• Journal of Veterinary Clinics
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• v.29 no.6
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• pp.470-473
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• 2012

Aromatherapy and apipuncture was evaluated for its efficacy on canine Malassezia-related otitis externa. Ten dogs with Malassezia-related otitis externa were used in the present study. The control group was treated with ketoconazole, and the experimental group was treated with aromatherapy (topical aroma-oil drop) and apipuncture (injection-acupuncture of apitoxin). Clinical scores of the control group after 2-week treatment (p < 0.01) revealed a significant decrease compared with scores of pre-treatment. Experimental group scores after 2-week treatment revealed a significant decrease compared with scores of pre-treatment (p < 0.05). In the control group, ALT levels were significantly increased in the 1-week treatment (p < 0.05) and the 2-week treatment (p < 0.01), compared with the pretreatment levels. The experimental group ALT levels did not significantly change after 1-week and the 2-week treatments, compared with pre-treatment. ALT levels of the experimental group after the 1-week treatment (p < 0.05) and the 2-week treatment (p < 0.01), was significantly lower than those of the control group. In conclusion, a combination therapy of apipuncture and topical aroma-oil drop is not hepatotoxic and similar to the effect of ketoconazole treatment for Malassezia-related otitis externa in dogs.

• Journal of Veterinary Clinics
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• v.30 no.3
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• pp.172-177
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• 2013

The aim of this study was to evaluate the in vivo and in vitro efficacy of enrofloxacin-silver sulfadiazine (Baytril$^{(R)}$ otic, Bayer, USA) for the treatment of otitis externa in dogs. Twenty-four dogs with otitis externa were included in this double-blinded, randomized study. The experimental group was treated with the Baytril$^{(R)}$ otic and the distilled water was applied to the control group. Both groups were administered each solution twice daily for 7 days and next 7 days off treatment. On days 0, 7 and 14, clinical signs, bacteriological and fungal counts were graded using semi-quantitative scales, respectively. For the evaluation of in vitro efficacy of Baytril$^{(R)}$ otic, we also performed Minimal Inhibitory Concentration (MIC) test by agar dilution method against Staphylococcus pseudintermedius, Pseudomonas aeruginosa and Malassezia pachydermatis. In the experimental group, the sum of clinical scores was decreased 81.0% and microbial scores were significantly reduced 87.0% at days 14, compared with day 0. The results of MIC testing were showed the concentration of enrofloxacin and silver sulfadiazine in Baytril$^{(R)}$ otic is high enough to kill for 3 infectious agents. No adverse reactions were observed in any of the dogs during this study. These results suggest that Baytril$^{(R)}$ otic are efficient and safe treatment for canine otitis externa.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1979.05a
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• pp.3.2-3
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• 1979

Bone conduction loss is one of the most common complication in chronic otitis media, and is mostly high frequency loss. Of 233 tympanomastoidectomy ears, 187 ears were considered eligible for this study. A histopathological change was examined in the natural otitis media of guinea pigs. It is our intention to analyze the pattern of bone conduction loss in chronic otitis media, and to correlate this findings with clinical and pathological changes in human and animal otitis media. l) In unilateral cases, a significant difference in bone conduction threshold was observed between normal and diseased ears, and between each frequency with significant interaction between 2KHz and 4KHz (p 0.01). 2) Using one way analysis of variance, mean bone conduction was compared with the duration of disease. We observed a significant difference (p 0.05) between each group of duration, except between 11-15 and 15-20 years group. 3) A comparison of bone conduction between stapes loss group and intact stapes group revealed significant t ratio (p 0.01) at each frequency. The effect of stapes loss on each frequency was evaluated, using one way analysis of variance. there were significant difference(p 0.05) between 250Hz and 500Hz. and between 2KHz and 4KHz. 4) A comparison of bone conduction between round window obliteration and nonobliteration group revealed significant t ratio (p 0.01) at each frequency. Using one way analysis of variance. the effect of round window obliteration was evaluated in each frequency. We observed significant difference (p 0.05) between 250Hz and 500Hz. and between 2KHz and 4KHz. 5) A comparison of bone conduction between cholesteatoma and non -cholesteatoma group revealed significant t ratio (p 0.01) only in 2KHz and 4KHz. No significant differency was observed in mean bone conduction. 6) In a histopathological study of natural otitis media in guinea pig, we observed inflammatory infiltration of the round window membrane, serofibrinous precipitate in the scala tympani, and degeneration of the organ of Corti most significant near the basal turn. These changes would explain high tone bone conduction loss in the process of chronic otitis media.

• Korean Journal of Veterinary Research
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• v.55 no.3
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• pp.205-208
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• 2015

Ten dogs were enrolled in this study: two healthy dogs, two obese dogs without other medical issues and six obese dogs with underlying diseases including pemphigus, chronic active hepatitis, hyperadrenocorticism, narcolepsy, otitis media and heartworm infection. Pyrosequencing of the 16S rRNA gene to explore the gut bacterial diversity revealed that distal gut bacterial communities of samples from patients with pemphigus, otitis media and narcolepsy consisted primarily of Firmicutes, while the major phylum of the distal gut bacterial communities in patients with chronic active hepatitis and hyperadrenocorticism was Fusobacteria. Proteobacteria were the dominant phylum in heartworm infected obese patients.

• Proceedings of the Korean Society of Veterinary Clinics Conference
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• 2008.10a
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• pp.173-173
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• 2008

• Journal of Veterinary Clinics
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• v.15 no.2
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• pp.410-416
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• 1998

These experiments were designed to evaluate the possibility of brain-stem auditory evoked responses(BAER) as a diagnostic tool for deafness in dogs. The BAER was recorded from three different groups of dogs; the normal dogs,'dog with otitis externa and dogs with unilateral destruction of cochlear. BAER of the normal dogs was consisted of distinct five peaks(I, II, III-IV, V). Furthermore, the clear shapes of waveform were observed at 85 dB. The latency of BAER was increased with reducing the intensity of sound-stimulus. The highest threshold of BAER was measured at 2 KHz with 10-30 dB. Dog with otitis externs demonstrated unclear shapes of BAER compared to the that of normal dogs. In the dogs with unilateral destruction of cochlear, the flat and indistinct waveform of BAER was recorded from the cochlear destroyed ear while that of BAER from normal side of ears did not show any differences from the normal BAER. These results indicate that the BAER can be clinically used in order to diagnose the deafness in dogs.

• Proceedings of the Korean Society of Veterinary Clinics Conference
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• 2008.05a
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• pp.133-133
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• 2008

• Proceedings of the Korean Society of Veterinary Pathology Conference
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• 2000.09a
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• pp.12-16
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• 2000

In domestic rabbits, pasteurellosis is a primary respiratory disease entity caused by Pasteurella multocida. Respiratory pasteurellsos in rabbits is highly contagious due to dissemination of the organism in the nasal discharge (Benirschke, et al., 1978). The disease reflects a varied and complex host-parasite relationship. Acute infection with high mortality occurs sporadically especially in stressed rabbits less than 10 weeks old, in the form either an enzootic pneumonia, infection of the upper respiratory tract or septicemia. In addition to respiratory form, infection with P. multocida results in a variety of disease processes in rabbits including rhinitis, otitis media, otitis interna, abscesses, metritis, orchitis and meningoencephalaitis (Manning et al., 1989). The deleterious effects of pasteurellosis are common and pose serious problems for rabbit breeders and researchers (Flatt, 1974). (omitted)

• Journal of Dental Anesthesia and Pain Medicine
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• v.20 no.3
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• pp.161-163
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• 2020

Myringotomy and ventilation tube insertion are widely performed in pediatric patients with chronic otitis media. This procedure is performed under general anesthesia or sedation with local anesthesia infiltration in pediatric patients. In this case report, we report a case of transient facial paralysis in a pediatric patient who underwent myringotomy and ventilation tube insertion using sevoflurane inhalation and four-quadrant blocks with lidocaine.

• Korean Journal of Audiology
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• v.24 no.4
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• pp.210-213
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• 2020

Fungal balls consist of rounded conglomerates of fungal mycelia, which can form within a preexisting cavity. They are mostly found in the paranasal sinuses in the head and neck regions. Cholesterol granuloma is a fibrotic lesion that develops as a tissue response to a foreign body such as cholesterol crystals or hemosiderin and is often associated with chronic otitis media. We present the unusual case of a 62-year-old male who was treated for chronic otitis media, which was histologically confirmed as a fungal ball and cholesterol granuloma in the middle ear cavity following tympanomastoidectomy. This is the first reported case of synchronous fungal ball and cholesterol granuloma in the middle ear cavity.