• Asian Pacific Journal of Cancer Prevention
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• v.15 no.16
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• pp.6799-6804
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• 2014

Background: Chemotherapy is the mainstay of treatment for the majority of patients with advanced non-small cell lung cancer (NSCLC) without driver mutations and many receive therapies beyond first-line. Second-line chemotherapy has been disappointing both in terms of response rate and survival and we know relatively little about the prognostic factors. Materials and Methods: One thousand and eight patients with advanced NSCLC who received second-line chemotherapy after progression were reviewed in Shanghai Pulmonary Hospital, China, from September 2005 to July 2010. We analyzed the effects of potential prognostic factors on the outcomes of second-line chemotherapy (overall response rate, ORR; progression free survival, PFS; overall survival, OS). Results: The response and progression free survival of first-line chemotherapy affects the ORR, PFS and OS of second-line chemotherapy (ORR: CR/PR 15.4%, SD 10.1%, PD2.3%, p<0.001; PFS: CR/PR 3.80 months, SD 2.77 months, PD 2.03 months, p<0.001; OS: CR/PR 11.60 months, SD 10.33 months, PD 6.57 months, p=0.578, p<0.001, p<0.001, respectively). On multivariate analysis, better response to first-line therapy (CR/PR: HR=0.751, p=0.002; SD: HR=0.781, p=0.021) and progression within 3-6 months (HR=0.626, p<0.001), together with adenocarcinoma (HR=0.815, p=0.017), without liver metastasis (HR=0.541, p=0.001), never-smoker (HR=0.772, p=0.001), and ECOG PS 0-1 (HR=0.745, p=0.021) were predictors for good OS following second-line chemotherapy. Conclusions: Patients who responded to first-line chemotherapy had a better outcome after second-line therapy for advanced NSCLC, and the efficacy of first-line chemotherapy, period of progression, histology, liver metastasis, smoking status and ECOG PS were independent prognostic factors for OS.

• Transactions of the Korean Society of Automotive Engineers
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• v.12 no.3
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• pp.145-151
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• 2004

In this paper, a pressure control type ratio control valve(RCV) is designed for a metal belt CVT. Steady state and transient characteristics of the pressure control CVT are investigated by simulations and experiments. In addition, P-line is proposed to predict the shift performance. It is found that the bigger the pressure margin, the faster the shift response. It is expected that the P-line can be used in design of the RCV to meet the desired shift performance.

• International Journal of Arrhythmia
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• 제18권2호
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• pp.66-76
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• 2017

Background and Objectives: Although an anterior linear ablation is an effective lesion set in radiofrequency catheter ablation (RFCA) for longstanding persistent atrial fibrillation (L-PeAF), its durability for bidirectional block (BDB) is only about 60% at repeat procedure. We hypothesized that changes in electrocardiogram (ECG) may predict an anterior line block state and the clinical outcome of L-PeAF ablation. Subjects and Methods: We studied 304 L-PeAF patients (77% male, $60{\pm}10yrs$), who consistently underwent RFCA Dallas lesion set (circumferential pulmonary vein isolation, posterior box lesion, and anterior line) protocol with subsequent comparison of pre-procedural and post-procedural P wave axes, and one year follow-up (n=205) sinus rhythm (SR) ECGs. Results: 1. P wave axis shifted inferiorly at immediate post-procedure (p<0.001), and was independently correlated with BDB of anterior line (${\ss}=10.4$, 95% confidence interval [CI] 2.79-17.94, p=0.008). 2. The degree of post-procedural inferior shift of P wave axis did not reflect clinical recurrence within one-year (n=205, p=0.923), potentially due to conduction recovery of an anterior line. However, among 160 patients without clinical recurrence within one-year, P wave axis at one-year ECG was independently associated with very late recurrence of AF after one-year (n=160, hazard ratio [HR] 0.98; 95% CI 0.97-0.99, p=0.001), during $45.6{\pm}16.7$ months of follow-up. 3. Among 22 patients who underwent repeat procedures, P wave axis shift was more significant in patients with maintained BDB of an anterior line than in those without (p=0.015). Conclusion: An inferior shift of P wave axis reflects the achievement and the maintenance of an anterior line BDB, and is associated with better long-term clinical outcome after catheter ablation for L-PeAF based on Dallas lesion set.

• Korean Journal of Poultry Science
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• v.29 no.2
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• pp.81-88
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• 2002

The objective of this study was to investigate the line-by-feed additive interaction on egg traits and yolk cholesterol level in laying hens. Hy-line W-98 (white shell line) and Hy-line Brown (brown shell line) were used as experimental stocks and three groups were assigned in each line. The age of hens used in this study were from 40- to 46-wk-old. Two different levels of chitosan were also used as additive in chicken diet. The first (CH$_{30}$) and second (CH$_{60}$) experimental groups were fed basal diet added 30mg and 60mg chitosan/kg feed, respectively. And the control group (CON) hens were fed with basal diet only. The eggs were collected and analyzed at the end of 40, 42, 44, and 46-wk-old. In the mean egg weight, the CH$_{30}$ in Hy-line Brown was significantly heavier (P<0.05) than CON, but the CH$_{30}$ in Hy-line W-98 was significantly lighter (P<0.05) than CON. Whereas, the mean egg weight did not significantly differ between CH$_{60}$ and CON in both line. The mean albumen percentage in Hy-line Brown did not show significant between experimental groups and control group. On the other hand, the mean albumen percentage of CH$_{60}$ in Hy-line W-98 was significantly lower (P < 0.05) than that of CON, but there was no significantly different between CH$_{30}$ and CON. In the mean yolk percentage, it showed a reverse trend as shown in the mean albumen percentage; there were significantly higher (P<0.05) in CH$_{60}$ than in CON fur the Hy-line W-98, and higher in CH$_{30}$ than in CON for the Hy-line Brown. However, the mean shell percentages did not significantly differ between experimental groups and control group in both lines. In the mean yolk cholesterol levels, the CH$_{30}$ and CH$_{60}$ in both lines were lower by 0.46 mg ∼2.80 mg per gram yolk than CON. Although the interaction effect of line-by-supplementing level of chitosan in hens diet on the pooled mean of yolk cholesterol level was no significant, it showed a highly significant interaction (P<0.01) at three of four experimental ages.

• KSBB Journal
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• v.13 no.4
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• pp.461-467
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• 1998

A fermentation system was supplemented with a device for the measurement of the durations of alkali pump feeding for automatic pH control and an A/D convertor for precise monitoring of pH value by computer. A software program was developed to measure buffer capacities from the pH signal and the pH control signal during fermentation. By measuring the buffer capacity on-line, levels of acetic acid were estimated by a software sensor using pH signal in a fermentation process of E.coli growing in a minimal medium. The measured values of acetic acid showed correlation to those of estimated by the software sensor. Lacitic acid production was also successfully estimated by the values of buffer capacities measured on-line.

• Korean Journal of Poultry Science
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• v.29 no.3
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• pp.151-156
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• 2002

The objective of this study was to compare the two different eggshell lines of commercial layers on egg traits and egg production rate. Hy-line W-98 (white shell line; WSL) and Hy-line Brown (brown shell line; BSL) were used as experimental stocks. The birds in each line were allocated to three floor pens each containing 25-birds. They were fed a ration containing 15.5% CP and 2,700 ㎉/kg ME, and were supplied 16 h of light per day throughout the experimental Periods. The egg traits and egg Production rate were measured from 53 to 56-wk-old and 20 to 56-wk-old, respectively. The mean egg weight and the mean percentage albumen were significantly heavier and higher (P<0.05) in the BSL than in the WSL, respectively. The mean eggshell thickness and the mean percentage shell were also significantly thicker and higher (P<0.05) in the BSL than those in the WSL, respectively. However, the mean percentage yolk and the yolk to albumen ratio showed a reverse trend as shown in the mean percentage albumen or percentage eggshell. Although the WSL birds started laying 4 d earlier than the BSL ones, the overall mean egg Production rate for BSL during 20 to 56 wk of age was significantly higher (P<0.05) by 6.6% than the WSL. It was concluded that the eggs of brown eggshell line had heavier egg weight and thicker shell, and they had more percentage of albumen, but less percentage of yolk than those of the white eggshell line. These results suggest that the brown eggshell line raised on the floor might be more beneficial than the white eggshell line not only for the preference of the table egg consumers, but also for the efficient production of the eggs.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.14 no.3
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• pp.57-69
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• 2011

This study examined the relationship between Phragmites australis' growth and sediment properties at mud tidal flat of Donggum-ri, Gilsang-myeon, Gangwha-gun, Incheon city. Field survey was carried out from May, 2010 to October, 2010. Water content, soil texture, electric conductivity and water table depth for sediment, density, height, dry weight and flowering for P. australis were examined at several plots from the starting point (the coastal embankment) to the end point of the two populations. The result was as follows. Firstly, the water table increased along distance from the embankment at one line (N-line) but was similar at the other line (S-line) in a P. asustralis population. Water tables were higher out of than within a P. australis population at two populations. Secondary, in N-line, the height and dry weight of P. australis decreased along the distance from embankment but, in S-line, those were similar in its population. P. australis' growth was dependent on electric conductivity at lower layer (water table level) rather than upper one (the surface). Thirdly, density of P. australis changed during growing season and was similar in a population, except for the end point of patch. In summary, the growth and distribution of P. australis were dependent on salt content of tidal flat's sediment (water table level) and this was affected by fresh water of the inland.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.31 no.3
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• pp.266-273
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• 2005

Purpose: To assess the relationship between soft tissue reference line and hard tissue reference line using the standardized photographs and the posteroanterior cephalometric radiographs(P-A)in facial asymmetric patients and to compare the differences of angular measurement between normal group and asymmetry group. Methods: Normal group consisted of 44 persons with normal occlusion and normal facial morphology. Asymmetry group consisted of 90 patients with facial asymmetry. Standardized facial photographs and P-A were taken in all subjects. The horizontal reference lines were bipupillary line in photographs and latero-orbitale line in P-A respectively. The vertical reference line were the line from the midpoint of horizontal reference line perpendicularly. Angular measurement of otobasion canting, lip canting, nose deviation, chin deviation, and maxillary deviation were compared and analyzed in photographs. And angular measurement of mastoid canting, mandibular canting, nose deviation, chin deviation, and maxillary deviation were compared and analyzed in P-A. Results: 1. The variables of photographs and P-A were significantly related in the asymmetry group. 2. Significant differences between all variables except for PT2 and PA2 were shown in the asymmetry group and between PT1 and PA1, PT3 and PA3 in the normal group respectively. 3. Comparison measurement scores of angular difference between control group and experimental group concerning each variable showed significant difference except for PA1. Conclusions: Soft tissue components may not compensate for underlying skeletal imbalance in nose deviation and chin deviation. The horizontal reference lines in photographs were significant related with the P-A, but angular variables between the two studies show significant differences. Therefore, we do not recommend use photography in the assessment the facial asymmetry as complemented in the P-A.

• Korean Journal of Food Science and Technology
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• v.10 no.1
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• pp.27-35
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• 1978

Ultrastructural changes in Z-line, M-line and myofilaments of bovine psoas muscle produced by leukocyte lysosomal enzymes in vitro at different pH values (pH 7.0 and 4.0), temperatures (37 and $4^{\circ}C$) and time intervals (12, 24 hours at $37^{\circ}C$ and 36, 168 hours at $4^{\circ}C$) were studied by transmission electron microscope. Muscle incubated with leukocyte lysosomal enzymes at pH 7.0 produced distinguishable degradation of Z-line, M-Line and H-zone at both temperatures but at acidic pH (pH 4.0), Z-line were very stable and myofilaments were severely disintegrated.

• 제어로봇시스템학회:학술대회논문집
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• 2002.10a
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• pp.58-58
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• 2002

Recently Many technologies of the P.L.N (Power Line Network) are introduced for an efficient communication. P.L.N transmits information using power line channel. A medical information transmission system is proposed in this paper for the effective transmission. The Power Line Networks have an advantage in low cost because it uses existent power line. It can be easily applied anywhere that a power line socket is available. But the power line channel is very noisy, because many electronic devices in generate electronic noise in modulated signals. This problem should be considered carefully in the design of medical information transmission system using P.L.N. The proposed system can be applied...I propose a telemedicine system using the power line network.