)을 대상으로 $SNaPShot^{TM}$ assay를 이용하여 유전자형을 결정하였다. 두 종류의 다형성 가운데 $CYP2C19^*3$의 대립인자형 및 유전자형의 빈도 분포가 환자군과 대조군 간에 유의한 차이를 나타냈다(p=0.019, p=0.023). 다중 로지스틱 회귀분석 결과, dominant model에서, CYP2C193 A 대립인자형은 본태성 고혈압과 매우 유의한 연관성을 나타냈다(OR, 0.723, p=0.032). 또한 CYP2C19 G-A haplotype은 고혈압 발생 위험을 매우 유의하게 감소시키는 것으로 조사되었다(OR, 0.714, p=0.015). 따라서 본 연구 결과는 $CYP2C19^*3$ 다형성이 본태성 고혈압 발생에 대한 보호 효과작용에 관여할 것이라는 증거를 제시하고자 한다.

• 대한간호학회지
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• 제23권4호
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• pp.678-693
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• 1993

The purposes of this study were to describe the level of vision and hearing impairments, depression and functional capacity, among Korean institutionalized elderly and to examine the relation-ship between sensory impairments, depression, and functional capacity in these people. The final pupose was to test the cognitive function path model using sensory competencies as predictors. A convenience sample of thirty nine male and 90 female subjects with a mean age of 80.5 were the subjects of this study. The subjects were tested for cognitive function, and vision and hearing impairments. Physical function and social function were measured by observation of designated task performance by the subjects. Their level of de-pression was measured using a Geriatric Depression Scale administered through an interview. Individual subjective ratings of hearing and vision were marked by the subjects, on a ladder scale. The results of the study showed that 48.8% of the subjects had a hearing impairment, 63.5% had a vision impairement, and 36.4% had both a vision and hearing impairement. The four sensory groups (no sensory impairement, hearing impairement, vision impairement, hearing and vision impairement) were tested for differences in depression, physical function, social behavior and cognitive function. The only significant difference that was found was in cognitive function, between the no sensory impairement group and the hearing and vision impairement group(F=3.25, P<.05), Subjective ratings of hearing showed a significant correlation with cognitive function(r=.34, p<.001) and with social behavior(r=.31, p<.001). There was no correlation between subjective vision ratings and cognitive function or social behavior. However there was a significant correlation between vision and hearing(r=.49, p<.001). There was also a significant negative correlation between age and vision(r=-.21, p<.01) and between age and hear-ing(r=-.34, p<.001). There was a significant correlation between depression and physical function (r=-.32, p<.001) but there was no correlation between depression and cognitive function or social behavior. Based on the literature review and the result, this study, a path model of sensory competence-> cognitive function- >social behavior was developed and tested : Perceived vision and perceived hearing were the exogenous variahles and cognitive function and social behavior were the endogeneous variables in the model. The path analysis result demonstrated an accept-able fit (GFI=.997, AGFI=.972, X$^2$=.72 (p=.396), RMSR=.019) between the data and the model. There was a significant direct effect($\beta$=.38) of perceived hearing on cognitive function. There was a significant direct effect ($\beta$=.32) of cognitive function on social behavior. The total effect of hearing on social behavior was $\beta$=.32 including the indirect effect ($\beta$=.12) . However perceived vsion had little effect ($\beta$=-.08) on cognitive function. The result of path analysis confirms that hearing levels influence cognitive function, and both hearing and cognitive function levels influence social behavior. However, vision has little effect on cognitive function or on social behavior. For the next study, a combined model of the pre viously developed environment - >depression- > physical and social function model, and the present cognitive function model, should be tested to further refine the functional capacity model. There also a need for longitudinal study of functional capacity and sencory competence in order to better understand how declining sensory competence influences functional capacity and how it effects in-creasing dependency and nursing needs in the elderly.

• 대한치위생과학회지
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• 제4권2호
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• pp.89-98
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• 2021

Background: To analyze the effect of self-regulation on the fear of dental treatment in order to use it as basic data for efficient oral health care among male adolescents. Methods: A survey was administered to 241 first graders of specialized high schools in Daegu using a self-entry method. Twenty questions about fear of dental treatment and fifteen questions about self-regulation were included. The higher the score, the higher the fear of dental treatment and the self-regulation ability, showing a high reliability of 0.972 and 0.750, respectively. Results: The mean score of the participants' self-regulation ability was 3.25±0.51 and that of the degree of fear for dental treatment was relatively low at 1.72±0.85. It was confirmed that the higher the academic performance (F=7.635, p<0.01), the better was the self-regulation based on self-diagnosis (F=3.142, p<0.05), and was associated with higher health awareness (F=5.894, p<0.01). The degree of fear for dental treatment was significantly higher in the self-diagnosis-induced poor health group (F=4.933, p<0.01) and associated with a lower awareness of health (F=3.093, p<0.05). The participants' self-regulation ability was significantly negatively correlated with the degree of fear regarding dental treatment (r=-0.269, p<0.01). Regression analysis was performed using the degree of fear as a dependent variable and including sub-area variables of self-diagnosis-based health status, perception of health, and self-regulation ability as independent variables (β=-0.163, p<0.05). Among the self-regulation abilities, controlled composition (β=-0.232, p<0.01) had a significant effect; the higher the composition, the lower the degree of fear. The total explanatory power of this variable was 8.5%. Conclusion: An appropriate customized education program that can encourage individuals to practice self-care and maintain oral hygiene along with a clear understanding of underlying individual oral health conditions during adolescence is essential for promoting oral health.

• 대한수의학회지
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• 제40권4호
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• pp.683-689
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• 2000

The present study was carried out to investigate the blood markers of Thoroughbred horses (TB) The blood red cell types and blood protein types (biochemical polymorphisms) were tested from 1,125 Thoroughbred horses by serological and electrophoretic procedures, and their phenotypes, gene frequencies, heterozygosity, polymorphic information content values and exclusion probability were estimated. The blood group and biochemical polymorphism phenotypes observed with high frequency were Aaf(91.7%), Ca(94.7%), K-(94.5%), Ua(75.9%), P-(50.6%), Qabc(82.6%), ALB-BB(67.7%), GC-FF(92.7%), AIB-KK(99.6%), ES-II(77.9%), TF-DF1(23.6%), PI-LL(23.2%), HB-B2B2(73.6%), PGD-FS(45.4%) and genotypes Dcgm/dk(16.9%), Dbcm/cgm(13.6%), Dbcm/dk(11.9%), Dcegmn/cegmn(10.0%), Dcgm/cgm(8.7%) in TB. Alleles observed with high frequency were Aaf(0.796), Ca(0.769), Ddk(0.266), Dcgm(0.261), Dbcm(0.211), K-(0.972), P-(0.710), Qabc(0.565), Q-(0.368), Ua(0.509), $HB^{B2}$(0.858), $PGD^F$(0.634), $ALB^B$(0.825), $GC^F$(0.927), $AIB^K$(0.998), $ES^I$(0.881), $TF^{F1}$(0.346), $TF^D$(0.319), $TF^{F2}$(0.184), $PI^L$(0.479), $PI^N$(0.214), $PI^U$(0.116) in TB. The heterozygosity, polymorphic information content (PIC) and exclusion probability (PE) were calculated. The mean heterozygosity and PIC value were 0.3899 and 0.3375, respectively. The highest heterozygosity and PIC were estimated 0.7834 and 0.7492 in blood group D locus, respectively. The cumulated PE obtained by blood groups and biochemical polymorphisms was 0.9813.