• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.5
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• pp.1126-1134
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• 2006

Human fungal infections are uncommon in normally healthy persons, being confined to conditions such as candidiasis (thrush) and dermatophyte skin infections such as athlete's foot. However, in the immunocompromised host, a variety of normally mild or nonpathogenic fungi can cause potentially fatal infections. Furthermore, the relativeease with which people can now visit 'exotic' countries provides the means for unusual fungal infections to be imported into this country. Mycoses appear in many different forms and areas. Fungal infections or mycoses are classified depending on the degree of tissue involvement and mode of entry into the host. These are Cutaneous, Subcutaneous, Systemic, and Opportunistic. Cutaneous mycoses specially appears symptoms on the skin. They are treated by amphotericinB, nystatin, grycelfulvin, micronazole and ketaconazole, etc, but these medicines are been careful about using, because most of them have serious side effects and toxicities. So, on the purpose of finding safe novel medicines, we have researched oriental medicines and search them to treat mycoses. In oriental medicines treating mycoses, we pay attention to orient applications that directly have an effect on disorder lesions. Oriental applications consists of various herbs and have a lot of forms, so we try to classify them as herbs and forms

• Korean Journal of Pharmacognosy
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• v.32 no.4 s.127
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• pp.257-268
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• 2001

Analgesic and antiinflammatory activities of several herbal medicines were investigated in order to develop the antiinflammatory drugs from oriental herbal medicines. 80% Ethanol extracts of Ephedra sinica, Chaenoleles sinensis, Asiasarum siboldi, Nelumbo nucifera, Scolopendra subspinipes mutians, Evodia officinalis, Aremarrhenae asphodeloides, Bufo bufo gargarizans, Gardenia jasminoides, Piper longum, Carthamus tinctorius, Piperus nigrum, Magnolia officinalis and Siegesbeckia glabrescens showed significant inhibitory effects on hyaluronidase, trypsin, and albumin denaturation in vitro. They also decreased the acetic acid-induced pain and vascular permeability induced by histamine in mice.

• The Journal of Korean Medical History
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• v.21 no.1
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• pp.1-12
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• 2008

San-Cheong region is the mountainous region in the southeastern part of Jiri-San where herbs with superior quality has been produced and famous doctors in history of Oriental Medicins such as Eui-Tae Ryu, Yi-Tae Yu, Cho-Gek Huh, and Cho-Sam Huh has lived. The most famous of all is Eui-Tae Ryu, who was a court physician under the reign of Suk-Jong in late 1660s. He wrote many classics on Oriental Medicines such as 痲疹編, a professional literature on measles, 實驗單方, a classic on miscellaneous diseases, 麟西聞見錄. Also, Cho-Gek Huh, and Cho-Sam Huh brothers wrote 晋陽神方, 晋寓神方, and various tales on medicines.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.6
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• pp.1528-1532
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• 2003

To investigate the antioxidant capacity of traditional Korean medicines, water extracts from 57 species were tested on their antioxidant activity using radical scavenging effects against ABTSㆍ+. Of which, Rhus javanica, Caesalpinia sappan, Rosa rugosa, Spatholobus suberectus, and Magnolia obovata showed strong antioxidant capacities at 10㎍ concentration. Therefore, antioxidant capacities of 5 traditional medicine extracts in the different concentration (1㎍, 5㎍, and 10㎍) were determined. The 5 traditional medicine extracts was detected in antioxidant capacity dose dependently. R. javanica was showed the highest antioxidant capacity, the antioxidant activity at 1 ㎍ of herbal extract being 0.85 mM TE. At the same time, the antiperoxidation effects of these 5 medicines were determined. Lipid peroxidation in brain homogenates induced by NADPH and ADP-Fe/sup 2+/ was strong inhibited by S, suberectus, R. rugosa, and M. obovata. Extract of C. sappan was showed the highest inhibition against lipid peroxidation compared with 4 herbal extracts in vitro. These traditional medicines are a potent antioxidant capacity and antiperoxidation activity, further investigation into the in vivo antioxidant therapeutic potential for treatment of human disorders such as Alzheimer's disease.

• Journal of Evidence-Based Herbal Medicine
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• v.2 no.1
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• pp.13-18
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• 2009

The aim of this study was to find out the time when the Araliae Continentalis Radix and Osterici Radix were classified into different divisions as the period were not known to oriental medical science in Korea. It could be said that the Araliae Continentalis Radix and Osterici Radix had been recognized the different shapes since Sui-Tang eras and they had been differently used in their shapes and effects as separated medical plants since Song-Yuan eras. This thesis also presented the effects and shapes of Araliae Continentalis Radix and Osterici Radix as well as showed prescriptions and the uses of them in each dynasty of China.

• Journal of Korean Medical classics
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• v.19 no.1 s.32
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• pp.128-136
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• 2006

This study is on Yoshimasu Todo's thought of medicines. Conclusions are as below. Medicines are poisons. Therefore, they don't have the ability to restore the vital energy. Medicine-processing(法製) can only be done for doubling the toxicity, since the poison itself is the very effect of a medicine. One poison has an ability to treat only one main symptom. If the poison strikes the main symptom right, it doesn't harm the human body. Since warm-heat-cool-cold(溫熱凉寒) of a medicine can't be known by human ability, it can't be used as the standard of judgment when selecting a medicine.

• Journal of Evidence-Based Herbal Medicine
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• v.2 no.1
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• pp.25-31
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• 2009

The origin and description of the Herba Plantaginis was contemporarily analyzed (family names, scientific names, target regions, preparation, etc.) by comparison to enormous literature in addition to the external features written in the existing books on traditional Korean medicine. Also, galenical description were analyzed in connection with external morphology, internal morphology, microscopy and five senses. The official documents and ancient documents of other countries were reviewed. The technical books on herbage, published in the country and other countries, were compared with each other. Also, on-the-spot surveys were made to learn specialists' know-how. The description of the collected drugstuffs were analyzed in connection with external morphology (size, color, etc.), internal morphology and microscopy. The results of this study can be applied to the publicity and education of galenical test agencies; the effective management of foods and drugs; the improvement of public medical service; the publicity of galenical safety.

• Journal of Oriental Neuropsychiatry
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• v.9 no.2
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• pp.19-35
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• 1998

Some oriental medicine turned out to have a significant clinical effect on the cure for dementia. Therefore, thorough scientific tests for physiological effect of oriental medicne are needed. This study is aimed at doing experimental studies on the effects of two medicines, Jowiseungcheongtang and hyungbangjihwangtang, on the cure for dementia.For the demonstration of the effect of the two medicines on aged rats, we perfomed a radial arm medicines on aged rats, water maze task, known for their proper learning paradigm for behavior.Previous studies on aging and dementia show that aged rats displayed significant impariments in the learning of the radial arm maze task compared with younger rats. As in experiment 1, we found that the learning of the radial arm maze task compared with younger rats. As in experiment 1, we found that the learning deficits aged rats exhibit in radial arm maze task were improved with the application of each medicine. The resutls suggest that these two medicine can be effective to patients whose working or shortterm memory is impaired. In experiment 2 we studied the effect of the two medicines on the deficit of the aged rats with the Morris water maze task known for measuring long-tern memory. We did not find significant results between the performance of the ages rats and the younger ones. Considered the different results previous studies have reported, more thorough studies are needed to investigate the effect of the medicines on long-term memory.In conclusion, the results we found in experiment 1 and 2 suggest that Jowisengcheongtang and hyungbangjihwangtang can have useful effects for the cure of age-related memory (especially for short-term memory)deficits. Recent interests in dementia urges researchers concerned to explore the effect of oriental medicine on the disease. As there have been relatively few behavioral or scientific studies on dementia using oriental medicine to date, further studies are expected are expected to continue to elucidate 'what the wisdom of the oriental medicine tells about dementia'.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.4
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• pp.707-713
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• 2002

Astragali radix (AR) is one of the oldest and mast frequently used crude drug for traditional medicine in many Asian countries. This study designed to investigate the hepatoprotective effects of the aqueous extracted AR (ARE) against acetaminophen (APAP)-induced hepatic damage in ICR mice. APAP at the dose of 450 mg/kg i.p produced liver damage in ICR mice. Serum enzyme activities of alanine aminotransferase, aspartate aminotransferase and sorbitol dehydrogenese was dramatically decreased up to control level by pretreatment of ARE. However, hepatic glutathione level did not show a significant change between the tested groups. We also investigated TNF α mRNA gene expression on APAP-induced liver damage by RT-PCR. APAP dramatically induced TNF α mRNA gene expression in ICR mice. Pretreatment of mice with ARE led to a marked decrease of TNF α mRNA gene expression. These data indicate that 1) ARE has clearly revealed a hepatoprotective effect against APAP-induced hepatic damage in ICR mice, and 2) the protective effect of ARE may be, in part, associated with the regulation of TNF α mRNA gene expression.

• Korean Journal of Oriental Medicine
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• v.13 no.3
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• pp.165-178
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• 2007

This article explores how non-dominant medical practitioners shape their own self-images and the identity of relevant medicine and in what ways fashioning of self-images and accompanying modalities of medical practice informs the social evolution of the medicines at specific times and over specific places, by means of the historical configuration of osteopathy and chiropractic in the UK and the US. Attention is directed onto motivations and pursuits for professional recognition and actual strategies and activities of non-dominant medicines and its practitioners by turning to historical instances such as osteopathy and chiropractic in the UK and the US, not least drawing focus on professional desires with regard to circumstances it faces within and without. Some non-dominant medicines as a way with which to acquire and protect the exclusive monopoly of its knowledge and practical skills, adopted various forms of professionalism project, as dominant biomedical groups pressed up non-dominant medicines by virtue of marginalizing tactics. Meanwhile, non-dominant medicines took somewhat distinctive professionalisation strategies from each other. Strategies they took were diversified depending on medical philosophy, healing modality, the degree of occupational solidarity embodied as forms of medical organisation, and especially vocational aspiration and prospect. Change of socio-medical culture and the state's policy seems to have wielded critical influenceon the determination of the ups and downs of non-dominant medicines. From the perspective of long-term time span, dominant biomedicine eventually did not have much influence on the ups and downs of marginalized medicines in so far as in the case of osteopathy and chiropractic in Englandand the U. S.