Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)

Korean society of Clincal Toxicology (대한임상독성학회)
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A Case of Central Nervous System (CNS) Toxicity in Acute Organophosphate Intoxication

유기인계 농약 중독 환자에서 중추신경 독성으로 지속적인 의식장애를 보인 1례

  • Lee, Jae Sung (Department of Emergency Medicine, College of Medicine, Inha University) ;
  • Paik, Jin Hui (Department of Emergency Medicine, College of Medicine, Inha University) ;
  • Yun, Sung Hyun (Department of Emergency Medicine, College of Medicine, Inha University) ;
  • Kim, Ji Hye (Department of Emergency Medicine, College of Medicine, Inha University) ;
  • Han, Seung Baik (Department of Emergency Medicine, College of Medicine, Inha University) ;
  • Kim, Jun Sig (Department of Emergency Medicine, College of Medicine, Inha University) ;
  • Jung, Hyun Min (Department of Emergency Medicine, College of Medicine, Inha University)
  • 이재성 (인하대학교 의과대학 응급의학교실) ;
  • 백진휘 (인하대학교 의과대학 응급의학교실) ;
  • 윤성현 (인하대학교 의과대학 응급의학교실) ;
  • 김지혜 (인하대학교 의과대학 응급의학교실) ;
  • 한승백 (인하대학교 의과대학 응급의학교실) ;
  • 김준식 (인하대학교 의과대학 응급의학교실) ;
  • 정현민 (인하대학교 의과대학 응급의학교실)
  • Received : 2013.05.22
  • Accepted : 2013.06.10
  • Published : 2013.06.13
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Abstract

Acute organophosphate intoxication is important because of its high morbidity and mortality. The mortality is still high despite the use of atropine as specific antidotal therapy and oximes for reactivation of acetylcholinesterase. Inhibition of acetylcholinesterase by organophosphate can cause acute parasympathetic system dysfunction, muscle weakness, seizure, coma, and respiratory failure. Acute alteration in conscious state or a coma, which may occur following organophosphate intoxication, is an indication of severe intoxication and poorer prognosis. This acute decline in conscious state often reverses when the cholinergic crisis settles; however, it may be prolonged in some patients. We report on a case of a 60-year-old male who showed prolonged decline in conscious state due to of Central Nervous System (CNS) toxicity after a suicide attempt with organophosphate.

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