• Journal of Microbiology and Biotechnology
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• v.30 no.1
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• pp.21-30
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• 2020

Natural products are widely used due to their various biological activities which include anti-inflammatory, antioxidant, and anti-obesity effects. In this study, we determined the antioxidative and anti-obesity effects of Polygonum cuspidatum 50% ethanol extract (PEE). The antioxidative effect of PEE was evaluated using its radical scavenging activity, total phenolic content, and reducing power. The anti-obesity effect of PEE was investigated using 3T3-L1 adipocytes. The antioxidative activity of PEE was progressively increased in various concentrations, mainly due to the presence of phenolic compounds. PEE also alleviated lipid accumulation on 3T3-L1 adipocytes and downregulated the mRNA and protein production of adipogenesis-related (SREBP-1c, PPARγ, C/EBPα) and lipogenesis-related (aP2, FAS, ACC) markers. Furthermore, we found that the inhibitory effect on lipid accumulation via PEE was caused by the alleviation of NF-κB, p38 MAPK, ERK1/2, and JNK at the protein level. Taken together, our results imply that PEE is a potential antioxidant that can prevent obesity-associated disorders.

• Journal of Pharmaceutical Investigation
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• v.15 no.2
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• pp.53-62
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• 1985

Pivampicillin hydrochloride is a kind of broad spectrum antibiotics with bactericidal action, and is used in many countries, although it has bitter taste, unpleasant odour and side effects of irritating gastric mucosa, nausea, penicillin allergy, etc. For the improvement of such side effects of pivampicillin hydrochloride, microcapsules, with wall of ethylcellulose, have been prepared by coacervation method. The shape was observed through the scanning electron microscope, the release of the drug into an aqueous medium was studied and the effects of core: ethylcellulose ratio were interpreted as well as making sensory evaluation of taste and odour. There was decreasing trend in dissolution rate of the drug with the increase of core: ethylcellulose ratios, and the smaller microcapsules released their contents more rapidly. A linear relationship was established between the amount of ethylcellulose and the time for 60% release of the drug, and the release pattern was found to have similar characteristics to the release of the drug from an insoluble porous matrix. The release of the drug in the artificial intestinal fluids (pH 6.8) was found to be similar to that in water, while the release in the artificial gastric juice (pH 1.2) was slightly slower. Bioavailability of microcapsule was compared with that of pivampicillin hydrochloride in rabbits using serum concentration and urinary excretion measurements. Microcapsule gave showed slightly higher serum level than pivampicillin hydrochloride from 2 hours after administration, while no significant difference was observed in the accumulated urinary excretion rate between pivampicillin hydrochloride and microcapsule. The ulcer index of pivampicillin hydrochloride administered group was 2.6, and microcapsule administered group was 1.5, while control group was 0.8. Therefore it may be concluded that microencapsulation of pivampicillin hydrochloride is a useful pharmaceutical approach to protect the gastrointestinal tract from being injured by direct contact of pivampicillin hydrochloride without any significant difference of bioavailability.

• 월간 기계설비
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• no.11 s.184
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• pp.57-71
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• 2005

SHOP DWG의 현주소 어디까지 왔는가? 설계에서 제조에 이르는 전 과정을 컴퓨터로 제어하고 관리하는 기술. 캐드(CAD)와 캠(CAM)은 각각 computer-aided design,computer-aided manufacturing의 약칭으로 컴퓨터보조설계와 컴퓨터보조생산을 뜻한다. CAD는 설계도면을 한 장씩 수작업으로 제도하지 않고 설계 데이터베이스의 정보를 CRT(cathode ray tube)에서 화상을 보고 합성하면서 설계하므로 작업을 최적화 할 수 있다. CAD로 설계된 설계도의 내용은 CAM을 통해 NC(수치제어)공작기계에 정확한 작업동작을 지시하게 되며, 작업관리∙가공∙조립∙검사 등의 제조과정을 컴퓨터로 관리하여 작업속도와 제품의 정밀성을 높이게 된다. 최근에는 건축현장의 2D system이 보편화되어 있지만 건축현장의 핵심이라고 할 수 있는 기계설비의 기계실, 또는 조립화 공법 등에는 3차원 CAD∙CAM시스템이 개발되어 입체형상을 화면에 3차원으로 재현할 수 있고, 대상물의 표면적∙부피∙무게∙강도 등의 물리적 성질도 자동 계산하여 최적상태에서 현장의 시공에 적용할 수 있게 되었다. 1960년대 초 미국에서 자동차 모델∙엔진, 항공기 부품 등 의 설계에 수작업의 한계를 느껴 개발되었으며, 한국에서는 70년대 중반에 도입되어 운용되고 있다. 이에 따라 프로그램 회사들은 다양한 방법 등을 SHOP DWG에 적용하여 판매경쟁이 치열하다. (주)우진아이엔에스는 급속한 산업경제의 변화와 무한경쟁시대에 보다 나은 기술개발 투자에도 노력을 기울여, 2000년 11월 용인공장, 생산라인을 천안으로 이전, 확장 하여 배관 및 닥트의 CAD-CAM SYSTEM, P.F.P공법, 기계실3D, 블럭화배관, 닥트자동화 시스템, 설계, 용접공정을 공장화시켰으며, 신 개발품인 S.C.D(SEMI-CON DUCT)를 신설하여 모든 건축물에 맞는 필수적인 제품을 생산함으로써 선택의 폭을 넓히고, 현장 시공능력 효율을 높이고 있다. 이번 호에서는 (주)우진아이엔에스가 95년 설계팀을 발족하여 제로시스템의 3D공법을 공장 및 현장의 SHOP DWG에 적용해왔고 최근에는“서초 프로젝트A”현장에 SHOP DWG의 최대 결집체인 3D활용의 조립화 공법을 적용하여 초고층 오피스텔현장을 시공한 사례를 게재한다. 우진아이엔에스는 30여년의 기술 축척을 바탕으로 최고의 기술력과 풍부한 경험을 통해 아셈무역센타, 타워팰리스1차, 3차 및 목동트라팰리스, 분당트리폴리스, 수원삼성전자 R4, 등 국내굴지의 초고층빌딩 시공을 근거로 초고층의 기본설계를 이해하고 SHOP DWG을 통해서 기계설비공사의 향후 나아갈 지표를 제시하고 있다.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.21 no.12
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• pp.2241-2248
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• 2017

The coaxial line impedance transformer that performs impedance conversion using the coupling of two or more coaxial lines of the same length is often used for impedance matching in the low frequency region due to many advantages. This paper measures the phase and magnitude characteristics of each coaxial line in a 4:1 coaxial line impedance transformer using two 100mm coaxial lines. This experiment shows that it is more effective to make the length of the auxiliary coaxial line shorter than the main coaxial line by about 5 mm in order to realize a low loss impedance transformer. In addition, it measures the transmission characteristics by directly connecting a 4:1 impedance transformer and a 1:4 impedance transformer. This experiment shows that it is effective to connect a 1pF capacitor between the ground and the outer conductor input point of the main coaxial line in order to increase the operating frequency range.

• Korean Journal of Weed Science
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• v.17 no.1
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• pp.80-93
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• 1997

Allelopathic compounds as naturally occurring herbicide have originally reported from local vegetation since B.C. 300. These compounds are known as secondary plant metabolites which released from plants into the environment often attract or repel, nourish or poison other organisms. In recent, many natural plant allelochemicals be used to attempt to biologically or ecologically control weed among worldwide weed scientists. Some allelochemicals have also used as fungicides, insecticides, and nematodicides, and were less than man-made agrochemicals to damage the global ecosystem. It makes efficient use of resources internal to the farm, relies on a minimum of purchased inputs. Some scientists selected for allelopathic activity when breeding weed-controlling cultivars of rice, sorghum, cucumber, surflower etc. Thus, this paper is focused on allelopathic compounds isolated from cultivated crop with the high potential of prospective herbicides. The most environmentally acceptable and sustainable approach to utilization of allelopathy for weed control is to develop plant cultivars with proven allelopathic characteristics. In rice accessions, there are 60 cultivars/lines which have known as allelopathic activity and some of these cultivars control weed more less 90% within certain radius of activity. These accessions are originated from 15 countries including Korea, Japan, USA, India, Philippines, Indonesia, Laos, Taiwan, Afghanistan, Mali, Pakistan, Colombia, Egypt, China, and Dom. Rep. From these cultivars, the most common allelopathic compounds identified in rice are p-Hydroxybenzoic, Vanillic, p-Coumaric, and Ferulic acids. In addition, allelopathic lines of the following crop have shown inhibition of weed growth : beet (Beta vulgaris), lupin(Lupinus spp.), com(Zea mays), Wheat(Triticum aestivum), oats(Avena spp.) peas(Pisum sativum), barley(Hordeum vulgare), rye(Secale cereale), and cucumber(Cucumis sativus). Thus, future allelopathy research must be designed its potentially phytotoxic propertices and the ecotoxic features of the allelochemicals from release to degradation ; its ecological sustainability, its allelopathic effect in early growth. stages, and selectivity properties in combination with chemical stages, and selectivity properties in combination with chemical concentrations. Also, research approach in allelopathy might be screened for highly allelopathic germplasm collection of crops, the idea being to ultimately transfer this agronomic character into improved cultivars by either conventional breeding or other genetic transfer techniques.

• Korean Journal of Agricultural Science
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• v.3 no.2
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• pp.244-250
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• 1976

Candida brumptii was one of the best isolates which could grow on alcohol distillation slops (reported in the previous paper). Attempts were made to investigate the cultural conditions for cell mass production by this strain, and the results obtained were as follow. The supernatant of the alcohol distillation slops without dilution support ed better growth of the strain than diluted ones. The addition of ammonium sulfate (0.2%), ammonium phosphate (0.1-0.2%), potassium phosphate (0.2%) to the supernatant resulted in positive effects for the growth, among the various inorganic nitrogen and other salts supplements. BOD and COD of the supernatant were reduced approximately 30% and 20%, respectively in 3 days culture. Cell production was maximized when grown at $35^{\circ}C$ and pH 5.0. The yield of cell mass was 1.03% by dry weight and its crude protein content was about 52.65%

• Journal of The Korean Astronomical Society
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• v.41 no.6
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• pp.157-161
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• 2008

We have estimated the fractal dimension of the molecular clouds associated with the Hii region Sh 156 in the Outer Galaxy. We selected the $^{12}CO$ cube data from the FCRAO CO Survey of the Outer Galaxy. Using a developed code within IRAF, we identified slice-clouds (2-dimensional clouds in velocity-channel maps) with two threshold temperatures to estimate the fractal dimension. With the threshold temperatures of 1.8 K, and 3 K, we identified 317 slice-clouds and 217 slice-clouds, respectively. There seems to be a turn-over location in fractional dimension slope around NP (area; number of pixel) = 40. The fractal dimensions was estimated to be D = $1.5\;{\sim}\;1.53$ for $NP\;{\geq}\;40$, where $P\;{\propto}\;A^{D/2}$ (P is perimeter and A is area), which is slightly larger than other results. The sampling rate (spatial resolution) of observed data must be an important parameter when estimating fractal dimension. Fractal dimension is apparently invariant when varying the threshold temperatures applied to slice-clouds identification.

• Journal of the Korean Ceramic Society
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• v.48 no.1
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• pp.34-39
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• 2011

Systematic study on relationship between celadon coloring and glaze component was conducted by chromaticity analysis and M$\ddot{o}$ssbauer spectroscopic analysis. The chromaticity ($L^*$, $a^*$, $b^*$ values) and M$\ddot{o}$ssbauer analysis results were correlated to the amount of $Fe_2O_3$, $TiO_2$, MnO, and $P_2O_5$, which are the essential factors influencing celadon coloring. According to chromaticity analysis, celadon glaze color belongs to GY group when the addition of $TiO_2$ was 1.4%, whereas the color belongs to BG group when the addition of $TiO_2$ was 0.1%. For the GY group, the colors change from GY to YR with the decrease of brightness as the addition of $TiO_2$, MnO, and $P_2O_5$ increases. According to M$\ddot{o}$ssbauer analysis results, as the amount of divalent iron ion increases, the $a^*$ and $b^*$ values decrease, on the other hand, $L^*$ value increases. The ratio of divalent iron ion produced in reductive sintering process is found to be 80~95% in this study, which induces the increase of $L^*$ values in celadon glaze.

• The Korean Journal of Ecology
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• v.17 no.4
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• pp.523-531
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• 1994

Optimal conditions for the seed germination and growth of Hedyotis diffusa were studied. As photoperiod was increased from 12 hr to 24hr, the germination rate of Hedyotis diffusa was gradually increased. The photoperiod and temperature inflenced on the fermination synergistically. After the growth of 20 weeks under the natural condition (June~Oct.), the length of H. diffusa was $38.9{\pm}4.2cm$ (15.5~52.5cm), and total dry weight per $3.3m^2$ was $316.7{\pm}10.3g$. It is considered that H. diffusa could be cultivated in a part of inland. The anticancer effect of H. diffusa extract was examined. F-344 rats aged 6 weeks were divided into 3 groups and were given an I.P. of diethylnitrosamine at 200mg/kg body weight as a promoter, initially. And in two weeks after the beginnign of the experiment, group 1 was supplied iwth feed containing 0.02% 2-AAG as a promoter for 6 weeks. Group 2 was supplied with feed containing extracts of H.diffusa (0.02%) for two weeks. Group3 was supplied with only basal diet. All rats were sacrificed for partial hepatectomu, and the antipromoting effect was examined by the number 문 area per $cm^2$ of foci in river. In group 1, the number of hyperplastic nodule was $18.5{\pm}7.7$, but in group2, it was drastically reduced to $10.3{\pm}1.8$ rather thn those of group1. The total area of nodules $(mm^2)$ /whole liver $(cm^2)$ of group 1 and group2 were $19.2{\pm}7.7$ and $5.0{\pm}3.2$, respectively. These results indicate that extract of H.diffusa act as an anticancer agent at statistically significant level (p<0.001).

• Journal of Aquaculture
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• v.20 no.3
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• pp.178-183
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• 2007

We investigated the effect of salinity decrease, food supply and color of the rearing tank on the growth and survival of Amphiprion polymnus larvae. White tanks had the highest survival rate, followed by transparency, black and blue tanks(P<0.05). The transparency tank had the best growth, followed by black tank, white and blue tanks(P<0.05). Daily food intakes of larvae with $5.1{\sim}10.0mm$ in total length were $36.8{\sim}429.3$ Artemia nauplii. When salinity was lowered 5 psu per week from 32 psu, all the larvae died under salinity condition 17 psu. In lowered 2 psu per 3 days, its all died at 16 psu.