• 대한한방내과학회지
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• 제24권2호
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• pp.233-248
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• 2003

Objectives : This research examined about dietary therapy on the gastric & duodenal ulcer based on the literary findings, for clinical treatment and prevention of the gastric & duodenal ulcer. Methods : This Research examined on histories, compositions, applications, and effects of dietetic on about 200 cases of dietary therapy of the gastric & duodenal ulcer from recent Chinese literatures Results : 1. Various vegetables, animals and mineral materials including herbs, grains, vegetables, fruits, food and drink were used for the dietary therapy. 2. Methods of the preparation for use as therapeutics were decoction, pulvis, gruel, medicinal wine, cake, tea, paste and gelatin and etc. 3. Frequently used materials were cuttle fish bone, Bletillae rhizoma, oyster shell, egg shell, sugar, aloe, licorice, lily, red jujube, and pig stomach. 4. Four properties of cold, warm, cool and hot were equal in frequencies. Most common tastes were sweet and bitter. Conclusion : Though dietary therapy for the gastric & duodenal ulcer is not based on clinical or experimental data, but through experience. It is mostly based on Yin-Yang and five elements, visceral manifestation, channels and their collateral channels and chinese herbal medicine theories. If we use them properly according to oriental medicine method, it will be effective on treating and preventing the gastric & duodenal ulcer.

• 한국식품영양과학회지
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• 제39권6호
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• pp.859-863
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• 2010

본 연구는 식용식물로의 가치뿐만 아니라 약용으로 가치가 인정되는 뽕잎에 미생물 생균제를 이용한 뽕잎발효차 개발을 통하여 기능성 소재 개발 및 새로운 제품개발의 방안을 제시하고자 뽕잎차 및 뽕잎발효차의 유효성분을 분석하고 제품의 품질특성을 비교분석 하였다. 총 폴리페놀 함량은 뽕잎발효차가 4,022.82 mg/100 g, 뽕잎차가 3,932.32 mg/100 g으로 두 시료의 함량은 비슷하였고 녹차 및 황차에 함유된 양과 비슷하여 총 폴리페놀 함량이 매우 높은 것으로 분석되었다. 비타민 C는 두 시료 모두 미량으로 분석되었다. 카페인의 함량은 뽕잎차가 5.68 mg/100 g, 뽕잎발효차가 21.11 mg/100 g으로 두 시료 모두 미량으로 분석되었다. 뽕잎차 및 뽕잎발효차의 품질특성을 비교한 결과 색도 측정 시 a(적색도)값은 시료 간에 차이가 미미하였고, b(황색도)값은 뽕잎차가 뽕잎발효차보다 높았으며, L(명도)값은 뽕잎발효차가 뽕잎차보다 낮았다. 관능검사를 실시한 결과 두 시료 모두 쓴맛과 떫은맛이 적었으며 뽕잎발효차가 구수한 맛과 종합적인 기호도가 향상되었다. 이러한 결과를 볼 때 발효를 통한 생리 활성 물질의 변화에 관한 좀 더 구체적인 연구가 필요하다고 판단되며 이러한 점을 보완하여 제품개발에 응용하고 대중적인 면을 좀 더 개선한다면 새로운 기능성소재 및 제품이 될 것이라 사료된다.

• 동의생리병리학회지
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• 제21권1호
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• pp.219-225
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• 2007

동의보감에 의하면 음식과 의 ${\cdot}$ 약은 그 근원이 같다고 보고 있으며 현대 영양학에서 다루는 열량과 5대 영양소의 개념 이외에 모든 식물(食物)을 기미론(氣味論)적 방법으로 그 성질과 효능을 규명하여 약이적 특징을 중요시하였다. 또한 최근에는 식품이 갖는 주요 기능 중 생리조절 기능이나 항상성 유지에 관여하는 기능 등에 대한 연구가 진행되면서 이러한 기능을 갖는 식품은 건강증진, 질병의 예방이나 노화억제 등 인간의 건강을 증진하는데 중요한 역할을 한다고 판단하여 이런 성분들을 많이 함유하고 있는 식물자원에 관한 연구가 활발하며 우리 나라에도 한약재를 포함한 생약을 이용한 연구가 진행되고 있다. 본 연구는 현대 식이병이 있을 때 일반 음식의 형태로 섭취하여 질병 치료에 도움을 주고 건강을 증진시킬 수 있는 한방식사요법인 약선식에 관한 연구로서 약선의 효과를 과학적이고 객관적인 수준에서 평가해보고자 계획, 수행하였다. 이에 본 연구자들은 한약자원을 이용하여 생체의 고지혈 상태를 포함한 관상심장계 질환을 예방할 수 있는 약선차를 고안하였다. 이에 따른 연구의 일환으로 한약재를 군신좌사론(君臣佐使論)에 준하여 혼합하여 차를 고안하였고 일반 영양성분 및 안전성을 평가하였다. 분석한 결과를 토대로 본 연구에서 고안한 약선차의 식품영양학적 접근을 시도하여 활용가능성을 타진하였다. 본 연구의 조성물을 활용하여 차 형태뿐 아니라 다양한 약선식으로의 활용도 가능하리라 판단되며 이 결과는 한약자원의 식품으로서의 활용방안 및 과학화의 기초자료가 될 수 있을 것이고 또한 전 세계적으로 관심이 큰 기능성 식품의 연구 및 시장동향에 동양의 medicinal herb를 이용한 기능성 식품의 소개에 기초자료가 될 수 있으리라 사료된다.며, 종속영양 원생동물 생물량의 80% 이상을 차지하였다. Protoperidinium spp.에 의해 우점하는 종속영양 유각와편모류는 첫 번째 대증식기에 가장 우점하였으며, Gyrodinium spp.로 구성된 종속영양 무각와편모류는 두 번째 대증식기에 가장 우점 하였다. 그외 Noctiluca scintilla는 첫 번째 대증식기에 식물플랑크톤 소멸에 중요한 역할을 하는 것으로 나타났다. 결과적으로 식물플랑크톤의 대증식기 동안에 종속영양 원생동물 군집은 식물플랑크톤의 생물량 및 군집구 조의 변화에 빠르게 반응하였으며, 이와 같은 결과는 두 군집 사이에 잠재적인 피식-포식자의 관계가 있음을 암시한다. 따라서 조사기간 동안 종속영양 원생동물은 식물플랑크톤 대증식의 소멸과 관련된 중요한 섭식자로서, 식물플랑크톤 군집을 조절하는데 중요한 역할을 하였을 것으로 사료된다.<0.05) 질소 소화율에서는 S1구가 처리구중에서 가장 높은 결과를 보였다(p<0.05). 분변 내 휘발성 지방산 발생량에서는 분을 1일간 발효 후 측정한 결과 S1구와 S2구가 CON구와 비교하여 유의적으로 높게 나타났다(p<0.05). 결론적으로, 비육돈 사료 내 3.32%의 호맥 사일리지의 혼합급여는 혈액 내 코티졸 함량, 도체육의 명도와 황색도, 지방산 조성 및 영양소 소화율에 영향을 미치는 것으로 사료되나 이에 대한 보다 많은 연구가 필요할 것으로 판단된다.니티와 공원과의 관계로 공원 설계와 관리에 있어서 영국에서는 커뮤니티가 직접 고객(client)으로서 역할을 하고 있었다. 한국에서도 계획 및 설계 과정에 주민을 참여시키는 경우가 있으나 의견청취 정도에 머물고 있고, 몇몇 시민단체를 중심으로 시민들이 직접 공원 관리에 참여하는 경우도 있으나 운동(movement)차원에 머물고

• 한국한의학연구원논문집
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• 제16권2호
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• pp.33-41
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• 2010

Patterns are symbolic expressions of life style or sentiment of people as a product of culture. Furthermore, it is a type of language that the shape or implication does not change much over time. Patterns shown on the Korean medical containers are related to human life and health that they are not very diverse and splendid but closed used in real life. The medical containers include the alcohol container or tea-ware in broad sense, but under this study, it would be handled only for the Korean medical containers directly used to protect human health and treatment of diseases. They would be the Medicine Mortar and Pestle that is used to grind the herbal medical ingredients, pots that hold the liquid decoction, containers to keep the medical ingredients in general conceptual use for medical purposes. The patterns inscribed are classified in animal pattern, plant pattern or alphabet pattern. Turtle, crane, ginseng, and life patterns have the contemplation to pray for long life without disease or good fortune, while plum pattern, dragon pattern and the like are used in the medical containers used mainly in royal families with the social status and dignity shown. As such, patterns have not only ornament elements but also the symbolic implication to represent long life without illness for human. It provides the basic data of medical wisdom contained in the pattern and willingness of human to protect life from illness. On the basis of such research, it would require ensuing studies to make comparison and analysis with the medical containers with the patterns in the adjacent countries in the days to come.

• 동의생리병리학회지
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• 제19권3호
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• pp.743-748
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• 2005

This study was performed for the investigation of vasodilatory efficacy and its underlying mechanisms of Jagumhuan(JGH), a herbal remedy. JGH produced completely endothelium-dependent relaxation and relaxed phenylephrine(PE)-precontracted aorta in a concentration dependent manner. The magnitude of relaxation was greater in PE induced contraction than that of KCl, suggesting involvement of $K^+$ channel in the relaxant effect. Both glibenclamide$(10^{-5}M)$, a $K_{ATP}$ channel inhibitor and indometacin, a cyclooxygenase inhibitor, completely prevented this relaxation. The relaxation effects of JGH, involve in part the release of nitric oxide from the endothelium as pretreatment with L-NAME, an NOS inhibitor, and methylene blue, a cGMP inhibitor, attenuated the responses by 62% and 58%, respectively. In addition, nitrite was produced by JGH in human aortic smooth muscle cells and human umbilical vein endothelial cells. The relaxant effect of JGH was also inhibited by 55.41% by tetraethylammonium(TEA; 5mM), a $K_{Ca}$ channel inhibitor. In the absence of extracellular $Ca^{2+}$, pre-incubation of the aortic rings with JGH significantly reduced the contraction by PE, suggesting that the relaxant action of the JGH includes inhibition of $Ca^{2+}$ release from intracellular stores. These results indicate that in rat thoracic aorta, JGH may induce vasodilation through ATP sensitive $K^+$ channel activation by prostacyclin production. However, the relaxant effect of JGH may also mediated in part by NO pathways and $Ca^{2+}$ activated $K^+$ channel.

• 한국식품영양과학회지
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• 제39권3호
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• pp.421-427
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• 2010

본 연구는 식용식물로의 가치뿐만 아니라 약용으로 가치가 인정되는 뽕잎에 미생물 생균제를 이용한 뽕잎발효차 개발을 통하여 기능성 소재 개발 및 새로운 제품 개발의 방안을 제시하고자 뽕잎차 및 뽕잎발효차의 일부 성분을 분석하였다. 두 시료간의 일반성분 중에서 지방 함량이 뽕잎발효차가 더 높았고, 탄수화물의 함량은 뽕잎차가 더 높았다. 유리당을 분석한 결과 뽕잎발효차가 뽕잎차에 비해 전체 유리당 함량이 줄어들었으며, 특히 뽕잎차에서는 maltose 함량이 가장 높았으나 뽕잎발효차의 경우 maltose가 분석되지 않았고 lactose가 소량 분석되었다. 총 유리아미노산 함량은 뽕잎차가 뽕잎발효차보다 높았으며 뽕잎차에서는 glutamic acid, 뽕잎발효차에서는 cystine의 함량이 가장 많았다. 아미노산 유도체에서는 $\gamma$-aminobutyric acid(GABA) 성분 함량이 가장 높았으며 각 시료 간 함량은 비슷하였다. 지방산의 조성에서는 뽕잎발효차가 뽕잎차에 비해 불포화 지방산이 다소 감소하는 경향을 나타내었다. 따라서 본 연구의 결과를 종합해 보면 식용식물로서 뿐만 아니라 약용으로도 가치가 있는 뽕잎에 생균제를 이용하여 개발한 뽕잎발효차를 뽕잎차와 비교하였을 때 뽕잎발효차에서 유리당과 유리아미노산의 함량이 감소하는 경향을 나타내었으나 그 유용성분 및 특이성분의 함량은 충분히 유지되고 있었다.

• 한국조리학회지
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• 제24권3호
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• pp.196-203
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• 2018

This study was examined the quality characteristics of dough liquid according to the additional ratio of Doraji in seaweed snack manufacturing. Firstly, the results of Doraji type (dry & powder) were as follows: Carbohydrates 77.57~79.29, crude protein 9.10-9.25, crude fat 0.96~1.33 and calories 355~366 kcal, pH 5.42~5.45, sugar $3.53{\sim}3.96^{\circ}brix$, color 33.82~44.25 (L), 2.27~3.52 (B) and total free amino acids 2,200~2,699 mg/100 g. Total polyphenol contents had dry extracts 1,931.18 mg% and powder extract 1,382.43 mg%, DPPH and ABTs radical scavenging activities tended to increase with higher treatment concentration. Next, the results showed that dough liquid for seaweed snack manufacture which was added Doraji were as follows: Color became deep poppy red with increased addition of Doraji. The texture of adhesiveness, cohesiveness, chewiness, and brittleness tended to decrease with addition of Doraji. The springness showed the opposite tendency. Accordingly, these results suggest that 20% of dry Doraji extract is a proper proportion so that it can be added to the rice dough liquid to produce form Doraji (dry and powder) containing seaweed snacks.

• 대한한방내과학회지
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• 제45권1호
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• pp.55-74
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• 2024

Objectives: This study reviewed the status of adverse event (AE) reporting in VigiAccess using anti-obesity agents as examples and explored the possibility of its use and future challenges. Methods: AE reports related to some representative drugs among herbal medicines (HMs), complex HM prescriptions, ingredients of supplements, and over-the-counter and prescription medicines were investigated using VigiAccess on February 1, 2024. Results: AE reports on prescription drugs were overwhelmingly higher than those on HMs or supplements. Although most reports were submitted from North America, reports on Ephedra sinica and green tea extract (GTE) were more from Asia and Europe, respectively. The female population reported more, and the difference in the sex ratio was the smallest for Ephedra spp. The age group was concentrated on young adults, but many older patients reported GLP-1 receptor agonist-related AEs. Symptoms related to the gastrointestinal and nervous systems were most commonly reported, but mental and cardiac disorders were common in Ephedra-type HMs. Hepatobiliary disorders are also commonly found in GTE-related reports. Conclusions: VigiAccess was useful for easily checking the global status of AE reporting for prescription drugs. However, several limitations were observed in using VigiAccess for HMs because of the few reports. Thus, it is necessary to increase the number of reports by education and to promote AE reporting among HM prescribers and users. The full range of HMs should be included in the pharmacovigilance system, and the coding and classification of HMs should be revised.

• 한방재활의학과학회지
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• 제25권1호
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• pp.63-70
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• 2015

Objectives The purpose of this study is to understand the research trend of reports on forest therapy so far and analyze the Korean medicine therapy being applied in forest therapy programs. Methods We ran a keyword search on domestic databases with the following keyword 'forest therapy, forest healing, forest treatment, recreational forest, forest bath, forest experience'. The search took place in December 2014 and there was no limit to search time. A total of 334 forest therapy articles have been selected. Results The number of research on forest therapy continued to rise from 1985, with 334 articles being published from 84 journals. When those 188 articles were sorted by their contents and methods, except 146 articles of survey on simple satisfaction, recognition and visting, 94 were clinical studies, 79 were literature studies, 15 were experimental studies. Of the 94 clinical researches, there were 52 CCTs (Controled Clinical Trials), 39 ODs (efficacy studies with either a controlled or an Other than controlled Design) and 3 RCTs (Randomized Clinical Trials). Among the clinical researches, there were a total of 21 studies that used Korean Medicine programs, and meditation was the most popular, being used in 18 studies. Herbal food and tea therapy and Qigong were used in 3 studies each, and Korean medicine music programs were used in 2 studies. Conclusions A systematic and standardized Korean medicine forest therapy program must be developed, and based on the program, more research treating diseases should be conducted.

• 한국조리학회지
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• 제23권5호
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• pp.25-33
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• 2017

This study was to investigate the effects of enzyme on quality characteristics and antioxidant activities of wild peach (Prunus persica L.) juice. pH levels and S.S (soluble solid) values in all samples ranged from 3.86 to 4.13 and from 48.0 to $55.0^{\circ}Brix$, respectively. The TA (total acidity) values of control (not treatment enzyme) were higher than those of the others. The highest 'L', 'a' and 'b' values were observed on PWP (preserved wild peach (Prunus persica L.) juice of cellulase/pectinase (1:1, w/w) sample. Glucose (26.65 g/100 g) and fructose (17.42 g/100 g) in PWP product were determined, however sucrose and maltose were not detected. The predominating organic acid components analyzed in PWP sample were tartaric (32.36 g/100 g) and lactc acids (209.34 g/100 g), whereas citric acid, acetic acid and malic acid were not detected. Higher scores for taste, flavor, color and overall acceptance were found for PWP products compared to other samples. The total phenolic content (13.31 mg GAE/mg dry weight) analyzed using Folin-Ciocalteu's reagent, of PWP sample was higher than those of the others and the total flavonoid concentrations were also 10.95 mg CE/mg dry weight. The DPPH radical scavenging and ABTS radical scavenging activities in all samples ranged from 55.16 to 74.29% and from 39.59 to 82.79%, respectively. The antioxidant activities were affected by addition of enzyme. These results indicate that the use of the mixture of cellulase and pectinase could increase the quality, and antioxidant potentials of sugar preserved wild peach (Prunus persica L.) juice by enzymatic treatment.