• Title/Summary/Keyword: Overcome Factors

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The Cardiovascular Effect of Risperidone (리스페리돈이 심혈관계에 미치는 영향)

  • Choi, Se-Jin;Cheon, Jin-Sook;Choi, Young-Tai
    • Korean Journal of Biological Psychiatry
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    • v.7 no.2
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    • pp.191-197
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    • 2000
  • Objectives : Risperidone is a new antipsychotic drug developed to overcome the therapeutic limitation of conventional antipsychotics. It responses to negative as well as positive symptoms by blocking both dopaminergic and serotonergic receptors, causing no significant side effects such as agranulocytosis and seizure. It is, however, not known whether it induces any serious cardiovascular side effects as evoked by other conventional antipsychotic drugs. The aims of this study were to evaluate the effect of risperidone on cardiovascular function, and to discuss the factors affecting the cardiovascular function. Methods : For 42 patients(22 males and 20 females) diagnosed as schizophrenia, schizophreniform disorder or schizoaffective disorder according to the DSM-IV classification, the cardiovascular fuctions such as heart rate, systolic and diastolic blood pressure, PR interval, QRS interval and QT interval were successively checked before and after 2 weeks and 4 weeks risperidone administration. Furthermore, variables such as body weight, Brief Psychiatric Rating Scale(BPRS), Clinical Global Impression(CGI), Extrapyramidal Symptom Rating Scale(ESRS), Anticholinergic Rating Scale(ARS), serum cholesterol level, serum triglyceride level, serum high-density-lipoprotein level, serum WBC, serum Hb, serum platelet level, prothrombin time and partial thromboplastin time were also analyzed before and after 2 weeks and 4 weeks risperidone administration. Results : 1) Risperidone treatment resulted in a significantly decreased heart rate and increased QT interval after 4 weeks administration(p<0.005 respectively). 2) The scores of BPRS and CGI were significantly decreased after 2 weeks and 4 weeks risperidone administration as compared with baseline(p<0.001 respectively). The scores of ESRS and ASRS were significantly increased after 2 weeks and 4 weeks risperidone administration as compared with baseline(p<0.001 respectively). 3) There were positive correlations between heart rate after 4 weeks and total dose(P<0.05). Blood pressure was significantly(p<0.05) correlated with sex(higher in male) and significantly(p<0.05) positive correlated with body weight. QT interval was significantly(p<0.05) correlated with sex(longer in female) and smoking history(shorter in smokers). Conclusions : Risperidone could induce significant change in heart rate and Q-T interval. Therefore, the cardiovascular safety for risperidone should be reconsidered according to the duration and dosage increase.

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Study on ICT convergence in Lentinula edodes (Shiitake) cultivation system using Automated container (컨테이너형 수출용 버섯식물공장시스템설계 및 표고버섯 생산 연구)

  • Jo, Woo-Sik;Lee, Sung-Hak;Park, Woo-Ram;Shin, Seung-Ho;Park, Chang-Min;Oh, Ji-Hyun;Park, Who-Won
    • Journal of Mushroom
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    • v.15 no.4
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    • pp.264-268
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    • 2017
  • In the 21st century, information and communication technology (ICT) worldwide presents a new vision for agriculture. Time and place, as well as the high-tech industry, to overcome barriers to the fusion of the so-called "smart agriculture," are changing the agricultural landscape. Core container production in precision agriculture for mushroom cultivation, optimal temperature, humidity, irradiation, self-regulation of factors such as carbon dioxide, and environment for mushroom cultivation were adopted. Lentinula edodes (shiitake) is an edible mushroom native to East Asia, cultivated and consumed in many Asian countries. It is considered to be medicinal in certain practices of traditional medicine. We used different controlled light sources (Blue-Red-White-combined LED, blue LED, red LED, and fluorescent light) with different LED radiation intensities (1.5, 10.5, and $20.5{\mu}mol/m^2s$ for LEDs) to compare growth and development. Mushrooms were treated with light in a 12-hour-on/12-hour-off cycle, and maintained in a controlled room at $19{\sim}21^{\circ}C$, with 80~90% humidity, and an atmospheric $CO_2$ concentration of 1,000 ppm for 30 days. Growth and development differed with the LED source color and LED radiation intensity. Growth and development were the highest at $10.5{\mu}mol/m^2s$ of blue LED light. After harvesting the fruit bodies, we measured their weight and length, thickness of pileus and stipe, chromaticity, and hardness. The $10.5{\mu}mol/m^2s$ blue-LED-irradiated group showed the best harvest results with an average individual weight of 39.82 g and length of 64.03 mm, pileus thickness of 30.85 mm and pileus length of 43.22 mm, and stipe thickness of 16.96 mm with fine chromaticity and hardness. These results showed that blue LED light at $10.5{\mu}mol/m^2s$ s exerted the best effect on the growth and development of L. edodes (shiitake) mushroom in the ICT-system container-type environment.

Analysis of Groundwater Flow into Underground Storage Caverns by Using a Boundary Element Model (경계요소모형을 이용한 지하 저장공동의 지하수 유입량 분석)

  • Chung, Il-Moon;Lee, Jeong-Woo;Cho, Won-Cheol
    • Journal of Korea Water Resources Association
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    • v.38 no.7 s.156
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    • pp.537-544
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    • 2005
  • For the proper management of high pressurized gas storage caverns, analysis of groundwater flow field and inflow quantity according to the groundwater head, gas storage pressure and water curtain head should be performed. The finite element method has been widely used for the groundwater flow analysis surrounding underground storage cavern because it can reflect the exact shape of cavern. But the various simulations according to the change of design factors such as the width of water curtain, shape of cavern etc. are not easy when elements were set up. To overcome these limitations, two dimensional groundwater flow model is established based on the boundary element method which compute the unknown variable by using only the boundary shape and condition. For the exact computation of drainage rate into cavern, the model test is performed by using the exact solution and pre-developed finite element model. The test result shows that the model could be used as an alternative to finite element model when various flow simulations are needed to determine the optimizing cavern shape and arrangement of water curtain holes and so forth.

Mass Screening Method for Rice Virus Resistance Using Screen House (망실을 이용한 벼 바이러스병 저항성 대량 검정체계)

  • Kwak, Do-Yeon;Yeo, Un-Sang;Lee, Jong-Hee;Oh, Byeong-Geun;Shin, Mun-Sik;Ku, Yeon-Chung
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.52 no.2
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    • pp.129-133
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    • 2007
  • To breed virus resistant rice variety, developing an efficient screening method is the most important. Two screening methods such as field screening and tray screening method have been used, but the efficiency of the field screening method is too low because of environment factors and the that of the tray screening method is good but screening capability is limited with only $200{\sim}300$ lines per year. To overcome those problems, mass screening method using screen house was developed. Barely as host plant of vector insect was grown in screen house in winter season. Then viruliferous insects are spread in the first spring of the initiation year and sustain them annually. Screening of virus resistance was tested two times in a year, the first screening was from April to June and the second from July to September. The virus infected rate of each susceptible varieties was increased to 92% for RSV and 100% for RDV from the second year. Also, this method can evaluate as many as $1,500{\sim}2,000$ pedigree lines in one time compared with the tray screening method. The result indicates that the mass screening method using screen house, which combines the advantages of the field and tray screening methods, is proven to be more efficient and reliable.

Analysis of Success Factors For Creating A Korean Theme Park - With a Focus on Culture Contents-Based Theme Park Strategy - (한국형 테마파크 조성을 위한 성공 요인 분석 - 문화콘텐츠 기반형 테마파크 전략을 중심으로-)

  • Lee, Kee-ho;Kim, Hyeong-soo
    • Cartoon and Animation Studies
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    • s.51
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    • pp.321-359
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    • 2018
  • A theme park, in general, can be defined as a space that has both 'theme factor' and 'hands-on factor'. But theme parks in Korea are not recognized as having unity even though they provide diverse services, because they lack in a theme factor, which is the essence of a theme park. On the other side of the issue, themes and concepts that a theme park claims to stand for are not consistent, and they fail to provide representative themes as well. For this reason, although a business plan to invite overseas theme parks is pushed ahead, it causes a vicious circle to weaken the competitive edge of domestic theme park industry as well as capital outflow. Consequently, from a theoretical viewpoint, a theme park with no specific theme is in critical situation to be out of the limelight by failing to provide visitors with purposefulness and attract their attention. To overcome the limitations in domestic theme park industry, and to gain profitability and expanded customers lie in heightening their receptiveness through creating unique image of each theme park. With the awareness of the issue, this study aims to propose a theme-centered park which has culture contents in it and to suggest a viable alternative that helps to create hands-on theme parks that reflect customers' receptiveness.

A Study on the Effect of Delinquency Rate of Real Estate PF on Macroeconomic Variables (거시경제변수에 따른 부동산PF 연체율에 관한 연구)

  • Roh, Chi-Young;Kim, Hyung-Joo
    • The Journal of the Korea Contents Association
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    • v.18 no.4
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    • pp.416-427
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    • 2018
  • As the loan size of real estate PF is huge, its market ripple effect gets bigger when overdue occurs. Accordingly, the management of the delinquency rate and macroeconomic analysis are required. As the preceding research mainly proceeded with microeconomic analysis through the real estate PF data of individual banks to evaluate importance of list or analyzed core factors for delinquency, it lacked research on comprehensive real estate PF size. In order to overcome the limitations of such data, this research studied real estate PF delinquency rate of the entire market and effect relationship by the size. The research utilized the size of real estate PF loans, money supply, interest rate, consumer price index(CPI), and GDP data. Also, it applied the first model of VECM as linear relationship between at least two or more variables, following the result of co-integration test. As a result of Granger-causality test, the real estate PF loans delinquency rate is influenced by their loan size, and as a result of impulse response analysis, the interest rate is shown to be affecting delinquency rate the most. Interest rate could risesomeday and aggravate the delinquency rate of real estate PF. Also, risk exposure could be serious as the loan size increases.Therefore, the management of real estate PF delinquency rate requires continuous monitoring, tracking and observing issued loans from a macro point of view. The plans to prevent delinquency will be necessary.

A Study on Switching Intention of Broadcasting Service to MCN Service by Migration Theory (새로운 방송 서비스로의 이전 : 이주 이론을 통한 MCN으로 전환의도 연구)

  • Kim, Yonghee
    • The Journal of Industrial Distribution & Business
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    • v.10 no.1
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    • pp.59-67
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    • 2019
  • Purpose - The Millennial Generation, which grew in the wake of the spread of the Internet and rapid changes in the media environment, is rapidly moving from the traditional broadcasting environment to the Internet-broadcasting environment in terms of content acceptance. With the emergence of UGC (User-generated content), the change in the status of single-person content creators enables the growth of multi-channel networks (MCN), a new content-distribution platform and an agency concept for single creators. Youtube-based MCN produces multiple single star producers and casts and provides its own video series through Youtube. It is also emerging as a major M&A target for global media providers in terms of providing content to a wide range of consumers with the same interests and consumption characteristics. In addition, for the Millennials generation, which are part of their lives, MCN is becoming the most suitable media for TGIF (Twitter, Google, i-phone, Facebook). Accordingly, this study defines newly emerging MCNs and analyzes the factors for accepting MCN-produced content based on the push-pull-mooring (PPM) model. Research design, data, and methodology - An empirical analysis is performed through a questionnaire survey. For this purpose, 204 people who have experience of watching MCN were studied. Collected data is processed through analysis of a structural equation model using R to test the hypothesis. Results - For the MCN service to become an alternative to existing media, it is necessary to continuously promote cultural diversity and diversity of attempts that conventional media cannot provide. It is the attractiveness of the alternative that has the greatest influence on the intention to switch to a MCN service. When we look at MCN content so far, certain patterns such as game progress, introduction, food, and chat rooms have already appeared. We need to overcome this and develop a completely new conceptual content that we have never seen before. This requires a more generous viewer perception of the topics covered. For diversity, linguistic and verbal violence should be tolerant in common sense to provide a foundation for securing cultural diversity. Conclusions - In this study, we tried to develop a comprehensive approach to the substitution effect of MCN. In terms of academic achievement, the PPM model is used to enhance the utilization of media and broadcasting. Practical implications are to provide an analytical framework for verifying alternative or complementary effects when viewers switch to MCN.

A Phenomenological Study on the Recovery Process of Elderly Women Living Alone in Suicide Crisis (자살위기를 벗어난 여성독거노인의 회복과정에 관한 현상학적 연구)

  • Lim, Jong-Rin;Kim, Joung-Sung
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.8
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    • pp.304-314
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    • 2020
  • This study examined the experiences of the suicide crisis and recovery process by elderly women living alone to identify the essential meaning and components of life as a life to live again. In addition, the recovery of the research participants, as well as the phenomenon of such changes in thought and life, were examined. The results of this study were as follows. Data analysis yielded four components, eight sub-components, and 16 semantic unit reductions. There were four components of suicide attempts and recovery experiences of elderly women. They were "disconnection and disqualification," "repeated hardships," "road of prosperity in trouble," and "generous tolerance." The essential topics of these components have emerged not as individual but as holistic and contextually connectable topics. Finally, to summarize the results, the essential semantic structure of the suicide attempt and recovery experience of elderly women living alone is a result of a dysfunctional social structure and environment, which has placed pressure on the life of research participants. As an alternative method to overcome, they tried to solve the problem through the extreme practice of suicide attempts, but positive energy to live again due to emotional recovery factors recognized through suicide failures have made it possible to cope with the difficult reality.

A New Similarity Measure for Categorical Attribute-Based Clustering (범주형 속성 기반 군집화를 위한 새로운 유사 측도)

  • Kim, Min;Jeon, Joo-Hyuk;Woo, Kyung-Gu;Kim, Myoung-Ho
    • Journal of KIISE:Databases
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    • v.37 no.2
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    • pp.71-81
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    • 2010
  • The problem of finding clusters is widely used in numerous applications, such as pattern recognition, image analysis, market analysis. The important factors that decide cluster quality are the similarity measure and the number of attributes. Similarity measures should be defined with respect to the data types. Existing similarity measures are well applicable to numerical attribute values. However, those measures do not work well when the data is described by categorical attributes, that is, when no inherent similarity measure between values. In high dimensional spaces, conventional clustering algorithms tend to break down because of sparsity of data points. To overcome this difficulty, a subspace clustering approach has been proposed. It is based on the observation that different clusters may exist in different subspaces. In this paper, we propose a new similarity measure for clustering of high dimensional categorical data. The measure is defined based on the fact that a good clustering is one where each cluster should have certain information that can distinguish it with other clusters. We also try to capture on the attribute dependencies. This study is meaningful because there has been no method to use both of them. Experimental results on real datasets show clusters obtained by our proposed similarity measure are good enough with respect to clustering accuracy.

The estimation of selection probability on the preference of unbundled parking system and sales discount rate -targeted for the public apartment residents in Seoul- (공동주택 주차장 분리분양제의 선호 및 분양 할인율에 대한 선택 확률 추정 -서울시 공동주택 입주민을 대상으로-)

  • Chung, Sang-Woon;Rho, Jung-Hyun
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.18 no.5
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    • pp.587-595
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    • 2017
  • The study examinesthe hindrance factors including various laws and institutions with regard to the Unbundled Parking System (UPS) that has recently attracted the greatest attention as a way to manage traffic demand for sustainable development, efficient utilization of parking spaces, and to overcome the unstable housing market.The direction of improvement of related laws and institutions is also suggested. Its usage is proven by countries such as the United States of America and France, as they have already implemented this institution. To lay the foundation for the introduction of UPS of our own country, a survey on the preference for UPS was conducted. The survey equally divided 300 respondents into three clusters based on the sales price of apartments in Seoul. The analyses revealed that all three clusters have similar preferences (cluster 1: 68%, cluster 2: 62%, cluster 3: 65%) on UPS, and younger groups seem to answer in the affirmative more than the other age groups no matter what cluster they belong to. In conclusion, the results on the estimation of selection probability on the preference of unbundled parking system and sales discount rate are as follow. The groups of non-vehicle users have higher preference on UPS. When the discount rate is 14%, 69%, 77% and 62%ofrespondents would choose unbundled parking system for clusters 1, 2 and 3, respectively (₩6,370,000/PY,₩3,930,000/PY and ₩2,270,000/PY reduce when applying avg. sales price, respectively).