• The Journal of Korean Physical Therapy
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• 제26권4호
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• pp.234-239
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• 2014

Purpose: The purpose of this study is to use P300 latency to determine whether methods of motor learning in terms of massed and distributed practice can affect motor sequential learning in healthy adults. Methods: Twenty-four healthy subjects participated in this study. They were randomly allocated into three groups: a 10 minute, a 12 hour, and a 24 hour group. In the SRT task, eight numbers were adopted as auditory stimuli. During an experiment, participants were instructed to press the matching key as quickly and accurately as possible when one of the eight numbers was presented randomly. The subjects practiced for three sessions, each of which comprised five blocks of 40 serial reaction time tasks. While they practiced during these three sessions, P300 latency was measured. The data were analyzed using ANCOVA. Results: The P300 latency of Fz, Cz, and Pz decreased in all groups except for the Fz area of the 10 min group. Overall, the P300 latency of the 10 min group showed a smaller decrease compared with the 12 hr and 24 hr groups. Statistically, no significant differences in the Fz and Cz areas were observed among the three groups. The P300 latency in the Pz area of the 10 min group showed a significantly smaller decrease compared with the other groups. Conclusion: These findings suggest that short-term sequential motor training can alter brain functions such as the P300 latency. We also found that better acquisition of a motor skill was obtained with distributed practice of a task than with massed practice.

• 동의신경정신과학회지
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• 제17권1호
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• pp.129-136
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• 2006

Objective : Audio-evoked potential is technique used for measuring brain functions such as memory, attention, and concentration. Although a number of studies on acupuncture for pain, there are few reports on the effect of acupuncture cognitive function. Methods : Fifteen healthy volunteers with no neurological condition took part of the study. $(23.27{\pm}2.09)$. In this study, we examined the changes in auditory P300 by acupuncture stimulation to 'Oegwan' on the left hand. Auditory P300 was recorded before, during and after acupuncture. The amplitude and latency of P300 at Fz, Cz, Pz point were calculated. Results : Auditory P300 amplitude decreased during and after acupuncture, but there was no statistical significance.(P< .05) Auditory P300 latency significantly decreased during and after acupuncture.(P< .05) Conclusions : The decrease of Auditory P300 latency time suggests that acupuncture at Oegwan has some effects on the cognitive function.

• 생물정신의학
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• 제19권3호
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• pp.115-120
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• 2012

Objectives : Event-related potentials have been suggested as an objective marker for brain functions in psychiatric disorders. This study was aimed to investigate the relationships between P300, the mismatch negativity (MMN), the loudness dependence of the auditory evoked potential (LDAEP), demographic and clinical variables including neurocognitive abilities in patients with schizophrenia. Methods : P300, the MMN, and the LDAEP were measured and the Korean Stroop color-word test (K-stroop test) and the Wisconsin Card Sorting Test (WCST) were performed in 43 patients with schizophrenia. The relationship of the latency and amplitude of P300 and the MMN as well as regression slope of the LDAEP with demographic and clinical variables were analyzed by t-test and correlation analyses for categorical and continuous variables, respectively. Results : After controlling for age, the latency of central (Cz) and parietal (Pz) P300 posivitively correlated with GAF at admission (Cz ; ${\gamma}$ = 0.385, p = 0.047, Pz ; ${\gamma}$ = 0.421, p = 0.029). The amplitude of parietal P300 correlated with the correction rate of the K-stroop test (${\gamma}$ = 0.575, p = 0.002). In addition, the frontal (Fz) P300 latency tended to negatively correlated with the correction rate of the WCST (${\gamma}$ = -0.371, p = 0.057). Conclusions : Our findings suggest that the values of P300 latency and amplitude might be correlated with GAF at admission and working memory measured by the K-Stroop test and the WCST. Meanwhile, the MMN and the LDAEP did not correlate with demographic and clinical variables. These results support the results of previous studies showing associations with P300 and impaired cognitive ability.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 2002년도 추계학술대회 논문집
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• pp.148-152
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• 2002

This study is to develop the Alzheimers disease (AD) detection and analysis system using event-related potential (ERP) of AD patients. We recorded ERP in an auditory oddball paradigm in mild AD (n=25), severe AD (n=12), age-matched normal aged controls (n=17), and young controls (n=7). The amplitude and latency of target P300 components were compared among 4 groups. The relationship between P300 measures and neuro psychological test (K-DRS) scores were evaluated by correlations. The latency of P300 was prolonged in AD and the effects were correlated with the severity of dementia. The P300 amplitude was not affected significantly in AD. Theres no difference between normal aged group and young group. These results suggest that the P300 component is specifically affected by Alzheimer type dementia.

• 대한통합의학회지
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• 제8권2호
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• pp.131-138
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• 2020

Purpose : The purpose of this study was to investigate the effects of the frequency band pass filter on the P300 event-related potential in the working memory. Methods : The subjects were 20 women in their 20s who applied for participation in the experiment. Event-related potentials (ERPs) were elicited using 3-back tasks for the working memory, and were recorded from Fz, Cz, and Pz scalp electrodes. The high-pass filters were set to 0.01, 0.1, and 0.3 Hz for analysis purposes, and the low-pass filters were set to 30 and 15 Hz. The 3-back task was presented for a total of 100 times, among which 30 times were designated for the target stimulation (a matched number) and 70 times for the non-target stimulation (an unmatched number). The temporal interval between each stimulation was set at 1 second, while each time duration was randomly presented between 2 to 4 seconds. ERP were analyzed for the P300 recorded from Fz, Pz and Cz scalp electrodes. Results : Latency and amplitude had no significant interaction effects in both the high- and low-pass filters. For the main effects, the latency and amplitude of the P300 event-related potential had no significant difference in the high-pass filters, but the latency had a significant difference in the low-pass filter of Fz, and the amplitude had a significant difference in the low-pass filter of Pz. Conclusion : The results of this study showed that the less than 0.3 Hz high filters had no effects on the differences between the latency and amplitude of the P300 event-related potential in the working memory. The 30Hz low-pass filter, however, was found to be useful for recording the P300 event-related potential in the working memory.

• 한국심리학회지:법
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• 제12권2호
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• pp.151-169
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• 2021

P300 숨긴정보검사에서 거짓말 여부를 판단하기 위하여 가장 많이 사용되는 기법은 부트스트랩 진폭차이(BAD) 방법과 부트스트랩 상관차이(BCD) 방법이다. 두 방법의 정확판단율을 비교한 선행연구들은 일관되지 않은 결과를 보고하였다. 일부의 연구들에서 BAD 방법이 BCD 방법보다 더 정확하다고 보고되고 있지만, 다른 연구에서는 BCD 방법이 BAD 방법보다 더 정확한 것으로 나타났다. 본 연구의 목적은 BAD 방법의 정확도가 더 높은 조건과 BCD 방법의 정확도가 더 높은 조건을 확인하는 것이다. 몬테 카를로 연구결과, 전반적으로 BAD 방법의 오경보율이 BCD 방법의 오경보율보다 더 높았으며, BAD 방법의 적중률이 BCD 방법의 적중률보다 더 높았다. 관련자극과 무관련자극의 P300 잠재시간이 비슷한 경우에 비교하여 관련자극의 P300 잠재시간이 약 100ms 빠른 경우에는 BCD 방법의 적중률이 크게 감소하였으며, 약 100ms 느린 경우에는 BCD 방법의 적중률이 증가하였다. 관련자극의 P300 진폭이 무관련자극의 P300 진폭보다 약간 더 크면서 관련자극의 P300 잠재시간이 목표자극의 P300 잠재시간보다 긴 경우에는 BCD 방법의 적중률이 BAD 방법의 적중률보다 더 높았다. BAD 방법의 오경보율이 높은 이유와 BCD 방법의 적중률이 관련자극의 P300 잠재시간에 영향을 받는 이유에 대해서 논의하였다.

• 생물정신의학
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• 제11권1호
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• pp.40-48
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• 2004

Objective:Event-related potentials(ERPs) are electrical changes recorded at the surface of the scalp in response to stimulus presentation, and their latency and amplitude change according to cognitive processes. Through past studies of the auditory ERP in schizophrenia, the P300 has been reported to be statistically smaller and delayed in schizophrenia than comparison groups. However, studies of the visual ERP have not been systematically examined. The present study was designed to investigate the visual P300 in patients with schizophrenia and normal controls and to compare the pattern of P300 between them. Methods:The subjects were composed of patients(N=22) with schizophrenia by DSM-IV and normal controls(N=22). The visual ERPs were measured by the visual continuous performance test. P300 amplitude and latency measured on 5 scalp electrodes(Fz, Cz, Pz, $T_7$, $T_8$) were compared between patients and controls. Results:The P300 latencies measured on Fz, Cz, Pz, and $T_7$ electrodes were significantly longer in patients than controls(p<0.05). The P300 amplitudes in patients were smaller than controls. However, the difference between them was not statistically significant. Conclusion:Analysis of the visual ERPs showed that the P300 latency is significantly delayed and the P300 amplitude is slightly smaller in patients than controls. These results are similar to established studies of the auditory P300 in schizophrenia.

• Journal of information and communication convergence engineering
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• 제8권2호
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• pp.234-237
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• 2010

P300 component of the event-related potential(ERP) has been studied for theoretical, empirical, and clinical applications. Nowadays the 1-, 2-, and 3-stimulus oddball paradigms are used for eliciting P300 component of EEG in the auditory stimulus experiments. In this paper, we used a method to add one more stimulus to the 3-stimulus auditory paradigm. The adding stimulus has not the same volume but the same tone of the target stimulus. The 4-stimulus oddball paradigm to use two targets is used to elicit the P300 event-related potentials. In 4-stimulus oddball paradigm, an infrequent non-target (p=0.10) is presented in addition to two infrequent targets (p=0.10) and a frequent standard (p=0.70). Two target stimuli elicited a P300 component with a parietal maximum distribution. The amplitude of the P300 in target 2 was larger than that in target 1 and the latency of the P300 in target 2 was longer than that in target 1. The P300 component due to target 2 stimuli was larger than that due to target 1 stimuli. The experimental results approve that the 4-stimulus oddball paradigm can elicit P300 component clearly. The results are compared with the results of the traditional oddball paradigm.

• 수면정신생리
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• 제1권1호
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• pp.76-86
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• 1994

연구배경 : 사건관계 전위와 신경심리 검사의 상호관계를 연구함으로 각각의 사건 관계 전위의 신경심리학적 의미와 그 전위가 발생되기 위해 어떠한 뇌 기능과 뇌 구조가 연관되는지를 조사해 보려고 하였다. 연구방법 : 56 명의 환자에서 시각 유발 전위 P100과 사건 관계 전위 N120 과 P300 의 전위 및 잠복기와 여러 신경심리 검사의 상호관계를 조사하였다. 결 과 : 시각 유발 전위 (VEP) 의 P100의 잠복기와 상관 관계를 보인 신경심리 검사는 시각지속수행 검사, 조건화 지속 수행 검사였다. 그러나 P100 의 전위와는 유의한 상관관계가 있는 검사는 없었다. N120 잠복기와 범주 검사, KWIS 의 언어성 지능 등이 유의한 상관관계를 보였다. N120 전위는 수지력 검사, 시각 지속 수행 검사, 조건화 지속 수행 검사, 숫자 상정 검사 등이었다. P300 의 잠복기는 선로 잇기 A 검사와 Stroop 검사와 유의한 상관관계를 보였다. P300의 전위는 선로 잇기 B 검사, 숫자 상정 검사, Wechsler 기억 척도, 수지력 검사, Stroop 검사, 시각 지속 수행 검사, 조건화 지속 수행 검사 등과 유의한 상관관계를 보였다. 결론 : N120 은 전두엽의 내측을 가장 예민하게 반영할 수 있는 검사이며 P300 은 내측두엽, 해마체, 시상, 기저핵 및 내전두엽 동의 피질하 구조가 밀집하게 관계되어 발생되는 전위로 생각된다.

• 대한의용생체공학회:의공학회지
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• 제30권4호
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• pp.306-310
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• 2009

The purpose of this study is to observe the change in gamma-band cortical activities (GBAs) due to task difficulty. Event-related potential and gamma-band activity were investigated using electroencephalograms recorded during auditory oddball tasks with two difficulty levels. For more difficult task, the amplitude of P300 decreased and the peak latency of P300 was delayed significantly compared to easier task. The induced GBA decreased considerably during the P300 latency period and the peak latency of the induced GBA was delayed for more difficult task. The results imply that the difficulty-related change in cortical information processing may be implemented as a change in the strength of local neuronal association.