• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.40 no.6
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• pp.291-296
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• 2014

Objectives: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a side effect of bisphophonate therapy that has been reported in recent years. Osteoclastic inactivity by bisphosphonate is the known cause of BRONJ. Bone morphogenetic protein-2 (BMP-2) plays an important role in the development of bone. Recombinant human BMP-2 (rhBMP-2) is potentially useful as an activation factor for bone repair. We hypothesized that rhBMP-2 would enhance the osteoclast-osteoblast interaction related to bone remodeling. Materials and Methods: Human fetal osteoblast cells (hFOB 1.19) were treated with $100{\mu}M$ alendronate, and 100 ng/mL rhBMP-2 was added. Cells were incubated for a further 48 hours, and cell viability was measured using an MTT assay. Expression of the three cytokines from osteoblasts, receptor activator of nuclear factor-${\kappa}B$ ligand (RANKL), osteoprotegerin (OPG), and macrophage colony-stimulating factor (M-CSF), were analyzed by real-time polymerase chain reaction and enzyme-linked immunosorbent assay. Results: Cell viability was decreased to $82.75%{\pm}1.00%$ by alendronate and then increased to $110.43%{\pm}1.35%$ after treatment with rhBMP-2 (P<0.05, respectively). OPG, RANKL, and M-CSF expression were all decreased by alendronate treatment. RANKL and M-CSF expression were increased, but OPG was not significantly affected by rhBMP-2. Conclusion: rhBMP2 does not affect OPG gene expression in hFOB, but it may increase RANKL and M-CSF gene expression.

• Asian-Australasian Journal of Animal Sciences
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• v.16 no.5
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• pp.719-725
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• 2003

An experiment was conducted to study the requirement of calcium (Ca) and non-phytin phosphorus (NPP) in commercial broilers during starter phase. Seven hundred and twenty day-old Vencob male broiler chicks were randomly distributed into 144 stainless steel battery brooders, 5 birds in each. Four levels each of Ca (6, 7, 8, and 9 g/kg) and NPP (3, 3.5, 4, and 4.5 g/kg diet) were fed in a factorial design in a corn-soya basal diet. Levels of dicalcium phosphate and oyster shell grit were adjusted to obtain the desired levels of Ca and NPP. Each diet was fed ad libidum to chicks in 9 battery brooders from one d to 21 d of age. Body weight gain and feed intake were depressed (p<0.01) by increasing the dietary Ca level (8 and 9 g/kg) at lower levels of NPP (3 and 3.5 g/kg diet). The growth depression observed at lower NPP level was alleviated by reducing the Ca content to 6 g/kg diet. The tibia ash content and tibia breaking strength increased with increase in both Ca (>6 g/kg) and NPP (>3 g/kg) levels. The leg abnormality score decreased (p<0.01) with increase in NPP content in the diet at all levels of Ca tested. The serum Ca and inorganic P levels were increased with increase in the level of the respective mineral in the diet, but the serum concentration of Ca and P were inversely related to the level of NPP and Ca, respectively /kg diet. In general, the excretion of macro minerals (Ca, and P), and micro minerals {zinc (Zn), manganese (Mn), iron (Fe), and copper (Cu)} was significantly lower at lower levels of Ca and NPP tested (6 and 3 g/kg diet, respectively). The mineral excretion increased with increase in dietary Ca and NPP levels, more conspicuously at the disproportionate ratio of these minerals (>2:1, Ca and NPP). Similarly, the retention of Zn, Mn, and Fe in liver was significantly higher (p<0.01) at lower levels of Ca and NPP tested. Results from this study indicate that the commercial broilers do not require more than 3 g NPP and 6g Ca/kg diet during starter phase (up to 21 d of age) for optimum weight gain, feed efficiency and utilization of Ca, P, Zn, Mn, Fe and Cu. However, the requirements of these minerals for optimum bone mineralization were higher than the levels suggested above.

• Journal of Pharmaceutical Investigation
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• v.27 no.1
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• pp.71-77
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• 1997

With the aim of improving periodontal regeneration efficacy, as a biodegradable local drug delivery device, drug releasing chitosan beads were prepared. Chitosan beads were prepared through the formation of intermolecular or intramolecular ionic interaction bewteen chitosan and sodium tripolyphosphate and were loaded with flurbiprofen. The mean diameter of the beads was $250\;{\mu}m$. Drug loading efficiency was improved by regulating the pH of tripolyphosphate solution. The drug release kinetics mainly depended upon the hydrophobic properties of the flurbiprofen, that is, the release of flurbiprofen showed initial burst with rapid release for the first day followed by a levelling off of the release rate. However, the release rate could be controlled by the formulation factor including the pH, concentration of the tripolyphosphate solution, gelation time, drug contents. From these results, flurbiprofen loaded chitosan beads were anticipated as biodegradable local drug delivery devices for periodontal regeneneration.

• Proceedings of the Korean Society for Agricultural Machinery Conference
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• 1993.10a
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• pp.1043-1052
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• 1993

Field experiments were conducted to determine the optimum combination of performance parameters of a single-shank, tractor-mounted oscillating subsoiler. Tests were conducted at frequencies of oscillation of 3.7 , 5.67, 7.58, 9.48 and 11.456Hz ; amplitudes of 18, 21, 23.5, 34 and 36.5 mm ; and forward speeds of 1.84, 2.19 and 3.42 kmph at moisture content close to the plastic limit of the soil. It was observed that there was a reduction in average draft but an a increase in average total power requirement for oscillating than non-oscillating subsoiling. The draft and power ratios were significantly affected by the forward speed, frequency and amplitude. Their combined interaction expressed in terms of the velocity ratio parameter( the ratio of peak tool velocity and forward speed) however has the strongest influence. At the same velocity ratio, the draft reduction and power increase were less at higher amplitude of oscillation . As the oscillating frequency is increased toward the soil resonance the draft requirement becomes less. For the field conditions tested. the optimum operation was obtained at an amplitude of 36.5mm, frequency of 9.48Hz and speed of 2.19 kmph with a draft ratio of 0.33 and a power ratio of only 1.24.

• Journal of Integrative Natural Science
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• v.8 no.3
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• pp.192-203
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• 2015

In view of the growing medicinal importance of pyrazole and its derivatives, the single crystal X-ray diffraction study was carried out for the potential active 2-Benzyl-3-[3-(4-bromo-phenyl)-1-phenyl-1H-pyrazol-4yl]-4,6-dioxo-5-phenyl-octahydro-pyrrolo[3,4-C]pyrrole-1-carboxylic acid ethyl ester ($C_{37}H_{31}BrN_4O_4$, H2O). In the title compound are two molecules exist in the asymmetric unit. It crystallizes in the monoclinic space group $P{\hat{i}}$ with unit cell dimension $a=13.361(18){\AA}$, $b=13.424(17){\AA}$ and $c=21.649(2){\AA}$ [${\alpha}=80.745(9)^{\circ}$, ${\beta}=79.770(10)^{\circ}$ and ${\gamma}=60.788(6)^{\circ}$]. The pyrazole ring adopts planar conformation. The sum of the bond angles at nitrogen atom of the pyrazole ring indicates the $Sp^2$ hybridized state. The crystal structure is stabilized by intramolecular C-H...O hydrogen bond interaction.

• Journal of Korean Society of Steel Construction
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• v.13 no.2
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• pp.201-210
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• 2001

A numerical analysis and experimental study were performed to investigate the behavior and strength of tube-gusset connection subjected to axial and lateral forces. To investigate the behavior of the connections, experiment was conducted by applying three directional loads. Local buckling and local plastic bending deformation of the connection were observed from the test. Analytical results were compared with test results for the limited cases. Primary interests here are the effect of eccentricity on the strength of the connection. To suggest a formula for the strength of tube-gusset connection, lateral forces were replaced with equivalent wall moment and eccenrtric vertical component force of lateral force. Ultimate strength formula for the each force was proposed. Finally, nondimensionalized ultimate strength interaction relationships between the wall moment of tube($M_w$), vertical axial force($P_v$), and eccentric vertical component of lateral force($P_e$) were formulated through parametric study.

• Geomechanics and Engineering
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• v.15 no.4
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• pp.973-986
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• 2018

The objective of this paper is to present abacuses obtained from a parametric study of deep-lined tunnels using a numerical finite element model. This numerical model was implemented in software GEOMEC91, which is a two-dimensional axisymmetric model that considers the progress of excavation and the placing of the lining through the activation and deactivation of elements. It is adopted a step of excavation constant (1/3 of radius), constant velocity and circular cross section along the tunnel axis. It is used for rock mass a viscoplastic constitutive law with von-Mises criterion of viscoplasticity without hardening whose deformation rate over time is given by the Bingham model. The lining uses a linear elastic constitutive law. In total are 1716 analysis presented in 60 abacuses that show the value of ultimate convergence ($U_{eq}$) due to tunneling speed. In addition, it is shown an example of the use of the abacuses to determine the ultimate convergence ($U_{eq}$) of the tunnel and pressure ($P_{eq}$) on the lining.

• Proceedings of the KIEE Conference
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• 2007.04a
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• pp.261-263
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• 2007

Authentication is a mechanism to establish proof of identities, the authentication process ensure that. Who a particular user is. Nowadays PC and laptop user authentication systems are always done once a hold until s explicitly revoked by the user, or asking the user to frequently reestablish his identity which encouraging him to disable authentication. Zero-Interaction Authentication (ZIA) provides solution to this problem. In ZIA,. a user wears a small authentication token that communicates with a laptop over a short-range, wireless link. ZIA combine authentication with a file encryption. Here we proposed a Laptop-user Authentication Based Mobile phone (LABM). In our model of authentication, a user uses his Bluetooth-enabled mobile phone, which work as an authentication token that provides the authentication for laptop over a Bluetooth wireless link, m the concept of transient authentication with our combining It with encryption file system. The user authenticate to the mobile phone infrequently. In turn, the mobile phone continuously authenticates to the laptop by means of the short-range, wireless link.

• Journal of Korean Academy of Nursing
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• v.35 no.5
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• pp.842-849
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• 2005

Purpose: The main purpose of this study was to establish a nursing intervention data base to improve maternal attachment. Method: The first group of mothers( control group), experienced their first physical contact with their infants after being discharged from the hospital. The second group (experimental group) practiced early initial mother-infant postpartum contact known as the most sensitive period for founding maternal-infancy attachment. The subjects of this study gave birth to normal infants at M hospital from Aug.25 to Sept.30, 2004. During the same time, data was collected through direct observation, with instruments designed by Cropley et al., to assess the behaviors of normal attachment. The statistical methods for data analysis were percentage, mean, standard deviation and t-test with an SPSS program. Result: The group practicing initial mother-infant contact, showed a higher degree of physical and functional bonding than the group experiencing the first contact after discharge from the :10spital (control group)(p<.0l). The group practicing initial mother-infant contact, showed higher degrees of bonding attachment assessments than the group experiencing their first initial contact after their discharge from the hospital(p<.01). Conclusion: The group practicing early mother-infant contact, showed more maternal-infant interaction than the group experiencing their initial contact after their discharge from the hospital. These results show that maternal attachment behavior increases according with an early initial mother-infant contact.

• Journal of fish pathology
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• v.30 no.1
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• pp.51-61
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• 2017

The effect of electromagnetic field on aquatic organisms has received little attention. In the current study, the effect of 50Hz electromagnetic field on muscle histopathology of Caspian Sea Cyprinus carpio, a species of economic importance, was investigated. A total of 120 healthy fish were used in this study. They were classified randomly in one of two groups as follows: Control or unexposed EMF group and experimental group with 5 different magnetic field intensities (0.1, 1, 3, 5 and 7mT) at 2 different exposure times including 30 and 60 minutes. Fish in the experimental group were exposed only once. Two weeks after exposure, dorsal muscles sectioned transversely, stained and were examined using a light microscope. Histopathologic assessments showed significant difference between control and EMF exposed groups at both 30 min. (p<0.01) and 60 min. (p<0.001) exposure times. We report for the first time that electromagnetic field in interaction with muscular tissue of Cyprinus carpio exhibits a dual effect which depends on the field intensity, and exposure time. At short exposure time (30 min.), EMF stimulates muscle growth process. At longer exposure time (60 min.), EMF can damage muscle tissue and result in muscle necrosis. More research is required to elucidate precise mechanisms involved in muscle hypertrophy and pathologic changes.