• 품질경영학회지
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• 제25권1호
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• pp.173-181
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• 1997

A modified periodic inspection policy is examined. It is troublesome to know the life distribution and burdensome to compute an optimum planned inspection time numerically as well. A nonparametric a, pp.oximation is used so that equations for the optimum inspection time are expressed as closed forms. To show that the a, pp.oximation can be used in practice, simulations are conducted in the case of Weibull failure times.

• 품질경영학회지
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• 제25권3호
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• pp.74-85
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• 1997

In this paper we calculate the subgroup size necessary for detecting the change of percent defective with several detection probabilities for orginal population fraction nonconforming p, changed population fraction nonconforming $p^*$, and the ratio k=$p^*$/p in the usage of p control charts. From our calculation we can know the error level of normal a, pp.oximation in detection probability calculation and recommend the subgroup size with lower error levels of normal a, pp.oximation, and then we show the reasonable subgroup size necessary for p, $p^*$, k, and the detection probability of the change of fraction nonconforming in a process. The information that we here show in tables will be useful when p control chart users decide the subgroup size in the p control chart users decide the subgroup size in the p control chart.

• 분석과학
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• 제29권1호
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• pp.49-55
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• 2016

케톤체는 생체 에너지 생산과정이 탄수화물보다는 지방산의 의존도가 높을 때 생성되며, 과도한 분비는 당뇨병성 케토시스나 선천성 유전성 대사이상질환을 의심할 수 있는 근거가 된다. 따라서 이의 신속 정확한 분석법의 개발이 필요하다. 본 연구에서는 혈장을 제단백한 후 hydroxylamine을 가하여 60 ℃에서 30 분간 반응시켜 oximation 후 BSTFA를 가한 후 trimethylsilylation 유도체화하여 혈장 중에서 케톤체를 신속하게 정량할 수 있는 GC-MS/SIM 분석법을 개발하였다. 케톤체의 직선성의 범위는 0.001-250 μg/mL 이었고, 혈장에서의 검출한계는 0.1 pg 이었다. 직선성을 가지는 범위에서의 상관계수(R2)는 0.998-0.999이었고, 회수율은 1 μg/mL의 표준품을 첨가하였을 때 88.2-92.3 %, 10 μg/mL의 농도를 첨가하였을 때 89.5-94.8 % 였으며 RSD는 6.3-9.4 %였다. 이 분석법을 정상인과 케토시스 환자의 검체에 적용하여 벨리데이션 하였으며, 본 분석방법은 어린이나 성인의 당뇨성 케토시스나 여러 유전성대사질환 환자 중 케토시스를 보이는 환자의 혈장 중 β-hydroxybutyric acid/acetoacetic acid의 비를 계산하여 케톤체를 신속하고 효율적으로 임상검체 분석에 응용할 수 있음을 보여주었다.

• 대한화학회지
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• 제56권3호
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• pp.357-362
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• 2012

5-Nonylsalicylaldoxime and salicylaldehyde are two derivatives of phenolic compounds which are very applicable materials in industries. Formerly the formylation of phenolic derivatives were carried out by Rimer-Tiemann method. In this work both of these two materials were synthesized by magnesium meditated formylation technique and their structural characterizations were compared by instrumental analysis technique. In order to achieve a selectively orthoformylated product, the hydroxyl group of nonylphenol (or phenol) was first modified by magnesium methoxide. The nonylphenol magnesium salt was then formylated by paraformaldehyde. The oximation reaction was finally applied to the prepared nonylsalicylaldehyde magnesium salt by liquid extracting via water and acid washing and other extractions. The solvent was finally removed by evaporation under reduced pressure. Some instrumental analysis such as $^1H$-NMR, GC/MS and FT-IR spectra were taken on the product in order to interpret the reaction characterization quantitatively and qualitatively. The formaldehyde and oxime functional groups of two compounds were investigated through $^1H$-NMR and FT-IR spectra and were compared. The yield of methoxilation was very good and the yields of formylation and oximation reactions were about 90%and 85% respectively. The orthoselectivity of formylation reaction were evaluated by comparing of the relevant spectra. The GC/MS spectra also confirmed the obtained results.

• 약학회지
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• 제50권6호
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• pp.403-408
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• 2006

1-Amino-5,6-dimethoxyindan hydrochloride was synthesized from 3- (3,4-dirnethoxyphenyl)propionic acid by intramolecular Friedel-Crafts acylation, oximation with hydroxylamine, and reduction with an overall yield of 74%. 2-Amino-5,6-dimethoxyindan hydrochloride was synthesized from 3-(3,4-dirnethoxyphenyl)propionic acid by intramolecular Friedel-Crafts acylation, oximation with isoamylnitrite, reduction in NaOH and reaction with HCI to form 5,6-dimethoxy-2-indanone, which was reacted with hydroxylamine and reduced with an overall yield of 42%. 5,6-Dimethoxyindan-1,2-dione-2-oxime, which was catalytically hydrogenated to afford cis-, and trans-1-amino-5,6-dimethoxyindan-1-ol as 3 : 1 ratio. This mixture was treated with Li and reacted with chloroacetyl chloride. Cis isomer was acylated and cyclized to synthesize rir -( ${\pm}$ )-7,8-dimethoxy-4,4a,5,9b-tetrahydroindeno[1,2-b][1,4]oxazin-3(2H)-one, but trans isomer was just acylated to form amide.

• 대한화학회지
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• 제52권5호
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• pp.523-529
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• 2008

• 대한화학회지
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• 제57권2호
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• pp.295-299
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• 2013

• 약학회지
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• 제43권6호
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• pp.751-755
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• 1999

3,4-Difluoroamphetamine.HCI and 5,6-difluoro-2-aminoindan.HCI were synthesized as serotonergic agents. 3,4-Difluorobenzaldehyde was condensed with nitroethane and reduced with $LiAlH_4$ to obtain 3,4-difluoroamphetamine. And 5,6-difluoro-2-aminoidan.HCI was synthesizd through reactions of condensation with malonic acid, 10% Pd-C reduction, cyclization with polyphosphoric acid, oximation and catalytic hydrogenation.

• 대한화학회지
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• 제41권9호
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• pp.471-482
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• 1997

기체크로마토그래피/질량분석법(GC/MS)을 이용하여 소변 내에 존재하는 유기산들을 동시에 분리 정량분석할 수 있는 최적의 분석조건을 확립하기 위해 액체-액체추출법을 이용하여 분리하였고 이 때 pH의 영향 및 역추출방법과 그리고 옥심화 과정 첨가의 효과를 알아보았다. 그 결과 옥심화 과정 없이 pH가 0.5일 때 회수율이 좋았고 RSD값은 0.3-12.4%로 가장 적었다. 역추출과정을 통하여 방해물질이 제거되어 15-16분대의 머무름 값을 갖는 몇가지 유기산 검출이 확실시 되었다. 이를 토대로 51종의 유기산들에 대한 검량곡선을 작성하여 한국 정상어린이(n=16) 요시료 중의 유기산 함량분포를 얻었다.

• 품질경영학회지
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• 제25권1호
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• pp.182-192
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• 1997

The well-known standard normal distribution has been used within the limit of standard variable value of u=3.59. However, the probability values above the limit are not given in the literature. In this study, a probability computation program for standard normal distribution to u=5.99 with the proportional normal distribution a, pp.oximation suggested by Abramowitz and Stegun, Hastings is developed. The new standard normal distribution table developed by the program is presented and will be of help to estimate of probability values for testing and estimation of process mean value, lot acceptable probability, defective percentage of PPM unit of an out-of specification limit, process capability, test power of control charts, probability and statistics.