• 핵의학기술
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• 제28권1호
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• pp.41-47
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• 2024

Purpose: ¹⁸F-FET, a radiopharmaceutical based on a Tyrosine amino acid derivative using the Sodium-Potassium Pump-independent Transporter (System L) for non-invasive evaluation of primary, recurrent, and metastatic brain tumors, exhibits distinct characteristics. Unlike the widely absorbed ¹⁸F-FDG in both tumor and normal brain tissues, ¹⁸F-FET demonstrates specific uptake only in tumor tissue while almost negligible uptake in normal brain tissue. This study aims to compare and evaluate the usefulness of ¹⁸F-FDG and ¹⁸F-FET Brain PET/CT quantitative analysis in brain tumor diagnosis. Materials and Methods: In 46 patients diagnosed with brain gliomas (High Grade: 34, Low Grade: 12), Brain PET/CT scans were performed at 40 minutes after ¹⁸F-FDG injection and at 20 minutes (early) and 80 minutes (delay) after ¹⁸F-FET injection. SUV_max and SUV_peak of tumor areas corresponding to MRI images were measured in each scan, and the SUV_max-to-SUV_peak ratio, an indicator of tumor prognosis, was calculated. Differences in SUV_max, SUV_peak, and SUV_max-to-SUV_peak ratio between ¹⁸F-FDG and ¹⁸F-FET early/delay scans were statistically verified using SPSS (ver.28) package program. Results: SUV_max values were 3.72±1.36 for ¹⁸F-FDG, 4.59±1.55 for ¹⁸F-FET early, and 4.12±1.36 for ¹⁸F-FET delay scans. The highest SUV_max was observed in ¹⁸F-FET early scans, particularly in HG tumors (4.85±1.44), showing a slightly more significant difference (P<0.0001). SUV_peak values were 3.33±1.13 for ¹⁸F-FDG, 3.04±1.11 for ¹⁸F-FET early, and 2.80±0.96 for ¹⁸F-FET delay scans. The highest SUV_peak was in ¹⁸F-FDG scans, while the lowest was in ¹⁸F-FET delay scans, with a more significant difference in HG tumors (P<0.001). SUV_max-to-SUV_peak ratio values were 1.11±0.09 for ¹⁸F-FDG, 1.54±0.22 for ¹⁸F-FET early, and 1.48±0.17 for ¹⁸F-FET delay scans. This ratio was higher in ¹⁸F-FET scans for both HG and LG tumors (P<0.0001), but there was no statistically significant difference between ¹⁸F-FET early and delay scans. Conclusion: This study confirms the usefulness of early and delay scans in ¹⁸F-FET Brain PET/CT examinations, particularly demonstrating the changes in objective quantitative metrics such as SUV_max, SUV_peak, and introducing the SUV_max-to-SUV_peak ratio as a new evaluation metric based on the degree of tumor malignancy. This is expected to further contributions to the quantitative analysis of Brain PET/CT images.

• PNF and Movement
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• 제8권3호
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• pp.9-16
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• 2010

Purpose : The purpose of this study was to investigate effects of kinesio taping of thigh muscle on isokinetic muscular function during closed kinetic chain exercise of lower extremity. Methods : Twenty healthy males were participated in this study. The isokinetic muscular function of closed kinetic chain were measured for peak torque, peak torque % body weight, average power, max rep tot work before and after application of kinesio taping on thigh muscles. Results : At $60^{\circ}/s$ peak force and peak force % body weight were significant increased in both extension(p<0.01) and flexion(p<0.001) after applying kinesio taping. At $180^{\circ}/s$ average power was significant increased in both extension and flexion after applying taping(p<0.001). At $240^{\circ}/s$ max rep tot work was significant increased in both extension(p<0.001) and flexion(p<0.05). Conclusion : This study suggests that application of kinesio taping on thigh muscle was more effective to improve isokinetic muscular function in closed kinetic chain exercise of lower extremity.

• 한국임상약학회지
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• 제17권1호
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• pp.33-37
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• 2007

The purpose of this study was to investigate the effect of atorvastatin on the pharmacokinetics of diltiazem (15 mg/kg) after oral administration of diltiazem with or without atorvastatin (0.5, 1.5 and 3.0 mg/kg) in rats. Coadministration of atorvastatin increased significantly (p<0.05, 3.0 mg/kg) the plasma concentration-time curve (AUC) and the peak concentration $(C_{max})$ of diltiazem compared to the control group. The total plasma clearance (CL/F) of diltiazem was decreased significantly (p<0.05, 3.0 mg/kg) compared to the control group. The relative bioavailability (RB%) of diltiazem was increased from 1.14- to 1.49-fold. Coadministration of atorvastatin did not significantly change the elimination rate constant $(K_{el})$, terminal half-life $(T_{1/2})$ and the time to reach the peak concentration $(T_{max})$ of diltiazem. Based on these results, we can make a conclusion that the significant changes of these pharmacokinetic parameters might be due to atorvastatin, which possesses the potency to inhibit the metabolizing enzyme (CYP3A4) in the liver and intestinal mucosa, and also inhibit the P-glycoprotein (P-gp) efflux pump in the intestinal mucosa.

• KSBB Journal
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• 제18권6호
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• pp.443-447
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• 2003

황 화합물 악취를 제거하기 위하여 분뇨처리장에서 황 산화 세균을 분리하여 최적성장 조건을 조사하였다. 분뇨처리장에서 1차로 분리한 균주의 생리$.$생화학적 특성 등을 비교한 결과 Thiobacillus novellus SRM으로 명명하였고, 최적 pH와 배양온도는 pH 7.0과 3$0^{\circ}C$이며, 균주의 공기 주입량은 1.0vvm이었다. 균주농도에 따른 균의 비증식 속도를 직선화한 결과 미생물의 최대 비 증식속도는 0.032$hr^{-l}$ , V$_{max}$ 는 1.83h$^{-l}$ 이 되고, $K_{m}$ 은 0.42였다. Thiobacillus 종의 증식속도는 비교적 느리나, 본 연구에서 사용한 Thiobacillus novellus SRM은 증식속도가 빨라 기상의 황 화합물 악취 제거에 이용할 수 있는 유용한 균주로 판단되어진다.

• 약학회지
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• 제51권3호
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• pp.169-173
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• 2007

The aim of this study was to investigate the effect of morin on the pharmacokinetics of nifedipine in rats. The pharmacokinetic parameters of nifedipine were measured after the oral administration of nifedipine (5 mg/kg) in the presence or absence of morin (1.5, 7.5 and 15 mg/kg, respectively). Compared to the control groups, the presence of 7.5 mg/kg and 15 mg/kg of morin significantly (p<0.05) increased the area under the plasma concentration-time curve (AUC) of nifedipine by 48.5${\sim}$68.2%, and the peak concentration (C$_{max}$,) of nifedipine by 59.9~84.2%. The absolute bioavailability(AB%) of nifedipine was significantly (p<0.05) increased by 21.5${\sim}$24.5% compared to the control (14.5%). While there was no significant change in the time to reach the peak plasma concentration (T$_{max}$) and the terminal half-life (T$_{1/2}$) of nifedipine in the presence of morin. It might be suggested that morin altered disposition of nifedipine by inhibition of both the first-pass metabolism and p-glycoprotein (P-gp) efflux pump in the small intestine of rats. In conclusion, the presence of morin significantly enhanced the oral bioavailability of nifedipine, suggesting that concurrent use of morin or morin-containing dietary supplement with nifedipine should require close monitoring for potential drug interaction.

• 한국염색가공학회지
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• 제8권5호
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• pp.49-67
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• 1996

이 연구의 목적은 에틸렌이민 유도체를 갖는 아조계 분산 염료의 나일론 6.6 섬유에의 응용과 최적화된 나일론 염색 조건의 확립이다. 두 쌍의 염료 A-1/A-2와 D-1/D-2의 최대흡수파장(&{\lambda}_{max}&)을 비교할 경우, 아세톤 최대흡수파장(λ$_{max}$)의 차이가 없거나 적어졌다. 세가지 아지리디닐 모노 아조 염료와 이들 염료의 가수분해 된 형태 그리고 디메닐아닐린계 아조 염료의 나일론 6.6 섬유에 대한 염색 및 견뢰도 성질이 조사되었다. 아지리디닐 염료의 나일론 섬유상의 최대 염착은 pH 5에서 얻어졌으며, 염색된 나일론 섬유에서의 용매추출의 경우 최소 염료 추출은 pH 8.0-10.0 에서 얻어졌다. 아지리디닐 염료 염색된 나일론 섬유상의 세탁 견뢰도와 광 견뢰도는 염색 시 pH의 증가에 따라 증가하였으나, pH 8에서의 견뢰도 성질이 pH 10에서와 비교하여 보다 개선되었다. 세가지 아지리디닐 염료가 이들 염료의 가수분해 된 형태 그리고 디메틸아닐린계 아조 염료와 비교해서 나일론 6.6 섬유상에서 보다 개선된 견뢰도를 나타내었고 이는 염료와 섬유간의 공유 결합으로 기인한 것으로 여겨진다.

• Applied Biological Chemistry
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• 제45권4호
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• pp.223-227
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• 2002

그늘쑥(Artemisia sylvatica Max.)으로부터 분리된 sesquiterpene lactone계 화합물들의 구조적인 특성과 FPTase 저해활성을 나타내는 dehydromatricarin A, B 분자들 사이 biogenic Diels-Alder 반응의 경계분자 궤도함수 (FMO)상호작용에 대한 배향성을 검토하였다. 그 결과, 주 생성물이 얻어지는 반응은 B1(diene)의 HOMO와 A16(dienophile)의 LUMO간 hard-hard한 charge-control 반응이었다. 그리고 AO계수 분극간의 상호작용에 따른 배향성은 분리된 8-acetylarteminolide와 artanomaloide들이 모두 biogenic Diels-Alder 반응의 부 생성물들임을 시사하였다. 또한, 8-acetyl-arteminolide의 FPTase 저해활성($pI_{50}=3.75$ 및 logP=2.62)은 큰 반면에 artanomaloide 및 dehydromatricarin은 작았다.

• Journal of Ginseng Research
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• 제16권2호
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• pp.124-128
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• 1992

인삼의 엽소현상과 광계 II(photosystem II)의 광수확 엽록소-단백질 복합체(LHCP II)의 광에너지 분배 기작과의 관계를 구명코저 LHCP II의 인산화에 따른 형광 quenching과 광량별 인산화 정도, 그리고 단백질 조성을 조사하였다. 인삼은 DCMU의 존재 하에서 photosystem II의 형광발생량이 양지식물인 콩에 비해 많았으며, 인간화에 따른 형광 quenching율도 현저히 높았다. 또한, 강광(25k1ux 이상)에서 인삼은 인산화에 따른 형광 quenching율이 콩에 비해서 2배정도 높다는 사실을 확인하였다. 엽록소-단백질 복합체(CP-complex)의 조성비율 및 LHCP II를 구성하고 있는 단백질의 앙과 수적인 면에서 비교식물과 큰 차이를 나타내었는데, 24~29kD 범위에서 인삼은 25, 26, 27kD의 major 밴드와 24, 25.3, 28.3kD의 minor밴드로 구성되어 있었으며 광량에 의존적으로 인산화가 증가하는 인삼의 LHCP II 단백질은 24kD 이었다.

• 치위생과학회지
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• 제19권3호
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• pp.154-161
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• 2019

Background: The market for vitamin drinks is expanding both in Korea and worldwide. However, it was difficult to find studies regarding the possibility of tooth erosion induction due to vitamin drinks. The purpose of the present in vitro study was to evaluate the effect of tooth erosion caused by a few commercial vitamin beverages on bovine teeth enamel in terms of erosion depth and fluorescence loss. Methods: Three experimental groups (vitamin drinks), a positive control group (Coca-Cola), and a negative control group (mineral water) were established. Each group consisted of 5 specimens obtained from sound bovine teeth. The pH and titratable acidity of beverages were measured. Specimens were immersed in the beverages and artificial saliva for 6 and 18 hours, respectively. This cycle was repeated for 5 days. The depth of the tooth loss caused by tooth erosion (erosion depth) and maximum loss of fluorescence (Max ${\Delta}F$) were measured using the microscope and quantified light-induced fluorescence-digital, respectively. For the statistical analysis, the Kruskal-Wallis test and ANOVA were used to compare the erosion depth and Max ${\Delta}F$ of the enamel surfaces. In addition, Spearman correlations were estimated. Results: The pH of the three vitamin beverages ranged from 2.65 to 3.01, which is similar to that of the positive control group. All beverages, except mineral water, had sugar and acidic ingredients. Vitamin drinks and the positive control, Coca-Cola, caused tooth erosion lesions, and showed significant differences in erosion depth compared to mineral water (p<0.05). The vitamin beverages with low pH were associated with high erosion depth and Max ${\Delta}F$. Conclusion: Vitamin drinks have the potential to cause tooth erosion.

• 한국환경성돌연변이발암원학회지
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• 제21권1호
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• pp.1-8
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• 2001

We have synthesized $^{99m}$Tc-mercaptoacetyltriglycine (MAG3)-biocytin as a new imaging agent for hepatobiliary scintigraphy. The aim of this study was to evaluate the usefulness of $^{99m}$Tc-MAG3-biocytin scintigraphy in differentiating carbon tetrachloride ( $CCl_4$)-induced hepatotoxicity from $\alpha$-naphthylisothiocyanate (ANIT)-induced cholestasis in mice, which reflecting the differential diagnosis of neonatal jaundice caused by neonatal hepatitis from congenital biliary atresia in humans. Methods: Balb/c mice (female, 20 g, n=4-6) were pretreated with $CCl_4$(0.5 or $1.0m\ell$/kg) and ANIT ($150 or 300 m\ell$/kg) 18 h before scintigraphy. Biochemical and histopathological examinations showed a pattern of typical acute hepatitis (increase of transaminases and hepatocellular necnsis) in $CCl_4$-treated mice and cholestasis (increase of alkaline phosphatase and ${\gamma}$-glutamyltransferase, and biliary hyperplasia) in ANIT-treated mice, respectively, Mice were fasted at least 4 hr prior to the intravenous injection of $^{99m}$Tc-MAG3-biocytin (18.5 MBq/20$\mu\textrm{g}$) in 2% human serum albumin in saline. Scintigraphy was performed with a ${\gamma}$-camera equipped with a 1-mm diameter pin-hole collimator for 30 min and images were acquired every 15 s. We compared the values of physical parameters, such as peak liver/heart ratio ($${\gamma}$_{max}$) and peak ratio time ($t_{max}$) far $^{99m}$Tc-MAG3-biocytin scintigraphy. Results: Scintigraphic parameters of the $CCl_4$-pretreated (0.5 $m\ell$/kg) group showed a 81.9% decrease of r$_{max}$, and 42.2% decrease of $t_{max}$, whereas the ANIT-pretreated ( $150m\ell$/kg) group showed a 53% decrease of $r_{max}$, and 2.36-fold increase of $t_{max}$, (P<0.05). These results demonstrate that the decrease of $r_{max}$ and the shortening of $t_{max}$ are characteristic features for hepatotoxicity, in contrast to the increase of $t_{max}$ and decrease of $r_{max}$ for biliary hyperplasia. Conclusion: $^{99m}$Tc-MAG3-biocytin hepatobiliary scintigraphy can distinguish hepatitis from cholestasis in mice model and may be similarly useful in humans which differentiating the cause of neonatal jaundice in clinical study.cal study.cal study.cal study.