• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제38권2호
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• pp.121-126
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• 2012

Aberrations on the short arm of chromosome 8 (8p) are frequently observed in several human cancers. In this study, 20 squamous cell carcinoma (SCC) specimens from the tongue were examined in order to evaluate the role of 8p in SCC of the tongue. Microsatellite analysis using 14 markers demonstrated two commonly deleted regions (CDRs) on 8p. Reverse transcription-polymerase chain reaction (RT-PCR) revealed frequent down-regulation of the FEZ1 gene, mapped to 8p22, and frequent over-expression of the cathepsin B gene, mapped to 8p-21-22. These results suggested that genetic aberrations are involved in the development of SCC of the tongue. However, no significant relationship was observed to be established between the genetic alterations and clinicopathological features. Thus, further investigation is necessary in order to clarify the clinical role of 8p in carcinoma of the tongue.

• 한국치위생학회지
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• 제21권1호
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• pp.5-16
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• 2021

Objectives: To evaluate the impact of an oral exercise program including whole-body exercises on oral function in older people. Methods: The participants (aged ≥65 years) were divided into three groups: intervention group I (only oral exercise), intervention group II (oral exercise with whole-body exercises), and control group (no intervention). The oral health status, saliva flow rate, and oral muscle strength were evaluated. Analyses were performed to compare the three groups and identify the changes in the aforementioned parameters before and after the program. Results: The saliva flow rate significantly increased in intervention groups I and II after the program. Oral muscle strength evaluation using the Iow a oral performance instrument showed that the anterior tongue strength increased significantly in intervention group I; the posterior tongue strength and cheek strength also increased but not significantly. The anterior tongue, posterior tongue, and cheek strengths significantly increased in intervention group II. Conclusions: The oral exercise program including whole-body exercises showed positive effects on the saliva flow rate and oral strength. No significant differences were observed in the quality of life related to oral health.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제29권5호
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• pp.315-322
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• 2003

Background : Important factors to determine treatment method and prognosis of oral cancer are anatomical site, tumor size, metastatic lesion, histologic cell differenciation and microvascular invasion. Anatomical site has great effect to oral cancer patient's survival rate because each site's accessibility and lymph node metastasis is different but this factor was't studied much than other factors. Patients and Methods : 228 patients with squamous cell carcinoma of common primary sites(Mandible, Maxilla, Floor of Mouth and Tongue) in oral cavity who were diagnosed in the Korea Cancer Center Hospital from January 1989 to December 1999, were clinically studied and analyzed on survival rate. Results : 1. Survival rates of each anatomical sites were Tongue(36.8%), Mandible(33.3%), Maxilla(28.7%) and Floor of Mouth(24.5%). Survival rates difference between Tongue and Floor of Mouth has significance(p<0.05). 2. Survival rates for early cancer of each site were Maxilla(100%), Mandible(57.1%), Tongue(54.2%) and Floor of Mouth(46.7%). Survival rates difference between Maxilla and Floor of Mouth has significance(p<0.05). 3. Survival rates by surgery method of each site were Maxilla(60.6%), Tongue(56.9%), Mandible(44.8%) and Floor of Mouth(26.3%). Survival rates difference between Maxilla and Floor of Mouth has significance(p<0.05). 4. Survival rates by radiation or chemo method of each site were Floor of Mouth(23.5%), Mandible(20.0%), Maxilla(9.5%), and Tongue(9.1%). Survival rates difference between each site doesn't have significance(p>0.05). 5. In advance stage, Survival rates by single therapy of each site were Tongue(33.6%), Mandible(23.5%), Floor of Mouth(16.7%), Maxilla(0%), and Survival rates difference between Maxilla and Tongue has significance (p<0.05). Survival rates by combination therapy of each site were Mandible(38.1%), Maxilla(30.0%), Floor of mouth(18.2%), Tongue(12.5%), and Survival rates difference between Mandible and Tongue has significance(p<0.05). Conclusion : Survival rate of tongue is higher than the other sites, early detection of oral cancer can increase survival rate at any site and combination therapy is the most effetive method, especially at maxilla.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제26권2호
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• pp.164-171
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• 2000

Purpose : This study was aimed at measuring the changes in the hyoid bone position, tongue position, and pharyngeal airway space in subjects with mandibular setback osteotomies. Methods : Twenty patients were evaluated retrospectively for their changes in pharyngeal airway space, tongue and hyoid bone positions. All patients underwent surgical mandibular setback using bilateral sagittal split osteotomies. The cephalometric analysis was performed preoperatively, and 1 week, 3-6 months, and 1 year postoperatively. Result : The hyoid bone moved inferiorly and posteriorly immediately after surgery, and it returned to the preoperative position during follow-up period. The nasopharyngeal airway space was not significantly changed after surgery. A considerable decrease in the oropharyngeal and hypopharyngeal airway spaces following mandibular setback surgery was found. The upper and lower tongue was posteriorly repositioned immediately after surgery. During follow-up period, the hypopharyngeal airway space and lower tongue posture returned to the preoperative positions, but the oropharyngeal airway space and upper tongue posture were not significantly changed. The position of pogonion remarkably changed to backward immediately after surgery, but slightly anterior advancement was found during follow-up period. Conclusion : Immediately after mandibular setback surgery, the oropharyngeal and hypopharyngeal airway spaces obviously decreased due to posterior and inferior repositions of the tongue and hyoid bone. During follow-up period, lower tongue and hyoid bone returned to the preoperative positions, it was related to advancement of the pogonion in this period. The narrowing of the oropharyngeal airway space and posterior movement of the upper tongue posture were relatively permanent after mandibular setback surgery. We suspected this phenomenon had an influence on maintaining the total volume of oral cavity against mandibular setback.

• Journal of Oral Medicine and Pain
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• 제39권1호
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• pp.15-21
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• 2014

Purpose: The purpose of this study was to investigate the relationship between personality type and oral hygiene controllability. Methods: Four hundred eighty-two college students in Gyeonggi-do completed the Myers-Briggs type indicator (MBTI) and a questionnaire and collected data were analyzed by SAS 9.2 program. Results: Compared to extroverted subjects, a significantly increased percentage of introverted subjects demonstrated oral malodor and stress (p<0.05). Tongue coating and stress seemed to occur the most frequently in intuition-feeling (NF) type, while oral malodor seemed to occur the most frequently in sensation-feeling (SF) type among four fuctional types. Tongue coating and stress seemed to occur the most frequently in NF type, while oral malodor seemed to occur the most frequently in sensation-perceiving (SP) type among four temperaments. Significantly increased mean scales of tongue scraping index and oral hygiene controllability index were found for extroverts (p<0.05). Mean scales of tooth brushing index and oral hygiene controllability index appeared to be the highest in NF type among four fuctional types. Mean scales of tongue scraping index and oral hygiene controllability index appeared to be the highest in sensation-judging (SJ) type among four temperaments. Conclusions: Oral hygiene controllability was associated with personality type and it is necessary to develop oral health education program considering personality type.

• 한국콘텐츠학회논문지
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• 제17권11호
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• pp.156-166
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• 2017

본 연구는 만성 뇌졸중 환자들을 대상으로, 혀의 객관적인 수치로 측정할 수 있는 기계(Iowa Oral Performance Instrument, IOPI)를 사용하여 혀의 최대 저항 훈련프로그램을 수정하고, 혀 정확도 훈련을 추가한 프로그램을 적용하여 혀 근력과 구어기능에 미치는 효과를 비교하고자 실시하였다. 뇌졸중으로 진단받은 입원 및 외래환자를 각각 20명씩 실험군인 혀 저항정확도훈련 치료군과 대조군인 구강안면운동 치료군으로 나누어 각 치료를 대상자들에게 총 4주간 30분씩, 주 5회 실시하였고, 혀 근력과 구어기능 능력을 변화를 알아보기 위해 중재 전, 후에 혀 전방거상 압력(Anterior Tongue Pressure; ATP), 혀 후방거상 압력(Posterior Tongue Pressure; PTP), 최대발성시간(Maximum Phonation Time; MPT)을 측정하였다. 본 연구의 결과 중재 전 후 혀 저항정확도훈련 치료군과 구강안면운동 치료군의 혀 근력과 구어기능은 유의하게 향상하였으나, 두 군 사이의 비교에서 혀 저항정확도훈련 치료군과 구강안면운동 치료군 간의 혀 근력과 구어기능의 변화량은 유의한 차이가 없었다. 따라서 혀 저항정확도훈련이 기존 구강안면운동 치료보다 혀 근력 및 구어기능 향상에 효과적이지는 않은 것으로 나타났다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제17권1호
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• pp.73-81
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• 1995

The poor survival rates of patients with carcinoma of a tongue, despite of modern therapy, is well recognized. One of the most important prognostic factors is status of the cervical lymph nodes. There have been a long-standing debate about the treatment of cervical lymph nodes in early-stage tongue cancer. There are two major treatment opinion. The one is surgical excision of primary tumor with prophylactic neck dissection, simultaneously, and the other is to delay the cervical therapy until cervical lymph node is palpable. Recently we have experienced the early cervical metastasis in three patients who had been diagnosed as a carcinoma of the tongue. They were T1, T2 lesion and no palpable node was found. But histopathologic examination showed the occult metastasis or delayed cervical metastasis was occured. By the review of literature and clinical experience, we could conclude the prophylactic neck dissection offers a better chance for success than therapeutic neck dissection of palpable lymph nodes, in case of oral tongue cancer.

• Journal of Oral Medicine and Pain
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• 제36권2호
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• pp.123-130
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• 2011

이갈이나 이악물기 등과 같은 비정상적인 구강기능장애의 주된 임상 소견으로 흔히 관찰되는 설 함요가 긴장성 두통의 통증양상에 어떠한 영향을 미치는가를 관찰하고자 국제두통학회의 진단기준에 부합되는 긴장성 두통이 있는 환자 중 설함요가 있는 65명을 실험군으로 하고, 설 함요가 없는 환자 65명을 대조군으로 하여 통증의 질과 강도, 양측성 유무 그리고 일상생활에서의 증감 유무 등을 관찰하고 통계 처리하여 다음과 같은 결과를 얻었다. 1. 긴장성 두통환자의 통증의 질은 설 함요의 유무에 따라서 통계학적인 차이가 있었다(p=0.049). 2. 긴장성 두통환자의 통증의 강도는 설 함요의 유무에 따라서 통계학적인 차이가 있었다(p=0.010). 3. 긴장성 두통환자의 통증의 양측성 유무는 설 함요의 유무에 따라서 통계학적인 차이가 없었다. 4. 긴장성 두통환자의 통증의 일상생활에서의 증감 유무는 설 함요의 유무에 따라서 통계학적인 차이가 없었다. 이상의 결과로 설 함요가 있는 긴장성 두통 환자는 설 함요가 없는 긴장성 두통 환자에 비해서 통증의 예통과 심도통이 더 심하기 때문에 임상적으로 진료에 임 할 때 고려해야 하며, 이에 따른 추가적이고 지속적인 연구가 필요하리라고 생각된다.

• Journal of Oral Medicine and Pain
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• 제38권2호
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• pp.97-101
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• 2013

모설(hairy tongue)은 혀의 사상유두(filiform papillae)가 과도하게 신장되어 발생하는 질환이다. 임상적으로 혀의 배면후방 1/3 부위에 주로 발생하며, 혀의 측면과 첨부에 생기는 경우는 드물다. 섭취하는 음식물과 색소유발 박테리아 등에 따라 백색에서 갈색, 검은색까지 다양한 색의 착색을 보인다. 대부분 증상이 없지만, 환자들은 주로 심미적인 문제로 병원을 찾으며, 드물게 오심, 구취, 미각이상, 불쾌한 느낌 등을 유발할 수 있다. 정확한 병인은 알려져 있지 않지만, 구강위생 관리 소홀, 구강 내 세균총의 변화, 감염, 방사선치료, 항생제, 면역 억제제 등의 사용, 과도한 음주, 흡연, 타액분비 감소 등이 소인으로 작용할 수 있다. 임상 소견이 매우 전형적이므로 육안으로도 진단이 충분히 가능하며, 생검은 필요하지 않다. 모설의 치료는 기본적인 유발요인들을 찾아서 제거해 주며, tongue cleaner 등을 이용해 혀를 부드럽게 닦아주도록 교육하고, 일부 경우에 있어서는 keratolytic agent를 사용하기도 한다. 모설 치료에 외과적 술식을 사용하는 경우는 드물지만, 유발 요인 제거 등의 다양한 치료법을 적용하였음에도 불구하고 장기간 호전이 없는 모설 환자에서, 이산화탄소 레이저(Carbondioxide laser, $CO_2$ laser)를 적용하여 효과적으로 치료한 증례를 보고하고자 한다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권9호
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• pp.5061-5065
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• 2013

Background: Oral tongue squamous cell carcinoma (OTSCC) is the most common cancer diagnosed within the oral cavity worldwide. Many studies in India report OTSCC ranking among the top two most common subsites within the oral cavity. India is often labeled the oral cancer capital of the world. The incidence of tongue cancers in the population-based cancer registry (PBCR) of Chennai is showing an increasing trend. A majority of the oral cavity cancers (85%) in our cancer center present in advanced stages (III and IV). In contrast, early tongue cancers (stages I and II) constitute nearly 45% of all OTSCCs. Aim: The aim of this study was to analyze the clinical profile and epidemiological trends in our early stage tongue cancer patients with an emphasis on tobacco and alcohol habits. Materials and Methods: This retrospective analysis was based on a prospectively collected database of 458 consecutive early stage OTSCC in-patients at a tertiary care oncology centre in Chennai between 1995 and 2008. Results: Our study suggests that the earlier trends have clearly changed whereby nearly half of our patients are now never-tobacco users. The findings of the study indicate that a majority of the patients were never alcohol users (86.4%) and nearly half of them were never tobacco users (49.3%), and they had the best survival outcomes. This increasing trend of OTSCC among non-tobacco users is in contrast to our earlier experience of tongue cancer more than five decades ago.The median age of patients in our study was 53.3 years; the male to female ratio was approximately 2:1. The median follow up for the 458 patients was 53 months. Conclusions: Our study importantly as well as interestingly shows a conspicuous absence of association with the traditional risk factors, tobacco and alcohol.