• Journal of the Korean Chemical Society
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• v.57 no.2
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• pp.295-299
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• 2013

• Bulletin of the Korean Chemical Society
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• v.13 no.2
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• pp.184-187
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• 1992

Regeneration methods of oximes, hydrazones, and N,N-dimethylhydrazones to the related carbonyl compounds were effected using various dicarbonyl compounds which are activated with electron withdrawing substituents such as trifluoromethylated $\beta-diketones$, $\beta-acylpyruvates$, and $\alpha-diketones$ via an equilibrium exchange reaction. The chemical transformations of the dicarbonyl compounds in the exchange reaction were investigated by various spectroscopic methods.

• Journal of the Korean Chemical Society
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• v.36 no.2
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• pp.305-310
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• 1992

(${\eta}^5$-Cyclopentadienyl)bis(ethylene)cobalt (Jonas reagent), (${\eta}^5$-cyclopentadienyl)di(carbonyl)cobalt, and bis(${\eta}^5$-cyclopentadienyl)cobalt (cobaltocene) were reacted with oximes, respectively, under various conditions for synthesizing cobalt oxime sandwich complex. Jonas reagent and a dienemonooxime, 2,4-hexadienealdoxime underwent the reaction. This produced unexpected compound, (${\eta}^5$-cyclopentadienyl)(2,4-hexadienenitrile)cobalt [VII]. The compound [VII] was identified by NMR, mass spectrometer, IR and elemental analyzer etc.

• Bulletin of the Korean Chemical Society
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• v.27 no.9
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• pp.1401-1404
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• 2006

Eight structurally different acetylcholinesterase reactivators derived from currently commercially available oximes were tested for their potency to reactivate acetylcholinesterase inhibited by pesticide paraoxon (P) and DFP (D). Housefly AChE (F) and bovine red blood cell AChE (B) were used as the source of the cholinesterases. Ellman's method was taken to examine cholinesterases activity. The results show that four AChE reactivators are potent AChE reactivators, able to reach reactivation potency of more than 30% in all cases - PF, PB, DF and DB. Their reactivation potency was comparable with that of pralidoxime and even higher compared with that of HI-6, standard AChE reactivators currently available on the market.

• Natural Product Sciences
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• v.21 no.1
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• pp.25-29
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• 2015

In a continuation of our studies to discover bioactive secondary metabolites from marine sources, we further investigated samples from a tryptamine and phenyl-alkane producing sponge, which resulted in the isolation of four uncommon small molecules and five nucleosides. Their structures were determined to be 7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one (1), 5-chlorocavernicolin (2), maleimide-5-oxime (3), 3-methylmaleimide-5-oxime (4), uridine (5), 2'-deoxyuridine (6), thymidine (7), adenine (8), and adenosine (9) by spectroscopic analyses. The isolated compounds were evaluated for inhibitory activity against soluble epoxide hydrolase (sEH) as well as the Wnt/${\beta}$-catenine signaling pathway.

• Bulletin of the Korean Chemical Society
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• v.32 no.9
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• pp.3323-3326
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• 2011

Various aldoximes and ketoximes were efficiently reduced to their corresponding amines with $NaBH_3CN$ in the presence of $MoCl_5/NaHSO_4{\cdot}H_2O$ system. Reduction reactions were carried out in refluxing EtOH or DMF within 0.3-3.8 h to afford the amines in high to excellent yields.

• Bulletin of the Korean Chemical Society
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• v.32 no.9
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• pp.3448-3452
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• 2011

Solvent-free reduction of various aldoximes and ketoximes to the corresponding amines was performed easily and efficiently with $NaBH_4$ in the presence of $ZrCl_4$ supported on $Al_2O_3$. The reactions were carried out rapidly (within 2 min) at room temperature to afford the amines in high to excellent yields.

• Journal of the Korean Chemical Society
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• v.19 no.1
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• pp.21-33
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• 1975

cis-and trans-2-butenedialdioximes are synthesized via 2-butenedials, very unstable precursors, and the conformation of the cis-isomer of those compounds is determined by the NMR spectra of 1,4-dideutero-and 1-deutero-cis-2-butenedialdioximes; it is certain that the conformation has an unsymmetrical structure as shown below.

• Journal of the Korean Chemical Society
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• v.20 no.6
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• pp.507-513
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• 1976

Conformation of cis-2-butenedialdioxime, a newly synthesized compound, was assigned by means of nuclearmagnetic resonance, extended Huckel molecular orbital method, and Pople's model of anisotropic effect. It was confirmed that two carbon-carbon single bonds are conrotatorily twisted from the molecular plane of six $sp^2$ orbitals of carbon-carbon double bond. The conformation of minimum energy is found to be twisted by$25^{\circ}C.$

• Journal of The Korean Society of Clinical Toxicology
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• v.11 no.1
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• pp.31-35
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• 2013

Acute organophosphate intoxication is important because of its high morbidity and mortality. The mortality is still high despite the use of atropine as specific antidotal therapy and oximes for reactivation of acetylcholinesterase. Inhibition of acetylcholinesterase by organophosphate can cause acute parasympathetic system dysfunction, muscle weakness, seizure, coma, and respiratory failure. Acute alteration in conscious state or a coma, which may occur following organophosphate intoxication, is an indication of severe intoxication and poorer prognosis. This acute decline in conscious state often reverses when the cholinergic crisis settles; however, it may be prolonged in some patients. We report on a case of a 60-year-old male who showed prolonged decline in conscious state due to of Central Nervous System (CNS) toxicity after a suicide attempt with organophosphate.