• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.11
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• pp.459-468
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• 2017

This study investigated the factors influencing how obesity stress and health belief impact weight control behavior among nursing students. Data were collected from nursing students in U city between September 1 and October 10, 2016 and analyzed using descriptive statistics, t-test, ANOVA, Pearson's correlation coefficient, and hierarchical multiple regression. Among the general characteristics of the subjects, gender (t=2.30, p=0.044) and health status (F=8.03, p<0.001) significantly influenced weight control behavior. There were negative correlations between diet therapy of weight control behavior (r=-0.26, p<0.001), exercise therapy (r=-0.25, p<0.001), behavior modification therapy (r=-0.29, p<0.001), and perceived barriers in health belief. In addition, acquiring special knowledge for weight control behavior showed positive correlations in obesity stress (r=0.42, p<0.001), perceived susceptibility (r=0.25, p<0.001) and perceived benefits (r=0.19, p<0.001). Furthermore, the significant factors influencing weight control behavior were perceived barriers (${\beta}=-0.30$, p<0.001) and obesity stress (${\beta}=0.20$, p<0.05) in health belief, and these factors explained 17.2% of the variance. Based on the study results, it is necessary to develop and apply effective educational programs that can influence weight control behavior through gender, health status, obesity stress and health beliefs, which determine weight control behavior of nursing students.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.1
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• pp.103-111
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• 2020

This study investigated how the awareness about marriage, the value of children, and the motivation for childrearing influences childbirth will in nursing students. The data was collected from May 1 to May 30, 2019, and 248 data samples were finally used for analysis. The collected data was analyzed using the SPSS /WIN 22.0 program. Descriptive statistics, Pearson's correlation coefficients, t-tests, ANOVA, Scheffe's test and multiple regression analysis were all calculated. The average of awareness about marriage was 3.39±.38, the average of the value of children was 2.72±0.39, the average motivation of childrearing was 2.73±0.78 and the average of childbirth will was 3.12±0.48. The childbirth will according to the general characteristics, was significantly different according to age (F=6.002, p=.003). Among the awareness about marriage, conservative view on marriage(r=.207, p=.001), active view on marriage(r=.226, p<.001), instrumental view on marriage(r=.181, p=.004), and motivation of childrearing(r=.283, p<.001) showed positive correlation ed with childbirth will. Childbirth will was negatively correlated with passive view on marriage (r=-.292, p<.001), and the value of children (r=-.226, p<.001). The factors affecting childbirth will of the study subjects were age(β=.155, p=.007), passive view on marriage(β=-.383, p<.001), motivation of childrearing (β=.315, p<.001), and the explanatory power was 23.6%. According to this study, it is necessary to confirm the effects of developing an intervention program and applying this program to improve the decisions of nursing students concerning marriage and having children.

• Korean Journal of Health Education and Promotion
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• v.17 no.2
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• pp.125-149
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• 2000

The purpose of this study was practiced to investigate factors affecting dental hygienists's stress. The results executed by percentage and Likert scale (on a scale of 5) producing a mean standard deviation, T-test, one way ANOV A and person correlation coefficient using SPSS according to purpose of study. The results of study were as follows: 1. Mean point of stress from administration system dental hygienists's was 3.49 2. The dental hygienists's job place was significantly related to stress from duty volume (p=0.000), stress from personal relation(p=0.028) and stress from atmosphere of job(p=0.000). 3. The dental hygienists's career was significantly related to stress from safe job. 4. The dental hygienists's grade in rank was significantly related to stress from pride ＆ self-conceit. 5. The number of colleague worked public health center was significantly related to stress from duty volume. 6. There is a significant relationship between stress from duty volume and stress from conflict of job(p〈0.01, r=0.280). There is a significant relationship between stress from dissatisfaction and stress from personal relationship(p〈0.001, r=0.396). There is a significant relationship between stress from pride ＆ self-conceit and stress from personal relationship(p〈0.001, r=0.423). There is a significant relationship between stress from personal relationship and stress from atmosphere of job(p〈0.001, r=0.662).

• Animal Systematics, Evolution and Diversity
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• v.36 no.1
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• pp.10-14
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• 2020

Pagurus is the most diverse hermit crab genus in Korea. In this study, the cytochrome c oxidase subunit I (COI) and 16S rRNA of 24 individuals from four Korean Pagurus species (i.e., 7 Pagurus brachiomastus, 8 P. proximus, 8 P. simulans, and 1 P. rectidactylus) were sequenced and analyzed. No genetic difference was found between the COI and 16S rRNA sequences of P. brachiomastus and P. simulans, and the COI sequences of P. rectidactylus and P. quinquelineatus (comparative species from NCBI). Considering the morphological and ecological characteristics together, we assume that P. simulans and P. rectidactylus are subspecies of P. brachiomastus and P. quinquelineatus, respectively. This study should facilitate further research on the taxonomic status of these species.

• Molecules and Cells
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• v.45 no.3
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• pp.122-133
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• 2022

The aim of this study was to investigating whether lncRNA H19 promotes myocardial fibrosis by suppressing the miR-29a-3p/miR-29b-3p-VEGFA/TGF-β axis. Patients with atrial fibrillation (AF) and healthy volunteers were included in the study, and their biochemical parameters were collected. In addition, pcDNA3.1-H19, si-H19, and miR-29a/b-3p mimic/inhibitor were transfected into cardiac fibroblasts (CFs), and proliferation of CFs was detected by MTT assay. Expression of H19 and miR-29a/b-3p were detected using real-time quantitative polymerase chain reaction, and expression of α-smooth muscle actin (α-SMA), collagen I, collagen II, matrix metalloproteinase-2 (MMP-2), and elastin were measured by western blot analysis. The dual luciferase reporter gene assay was carried out to detect the sponging relationship between H19 and miR-29a/b-3p in CFs. Compared with healthy volunteers, the level of plasma H19 was significantly elevated in patients with AF, while miR-29a-3p and miR-29b-3p were markedly depressed (P < 0.05). Serum expression of lncRNA H19 was negatively correlated with the expression of miR-29a-3p and miR-29b-3p among patients with AF (r_s = -0.337, r_s = -0.236). Moreover, up-regulation of H19 expression and down-regulation of miR-29a/b-3p expression facilitated proliferation and synthesis of extracellular matrix (ECM)-related proteins. SB431542 and si-VEGFA are able to reverse the promotion of miR-29a/b-3p on proliferation of CFs and ECM-related protein synthesis. The findings of the present study suggest that H19 promoted CF proliferation and collagen synthesis by suppressing the miR-29a-3p/miR-29b-3p-VEGFA/TGF-β axis, and provide support for a potential new direction for the treatment of AF.

• Asian Oncology Nursing
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• v.11 no.3
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• pp.237-246
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• 2011

Purpose: The aim of this study was to investigate the relationships between stigma, distress, and quality of life (QOL) in patients with lung cancer. Methods: The subjects of the study were 123 lung cancer patients who visited the outpatient department of S hospital in Seoul from July 21st to August 29th, 2011. To measure stigma, distress, and QOL, Cataldo Lung Cancer Stigma Scale, Hospital Anxiety and Depression Scale (HADS), and EORTC QLQ-C30 (Quality of Life Questionnaire, Core 30) were used in this study. The collected data were analyzed using frequency, average, t-test, ANOVA, and Pearson correlation with SPSS WIN 19.0. Results: Stigma showed positive correlations with anxiety, depression, and symptom (r=.37, p<.001; r=.44, p<.001; r=.23 p=.012), while it showed negative correlations with global QOL and function (r=-.26, p=.003; r=-.40, p<.001). Anxiety and depression also positively correlated with symptoms (r=.43, p<.001; r=.58, p<.001) while anxiety and depression negatively correlated with global QOL (r=-.40, p<.001; r=-.56, p<.001) and function (r=-.64, p<.001; r=-.66, p<.001). Conclusion: The findings of the study demonstrated that lung cancer patients experienced stigma and distress that had a negative influence on the subjects' QOL. Thus the study's findings can be useful in developing psychosocial nursing strategies to improve QOL of lung cancer patients in the future.

• Physical Therapy Rehabilitation Science
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• v.9 no.4
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• pp.261-268
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• 2020

Objective: This study was conducted to provide basic data on physical function improvement activities of elderly care facilities by identifying the degree of physical improvement activities of elderly caregivers. Design: Descriptive correlational study. Methods: The instrument of this study consisted of 12 questions on the general characteristics of the subject. For the assessment of improvement in physical function activities, the measuring tool used for the elderly consisted of a total of 20 questions. For data analysis, Pearson's correlation coefficient & Spearman's rho and multiple regression were used. Results: The higher the age of the subjects, the lower their educational background (r=-0.273, p<0.05), and the higher the probability of having a religion (r=-0.258, p<0.05), the more stable the employment type (r=-0.333, p<0.05). The higher the level of education, the higher the monthly income (r=0.187, p<0.01), and the shorter the career (r=-0.204, p<0.05). The more stable employment, the more unstable duty (r=-0.245, p<0.05), and the more unstable work, the higher the monthly income (r=-0.206, p<0.05) and the longer the career, the higher the monthly income (r=0.247, p<0.05). The more stable the employment, the more activities to improve physical function were found (r=0.341, p<0.05), and the more unstable the duty, the more activities to improve physical function were found (r=0.321, p<0.05), and the higher monthly income, the less physical function improvement activities (r=-0.196, p<0.05). Conclusions: It is necessary to provide regular services by a dedicated physical therapist for physical function improvement activities in order to improve the quality of life of the elderly in the future.

• The Korean Journal of Physiology and Pharmacology
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• v.23 no.3
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• pp.171-179
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• 2019

Pituitary tumors are usually benign but can occasionally exhibit hormonal and proliferative behaviors. Dysregulation of the G1/S restriction point largely contributes to the over-proliferation of pituitary tumor cells. F-box protein S-phase kinase-interacting protein-2 (SKP2) reportedly targets and inhibits the expression of $p27^{Kip1}$, a well-known negative regulator of G1 cell cycle progression. In this study, SKP2 expression was found to be upregulated while $p27^{Kip1}$ expression was determined to be downregulated in rat and human pituitary tumor cells. Furthermore, SKP2 knockdown induced upregulation of $p27^{Kip1}$ and cell growth inhibition in rat and human pituitary tumor cells, while SKP2overexpression elicited opposite effects on $p27^{Kip1}$ expression and cell growth. The expression of microRNA-186 (miR-186) was reported to be reduced in pituitary tumors. Online tools predicted SKP2 to be a direct downstream target of miR-186, which was further confirmed by luciferase reporter gene assays. Moreover, miR-186 could modulate the cell proliferation and $p27^{Kip1}$-mediated cell cycle alternation of rat and human pituitary tumor cells through SKP2. As further confirmation of these findings, miR-186 and $p27^{Kip1}$ expression were downregulated, while SKP2 expression was upregulated in human pituitary tumor tissue samples; thus, SKP2 expression negatively correlated with miR-186 and $p27^{Kip1}$ expression. In contrast, miR-186 expression positively associated with $p27^{Kip1}$ expression. Taken together, we discovered a novel mechanism by which miR-186/SKP2 axis modulates pituitary tumor cell proliferation through $p27^{Kip1}$-mediated cell cycle alternation.

• Korean Journal of Clinical Pharmacy
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• v.25 no.2
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• pp.80-93
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• 2015

Objective: Pegfilgrastim is recently introduced that is long acting G-CSF for prophylaxis of febrile neutropenia. Treatment of non-Hodgikin's lymphoma (NHL) with R-CHOP is classified with relative high risk of febrile neutropenia. The study evaluated the prophylactic effect of pegfilgrastim to reduce the incidence of febrile neutropenia associated with R-CHOP of patient in NHL. And the risk factors associated with the incidence of FN and related events were evaluated. Methods: This retrospective study reviews the Electronic Medical Record of 68 NHL patients who received R-CHOP chemotherapy in single center between September 2013 and August 2014. These patients were classified who receive prophylaxis pegfilgrastim or no prophylaxis. Results: Sixty eight patients received R-CHOP with NHL. In 144 cycles of patients receiving pegfilgrastim, compared with no prophylaxis 178 cycles, had a lower incidence of febrile neutropenia (5.5% vs. 23.6%, p = 0.001), grade 3 or grade 4 neutropenia (14.4% vs. 89.8%, p < 0.001) and neutropenia related events (p < 0.05). The risk of febrile neutropenia after prophylaxis was significantly associated with age ${\geq}65$ (OR: 5.87, 95% CI 1.07-32.27, p = 0.042), $IPI{\geq}3$ (OR: 7.2, 95% CI 1.31-39.6, p = 0.023), S.alb < 3.5 g/dL (OR: 31.01, 95% CI 6.32-152.17, p < 0.0001). In multiple logistic regression analysis, lower baseline serum albumin (OR: 21.1, 95% CI 3.8-116.98, p = 0.001) was significantly associated with occurrence of febrile neutropenia. Conclusion: The study recommends prophylactic pegfilgrastim through risk assessment of febrile neutropenia in patients with non-Hodgikin's lymphoma receiving R-CHOP.

• Proceedings of the Korean Society of Crop Science Conference
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• 1989.02a
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• pp.80-81
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• 1989