• Journal of Oral Medicine and Pain
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• 제21권1호
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• pp.123-131
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• 1996

Bacteremia occurs in a wide variety of clinical procedures in oral cavity. Reduction of the number of causative microorganisms of infective endocarditis in oral cavity by local administration of antimicrobial agents decreases the magnitude of bacteremia and possibility of infective endocarditis. The effects of chlorhexidine on Streptococcus sanguis, Streptococcus mitis, Streptococcus mutans, Streptococcus oralis, Streptococcus gordonii, Staphylococcus aureus, and Staphylococcus epidermis were investigated by measurement of turbidity. The effects of 0.1% chlorhexidine gargling for 7 days on oral bacterial flora, total streptococci, S. mutans, S. aureus, and S. epidermis in whole saliv a of 7 healthy human subjects, were investigated by measurement of Colony Forming Units (CFU). The obtained results were as follows : 1. Chlorhexidine showed significant antimicrobial effects on Streptococcus snaguis, Streptococcus mitis, Streptococcus mutans, Streptococcus oralis, Streptococcus gordonii, Staphylococcus aureus, and Staphylococcus epidermis. However, the effects on S. sanguis and S. gordonii were not apparent compared with other microorganisms. 2. Oral gargling of 0.1% chlorhexidine decreased the CFU values of normal oral bacterial flora, total streptococci, S. mutans, S. aureus, and S. epidermis in whole saliva. The antimicrobial effects were significant after 4 days of chlorhexidine gargling. 3. Local antimicrobial administration in addition to systemic antibiotic prophylaxis can be highly recommended as an effective adjunct regimen for prevention of infective endocarditis.

• Journal of Oral Medicine and Pain
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• 제34권4호
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• pp.353-362
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• 2009

본 연구는 편백 피톤치드에 의해 사멸되지 않는 구강 상주균을 분리하고, 이 분리된 세균이 구강 병인균에 대하여 어떠한 영향을 미치는지를 관찰함으로써 편백 피톤치드에 구강 내 세균에 대한 지속적인 이차적 효과를 구명한 실험적 연구이다. 이에 건강한 사람의 타액에 1% 피톤치드를 첨가하여 최종적으로 생존해 있는 200개의 구강 상주균을 확인하여 이를 분석한 후 이들이 치주질환과 입냄새의 중요한 원인균인 F. nucleatum에 대한 억제효과를 관찰하여 다음과 같은 결론을 얻었다. 1. 선택된 200개의 잔존 세균 중, 70개(35.0%)가 F. nucleatum을 억제하였다. 2. F. nucleatum을 억제하는 70개의 잔존 세균 중, Streptococcus salivarius가 41.3%(45/109), Streptococcus sanguinis가 28%.(7/25), Streptococcus mitis가 20%(3/15), Streptococcus parasanguinis가 33.3%(3/9), Streptococcus alactolyticus가 100%(8/8), Streptococcus vestibularis가 28.6%(2/7), Streptococcus sp.가 50%(2/4)로 나타났다. 결론적으로 피톤치드 처리 후의 잔존 세균이 F. nucleatum을 억제함으로써 피톤치드가 구강 건강, 특히 치주질환을 예방하거나 치료하는데 큰 역할을 할 수 있을 것으로 생각하며, 구강 상주균을 건강하게 유지시킨 채로 병인균 만을 억제시킨다는 차원에서 향후 구강내 유익균의 배양가능성을 실용화 할 수 있다고 생각한다.

• Journal of Oral Medicine and Pain
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• 제45권1호
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• pp.17-21
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• 2020

Osteomyelitis of the jaw infected with Coagulase-Negative Staphylococci (CNS) is rarely reported in the Oral and Maxillofacial Region. Staphylococcus is a part of the normal body flora, but it may be cause severe infections and CNS are often described as the important pathogens in nosocomial infections. Although many studies on prevalence and antibiotics of Staphylococcus aureus have been done, but many of these studies focus only on Methicillin-resistant S. aureus and not on methicillin-resistant coagulase-negative Staphylococci (MRCNS). There was a less study about CNS or MRCNS infections in the Oral and Maxillofacial Region. This report describes a case of a 41-year-old male patient who developed osteomyelitis caused by MRCNS on condyle after open reduction and internal fixation and suggests guideline for the prevention of postoperative infection and appropriate recommendation for treatment and control.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제22권3호
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• pp.330-336
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• 2000

A large number of streptococci that do not fit readily into any of the established classification schemes have been relegated to a large heterogeneous group called the Streptococcus viridans, which are members of the normal flora of the mucous membranes of the body, including the oral cavity, the nasopharynx, and genitourinary tract. This group includes S. mitis, S. oralis, S. sanguis, S. salivarius, S. milleri, etc. Surveying on the literature, it has been reported that infective endocarditis, meningitis, rhabdomyolysis, cholangitis, appendicitis caused by Streptococcus viridans, which were the most important pathogen in children with malignant hematologic disease. Various antibiotics has been chosen for treatment or prophylaxis for these infections, but were generally lower antimicrobial susceptibilities because of an abuse of antibiotics and advent of resistant group. Therefore, surveillant culture must be performed to evaluate personal antimicrobial susceptibilities of intraoral microbes for proper antimicrobial choice for dental procedures. This study examined sampling from subgingival plaque of 60 chidren's microbes. The cultured bacterial isolates, Streptococcus viridans were examined 10 antimicrobial drugs with the Kirby-Bauer agar disk diffusion method. The used drugs were Penicillin, Ampicillin, Oxacillin, Cephalothin, Imipenem, Gentamicin, Erythromycin, Vancomycin, Ciprofloxacin, Clindamycin. The results were as follows : 1. Sampling Streptococcus viridans were S. mitis(65%), S. oralis(22%), S. sanguis(5%), S. intermedius(3%), S. salivarius(2%), S acidominimus(2%), Unidentified streptococcus(2%). 2. The antimicrobial susceptibility of total Streptococcus viridans : Oxacillin< Erythromycin< Pencillin=Ciprofloxacin< Cephalothin< Ampicillin< Clindamycin< Gentamicin< Imipenem=Vancomycin. 3. The antimicrobial susceptibility of S. mitis : Oxacillin=Erythromycin< Ciprofloxacin< Cephalothin< Penicillin=Ampicillin< Gentamicin< Clidamycin< Imipenem=Vancomycin. 4. The antimicrobial susceptibility of S. oralis : Oxacillin< Erythromycin< Penicillin=Ciprofloxacin=Clindamycin< Cephalothin=Gentamicin< Ampicillin< Imipenem=Vancomycin. 5. There was no significant difference in the antimicrobial susceptibility among each Streptococcus viridans group.

• Journal of Oral Medicine and Pain
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• 제46권3호
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• pp.88-92
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• 2021

Acute osteomyelitis caused by Klebsiella pneumoniae is rare in the oral and maxillofacial region. Klebsiella pneumoniae is a Gram-negative bacillus and the normal flora of the human body, but it can cause pneumonia, urinary tract infection, meningitis, and osteomyelitis in patient with compromised immune systems. These infections are mainly caused by nosocomial infection. Microbacterial osteomyelitis was developed by clinical cause such as tooth extraction, fracture, and surgical history, which requires long-term antibiotic administration and surgical treatment. This report describes that a 56-year-old male patient with acute osteomyelitis caused by Klebsiella pneumoniae infection after implant placement was treated with intravenous administration of ertapenem without open surgery treatment. Through this case, we report that antibiotic susceptibility test is essential for the treatment of acute osteomyelitis caused by a bacterial infection resistant to empirical antibiotics, and early administration of appropriate antibiotics can reduce the possibility of extensive bone destruction or additional open surgery.

• 미생물학회지
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• 제54권2호
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• pp.146-148
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• 2018

Fusobacterium animalis (예전에 Fusobacterium nucleatum subsp. animalis으로 알려짐)는 그람 음성이면서, 혐기성 및 선형의 세균이다. F. animalis는 사람 구강 내 정상 세균총의 하나이며 치주질환원인균이라 여겨지고 있다. F. animalis KCOM 1280 (= ChDC F318) 균주는 사람 치주질환 병소에서 분리되었다. 본 논문에서 F. animalis KCOM 1280 균주 유전체 염기서열을 해독하여 보고하고자 한다.

• 미생물학회지
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• 제54권1호
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• pp.74-76
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• 2018

최근 Fusobacterium nucleatum subsp. vincentii는 average nucleotide identity 및 genome-to-genome distance 분석법에 의해 Fusobacterium vincentii로 재분류 되었다. F. vincentii는 그람 음성이면서, 혐기성 및 가는 섬유 모양의 세균이다. F. vincentii는 사람의 구강 내 정상세균총의 하나이고, 치주질환에 중요한 역할을 한다. F. vincentii KCOM 2931 균주가 사람 치주염 병소에서 분리되었다. F. vincentii KCOM 2931 균주 유전체 염기서열을 해독하여 보고한다.

• 미생물학회지
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• 제54권1호
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• pp.71-73
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• 2018

최근 Fusobacterium nucleatum subsp. polymorphum는 average nucleotide identity 및 genome-to-genome distance 분석법에 의해 Fusobacterium polymorphum로 재분류 되었다. F. polymorphum 그람 음성이면서, 혐기성 및 가는 섬유 모양의 세균이다. F. polymorphum은 사람의 구강 내 정상세균총의 하나이고, 치주질환의 원인 인자이다. F. polymorphum KCOM 1001 (= ChDC F119) 균주가 사람 치은염 병소의 치은연하치면세균막에서 분리되었다. F. polymorphum KCOM 1001 균주 유전체 염기서열을 해독하여 보고한다.

• 미생물학회지
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• 제55권1호
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• pp.67-68
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• 2019

Streptococcus constellatus는 그람 염색에 양성을 띄며, 조건 혐기성이면서 아포를 생성하지 않는 구균이다. S. constellatus는 사람 구강의 정상 세균 총에 속한다. 수술후 상악낭종 병소에서 S. constellatus KCOM 1039 균주가 분리되었다. 여기에서 S. constellatus KCOM 1039 균주의 유전체 염기서열을 결정하여 보고한다.

• Imaging Science in Dentistry
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• 제30권2호
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• pp.132-137
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• 2000

Actinomycosis is defined as a chronic, specific, suppurative, granulomatous disease caused mainly by the anaerobic, gram positive organism, Actinomyces israelii. Actinomycosis in the salivary gland is a rare disease that is caused by an inhabitant of the normal flora. We report the case of the actinomycosis of submandibular gland. A 53-year old man presented with the swelling on left submandiblar area. The lesion was not painful but had been increasing for about 10 days. In the CT view, the internal portion of the mass showed homogeneous moderate signal. The mass had continuities with the inferior portion of the left enlarged submandibular gland. In the MRI, there was a mass that showed a buldging pattern inferiorly in the left submandibular gland without bony invasion sign. The biopsy shows the colony of special organism. Many filaments are discovered with clubbed ends diffused from center of colony. We diagnosed this disease as actinomycosis in the submandibular gland by the postoperational biopsy.