• Tuberculosis and Respiratory Diseases
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• 제87권2호
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• pp.165-175
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• 2024

Background: The prevalence of small airway dysfunction (SAD) in patients with chronic obstructive pulmonary disease (COPD) across different ethnicities is poorly understood. This study aimed to estimate the prevalence of SAD in stable COPD patients. Methods: We conducted a cross-sectional study of 196 consecutive stable COPD patients. We measured pre- and post-bronchodilator (BD) lung function and respiratory impedance. The severity of COPD and lung function abnormalities was graded in accordance with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines. SAD was defined as either difference in whole-breath resistance at 5 and 19 Hz > upper limit of normal or respiratory system reactance at 5 Hz < lower limit of normal. Results: The cohort consisted of 95.9% men, with an average age of 66.3 years. The mean forced expiratory volume 1 second (FEV₁) % predicted was 56.4%. The median COPD assessment test (CAT) scores were 14. The prevalence of post-BD SAD across the GOLD grades 1 to 4 was 14.3%, 51.1%, 91%, and 100%, respectively. The post-BD SAD and expiratory flow limitation at tidal breath (EFL_T) were present in 62.8% (95% confidence interval [CI], 56.1 to 69.9) and 28.1% (95% CI, 21.9 to 34.2), respectively. COPD patients with SAD had higher CAT scores (15.5 vs. 12.8, p<0.01); poor lung function (FEV₁% predicted 46.6% vs. 72.8%, p<0.01); lower diffusion capacity for CO (4.8 mmol/min/kPa vs. 5.6 mmol/min/kPa, p<0.01); hyperinflation (ratio of residual volume to total lung capacity % predicted: 159.7% vs. 129%, p<0.01), and shorter 6-minute walk distance (367.5 m vs. 390 m, p=0.02). Conclusion: SAD is present across all severities of COPD. The prevalence of SAD increases with disease severity. SAD is associated with poor lung function and higher symptom burden. Severe SAD is indicated by the presence of EFL_T.

• 한국시뮬레이션학회:학술대회논문집
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• 한국시뮬레이션학회 2005년도 춘계학술대회 논문집
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• pp.139-143
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• 2005

The P2P is a network environment supporting data exchange which is directly connected peers without limit of existing server-client and intervening central server for resource or offered service with each peer. JXTA is a representative of P2P system. JXTA is a typical distributed computing model that proposed by Sun Microsystems. JXTA that doesn't require centralized services or resources is adaptable in extreme changes of network organization. MANET(Mobile Ad Hoc Network) is a representative wireless network that is composed of mobile nodes without infrastructure. So MANET establishes the path for the communication of each peers and maintains the newest routing information by exchanging routing information. In this paper, we propose a technique of JXTAMAUET which implements JXTA which is the P2P network system from the wireless network which is becoming the foundation of ubiquitous computing. For the performance evaluation of the JXTAMANET, we use simulation.

• 대한물리치료과학회지
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• 제15권1호
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• pp.1-9
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• 2008

Background and Purpose : This study serves the purpose to present the effective way on back pain therapy for women during their pregnancy by comparing and analyzing the effects influencing on pain index, limits on daily life, and diminution of lumbar curve, when having treated for 6 weeks, dividing into therapy group, applied by decompression therapy on spine without unnecessary effects on the pregnant women and their fetus and the existent general physiotherapy group, applied on diminution of their back pain. Subject & methods : We made impregnate women of 30(25${\sim}$34years), as the subject of this study, who understood, and agreed with, this study, among pregnant women who were diagnosed as back pain. Pain intensity, limit index on daily life, and lumbar curve test, prior to experiment was implemented as paired t－test, comparison of the difference of average by each group before and after experiment was analysed as independent t－test, and statistical examination level was set up as 0.05. Results : The difference of average of pain and limit on daily life between the group, SDTG(spinal decompression therapy group), and the group, GPTG(general physical therapy group), before and after experiment was diminished as much as 44.4% and 16.79% each after completed 6 weeks' experiment, limit on daily life in both groups showed as much as 37.2% and 21.5% each, in the end, they statistically showed conspicuous difference(p<.05). Comparison of lumbar curves between both groups, SDTG and GPTG, before and after experiment, were diminished from -23.13${\pm}$4.85 to -15.66${\pm}$3.71, and there was no remarkable difference(p<.05). Conclusion : As, in this study, decompression therapy is more effective than general physical therapy with pregnancy low back pain in pain, limitation of daily life, lumbar curve.

• Animal cells and systems
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• 제10권2호
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• pp.79-83
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• 2006

Tissue plasminogen activator (tPA) is used to lyse clots and reperfuse brain in ischemic stroke. However, sideeffects of intracerebral hemorrhage (ICH) and edema limit their clinical application. In part, these phenomena has been linked with elevations in matrix metalloproteinase-9 (MMP-9) in neurovascular unit. However little is known about their regulatory signaling pathways in brain cells. Here, I examine the role of MAP kinase pathways in tPA-induced MMP-9 regulation in rat cortical astrocytes. tPA $(1-10\;{\mu}g/ml)$ induced dose-dependent elevations in MMP-9 and MMP-2 in conditioned media. Although tPA increased phosphorylation in two MAP kinases (ERK, JNK), only inhibition of the JNK pathway by the JNK inhibitor SP600126 significantly reduced MMP-9 upregulation. Neither ERK inhibition with U0126 nor p38 inhibition with SB203580 had any significant effects. Taken together, these results suggest that c-jun N-terminal kinase (JNK) plays an essential role for tPA-induced MMP-9 upregulation.

• 산업경영시스템학회지
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• 제1권1호
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• pp.45-48
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• 1978

If two inspectors classify items in a lot into m classes, it is possible that each of them makes wrong classification in some cases, thus causing bias. Expressions have been obtained for the limits of this bias in estimating the proportion of the different classes. From the results of the classification they obtained limit for the estimates of Proportions have been worked out, based on assumption regarding the magnitudes of probabilities of misclassification. Now we suppose that $P_{ti}{\;}(t=1.2)$ is the probability that t the inspector classifies correctly an item in class $A_i$ and $q_{tji}$ is the probability that he misclassifies in $A_j$ an item actually belonging to $A_i$, therefor, $P_{ti}+ \sum\limits_{j{\neq}i}q_{tji}=1$ An estimate for the proportion $P_k$ of the class $A_k$ in the lot would be $\hat{P}_k=r_{kk}+(\frac{1}{2})\sum\limits_{j{\neq}k}r_{kj}+r_{jk}$ The % Bias in proportion $\hat{P}_k$ is $\frac{E(\hat{P}_k)-P_k}{P_k}{\times}100$

• 대한물리의학회지
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• 제12권1호
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• pp.67-74
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• 2017

PURPOSE: The purpose of this study was to determine the effect of action observation with observation type on the limits of stability and dynamic gait ability in stroke patients. METHODS: The 20 stroke patients who participated in this study were randomly divided into two experimental groups who underwent training three times a week for 4 weeks. Their balance was tested as the limit of stability with Biorescue. Their Dynamic gait ability was tested with the Dynamic Gait Index (DGI) before the intervention, and after 4 weeks. Independent and paired t-tests were used to analyze the results. RESULTS: The results confirmed the limit of stability on the moving areas of the paralyzed and non-paralyzed sides. The limit of stability and dynamic gait index measurements confirmed that the moving area showed a significant difference after the intervention in the whole movement observation group (p<.05), but the partial movement observation group showed no significant difference (p>.05). A significant difference was also noted for the comparison between the both groups after the interventions (p<.05). The functional walking ability showed a significant difference when compared to the ability before the intervention, as determined by the changes in scores obtained for the dynamic gait index (p<.05). CONCLUSION: Interventions utilizing whole movement confirm that training improves stability and functional walking ability in stroke patients with disabilities in balance and walking ability.

• Asian-Australasian Journal of Animal Sciences
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• 제14권9호
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• pp.1228-1232
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• 2001

Forty five Soviet Chinchilla rabbits weaned at 35 d of age were fed 5 experimental diets prepared by using oat plant meal ($T_2,\;T_4$) and tall fescue hay ($T_3,\;T_5$) at 25% and 50% level along with control ($T_1$). The gain in body weight at 84 d of age decreased with test material substitution, however, the differences were non significant when compared with oat plant meal and were significant (p<0.05) with tall fescue hay at both the levels. Feed conversion ratio also deteriorated with test material and its increasing proportion and the differences were significant (p<0.05). The performance-index calculated were 42.1, 36.7, 29.4, 33.3 and 18.8 in $T_1,\;T_2,\;T_3,\;T_4$ and $T_5$, respectively. Digestibility of all the organic nutrients decreased significantly (p<0.05) with test material incorporation, as a result nutritive value of the test diets decreased linearly. Nitrogen balance as per cent of intake was higher in oat plant meal substituted diet compared to tall fescue substituted diet. Cost per kg live weight gain was lowest with 50% oat plant meal followed by 25% oat plant meal incorporation. It was highest with tall fescue hay substitution. Nutritive value of oat plant meal as calculated was DCP 5.1%, TDN 35.8% and that of tall fescue hay was DCP 6.5%, TDN 30.8%. Thus, oat plant meal can be substituted safely up to 25% in the feeding regime of weaner rabbits whereas, for tall fescue hay the safe limit is below 25% level and needs to be ascertained.

• Environmental Engineering Research
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• 제25권2호
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• pp.212-221
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• 2020

This work discusses the palm oil mill processing carried out at Jugra Palm Oil Mill Sdn Bhd, situated at Selangor, Malaysia with the capacity of 45-t fresh fruit bunch (FFB)/h. Typically, oil palm residues and palm oil mill effluent (POME) from FFB are generated while processing. Prior to discharge, POME should be treated to remove pollutants in the effluent. As such, the performances of anaerobic and aerobic ponds were assessed in this study to determine temperature, pH, biological oxygen demand (BOD), sludge volume index (SVI), and dissolved oxygen (DO). From the experiments, mesophilic temperature due to better process stability was applied in anaerobic ponds. The pH results displayed a fluctuating trend between lower control limit and upper control limit, and, the pH value increased from one pond to another. The final discharge BOD and SVI appeared to be lower than 100 mg/L and 10 mL/L indicating low degree of pollution and good settling ability for biomass/solid. DO was close to normal, mostly below 2 mg/L. The experimental outcomes revealed the effective treatability of POME in adherence to the standard regulation, which is the priority for environmental sustainability within this industry domain.

• 한국안전학회지
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• 제6권4호
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• pp.13-20
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• 1991

Ion-selective electrode responsive to the thiocynate ion prepared by using the quaternary ammonium salts as a active material and PVC as a membrane matrix. The effect of chemical structure and composition of active material, and the membrane thickness on the linear response. the detection limit, and Nernstian slope of the electrode studied. Under the above optimum conditions of membrane, the effect of pH and the selectivity coefficients to various interfering anions were compared and investigated. It was concluded that the functions of thiocynate ion-selective electrode(ISE) were closely related to the chemical structure of the quaternary ammonium salts. The linear response, and the detection limit of the electrode potential increased with the increase of the carbon chain length of the alkyl group in the quaternary ammonium salts in the ascending order of Aliquat 336T, TOAT, TDAT, and TDDAT. The optimum membrane thickness was 0.3mm. The electrode characteristics was better with the decrease of the concentration of active material, and the best concentration was 3 weight percent. The membrane potential was independent of the pH variation in the region from pH 2 to 12. The order of the selectivity coefficients is as follows：Cl $O_4$$^{[-10]}$ ＞ $I^{[-10]}$ ＞N $O_3$$^{[-10]}$ ＞B $r^{[-10]}$ ＞ $F^{[-10]}$ ＞C $l^{[-10]}$ ＞O $A_{c}$ $^{[-10]}$ 〓S $O_4$$^{2-}$.

• Bulletin of the Korean Chemical Society
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• 제25권6호
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• pp.833-837
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• 2004

DeniLite$^{TM}$ laccase immobilized platinum electrode was used for amperometric detection of hydroquinone (HQ) and homogentisic acid (HGA) by means of substrate recycling. In case of HQ, the obtained sensitivity is 280 nA/ ${\mu}$M with linear range of 0.2-35 ${\mu}$M ($r^2$ = 0.998) and detection limit (S/N = 3) of 50 nM. This high sensitivity can be attributed to chemical amplification due to the cycling of the substrate caused by enzymatic oxidation and following electrochemical regeneration. In case of HGA, the obtained sensitivity is 53 nA/ ${\mu}$M with linear range of 1-50 $[\mu}M\;(r^2$ = 0.999) and detection limit of 0.3 ${\mu}$M. The response times ($t_{90%}$) are about 2 seconds for the two substrates and the long-term stability is 60 days for HQ and around 40-50 days for HGA with retaining 80% of initial activities. The very fast response and the durable long-term stability are the principal advantages of this sensor. pH studies show that optimal pH of the sensor for HQ is 6.0 and that for HGA is 4.5-5.0. This shift of optimal pH towards acidic range for HGA can be attributed to the balance between enzyme activity and accessibility of the substrate to the active site of the enzyme.