• 대한치과교정학회지
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• 제33권3호
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• pp.185-197
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• 2003

비증후군성 구순구개열을 발생시키는 주요유전자로 추측이 되는 OFC1 유전자(위치 염색체 6p24.3)의 한국인에서 나타나는 특성을 연구하였다. 3대에 걸쳐서 처음으로 비증후군성 구순구개열이 나타난 40 명의 환자(남자 20명, 여자 20명, 평균 나이 : 14.2세)와 3대에 걸쳐서 비증후군성 구순구개열을 포함한 어떤 선천성 기형도 나타나지 않았던 정상 성인 40명 (남자 20명, 여자 20명, 평균 나이 : 25.6세)을 연구 대상으로 하였다. 중합효소 연쇄 반응법을 이용하여 OFC1 유전자를 분리 증폭한 후, 염기 서열 분석을 통해서 대립유전자형을 밝히고, BLAST 와 Pedant-Pro 데이터베이스를 이용하여 단백질의 상동성 검색을 수행하였으며, 그 결과는 다음과 같다. 1. OFC1 유전자는 'CA' 연쇄반복서열을 가진 극소위성 표지자로 밝혀졌다. 2. 환자군과 대조군의 OFC1 유전자의 특별한 차이는 발견되지 않았다. 3. 한국인에서 나타난 'CA' 연쇄반복서열의 형태는 'ABI linkage map 2'의 TA(CA)11TA(CA)10과는 달리, TA(CA)n의 형태를 띄었으며, 연쇄반복의 수는 17회에서 26회로 다양하게 나타났다. 4. 'CA' 연쇄반복서열의 횟수에 따라서, 9가지의 대립유전자형이 발견되었으며, 나타나는 빈도는 환자군과 대조군에서 유사하였다. 5. 'ABI linkage map 2'의 'CA' 연쇄반복서열 사이의 염기서열 T가 한국인에서는 C로 치환되어 있었지만, ORF예측을 하였을 때 예상되는 아미노산의 배열 차이는 관찰되지 않았다. 6. 한국인 OFC1 유전자의 염기서열로 예측되는 단백질을 알아보기 위하여 BLAST 검색을 한 결과, Telomerase reverse transcriptase(TERT, locus 5p15.33, NCBI Genome Annotation ; NT023089)와 Nucleotide binding protein 2(NBP2, locus 17q22, NCBI Genome Annotation; NT010783)가 유사한 구조를 가지는 단백질로 밝혀졌다. 7. Pedant-Pro 데이터베이스로 단백질 구조의 상동성 검색을 한 결과, OFC1 유전자는 적어도 하나의 transmembrane region과 non-gloular region을 가지는 구조로 밝혀졌다.

• 대한치과교정학회지
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• 제32권5호
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• pp.313-325
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• 2002

3차원 CT에서는 환자의 움직임에 의한 오차와 상의 확대나 왜곡을 감소시킨 실측치를 얻을 수 있으며 두개안면부의 입체적인 영상을 구성할 수 있고 원하는 조직이나 구조물의 관찰이 용이하다 디지털 영상 기술이 빠르게 발전하고 있고 치료의 범위가 더욱 넓어지면서 두개악안면 구조의 3차원적인 분석법의 개발은 시급한 과제가 되었다. 이에 본 연구에서는 Vworks 프로그램$^{TM}$ (Cybermed Inc., Seoul, Korea)과 건조두개골을 이용하여 3차원 CT 영상의 오차와 확대율을 평가하고Vmorph-proto프로그램 $^{TM}$ (Cybermed Inc., Seoul, Korea)을 이용하여 정상인과 비대칭 환자의 3차원 CT영상에서 지정이 용이하고 반복재현성이 높은 계측점을 설정하고자 하여 다음과 같은 결론을 얻었다 ; 1. 건조두개골의 실측치와 Vworks 프로그램을 이용하여 구성한 3차원 CT영상에서 의 계측치를 비교한 결과 평균오차가 0.99mm, 확대율이 1.04%로 나타났다. 2. 3차원 CT영상에서 경조직 계측점으로 Supraorbitale, Lateral orbital margin, Infraorbitale, Natron, ANS, A point, Zygomaticomaxilla, Upper incisor, Lower incisor, B point, Pogonion, Menton, PNS, Condylar inner margin, Condylar outer margin, Porion, Condylion, Gonionl, Gonion2, Gonion3, Sigmoid notch, Basion 등이 임상적으로 유용하다고 판단되었다. 3. 3차원 CT영상에서 연조직 계측점으로 Endocanthion, Exocanthion, Soft tissue Nasion, Pronasale, Alare lateralis, Upper nostril point, Lower nostril point, Subnasale, Upper lip point, Cheilion, Stomion, Lower lip center, Soft tissue B, Pogonion, Menton, Preaurale 등이 임상적으로 유용하다고 판단되었다. Vworks 프로그램으로 3차원 CT영상을 구성하고 계측하는 것이 임상적으로 유용하다고 판단되었다. 또한 위에서 제안된 연조직 및 경조직 계측점들은 3차원 CT영상에서 반복 재현성이 높고 지정이 용이하며 해부학적 특징을 나타내주는 점들로 두개악안면 구조의 3차원적인 진단과 술전, 술후의 예측과 비교에 유용하게 사용될 것으로 사료되는 바이다.

• Journal of Periodontal and Implant Science
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• 제45권6호
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• pp.193-204
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• 2015

Purpose: With the increasing prevalence of orthodontic treatment in adults, clear aligner treatments are becoming more popular. The aim of this study was to evaluate the effect of orthodontic treatment on periodontal tissue and to compare orthodontic treatment with fixed appliances (FA) to clear aligner treatment (CAT) in periodontitis patients. Methods: A total of 35 patients who underwent orthodontic treatment in the Department of Periodontology were included in this study. After periodontal treatment with meticulous oral hygiene education, patients underwent treatment with FA or CAT, and this study analyzed patient outcomes depending on the treatment strategy. Clinical parameters were assessed at baseline and after orthodontic treatment, and the duration of treatment was compared between these two groups. Results: The overall plaque index, the gingival index, and probing depth improved after orthodontic treatment (P<0.01). The overall bone level also improved (P=0.045). However, the bone level changes in the FA and CAT groups were not significantly different. Significant differences were found between the FA and CAT groups in probing depth, change in probing depth, and duration of treatment (P<0.05). However, no significant differences were found between the FA and CAT groups regarding the plaque index, changes in the plaque index, the gingival index, changes in the gingival index, or changes in the alveolar bone level. The percentage of females in the CAT group (88%) was significantly greater than in the FA group (37%) (P<0.01). Conclusions: After orthodontic treatment, clinical parameters were improved in the FA and CAT groups with meticulous oral hygiene education and plaque control. Regarding plaque index and gingival index, no significant differences were found between these two groups. We suggest that combined periodontal and orthodontic treatment can improve patients' periodontal health irrespective of orthodontic techniques.

• 대한심미치과학회지
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• 제16권2호
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• pp.7-18
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• 2007

There is now an increased demand for harmony between the peri-implant gingiva and adjacent dentition. In the event of a pending loss of a single tooth in the aesthetic zone with healthy periodontium, expectation for optimal gingival and prosthodontic aesthetics are often very high. Unfortunately, bone resorption is common following the removal of an anterior tooth, compromising the gingival tissue levels for the eventual implant restoration. Also, improper implant placement and inadequate osseous-gingival support potentially deleterious aesthetic result. The creation of an esthetic implant restoration with gingival architecture that harmonizes with the adjacent dentitionis formidable challenge. The predictability of the peri-implant esthetic outcome may ultimately be determined by the patient's own presenting anatomy rather than the clinician's ability to manage state-of-the-art procedures. To more accurately predict the peri-implant esthetic outcome before removing a failing tooth, a considering of diagnostic keys is essential. This presentation addresses the useful diagnostic keys that affect the predictability of peri-implant gingival aesthetics and the overcoming of the risk factors in anterior single-tooth replacement; it also describes a surgical and prosthodontic technique in achieving a long term successful esthetic outcome. Proper diagnosis and understanding of the biological and periodontal variables of failing dentition and their response to surgical and prosthodontic procedures are the essence of predictability. Using a smart protocol that alters the periodontium toward less risk and more favorable assessment of the diagnostic keys before implant placement will provide the most predictable esthetic outcome. Simple diagnostic keys suggested this presentation are useful method to evaluate the overcoming of the risk factors in anterior single implant restoration.

• Archives of Plastic Surgery
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• 제35권3호
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• pp.303-308
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• 2008

Purpose: The purpose of this study is to develop three-dimensional computerized anthropometry(3DCA) and to compare its reliability and accuracy 3DCA with manual anthropometry(MA) for measurement of lips and nasal deformities in unilateral cleft lips and palate(UCLP) patients. Methods: Samples were consisted of six UCLP patients whose facial plaster models were available immediately before and 3 months after the cleft lip surgery. MA of the facial plaster models was carried out using an electronic caliper. In 3DCA, three-dimensional auto-measuring program was used to digitize landmarks and to measure three-dimensional virtual facial models (3DVFM), which was generated with a laser scanner and 3D virtual modeling program. Intraclass correlation coefficients(ICC) were calculated to evaluate reliability and reproducibility of the variables in both methods, and Wilcoxon's signed rank test was done to investigate the difference in values of the same variables of facial models of each patient between two methods. Results: All ICC values were higher than 0.8, so both methods could be considered reliable. Although most variables showed statistical differences between two methods(p<0.05), differences between mean values were very small and could be considered not significant in clinical situation. Conclusion: In clinical situation, 3DCA can be an objective, reliable and accurate tool for evaluation of lips and nasal deformities in the cleft patients.

• 대한치과교정학회지
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• 제32권2호통권91호
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• pp.71-78
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• 2002

보편적인 교정치료의 적기로 알려진 청소년기가 지나 성인 연령이 되어서야 교정치료를 목적으로 내원한 성인교정환자의 정신-심리학적 특성을 파악하기 위하여, 성인 312명, 청소년 765명, 총 1077명을 대상으로 두 가지 종류의 내외통제소재(locus of control) 척도를 측정한 후 연령군, 성별, 술자(교정의)에 의한 환자 협조도 평가, 진료보조원(치과위생사)에 의한 협조도 평가에 따라 분류한 후, 각각의 내외통제소재의 특성을 비교 분석하였다. 연구 결과 교정 환자들은 일반인에 비해 내적통제 경향을 보였으며, 성인은 청소년군에 비해 내적통제 경향을 보였고, 성인과 달리 청소년군은 여자가 남자보다 오히려 더 높은 내적통제 경향을 나타내었다. 협조적으로 분류된 성인환자는 외적통제 경향을 지닌 쪽이었지만, 청소년 환자는 내적통제 경향을 지닌 환자가 협조적인 환자로 분류되었다. 진료보조원은 술자에 비해 성인군에 대하여 더 호감을 보였으며, 전체적으로는 술자 측 분류에 비해 협조 불량군의 빈도가 높았다. 이러한 결과를 토대로 교정치료시에 반드시 필요한 환자측의 치료협조도를 미리 예측 가능하게 하기 위한 방편으로 내외통제소재척도와 같은 정신-심리학적 검사가 진단 자료의 일부로써 유용성을 지닐 수 있는 것으로 생각되었다.

• 대한두개안면성형외과학회지
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• 제14권1호
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• pp.11-15
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• 2013

Background: In cleft lip patients, the necessity of a thorough preoperative analysis of facial deformities before reconstruction is unquestioned. The surgical plan of cleft lip patient is based on the information gained from our preoperative anthropometric evaluation. A variety of commercially available three-dimensional (3D) surface imaging systems are currently introduced to us in plastic surgery for these use. However, few studies have been published on the soft tissue morphology of unrepaired cleft infants described by these 3D surface imaging systems. Methods: The purpose of this study is to determine the accuracy of facial anthropometric measurements obtained through digital 3D photogrammetry and to compare with direct anthropometry for measurement in unilateral cleft lip patients. We compared our patients with three measurements of dimension made on both sides: heminasal width, labial height, and transverse lip length. Results: The preoperative measurements were not significantly different in both side of labial height and left side of heminasal width. Statistically significant differences were found on both side of transverse lip length and right side of heminasal width. Although the half of preoperative measurements were significantly different, trends of results showed average results were comparable. Conclusion: This is the first study in Korea to simultaneously compare digital 3D photogrammetry with traditional direct anthropometry in unilateral cleft lip patients. We desire this study could contribute the methodological choice of the many researchers for proper surgical planning in cleft lip reconstruction field.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제28권4호
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• pp.249-255
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• 2002

Recently, Skeletal Anchorage System (SAS) has been focused clinically with the view point that it could provide the absolute intraoral anchorage. First, it began to be used for the patient of orthognathic surgery who had difficulty in taking intermaxillary fixation due to multiple loss of teeth. And then, its uses have been extended to many cases, the control of bone segments after orthognathic surgery, stable anchorage in orthodontic treatment, and anchorage for temporary prosthesis and so on. SAS has been developed as dental implants technique has been developed and also called in several names; mini-screw anchorage, micro-screw anchorage, mini-implant anchorage, micro-implant anchorage (MIA), and orthosystem implant etc. Now many clinicians use SAS, but the anatomical knowledges for the installed depth of intraosseous screws are totally dependent on general experiences. So we try to study for the cortical thickness of maxilla and mandible in Korean adults without any pathologic conditions with the use of Computed Tomography at the representative sites for the screw installation.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제33권6호
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• pp.694-700
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• 2007

It is a gel type high functional toothpaste containing vitamin C, E, propolis extract and the rest of herb with a nanoemulsion state. Vitamin C, E is known as the material with an eminent anti-oxidation effect. Propolis is known as the material with an antimicrobial and anti-inflammatory effect. We have been succeeding in making nanoemulsion of vitamin C, E and propolis through the high pressure homogenizer using stable oil and lecithin and the gel type high functional tooth paste were made from nanoemulsion of vitamin C, E and propolis. We observed the process of wound protecting effect and cure effect for a wound of soft tissue, gingival tissue and mucous membrane showing ulcer and inflammation in oral cavity after applying a gel type high functional toothpaste to patient. As a result, the wound were healed very fast and any side effects were not shown. We confirmed that a gel type high functional toothpaste with nanoemulsion of vitamin C, E and propolis extract has good effect not only for wound healing but also for treatment of ulcer-like lesion in oral cavity. So we report our cases with review of literatures.

• The Journal of Advanced Prosthodontics
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• 제10권2호
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• pp.155-162
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• 2018

PURPOSE. The aim of this study was to compare the fracture of implant component behavior of external and internal type of implants to suggest directions for successful implant treatment. MATERIALS AND METHODS. Data were collected from the clinical records of all patients who received WARANTEC implants at Seoul National University Dental Hospital from February 2002 to January 2014 for 12 years. Total number of implants was 1,289 and an average of 3.2 implants was installed per patient. Information about abutment connection type, implant locations, platform sizes was collected with presence of implant component fractures and their managements. SPSS statistics software (version 24.0, IBM) was used for the statistical analysis. RESULTS. Overall fracture was significantly more frequent in internal type. The most frequently fractured component was abutment in internal type implants, and screw fracture occurred most frequently in external type. Analyzing by fractured components, screw fracture was the most frequent in the maxillary anterior region and the most abutment fracture occurred in the maxillary posterior region and screw fractures occurred more frequently in NP (narrow platform) and abutment fractures occurred more frequently in RP (regular platform). CONCLUSION. In external type, screw fracture occurred most frequently, especially in the maxillary anterior region, and in internal type, abutment fracture occurred frequently in the posterior region. placement of an external type implant rather than an internal type is recommended for the posterior region where abutment fractures frequently occur.