• The Korean journal of internal medicine
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• 제33권6호
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• pp.1169-1181
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• 2018

Background/Aims: Data on dexamethasone, cytarabine, and cisplatin (DHAP) as a mobilization regimen, compared to high-dose cyclophosphamide (HDC), for up-front autologous stem cell transplantation (ASCT) in non-Hodgkin's lymphoma (NHL) is limited. Methods: Consecutive patients with aggressive NHL treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or rituximab-CHOP who underwent chemomobilization using HDC or DHAP plus granulocyte-colony stimulating factor (G-CSF) for up-front ASCT were enrolled from three institutions between 2004 and 2014. Results: Ninety-six patients (57 men) were included. Sixty-five patients (67.7%) received HDC; and 31 (32.3%), DHAP. The total CD34+ cells mobilized were significantly higher in patients receiving DHAP (16.1 vs. $6.1{\times}10^6/kg$, p = 0.001). More patients achieved successful mobilization with DHAP (CD34+ cells ${\geq}5.0{\times}10^6/kg$) compared to HDC (87.1% vs. 61.5%, respectively; p = 0.011), particularly within the first two sessions of apheresis (64.5% vs. 32.3%, respectively; p = 0.003). Mobilization failure rate (CD34+ cells < $2.0{\times}10^6/kg$) was significantly higher in patients receiving HDC (20.0% vs. 3.2%, p = 0.032). On multivariate analysis, the DHAP regimen (odds ratio, 4.12; 95% confidence interval, 1.12 to 15.17) was an independent predictor of successful mobilization. During chemomobilization, patients receiving HDC experienced more episodes of febrile neutropenia compared to patients receiving DHAP (32.3% vs. 12.9%, p = 0.043). Conclusions: The DHAP regimen was associated with a significantly higher efficacy for stem cell mobilization and lower frequency of febrile neutropenia. Therefore, DHAP plus G-CSF is an effective for mobilization in patients with aggressive NHL who were candidates for up-front ASCT.

• 대한정형도수물리치료학회지
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• 제16권2호
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• pp.53-60
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• 2010

Purpose : Neck pain is commonly experienced by both adolescents and adults. The purpose of this study was to measure neck disability index(NDI) and the cervical range of motion(CROM) following spinal manipulation and mobilization techniques. Methods : Thirty participants(manipulation=15, mobilization=15) with mild neck disability volunteered for this study. It was used to measure NDI with NDI questionnaire and six motions(neck flexion and extension, left and right lateral flexion, left and right rotation) with the CROM instrument. Independent t-test and paired t-test were used to estimate NDI and CROM, and compared left with right motions. Results : A significant decrease in NDI were found after spinal manipulation and mobilization treatment(p<.05). A trend toward increase in all cervical motions(flexion, extension, left and right lateral flexion, left and right rotation), after interventions, were revealed(p<.05). The significant differences were not found on NDI and CROM between the group(p<.05). It was presented asymmetric motions in cervical lateral flexion(p<.05) before and after treatment. Conclusions : Our results suggest that manipulation and mobilization probably provide at least short-term benefits for patients with mild neck pain. It is needed to be studied the factors and preventive methods influencing the asymmetric cervical motion.

• 대한정형도수물리치료학회지
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• 제15권2호
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• pp.69-79
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• 2009

Purpose : to investigate the effectiveness of joint mobilization and myofascial release on the neck pain and to provide the effective treatment. Methods : Twenty-two subjects with neck pain participated in the experiment. All subjects were randomly assigned to a joint mobilization group(n=11) or a myofascial release group(n=11). Both groups received treatment for 15 minutes four times during 2 weeks. Cervical range of motion(CROM) instrument was used to measure range of neck motion, and Algometer was used to measure tenderness. All measurements of the subjects were measured at pre-treatment and post-treatment. Results : 1. The range of neck right side-bending motion of the myofascial release group was significantly increased(P<0.05), and the range of neck extension, right side-bending, left side-bending, right rotation motion of the joint mobilization group was significantly increased(P<0.05). 2. There was no significant improvement of tenderness in both groups(p>0.05). Conclusion : These data suggest that joint mobilization is more effective against increasing the range of motion than myofascial release, but myofascial release is more beneficial to tenderness than joint mobilization although it does not have a significant difference in the tenderness because there was a little improvement.

• 대한정형도수물리치료학회지
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• 제25권2호
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• pp.11-20
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• 2019

Background: The purpose of this study was to investigate the immediate effect of thoracic self mobilization on balance and gait of acute stroke patients. Methods: Patients (n=10) with acute stroke applied to thoracic self mobilization. There are two thoracic self mobilization of both extension and rotation. Each thoracic self mobilization was performed ten times per direction in a total of three sets and the total time required for two thoracic self mobilization was twenty minutes. The break time between sets was one minute. Balance ability was measured using the timed up and go test and the five times sit to stand test for patients. The 10 meter walk test and the functional gait assessment were used for measurement of gait ability for patients. Results: Significant improvements were observed on balance ability (p<.05) and gait ability (p<.05). Conclusion: These results show that thoracic self mobilization is immediate effective on balance and gait ability. Thus, thoracic self mobilization will help recovery of balance and gait ability in acute stroke patients.

• 한국엔터테인먼트산업학회논문지
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• 제14권3호
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• pp.383-392
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• 2020

이 연구는 엉치엉덩관절 통증환자에게 관절가동술, 깔창착용 보행훈련, 그리고 관절가동술과 깔창착용 보행훈련 중재를 실시하고 환자의 통증, 골반 각 및 족저압에 대한 효과를 비교하였다. 무작위로 24명의 대상자를 관절가동술군(n=8), 깔창착용보행훈련군(n=8) 또는 관절가동술과 깔창착용보행훈련군(n=8)으로 배정하여, 하루에 30분씩, 일주일에 2번씩 4주 동안 중재하였다. VAS를 사용하여 통증을 평가하고 골반 각도를 Palpation Meter 사용하여 측정하였고, 족저압 (전 / 후비)을 Gateview AFA-50을 사용하여 측정하였다. 모든 측정은 중전·중재 4주 후에 실시하였다. 모든 그룹은 그룹 내 전·후 비교에서 유의한 통증 감소를 보였다(p<.01). 골반 각도에서 관절가동술군은 전방 기울기에서만 통계적으로 개선되었고, 관절가동술과 깔창착용 보해훈련군은 앞쪽 및 뒷쪽기울임 모두에서 통계적으로 유의미한 개선을 보였으며(p<.01), 깔창착용 보행훈련군은 통계적으로 유의한 변화가 없었다(p>.05). 또한 관절가동술과 깔창착용 보행훈련군은 족저압에서 유의한 차이를 나타냈다(p<.01). 모든 중재는 엉치엉덩관절 통증환자의 통증개선에 효과가 있었으며, 관절가동술과함께 깔창착용 보행훈련을 한 군이 골반각도와 족저압에 가장 효과적이었다. 이 연구는 엉치엉덩관절통증이 있는 환자뿐만 아니라 만성 허리통증 및 족저압 입력 문제가 있는 환자의 부상 예방, 자세교정, 그리고 보행훈련을 위한 기초자료가 될 것으로 사료된다.

• 산업융합연구
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• 제18권2호
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• pp.27-35
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• 2020

본 연구는 목뼈와 등뼈에 적용한 관절가동술이 전방머리자세를 가진 성인의 목통증, 목관절가동범위 및 균형에 미치는 영향을 알아보고자 실시되었다. 전방머리자세로 판명된 대학생 26명을 목뼈 관절가동술 그룹과 등뼈 관절가동술 그룹으로 13명 씩 무작위 배정하여 모든 대상자에게 각각 하루 10회, 1회당 30초 적용, 30초 휴식으로, 주 3회, 4주간 관절가동술을 적용한 후 변화를 비교하였다. 연구 결과, 통증과 관절가동범위에서 두 그룹 모두 유의한 효과가 있었고(p<.01), 그룹 간 비교에서는 유의한 차이가 없었다. 정적 균형의 그룹 내 변화에서 목뼈 관절가동술 그룹이 오른발 및 눈을 감았을 때 유의한 개선을 보였고(p<.05), 등뼈 관절가동술 그룹에서는 유의한 변화가 없었다(p<.05). 왼발 정적 균형은 두 그룹 모두 유의한 개선이 없었고(p<.05). 그룹 간 정적 균형의 비교에서도 유의한 차이가 없었다(p<.05). 동적 균형의 그룹 내 변화에서 목뼈 관절가동술 그룹이 앞쪽, 왼쪽, 오른쪽에서 유의한 개선을 보였고(p<.05), 등뼈 관절가동술 그룹이 앞쪽과 오른쪽에서 유의한 개선을 보였다(p<.05). 그룹 간 동적 균형에서는 왼쪽에서 유의한 차이가 나타났다(p<.05). 본 연구를 통하여 목뼈 및 등뼈 관절가동술은 전방머리자세 성인의 통증, 관절가동범위, 균형 능력에 대하여 유의한 효과가 있었다.

• Physical Therapy Rehabilitation Science
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• 제12권3호
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• pp.240-250
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• 2023

Objective: The purpose of this study was to characterize the movement of adjacent segments that occurred when posteroanterior joint mobilization was applied to the 3rd lumbar and thereby to provide basic clinical data. Design: Randomized controlled trial design. Methods: While the subjects were receiving posteroanterior joint mobilization of the 3rd lumbar vertebra, LD (lumbar displacement), LID (lumbar intervertebral distance), LIA (lumbar intervertebral angle), and LLA (lumbar lordosis angle) were measured using X-ray, and the data were then analyzed. Changes before and after posteroanterior joint mobilization were analyzed using a paired-sample t-test, and a one-way ANOVA of variance was performed to determine the difference between segmental movements. In addition, Pearson's correlation analysis was performed to determine the correlation between segmental movements. Results: The results revealed that there was a significant change in LD before and after the application of joint mobilization of the 3rd lumbar in all lumbar vertebrae (p<0.000), among which the 2nd lumbar vertebra, an adjacent segment, showed the most significant change. A significant change in LIA angle was observed in all segments (p<0.000), with the most significant change observed between the 2nd and 3rd lumbar vertebrae. There was a significant change in LLA before and after the application of posteroanterior joint mobilization (p<0.000). The correlation analysis showed a high correlation between displacement of the 3rd lumbar vertebra and displacement of all the other lumbar vertebrae. Conclusions: The presence of kinematic movements of the lumbar vertebrae when segmental movements were generated through the application of posteroanterior joint mobilization of the 3rd lumbar vertebra.

• 국제물리치료학회지
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• 제9권4호
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• pp.1614-1618
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• 2018

The purpose of this study was to evaluate the effect of joint mobilization and manual stretching exercises in patients with hallux valgus. Twenty-three participants were divided into two groups; joint mobilization (n=11) and manual stretching exercises (n=12). The subjects participated in the experiment for 15minutes, three times a week, four weeks. The joint mobilization (Grade III, Maitland) was performed to experimental group for a minute and then rested for 10 seconds for each set. The manual stretching was performed to control group with three exercise session (preparatory and finishing exercises, agonist contraction exercises, agonist contraction and hold-relax exercises). In the results of the study, intragroup comparison of the deformity angles (DA) was shown to decrease from $15.18^{\circ}$ to $13.09^{\circ}$ in the joint mobilization group (p<.05) and from $19.00^{\circ}$ to $16.83^{\circ}$ in the stretching exercises group (p<.05). However, left static foot pressure (LSFP), right static foot pressure (RSFP), left dynamic foot pressure (LDFP) and right dynamic foot pressure (RDFP) did not significantly increase or decrease after the experiment. Intergroup differences also were not statistically significant in all variables (p>.05). The current study suggests that JM and MSE are effective in decreasing the DA in patients with hallux valgus.

• 대한물리의학회지
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• 제10권4호
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• pp.69-80
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• 2015

PURPOSE: The purpose of the present study was to apply joint mobilization in a sitting position and in a prone position to patients with acute mechanical neck pain and compare the immediate treatment effects in these two positions. METHODS: After the baseline was assessed, 46 patients were randomly assigned to two groups: experimental group I ($n_1=23$) for joint mobilization in the sitting position and experimental group II ($n_2=23$) for joint mobilization in the prone position at the symptomatic cervical level. The patients in both groups received treatment by unilateral posterior-anterior gliding for 30 seconds per trial, 10 trials per session, for a total of 5 minutes, and two trials of 10 active extending motions with distraction per trial. RESULTS: In the Wilcoxon signed-rank test, all the pain and physical function variables were significantly improved after intervention in both groups (p<.05). In the Mann-Whitney U test, which compared the differences before and after the intervention between the two groups, experimental group I showed significant improvement over experimental group II in resting pain (p<.01), satisfaction with the treatment (p=.01), left rotation (p<.01) and CCFE (p<.01). In the analysis of covariance results, experimental group I showed significant improvement over experimental group II in the most painful motion pain (p<.01) and the most painful quadrant motion pain (p<.01). CONCLUSION: These outcomes suggest that joint mobilization should be applied in sitting positions for patients with acute mechanical neck pain that feel pain during sustained positions, extension or rotation.

• 대한정형도수물리치료학회지
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• 제24권1호
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• pp.23-29
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• 2018

Background: This study aimed to the effects of hip mobilization on pain, trunk flexibility, function for chronic low back pain patients. Methods: Patients were randomly assigned to control group (n=15) and experimental group (n=15). Both groups received conventional physical therapy, three times a week for four weeks. Experimental group was performed additional hip mobilization, three times a week for four weeks. All measurement of each subject were measured at pre-intervention and post-intervention (after 4 weeks). Results: Assessed items included the visual analog scale score (VAS), Korean version of the Oswestry disability Index (KODI) a significant reduction was observed post intervention compared to pre-intervention values in both group (p<.01). Trunk flexibility was significant increased post intervention compared to pre-intervention values in both group (p<.01). There were significant difference between two groups in VAS (p<.01), trunk flexibility (p<.05) and except KODI. Conclusions: Our results indicate that conventional physical therapy with the hip mobilization may be useful for improving chronic low back pain patient.