Korean Journal of Oriental Medicine (한국한의학연구원논문집)
- Volume 13 Issue 2 Serial No. 20
- /
- Pages.143-148
- /
- 2007
- /
- 1229-3377(pISSN)
Study on Anti-thrombotic Activities of KIOM2003-080
KIOM2003-080 처방에 대한 항혈전 효능 연구
-
Jeon, Won-Kyung
(Korea Institute of Oriental Medicine)
;
-
Kim, Ho-Kyoung
(Korea Institute of Oriental Medicine)
;
- Lee, Ju-Hyun (Korea Institute of Oriental Medicine) ;
-
Ko, Byoung-Seob
(Korea Institute of Oriental Medicine)
;
-
Lee, A-Yeong
(Korea Institute of Oriental Medicine)
;
- Lee, Kyung-Goo (Korea Institute of Oriental Medicine) ;
-
Shin, Hyeun-Kyoo
(Korea Institute of Oriental Medicine)
-
전원경
(한국한의학연구원)
;
-
김호경
(한국한의학연구원)
;
- 이주현 (한국한의학연구원) ;
-
고병섭
(한국한의학연구원)
;
-
이아영
(한국한의학연구원)
;
- 이경구 (한국한의학연구원) ;
-
신현규
(한국한의학연구원)
- Published : 2007.08.30
Abstract
The present study examined inhibitory effects of 20 efficient experience prescriptions on platelet aggregation induced by collagen in human whole blood using the impedance method of aggregometry. Among them, a hot water extract of KIOM 2003-080 was selected to be the most effective candidate. In an in vivo study using a mouse acute thrombosis model, the anti-thrombotic effects of the KIOM2003-080 crude extract were also observed. In addition, we accessed bio-marker of platelet activation using thromboxane B2 by ELISA assay. A significantly decrease in thromboxane B2 production was seen in the presence of KIOM2003-080. Consequently, the results from this experiment provide pharmacological evidence for the traditional use of KIOM2003-080 prescription, suggesting that its hot water extracts could be used to prevent platelet aggregation and thrombosis disease.