• Journal of Life Science
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• v.31 no.2
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• pp.248-255
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• 2021

Mammary gland tumors are one of the most common cancers in female dogs, and there are various types of cells depending on the tumor type. Complex carcinoma consists of a combination of luminal epithelial and myoepithelial cells with intra-tumoral heterogeneity. However, the origins of these tumor cells and their effects on the malignancies of tumors have not been identified. Recently, it has been reported that cancer stem cells, identified in several types of human tumors, are involved in tumor heterogeneity and may also contribute to malignancies such as tumor recurrence and metastasis. Interestingly, cancer stem cells share several abilities of self-renewal and cell differentiation into multiple types of cancer cells, but they have abnormal genetic mutation and signal transduction pathways to regulate the maintenance of stem cell characters. Moreover, it is known that these cell populations contribute to cell metastasis as well as cell resistance against chemo- and radio-therapeutics that promote tumor recurrence. The existence of cancer stem cells might explain the intra-tumoral heterogeneity and cancer aggressiveness during tumorigenesis in canine mammary gland tumors. This review summarizes the characteristics and types of canine mammary gland tumors, the definition of tumor stem cells, methods of isolation, and clinical significance.

• Economic and Environmental Geology
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• v.53 no.6
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• pp.781-792
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• 2020

Mine tailings, which are inevitably formed by the development of manganese nodules, manganese crusts, and hydrothermal seafloor deposits, have attracted attention because of their quantity and potential toxicity. However, there is a lack of data on the quantity of mine tailings being generated, their physicochemical properties, and their effects as environmental hazards and on marine ecosystems in general. The importance of treating mine tailings in an environmentally friendly manner has been recognized recently and related reduction/treatment methods are being considered. In the case of deep-sea mineral resource development, if mine tailings cannot be treated aboard a ship, the issue becomes one of the cost of transporting them to land and solving the problem of environmental pollution there. Therefore, the Korea Institute of Ocean Science and Technology conducted research on the harmfulness of mine tailings, their effect on marine ecosystem, the diffusion model of contaminated particles, and candidate purification treatment technologies based on five representative controlling factors: 1) effects of pollution /on the environment, 2) effects of environmental/ biological hazards, 3) diffusion of particles, 4) mineral dressings, and 5) reducing/processing mine tailings. The results of this study can provide a basis for minimizing environmental problems by providing scientific evidences of the environmental effects of mine tailings. In addition, it is also expected that these results could be applied to the treatment of pollutants of different origins and at land-based mining waste sites.

• (The)Korea Educational Review
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• v.23 no.2
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• pp.31-53
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• 2017

Drawing upon Vygotsky's theory, this paper explores the possibilities of imaginative education and those implications in relation to emotions. Imagination is an important element of future competencies as well as creativity. But there is a big dilemma in an educational intervention about imagination. If imagination is naturally occurring and therefore considered a mysterious ability that is specific to a child, education should not intervent as much as possible so that it can be expressed and preserved. It is linked to Piaget's influence, which regards imagination as a mental immaturity of childhood. Vygotsky who is a developmental psychologist argues that mind is generated from the socio-cultural origins in opposition to Piaget's spontaneous generation and emphasizes that it is a core characteristic of human to create something through interaction with the world. Vygotsky consider that 'imagination' which synthesizes empirical material and creates a new image is a key factor in human creativity. He reminded us of the possibilities and importance of imaginative education by revealing that imagination is not limited to childhood but constantly develops through cultural experience. Especially Vygotsky's understanding has important implications for future education in relation to emotion. Imagination plays a role of expressing and dealing with human emotions. Unlike the reason-centered society in the past, future society demands a big role of imagination in education for dealing with emotional knowledge and morality.

• Journal of The Geomorphological Association of Korea
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• v.25 no.3
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• pp.71-87
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• 2018

As part of further study on Gwangseungri coastal deposits which occurred at 10 ~ 15m above sea level and was analyzed as palaeo-coastal flood-type sediments, six burial ages of six additional samples from the two cross sections (KST1 and, KST2) near to the points of the past study were estimated and the geochemical analysis was performed. Further investigation on the cross section KST1 revealed a reversal of the burial age at the bottom of the section which was identified as palaeo-flooding sediments and supposed to have been buried about 350 years ago. At the lower part of the KST1, the burial age of the sediment layer was estimated to be 3,800 years. The lower part of KST2 sediments was identified as sediments that was formed about 6,600 years ago and about 20,000 years ago. Considering the inclination of the sediment layers, the coastal flooding sedimentsreported to have formed 700 years ago in the previousstudy are located at the top and the KST1 section analyzed in thisstudy seemed to be connected to the lower part. The chemical analysis showed that the relationship between these layers was not continuous but had a discontinuous characteristic influenced by a specific event, and the chemical composition also showed a rapid change. If we judge these together, the lowest part of Gwangseungrisediment layerseemed to have formed during the last glacial period but it was hard to find its origins clearly. On top of this layer, a fine sediment layer containing gravels was also formed.Itseemed thatsedimentation did not occur continuously, but was affected by temporary events in such a way that after a sediment layer was formed, it stopped. Since then, a coastal flooding event occurred about 700 years ago, and part of flooded sediments accumulated in the rear slope. After that, when a flood layer including additional granular materials about 350 years ago was formed, sedimentation along the slope seemed to have occurred.

• The Journal of Korean Philosophical History
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• no.57
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• pp.31-55
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• 2018

Professor Dowon (道原) Lew, Seung-Kook (柳承國: 1923~2011) was a master of Eastern philosophy in Korea, in the 20th century. 'Confucianism' was the root of his discipline. Nevertheless he studied extensively throughout Eastern philosophy. He was also a pioneer of 'Korean Philosophy', who devoted himself to 'establishing the original form (原型) of Korean thought'. Professor Lew showed a unique view on how Confucian thought was formed. He has done many years of precise comparative analysis of the results of archaeological studies before 1970, particularly the study of bone-and-shell inions, and what was said in previous literature. As a result, he concluded that "we cannot discuss the origins of Confucian thought by separating the relationship with the Dongyi tribe". Confucianism was formed in relation to Dongyi. The purpose of his attention to the Dongyi tribe - RenFang tribe (人方族) was not to examine Dongyi tribe and its culture. His purpose was to examine how Confucian thought was formed and to examine the relevance of Dongyi tribe in this process. This was in conjunction with the task of exploring 'the original form of Korean thought', whether he pretended or not. Professor Lew, Seung-Kook's theory differed not only from the conventional view of the academic world in his time but also from the conventional view up to now. It is a pity that it was not yet discussed it in the academic world. I consider that it is necessary to seriously review Professor Lew and Seung-Kook's theory at this point when China has outlined the Northeast project (東北工程).

• 한국사회정책
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• v.24 no.2
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• pp.181-215
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• 2017

The study found that the origins of modern Korean welfare regime are closely related to the political and economic order of the U.S. military rule between 1945 and 1948. The creation of developmental state in 1960s and 1970s can not be imagined from the standpoint of the U.S. military rule. The U.S. military government dismantled the labor movement and the farmers' movement, and dealt a devastating blow to leftist political forces. Through this process, the U.S. military government turned the political landscape of the Republic of Korea, which was dominated by left-wing political forces in August 1945, completely transformed into the political landscape dominated by right-wing political forces. Moreover, it would not have been possible without the physical force of the US military government to transplant American capitalism instead of the social (democratic) state that the majority of the Korean people wanted. Through farmland reform, the traditional landowning classes were broken down, the revolutionary farmers turned into conservative peasants, and the distribution of factories owned by the Japanese led to the birth of a new capitalist class that was subordinated to the state. From the viewpoint of the welfare regime, the most significant meaning of the US military government is that it laid the foundations for the developmental state in the 1960s and 1970s in Korea.

• The Journal of Korean Philosophical History
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• no.38
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• pp.275-302
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• 2013

The purpose of this paper is to investigate Chu Hsi's theory of Ge Wu by analyzing the $L{\ddot{u}}$ shi daxuexie (呂氏大學解) in the Critique of Adulterated Learning (雜學辨). Critique of Adulterated Learning was written by Chu Hsi(朱熹) for the purpose of criticizing the confucian scholars who inclined to Taoism and Buddhism. Chu Hsi criticized $L{\ddot{u}}$ Pen-chung(呂本中)'s theory of Ge Wu Zhi Zhi, especially focusing on his understandings based on the Buddhist tendency. $L{\ddot{u}}$ Pen-chung considered Ge Wu Zhi Zhi as the processes of emerging Liang Zhi of the Subject to discipline by investigating the Li of things. He said "Regard an awakening as the standard of Ge Wu Zhi Zhi", as he payed more attention to the mind of the Subject rather than a long process of accumulation of Li. In comparison with him, Chu Hsi considered enormous each step to accumulate Li as more important to reach the completions of knowledge. Especially, while grasping Li, he considered they should have an understandings of things from the routines to the origins of the principles - that is from the principles of things to the reasons of things are. Chu Hsi approached to the Ge Wu in the meaning of political theory in his early days. However, Chu Hsi expands the width of his thought with a theoretical tool of 'Li-i fen-shu (理一分殊)' in the course of criticizing $L{\ddot{u}}$ Pen-chung's theory of Ge Wu Zhi Zhi. In that sense, His criticism of $L{\ddot{u}}$ Pen-chung(呂本中)'s theory was not only the process of struggling against Buddhist philosophies, but also the process of deepening of his philosophy.

• (The)Study of the Eastern Classic
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• no.57
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• pp.41-66
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• 2014

The Purpose of this paper is, through the character-figuration aspect of existing Yeoheon Jang Hyungwang(旅軒 張顯光, 1554~1637)-related folk tales, to determine the relation between the people's awareness on Yeoheon and the change in the folk tales. Only 4 pieces of Yeoheon-related folk tales are existed ; ; Forgiving a rude son of the provincial governor generously. ; Predicting 'the frost of May' and Preventing the cold-weather damage, when he served as Euiseong governor, and ; The folk tales of origins of the place name - Chimabawi Rockand Yeoheondae. shows the great scholar's liberal-hearted and generous personality. One day Jang Hyungwang looked shabby and a young person was quite rude to him. But Jang Hyungwang forgive him generously. Also Yeoheon teach him the thrift and modesty. described him as a governor filled with a love for the people. He tried to edify the people with the Confucian ethics and improve the life's work of the people. embodied him as a government official of high integrity. When his wife received the silk slip from the people, as farewell gift, he ordered his wife return that. and show the images of the Predicting the future and an extraordinary moralizer. Generally These folk tales are based on his personality, whereabouts and the real case. So we could find his images in the folk tales are close to his actual feature - thrift, modest, noble-minded, well-versed in Iching and practicing moral statesmanship.

• 교육공학연구
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• v.33 no.1
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• pp.105-135
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• 2017

The purpose of this study is to clarify conceptually the difference of instructional coaching, instructional supervision, and instructional consulting by analyzing their own characteristics. The practices for instructional improvement are common in that fundamental objectives are improvement of instruction and development of teacher's professionalism in instruction. However, each area changed according to the social flow and the demands of the educational field and created a unique activity system. So, in order to get rid of this mixed use of these terms, it is meaningful to distinguish the concepts, attributes, and areas of each activity. The specific study questions were 1) what is the origin of coaching, supervision, and consulting? 2) how are instructional coaching, instructional supervision, and instructional consulting defined in existing research in korea? 3) how can we conceptually distinguish instructional coaching, instructional supervision, and instructional consulting? Based on reviewing various existing studies, First, this study investigated the conceptual origins and lexicons of coaching, supervision, and consulting, respectively, in addition reviewd the prior studies conducted in Korea with regard to instructional coaching, instructional supervision, and instructional consulting, and summarized how each concept is defined according to the researcher. Second, this study compared each two concept with another one. Finally, the existing definitions of instructional coaching, instructional supervision, and instructional consulting were analyzed to find out the inherent and common attributes of each concept. In conclusion, this study suggest that the concept of instructional consulting needs to be redefined to better reflect the characteristics of activities, and that studies that rethink the relationship between instructional coaching and instructional supervision are needed.

• Journal of Ginseng Research
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• v.45 no.1
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• pp.1-21
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• 2021

Panax species have gained numerous attentions because of their various biological effects on cardiovascular, kidney, reproductive diseases known for a long time. Recently, advanced analytical methods including thin layer chromatography, high-performance thin layer chromatography, gas chromatography, high-performance liquid chromatography, ultra-high performance liquid chromatography with tandem ultraviolet, diode array detector, evaporative light scattering detector, and mass detector, two-dimensional high-performance liquid chromatography, high speed counter-current chromatography, high speed centrifugal partition chromatography, micellar electrokinetic chromatography, high-performance anion-exchange chromatography, ambient ionization mass spectrometry, molecularly imprinted polymer, enzyme immunoassay, 1H-NMR, and infrared spectroscopy have been used to identify and evaluate chemical constituents in Panax species. Moreover, Soxhlet extraction, heat reflux extraction, ultrasonic extraction, solid phase extraction, microwave-assisted extraction, pressurized liquid extraction, enzyme-assisted extraction, acceleration solvent extraction, matrix solid phase dispersion extraction, and pulsed electric field are discussed. In this review, a total of 219 articles published from 1980 to 2018 are investigated. Panax species including P. notoginseng, P. quinquefolius, sand P. ginseng in the raw and processed forms from different parts, geographical origins, and growing times are studied. Furthermore, the potential biomarkers are screened through the previous articles. It is expected that the review can provide a fundamental for further studies.