• Bulletin of the Korean Chemical Society
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• 제5권5호
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• pp.207-208
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• 1984

The tris(hydroxymethyl)aminomethane (Tris)-catalyzed hydrolysis of p-nitrotrifluoroacetanilide was kinetically studied. On the contrary to the previously reported results (R. M. Pollack and T. C.Dumsha, J. Am. Chem. Soc., 1973, 95, 4463), the dependence of the rate on [Tris] consists of an initial curve portion and a subsequent linear increase. This indicates that erroneous conclusions were made in the reported work due to the insufficient amount of data. The initial portions of the rate[Tris] profiles are attributed to the catalyzed breakdown of the tetrahedral intermediate, and the linear portions to the general base-catalyzed water attack at the substrate.

• 대한기계학회논문집A
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• 제27권5호
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• pp.750-757
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• 2003

In order to determine creep stress intensity limit of high-temperature components, the usefulness of the creep work and time equation, defined as W$\_$c/t$\^$p/ = B(where W$\_$c/ = $\sigma$$\varepsilon$ is the total creep work done during creep, and p and B are constants), was investigated using the experimental data. For this Purpose, the creep tests for generating 1.0% strain for commercial type i16 stainless steel were conducted with different stresses; 160 MPa, 150 MPa, 145 MPa, 140 MPa and 135 MPa at 593$^{\circ}C$. The plots of log W$\_$c/ - log t showed a good linear relation up to 10$\^$5/ hr, and the results of the creep work-time relation for p, B and stress intensity values showed good agreement to those of isochronous stress-strain curves (ISSC) presented in ASME BPV NH. The relation can be simply obtained with only several short-term 1% strain data without ISSC which can be obtained by long-term creep data. Particularly, this relation is useful in estimating stress intensity limit for new and emerging class of high-temperature creeping materials.

• Journal of Korean Neurosurgical Society
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• 제60권5호
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• pp.577-583
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• 2017

Objective : Laminoplasty is an effective surgical method for treating cervical degenerative disease. However, postoperative complications such as kyphosis, restriction of neck motion, and instability are often reported. Despite sufficient preoperative lordosis, this procedure often aggravates the lordotic curve of the cervical spine and straightens cervical alignment. Hence, it is important to examine preoperative risk factors associated with postoperative kyphotic alignment changes. Our study aimed to investigate preoperative radiologic parameters associated with kyphotic deformity post laminoplasty. Methods : We retrospectively reviewed the medical records of 49 patients who underwent open door laminoplasty for cervical spondylotic myelopathy (CSM) or ossification of the posterior longitudinal ligament (OPLL) at Pusan National University Yangsan Hospital between January 2011 and December 2015. Inclusion criteria were as follows : 1) preoperative diagnosis of OPLL or CSM, 2) no previous history of cervical spinal surgery, cervical trauma, tumor, or infection, 3) minimum of one-year follow-up post laminoplasty with proper radiologic examinations performed in outpatient clinics, and 4) cases showing C7 and T1 vertebral body in the preoperative cervical sagittal plane. The radiologic parameters examined included C2-C7 Cobb angles, T1 slope, C2-C7 sagittal vertical axis (SVA), range of motion (ROM) from C2-C7, segmental instability, and T2 signal change observed on magnetic resonance imaging (MRI). Clinical factors examined included preoperative modified Japanese Orthopedic Association scores, disease classification, duration of symptoms, and the range of operation levels. Results : Mean preoperative sagittal alignment was $13.01^{\circ}$ lordotic; $6.94^{\circ}$ lordotic postoperatively. Percentage of postoperative kyphosis was 80%. Patients were subdivided into two groups according to postoperative Cobb angle change; a control group (n=22) and kyphotic group (n=27). The kyphotic group consisted of patients with more than $5^{\circ}$ kyphotic angle change postoperatively. There were no differences in age, sex, C2-C7 Cobb angle, T1 slope, C2-C7 SVA, ROM from C2-C7, segmental instability, or T2 signal change. Multiple regression analysis revealed T1 slope had a strong relationship with postoperative cervical kyphosis. Likewise, correlation analysis revealed there was a statistical significance between T1 slope and postoperative Cobb angle change (p=0.035), and that there was a statistically significant relationship between T1 slope and C2-C7 SVA (p=0.001). Patients with higher preoperative T1 slope demonstrated loss of lordotic curvature postoperatively. Conclusion : Laminoplasty has a high probability of aggravating sagittal balance of the cervical spine. T1 slope is a good predictor of postoperative kyphotic changes of the cervical spine. Similarly, T1 slope is strongly correlated with C2-C7 SVA.

• 설비공학논문집
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• 제5권1호
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• pp.10-17
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• 1993

This paper describes the boiling heat transfer phenomena to be divided into three regions, nonboiling, nucleate boiling and burn-out in the impinging subcooled water jet system. In the nonboiling region, Nusselt number is a function of Prandtl number, Reynolds number and ${\Delta}T_{sub}/T_{ast}$ In the nucleate boiling region, the heat flux increases with increment of the nozzle exit velocity. But the degree of liquid subcooling does not affect the shape of the nucleate boilng curve. The dimensionless correlations can be expressed in the form of $q{\ell}/K_f{\Delta}T_{ast}=C(Bo{\cdot}C_p{\cdot}{\Delta}T_{sat}/Vo^2)^m{\cdot}(Re/We)^n$. The burn-out heat flux increases linearly with increment of the nozzle exit velocity, but independs of degree of subcooling and the supplementary water height.

• 약학회지
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• 제27권2호
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• pp.117-124
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• 1983

For development of $EMIT-T_{3}$ assay, the conjugation of 3, 5, 3'-triiodothyroformic acid NHS ester to G6PDH was attempted in various reaction conditions. Up to now, the best conjugation condition was the ratio of $T_{3}$-NHS:G6PDH=100 in 25% carbitol-Tris buffer at pH 9, $0^{\circ}C$ during overnight. The obtained $T_{3}$-G6PDH conjugates usually had 20% residual enzyme activity which was inhibited by 40-70% with various $anti-T_{3}$ antibodies. Utilizing the conjugate I and an antibody (S2633G), a useful standard curve for $T_{3}$ assay was obtained in the range of 0 to 5ng/ml with 499 EMIT units of separation.

• 한국조경학회지
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• 제22권1호
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• pp.85-100
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• 1994

This study was to analyze the relationship between the community or species and environmental variables of the vegetation landscape in Naejangsan National Park. The analysis was performed by the ordination of DCA and CCA. The study was to compare and analyze the species composition status by the layer and the growth characterisics of the following vegetations ; Torreya nucifera community, Quercus variabilis - Acer palmatum community, Q. variabilis community, Q. variabilis - Sasa purpurascens community and Daphniphyllam macropodum community. The results are as follows; 1. The result of the study on the relationshkp between the stand scores of DCA ordination and environmental variables showed that the soil pH, the ammount of AV-P2O5 and the ammount of C.E.C. tend to increase while Pinus densiflora community changes to Q. variabilis - Q. serrata community and finally Carpinus laxiflora species community siginigicantly. The relation between the stand scores of CCA ordination and several enviromental variables suggested that the species of C. laxiflora and C. tschonoskii the species of Q. cariabilis and Q. serrata the species of C. pisifera, P. densiflora and Q. aliana in sequence grows in more fertile soil. 2. As the result of the analysis of the T. nucifera community showed, reproduction did not increase, and the characteristic of growth was not affected. The result is shown in the growth curve that was damaged by the climate and the human interference. 3. The A. palmatum was found to be as minor species in the middle layer and the crown areas did not have sufficient crown. 4. The result of the analysis of the relationship between Q. variabilis community and Q. variabilis - S. purpurascens community showed a decreasing tendency in the growth and number of species. 5. D. macropodum which constituted the dominance species in the middle layer had a nomal growth curve, and then the successional trend of D. macropodum species seems to be located in the climax species.

• 한국초전도저온공학회:학술대회논문집
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• 한국초전도저온공학회 2002년도 학술대회 논문집
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• pp.10-12
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• 2002

Single Josephson junctions of 50 $\mu$m $\times$ 50 $\mu$m were fabricated for several oxidation conditions to investigate controllabilities of critical current density ($J_{c}$) with the standard KRISS processes. Considering the self-field effect suppressing the observed critical current ($I_{c}$) at high $J_{c}$ region, we could reasonably estimate $J_{c}$ values from I-V observations. The dependence of the estimated $J_{c}$ as a function of exposure, which is equal to pressure(P) times time(t), was well fitted to a curve of $J_{c}$ ~ $(Pt)^{-0.36}$. The maximum $J_{c}$ value at the controllability margin was found to be 4 kA/$cm^{2}$ with the current equipment set up.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2013년도 춘계학술대회 논문집
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• pp.339-340
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• 2013

• Journal of Pharmaceutical Investigation
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• 제33권3호
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• pp.223-227
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• 2003

The purpose of this study was to investigate the effect of ketoconazole (20 mg/kg) on the pharmacokinetic parameters and the bioavailability of paclitaxel (40 mg/kg) orally coadministered in rats. The plasma concentration of paclitaxel in combination with ketoconazole was significantly (p<0.05) increased from 8 hr to 24 hr compared to that of control. Area under the plasma concentration-time curve (AUC) of paclitaxel with ketoconazole was significantly (coadministration p<0.05, pretreatment p<0.0l) higher than that of control. Peak concentration $(C_{max})$ of paclitaxel pretreated with ketoconazole were significantly (p<0.05) increased compared to that of control. Time to peak concentation $(T_{max})$ of paclitaxel pretreated with ketoconazole were significantly (p<0.05) shorter than that of control. Half-life at elimination phase $(t_{1/2{\beta}})$ of paclitaxel pretreated with ketoconazole was significantly (p<0.05) prolonged compared to that of control. Based on these results, it might be due to both inhibition of the enzyme cytochrome P450 and p-glycoprotein, which engaged in paclitaxel absorption and metabolism in liver and gastrointestinal mucosa.

• 약학회지
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• 제49권5호
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• pp.380-385
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• 2005

The aim of this study is to investigate the effects of verapamil on the pharmacokinetics of tamoxifen following oral administration of tamoxifen with verapamil to rats. Tamoxifen (10 mg/kg) was administered orally in the presence or absence of verapamil (1, 3 or 6 mg/kg). Compared to the control group (given tamoxifen alone), the presence of verapamil significantly (p<0.05 by 1 mg/kg, p<0.01 by 3 and 6 mg/kg) increased the areas under the plasma concentration-time curve (AUC) and the peak concentrations ($C_{max}$) of tamoxifen. Consequently, the relative bioavailability ($RB\%$) of tamoxifen with verapamil was 1.6-2.1 fold higher than that of the control. But the time to reach peak concentration ($T_{max}$) and the terminal half-life ($t_{1/2}$) of tamoxifen were not altered significantly in the presence of verapamil. The increased AUC and $C_{max}$ of tamox­ifen in the presence of verapamil might be associated with the inhibition by verapamil of the P-glycoprotein and the first­pass metabolizing enzyme CYP3A4 in small intestinal mucosa. The drug interaction should be taken into consideration when tamoxifen is used to the patient with verapamil in the clinical setting.