• Title/Summary/Keyword: P91

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20 Years-experience of 1000 Consecutive Vasovasostomy (20년간 정관정관문합술 1000례의 임상적 경험)

  • Seo, Ho-Kyung;Park, Nam-Cheol
    • Clinical and Experimental Reproductive Medicine
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    • v.25 no.2
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    • pp.189-198
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    • 1998
  • Since the male sterilization (vasectomy) has been performed on a large scale as an accepted family planning in Korea on 1980s and this, in turn, has been followed by an increase in the number of patients requesting vasovasostomy. We studies 1000 consecutive cases of vasovasostomy performed from January 1975 to July 1995 in Pusan National University Hospital. In this report, we are going to present serial studies of vasovasostomy through which we attempted to find out what factors are of impotence in influencing the successful outcome of vasovasostomy operation. We inquired the operative results data through the questionnaire and telephone interview with survey of medical records. A total of 259 cases was excluded due to the loss of follow-up. The overall patency and pregnancy rates of 741 cases were 86.9% and 51.1%, respectively. The age of man at the time of anastomosis ranged from 23 to 57 years old with an average of 34.9. The most frequent reason for requesting vasovasostomy was the desire to have more children (43.4%). The average obstructive interval was 60.6 months with range from 1 to 264 months. If the obstructive interval had been less than 5 years patency rate was 92.4% and pregnancy rate 64.8%, but 6 years or more 84.1% and 48.5% (p<0.01, p<0.01). Patency and pegnancy rates according to intraoperative vas fluid were 93.1% and 62.8% for presence and 83.7% and 53.1% for absence (p<0.01, p<0.05). Patency and pregnancy rates according to histologically proven sperm granuloma at vasectomy site were 87.7% and 49.2% for presence and 86.9% and 50.6% for absence (p>0.05, p<0.05). Patency and pregnancy rates were not significantly different between microscopic standard vasovasostomy (88.4%, 64.3%) and modified vasovasostomy (89.5%, 56.3%)(p>0.05, p>0.05). Both patency and pregnancy rates according to level of anastomosis were 89.8% and 59.8% in cases of straight vas and 91.5%, 60.1% in cases of convoluted vas (p>0.05, p>0.05). Patency and pregnancy rates according to the kind of suture materials were 91.5% and 56.2% for absorbable, 91.0% and 64.2% for non-absorbable and 93.3% and 53.3% for absorbable plus non-absorbable, respectively (p>0.05, p<0.05). Thus it is suggested that the important factor influencing the success rate of vasovasostomy is the interval of obstruction and vasal ooze with surgical skills.

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mPW1PW91 Study of Complexation of Alkali Metal Ions with Mixed [2 + 2'] Calix[4]aryl Derivatives

  • Choe, Jong-In
    • Bulletin of the Korean Chemical Society
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    • v.33 no.10
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    • pp.3321-3330
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    • 2012
  • The complexation characteristics of mixed [2 + 2'] calix[4]aryl derivatives (3 and 4) with alkali metal cations were investigated by the mPW1PW91 (hybrid HF-DF) calculation method. The total electronic and Gibbs free energies of the various complexes (cone, partial-cone, 1,2-alternate, and 1,3-alternate) of sodium and potassium cations with 3 and 4 were analyzed and compared. The structures of the endo- or exo-complexes of the alkali metal cation with the host 3 were optimized using the mPW1PW91/6-31G(d) method, followed by mPW1PW91/6-311+G(d) calculations. The structures of the endo- or exo-complexes of the alkali metal cation with the host 4 were optimized using the mPW1PW91/6-31G(d,p) method. The mPW1PW91 calculated relative energies of the various conformations of the free hosts (3 and 4) suggest that the cone conformers of 3 and 4 are the most stable. The mPW1PW91calculations also suggest that the complexation efficiencies of the sodium ion with hosts 3 and 4 are about 24 and 27 kcal/mol better than those of the potassium ion, respectively. These trends are in good agreement with the experimental results. The exo-complexation efficiencies of the sodium ion toward the conformers of hosts 3 and 4 are roughly 14 and 17 kcal/mol better than those for the endo-$Na^+$-complexes of 3 and 4, respectively. The exo-complexation of the cone isomer of 3 with cation could be confirmed by the differences of the diagnostic C=O bands in the free host and its complex's IR spectra.

Perceptions of Successful Aging and The Influencing Factors in Middle-aged Women (중년여성의 성공적 노화에 대한 인식과 영향요인)

  • Kim, Bomi
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.19 no.9
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    • pp.91-99
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    • 2018
  • This research was conducted to examine successful aging and influencing factors in middle aged women. Data were collected from 189 middle-aged women in two cities. Data were collected from July to August 2017 using structured questionnaires. Data collected were analyzed by descriptive statistics, t-test, ANOVA, Pearson correlations, and multiple regression analysis. The results indicate that the perception of successful aging mean was 128.49 points (range: 33-165). Depression (r=-.20, p=.005) had a significant negative association with perception of successful aging. Family resilience (r=.49, p<.001) and life satisfaction (r=.54, p<.001) were positively correlated with perception of successful aging. The significant predictors of successful aging were age (${\ss}=-.15$, p=.013), family resilience (${\ss}=.24$, p=.002), and life satisfaction (${\ss}=.37$, p<.001), explaining 33.9% of the variance. Based on the study results, we suggest that it is necessary to develop and apply educational strategy to improve perception of successful aging.

Effects of Academic Stress, Self-Efficacy and Problem Solving Ability on Subjective Happiness in Nursing College Student (간호대학생의 학업스트레스, 자기효능감, 문제해결능력이 주관적 행복감에 미치는 영향)

  • Byun, Eun Kyung;Kim, Mi Young
    • The Journal of the Convergence on Culture Technology
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    • v.8 no.1
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    • pp.167-174
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    • 2022
  • The purpose of this study was to evaluate the effect of academic stress, self-efficacy and problem solving ability on subjective happiness of nursing college students. Participants in this study were 348 nursing students from 2 universities in B city. Data analysis was performed using SPSS 22.0 program with real number, percentage, mean, standard deviation, t-test, ANOVA, Pearson correlation coefficient, and multiple regression analysis. The mean score for subjective happiness was 41.91±9.53(range: 9 to 63). Subjective happiness negatively correlated with academic stress(r=-.523, p<.001) and positively correlated with self-efficacy(r=.515, p<.001), problem solving ability(r=.466, p<.001). Significant predictors of subjective happiness included academic stress((β=-.351, p<.001), self-esteem(β=.255, p<.001), and problem solving ability(β=.132, p=.049), and the explanation power was 37.2%. Therefore, we need various program development that can enhance self-efficacy, problem solving ability, and academic stress management in order to improve nursing students' subjective happiness.

Effect of the Interval from Calving to First Insemination and Days Open on the Subsequent Reproductive Performance in Dairy Cows (젖소에서 분만 후 첫 수정 간격 및 임신 간격이 이후의 번식능력에 미치는 영향)

  • Lee, Soo-Chan;Lee, Tae-Ho;Jeong, Jae-Kwan;Kang, Hyun-Gu;Kim, Ill-Hwa
    • Journal of Veterinary Clinics
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    • v.30 no.6
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    • pp.435-441
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    • 2013
  • This retrospective study evaluated the effects of the interval from calving to first insemination (ICFI) and days open (DO) on the reproductive performance in dairy cows. In the first analysis, data from 705 cows were grouped based on the ICFI: short (30-60 days, n=217), medium (61-90 days, n=309), and long (91-150 days, n=179). The occurrence of endometritis was greater in the long group than in short and medium groups (p<0.05). The occurrence of ovarian cysts increased with increasing ICFI (p<0.05), while body condition score (BCS) during the 5 month postpartum period was lower with increasing ICFI (p<0.01). The hazard of pregnancy by 365 days in milk (DIM) was lower (hazard ratio [HR]=0.70, p<0.0001) in the long group, but higher (HR=1.41, p<0.0001) in the short group compared with the medium group. In the second analysis, data from 436 cows were grouped based on the DO: short (30-90 days, n=154), medium (91-180 days, n=183), and long (181-360 days, n=99). The occurrence of a retained placenta was greater in the long group than in the medium group (p < 0.05). Ovarian cysts occurred more frequently in medium and long groups than in the short group (p=0.08). BCS was lower in the short group compared with medium and long groups at month 1 postpartum (p<0.05). Milk yield (kg/day) was greater in the medium group compared with the short group at months 2 to 5 postpartum (p<0.05). The hazard of first insemination by 150 DIM was lower in the long group than in the short group (HR=0.73; p<0.02). The hazard of pregnancy by 365 DIM was lower (HR=0.64, p<0.0001) in the long group than in the medium group, while the hazard did not differ between short and medium groups (p>0.05). Moreover, the culling rate was greater in the long group than in the short group (p<0.05). In conclusion, a longer ICFI and DO resulted in reduced reproductive performance in dairy cows, which was attributable to an increase in postpartum diseases, a lower BCS and a greater milk yield.

Effects of Trophoblastic Vesicle and Estradiol-$17\beta$ on the Development in Vitro of Rabbit Embryos (Trophoblastic Vesicle과 Estradiol-$17\beta$의 첨가가 가토배의 발달에 미치는 영향)

  • 오하식;박충생
    • Korean Journal of Animal Reproduction
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    • v.10 no.1
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    • pp.76-82
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    • 1986
  • This experiment was conducted to determine the effects of trophoblastic vesicles (TV) and estradiol-17$\beta$ on the development in vitro of rabbit embryos. Thirty matured female rabbits were treated with PMSG followed by HCG injection and mating. Embryos were recovered with D-PBS (Dulbecco's Phosphate Buffered Saline) after superovulation, and normally developed to two-to four-cell embryos were used in the subsequent in vitro culture. Basal medium was Medium-199 su, pp.emented with 1.5% bovine serum albumin. Embryo on Day 5 after mating (Day 0) was cut into two or three pieces to remove the embryonic disc. Each piece of tissue was cultured for 24 hours at 37$^{\circ}C$ in 0.5 mlMedium-199 in 5% CO2. During culture, peices of trophoblastic tissue changed into spherical vesicles which were used for co-culture. These spheres were called trophoblstic vesicles. Two-to four-cell embryos were cultured for 4 days in Medium-199 in the absence or presence of trophoblastic vesicle, and two-to four-cell embryos cultured with varing concentration (0, 0.1, 1, 10ng/ml) of estradiol-17$\beta$ for 4 dyas. Culture vessels used were watch glass for coculture with trophoblastic vesicles and micortube for estradiol-17$\beta$ infusion. Compared with the Medium-199 alone as basal culture medium, more blastocysts (46.7% vs 15.1%; P<0.01) and morulae (84.4% vs 56.6%; P<0.05) were developed in the co-culture with trophoblastic vesicles. Estradiol-17$\beta$ infused in culture medium was not effective for embryo development to blastocysts (78.3% in control, 50.0% in 0.1ng/ml, 61.5% in 1ng/ml and 64.4% in 10ng/ml) and also to morulae (91.3% in control, 84.2% in 0.1ng/ml, 92.3% in 1ng/ml and 91.1% in 10ng/ml). Compared with the watch glass culture mehotd, more (P<0.01) blastocysts were developed in microtube culture (78.3% vs 56.6%) and more (P<0.01) morulae in microtube culture (91.3% vs 56.6%).

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Comparison of Electrochemical Corrosion Properties of Permanent Mold Casting GZ21 Alloy and AZ91 Alloy (금형 주조한 GZ21 합금과 AZ91 합금의 부식특성 비교)

  • Kim, Dae Han;Kim, Byeong Ho;Park, Kyung Chul;Chang, In Ki
    • Journal of Korea Foundry Society
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    • v.36 no.2
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    • pp.60-66
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    • 2016
  • In this study, comparison of corrosion properties of the Mg-1.5Ge-1Zn (GZ21) alloy and Mg-9Al-1Zn (AZ91) alloy were investigated. The studied alloys were fabricated by permanent mold casting method. And the potentiodynamic test, hydrogen evolution test, immersion test and A.C Impedance test were carried out in a 3.5% NaCl solution with pH7.2 at room temperature to measure the corrosion properties. The microstructure of GZ21 alloy was composed of ${\alpha}-Mg$ and $Mg_2Ge$ phases and AZ91 alloy was composed of ${\alpha}-Mg$ and $Mg_{17}Al_{12}$ phases. From the test results, the corrosion property was improved by adding Ge. It seemed that the corrosion mechanism was changed from galvanic corrosion (AZ91) to filiform corrosion (GZ21).

Detection of p53 Common Intron Polymorphisms in Patients with Gastritis Lesions from Iran

  • Sadeghi, Rouhallah Najjar;Damavand, Behzad;Vahedi, Mohsen;Mohebbi, Seyed Reza;Zojazi, Homayon;Molaei, Mahsa;Zali, Mohamad Reza
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.1
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    • pp.91-96
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    • 2013
  • Background: p53 alterations have been implicated in the development of many cancers, such as gastric cancer, but there is no evidence of p53 intron alterations in gastritis lesions. The aim of this study was to investigate the p53 intron alterations in gastritis along with p53 and mismatch repair protein expression and microsatellite status. Materials and Methods: PCR-sequencing was conducted for introns 2-7 on DNA extracted from 97 paired samples of gastritis lesions and normal adjacent tissue. Abnormal accumulation of p53 and mismatch repair proteins was investigated using immunohistochemistry. In addition, microsatellite status was evaluated with reference to five mononucleotide markers. Results: Gastritis cases included 41 males and 56 females in the age range of 15-83 years, 87.6% being H.pylori positive. IVS2+38, IVS3ins16 and IVS7+72 were the most polymorphic sites. Their minor allele frequency values were as follows: 0.38, 0.21 and 0.06, respectively. Samples with GG genotype at IVS2+38 and CT at IVS7+72 had no insertion. Moreover, most of the stable samples (91.9 %) had a G allele at IVS2+38. All of the samples were IHC negative for p53 protein, microsatellite stable and expressed mismatch repair proteins. p53 alterations were prominent in the H. Pylori+ group, but without statistical significance. Conclusions: According to our results, some p53 polymorphisms such as IVS2+38, IVS3ins16 and IVS7+72, because of their correlations together or with microsatellite status may contribute to gastritis development. However, so far effects on p53 expression and function remain unclear. Therefore, a comprehensive survey is needed to delineate their biological significance.