• Herbal Formula Science
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• v.16 no.2
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• pp.11-29
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• 2008

Objective : The aim of this study was to analyse the latest trend of medical science articles about Bojungikki-Tang published in Japan. Methods : We searched medical science articles published from 2003 to 2008 in Japan on the web site, CiNii and then these articles were reviewed and classified according to experimental subject and method. Results : Fifty-two articles, related to Bojungikki-Tang were searched and these were classified into three classes, pharmacological signaling studies, clinical case studies and the others. As a result of classification, clinical case studies were most abundant by 38 cases, pharmacological signaling studies were 10 and the others were 4. This result suggested that the study of Bojungikki-Tang was mainly focused on clinical study rather than experimental study. Among the clinical case studies, clinical studies related to immune disease took the most greatest number and number of other clinical studies were evenly distributed over the various disease. Immune intensification effect of Bojungikki-Tang can be thought continuous with reinforce the middle Jiao Qi in company with improvement effect on growth hormone failure and male infertility. A fact that the one prescription, Bojungikki-Tang could be used to treat various diseases reflects a viewpoint of Oriental medicine that is based on the respect for and understanding of individual constitution and disposition while paying attention to the gender difference and individuality. The clinical usefulness of Bojungikki-Tang on obstructive sleep apnea syndrome and visceroptosis concerns with ascend Yang and treat Qi sinking. Pharmacological signaling studies were mainly focused on diseases that were treated Bojungikki-Tang in clinic, however, there was one study that experimented on changes of numerous gene expression according to the treatment of Bojungikki-Tang using DNA array. Conclusion : The therapeutic system of Oriental medicine is different in various aspects form that of Western medicine and appropriate harmonization of east and west is expected to improve the quality of medical care. In this regard, continuous investigation and analysis about herbal medical science papers in Japan can also be useful to make progress in Korean traditional medicine.

• Journal of Sasang Constitutional Medicine
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• v.14 no.2
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• pp.69-77
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• 2002

Purpose: Atopic dermatitis, which is one the prevalent allergic diseases in toddlers and adolescent population, has not been treated with Sasang Constitutional Medicine due to the limitation of constitution differentiation in children. This study was aimed to examine the effect of treatment for atopic dermatitis with Sasang Constitutional Medicine. Method: Forty-three patients over age 3 who were diagnosed with atopic dermatitis by the criteria of Hanifin and Rajka were participated in this study from August, 2001 thru May, 2002 at the Pohang Oriental Medicine Hospital, Kyungsan University. Result: 1. Soyangin showed the highest proportion of 79% of the sample. 2. The symptom of the disease by patients' constitution according to the degree of affected skin and itching was severe in Soyangin, and mild in Soeumin 3. For treatment 9 kinds of prescription regimen were given; Yangkyuksanhwatang was mostly used for Soyangin followed by Hyungbangsabaksan. Hayngsayangwetang and Galgunhaegitang were prescribed for Soeumin and Taeumin, respectively. 4. The treatment effect was found in 84% (n=36) of the patients markedly. Six out of seven who showed no progress were Soyangin. Conclusion: The treatment based on the constitution differentiation and prescription of the Sasang Constitutional Medicine was effective for the symptom alleviation in a short term period in atopic dermatitis. Further clinical study is needed to prove the effect of Sasang Constitutional Medicine in a larger sample and various diseases.

• Journal of the Korean Institute of Oriental Medical Informatics
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• v.16 no.2
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• pp.89-161
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• 2010

"Byun Jeung Rok(辨證錄)" is composed of 14 volumes. In relation to the contents, it is organized into 126 gates(門) and 700 remaining syndromes(餘證) where internal medicine, external medicine, pediatrics, gynecology(內科 外科 小兒 婦人), etc. are divided into sub-sections of cold damage, cold stroke, wind stroke(傷寒 中寒 中風), etc. For every syndrome, the symptom, cause of disease, method of treatment, prescription, construction of prescription, instruction of medicine and prognosis.(症狀 病因 治法 處方 處方構成 服用法 預後) were explained thoroughly. This study, as an inquiry of the second volume, deals with wind stroke(中風), impediment disease(痹證), heart pain(心痛), side pain(脇痛), headache(頭痛), abdominal pain(腹痛), lumbago(腰痛) It was written very logically so it is easy to understand. The analysis of the symptoms are brief and appropriate. Also, in the usage of the medicine, the sovereign, minister, assistant and courier(君臣佐使) method was used as the basis for the prescriptions. Therefore, it is considered to have significant clinical value for future generations and is thus being applied by them.

• Korean Journal of Oriental Medicine
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• v.13 no.2 s.20
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• pp.143-148
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• 2007

The present study examined inhibitory effects of 20 efficient experience prescriptions on platelet aggregation induced by collagen in human whole blood using the impedance method of aggregometry. Among them, a hot water extract of KIOM 2003-080 was selected to be the most effective candidate. In an in vivo study using a mouse acute thrombosis model, the anti-thrombotic effects of the KIOM2003-080 crude extract were also observed. In addition, we accessed bio-marker of platelet activation using thromboxane B2 by ELISA assay. A significantly decrease in thromboxane B2 production was seen in the presence of KIOM2003-080. Consequently, the results from this experiment provide pharmacological evidence for the traditional use of KIOM2003-080 prescription, suggesting that its hot water extracts could be used to prevent platelet aggregation and thrombosis disease.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.1
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• pp.28-32
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• 2007

Cisplatin, an antitumor agent widely used in the treatment of cancers, has nephrotoxicity. This side effect is closely related to oxidative stress. In the present study, we studied to protective effect of ethanol extract of Bojungbangam-tang (EBJT) on cisplatin-induced nephrotoxicity. Bojungbangam-tang is a new herbal prescription composed of nine crude drugs. Pretreatment of EBJT prevented cisplatin-induced cytotoxicity and generation of ROS. Also, cellular GSH content and gluathione peroxidase activity were recovered by EBJT. EBJT also decreased cisplatin-induced expression of HO-1 via inhibition of ERK activation. Taken together, these results suggest that EBJT has a cytoprotective effect against cisplatin-induced nephrotoxicity through anti-oxidant activity.

• Korean Journal of Oriental Medicine
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• v.14 no.1
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• pp.59-66
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• 2008

We referred to twenty-two Korean medicinal literatures for application of a single-medicine prescription using Asparagi Tuber(Asparagus cochinchinensis) to form the groundwork for scientific modernization of Korean medicine. Our study revealed the following. 1. Principle expectant effects of Asparagi Tuber were prolong life; elevation of stamina or activity; improvement of asthenia; remedy of epilepsy, mental disease or convulsions; relief of xerosis; treatment of tumor, abscess or intumescence; extermination of endoparasite; solution of numbness, etc. 2. The records show that 95% of directions are per oral. 3. 38% of the cases, Asparagi Tuber was used without its jacket or core. 4. Alcohol and honey were generally used as solvent and additive. We suggest to perform the further studies for the scientific verification of the expectant effects of Asparagi Tuber and its different efficacy by processing, solvent and additives.

• Journal of Haehwa Medicine
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• v.16 no.2
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• pp.217-223
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• 2007

Over the period between October 2005 and February 2007, herbal medicine was administered to the patients coming to Dr. Cha Oriental Medical Clinic. As regards the prescription administered to children patients for treating their growth deficiency, Eukmigihwang-tang related to the kidney, the congenital factor, Bojungikgi-tang related to the spleen, the acquired factor. So I administered Eukmigihwang-tang plus Bojungikgi-tang(a union of both herb-remedy: Eukmigihwang-tang and Bojungikgi-tang) The results were obtained as follows. 1. The youngest is six years old, the oldest is thirteen years old. 2. A ratio of male and female children was same. 3. It was shown to be a greater increase than the average value of growth surveyed by the National Statistical Office. 4. It is considered that EukmigihwangtangHapBojungikgitang is effective on child growth.

• The Journal of Traditional Korean Medicine
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• v.15 no.1
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• pp.70-76
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• 2006

The aim of this study was to investigate the effect of ethanol extract of Fagopyrum escuentum(FE) on the melanogenesis. To determine whether ethanol extract of FE suppress melanin synthesis in cellular level, B16F10 melanoma cells were cultured in the presence of different concentrations of FE ethanol extract. In the present study, the author examined the effects of FE ethanol extract on cell proliferation, melanin contents, tyrosinase activity. Cell proliferation was slightly increased by treatment with ethanol extract of FE (25-200 ${\mu}$g/ml). The ethanol extract of FE effectively suppressed melanin contents at a dose of 100 ${\mu}$g/ml. It was observed that the color of cell pellets was totally whitened compared with the control. The ethanol extract of FE inhibited tyrosinase activity, regulate melanin biosynthesis as the key enzyme in melanogenesis. These results suggest that the ethanol extract of FE exerts its depigmenting effects through the suppression of tyrosinase activity. And it may be a potent depigmetation agent in hyperpigmentation condition.

• Journal of Korean Medical classics
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• v.25 no.3
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• pp.1-11
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• 2012

Objective : I will study about similarities and differences of furunculus section between Sonjininchungeumbang and Bigeupchungeumyobang. Method : I compare furunculus section of Sonjininchungeumbang with Bigeupchungeumyobang to investigate changes of texts. Result : I can find significant differences of furunculus section between Sonjininchungeumbang and Bigeupchungeumyobang, specially the 3rd prescription of Balbae(發背方第三), the 6th prescription of Pyojeo(瘭疽方第六). Conclusion : Sonjininchungeumbang is a prescription book which is compiled in Dang dynasty. And Bigeupchungeumyobangis is a revised version of Sonjininchungeumbang which is compiled by the Bureau for Revising Medical Texts(校正醫書局) in Song dynsasty. Bigeupchungeumyobangis shows the added medical knowledge about furunculus in Song dynsasty.

• The Journal of Internal Korean Medicine
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• v.18 no.1
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• pp.86-96
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• 1997

We examined clinical and reseach data about abdominal palpation conducted in japanese oriental medicine from the early stages of its medical history to the latest research, so as to introduce it into korean oriental medicine. That is to say, we studied clinical significance and suitable oriental medicine prescription about following : sweat and moistness of abdominal skin ; temperature of abdominal skin ; palpation and visible peristaltic movement ; meteorism ; tonus of the whole rectus abdominis muscle ; local tonus of parts rectus abdominis muscle ; palpitation of abdominal aorta ; resistance tender on pressure in epigastric region, subcostal region, umbilical region, lower abdomen, para-umbilical region, cecal region, sigmoid region and inguinal region ; sound of fluctuating liquid in the epigastric region. The result was that abdominal palpation was an immediately applicable method of clinical diagnosis in oriental medicine, and is being proven by western medicine methodology today. Therefore we suggest that korean oriental medicine would advance greatly if abdominal palpation were applied.