• 한국치위생학회지
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• 제17권5호
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• pp.865-874
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• 2017

Objectives: The purpose of this study was to evaluate the association of smoking and drinking status with gingival symptoms among the adolescents in Korea. Methods:We used the data from the web-based survey of the National Korean Youth Risk Behavior of Korean Center for Disease Control in 2016. The study subjects were 65,528 adolescents from middle- and high schools. Data were analyzed by SPSS Ver. 19.0. Multiple regression analysis was used to assess the factors related to gingival symptoms. Results: We observed 1.52 of odds ratio (OR) for gingival symptoms for those who smoked only without drinking in middle schools. In addition, we had ORs of 1.29 or 1.69 for those who drank only without smoking, or who smoked and drank in the middle schools, respectively, compared to nonsmoking nondrinkers. Risk of gingival symptoms for those who drank only or who smoked and drank in high schools were 1.18 or 1.17 times higher than nonsmoking nondrinkers. Conclusions: Smoking and drinking status among the adolescents are the risk factors to develop gingival symptoms. The problem of smoking and drinking in the adolescents should be considered when establishing the policies and institutions to improve oral health targeting the adolescents.

• 치위생과학회지
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• 제13권1호
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• pp.62-70
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• 2013

본 연구는 구강건조증 인식도와 관련요인을 분석하여 구강건조증 예방 및 환자관리법에 대한 기초자료를 제공하기 위하여 실시하였다. 2012년 8월 1일부터 9월 30일까지 인천 및 경기지역에 거주하는 만 30세 이상 성인 240명을 대상으로 설문조사를 시행하였으며, t검정과 일원배치분산분석 및 다중선형회귀분석을 시행한 결과 다음과 같은 결론을 얻었다. 1. 일반적 특성과 구강건조증 인식도의 관련성을 분석한 결과 51세 이상이고 직업이 없으며, 월 평균 수입이 300만원 미만이라고 응답한 집단에서 구강건조증을 더 많이 인식하였다(p<0.05). 2. 건강상태와 구강건조증 인식도의 관련성을 분석한 결과 전반적으로 구강건강이 좋지 않으며, 치아우식증과 치주질환 및 구내점막질환 증상이 2개 이상인 집단에서 구강건조증을 더 많이 인식하였다. 또한 전반적으로 전신건강이 좋지 않으며, 만성질환에 이환되고 매일 약물을 복용하는 집단, 수면상태에 만족하지 않고 절망감을 인식한 집단에서 구강건조증을 더 많이 인식하였다(p<0.05). 3. 삶의 질과 구강건조증 인식도와의 관련성을 분석한 결과 저작능력, 대화능력 및 일상활동에 문제가 있고, 통증 불편함이 있으며 불안 우울한 집단에서 구강건조증을 더 많이 인식하였다(p<0.001). 4. 전신건조감과 구강건조증 인식도와의 관련성을 분석한 결과 피부와 눈, 입술 및 비강 내 점막이 자주 건조한 집단에서 구강건조증을 더 많이 인식하였다(p<0.001). 5. 구강건조증 인식도와 연관성의 강도를 분석한 결과 구강건조증 인식도는 삶의 질($\beta$=0.436)과 가장 연관성이 높았 다. 다음은 매일 복용 약물 수($\beta$=0.239), 전신건조감($\beta$=0.200), 절망감 인식($\beta$=0.160), 구내점막질환 증상 수($\beta$=0.099)의 순으로 나타났다(p<0.05). 이상의 연구결과로 볼 때 구강건조증은 삶의 질 저하를 초래할 수 있으므로 사회적 관심이 필요하며, 특히 구강보건인력은 구강건조증의 원인이나 부작용 및 치료법 등에 대한 관심도를 더욱 높여야 할 것이다. 또한 계속구강건강관리체계의 운영을 통해 구강건조증 예방 및 완화법에 대한 교육을 더욱 강화하여야 하고, 구강건조증에 대한 환자의 느낌이나 타액분비저하로 인해 나타나는 구강 내 변화에 세심한 관심과 철저한 모니터링이 수반되어야 할 것이다.

• 대한의생명과학회지
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• 제22권4호
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• pp.189-198
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• 2016

The purpose of this study was to examine the effect of social support on type 2 diabetes by classifying it into diabetes and impaired fasting blood sugar, a pre-diabetic state. Subjects of this study were 22,846 adults aged 30 years or above who agreed and registered to participate in the "Korean Health Examine Cohort (KOEX)" study that simultaneously collects questionnaires and biological samples at 8 university hospitals around the nation. Normal fasting blood sugar was defined as below 100 mg/dL, and impaired fasting blood sugar was defined as 100~125 mg/dL. Diagnosis of diabetes was defined as fasting blood sugar of 126 mg/dL or above, diagnosis by a doctor, or medication of insulin or oral hypoglycemic agent. Social support groups were divided into 4 groups, and Group 1 (G1) had high positive support and low negative support. This is the reference group with the highest social support. During multivariate analysis, female group (G3) that had high positive support and high negative support showed prevalence of impaired fasting blood sugar 1.19 times higher (95% CI = 1.02~1.41) than G1. As this study confirmed that social support increases fasting blood sugar of women after correction for socioeconomic status, health behavior, and biological and medical variables, it implies the importance of social relations such as social support in addition to management of personal risk factors for prevention of type 2 diabetes.

• 한국치위생학회지
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• 제16권2호
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• pp.205-214
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• 2016

Objectives: The purpose of the study is to investigate the current status and radiographic safety management in Korea. Methods: A self-reported questionnaire was completed by 200 dental hygienists in Jeonbuk province from September 1, 2014 and October 31, 2014. The questionnaire consisted of general characteristics of the subjects, radiation knowledge, radiation safety management, and radiation exposure anxiety. Data were analyzed using SPSS 18.0 program. Results: Duration of clinical experience(r=0.142) and number of daily radiation shot(r=0.145) showed a positive correlation to radiation safety management, and a nrgative correlation to use of intraoral films and digital devices(r=-0.587). A logistic regression analysis was performed in order to evaluate the influence on radiography knowledge. The results showed that the factors had significant influences on the age group over 41 years old(OR 7.25; 95% CI 1.30-40.43) and those who took a position above team leader(OR 0.23; 95% CI 0.59-0.90). Conclusions: It is very important to have the safety management toward dental intraoral imaging and radiograpgic shot in the dental hygienists. Continuous efforts should be emphasized on radiographic safety management and behavior.

• 한국치위생학회지
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• 제16권1호
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• pp.19-25
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• 2016

Objectives: The purpose of the study is to investigate the relationship between the number of remaining teeth and depression in Korean adults. Methods: The subjects were the respondents of the Sixth Korea National Health and Nutrition Examination Survey(KNHANES). The questionnaire consisted of the general characteristics of the subjects, number of remaining teeth, and prevalence of depression. relationship of the prevalence of depression and the number of remaining teeth. The data were analyzed by chi-square test, t-test, and logistic regression using SPSS, and 95% confidence intervals were calculated. Results: There was a significant difference in number of remaining teeth and odds ratio(OR) was 1.940(95% confidence interval: 1.062-3.544). Statistically significant difference was not observed after adjusting for age and gender and OR was 1.515(95% confidence interval: 0.823-2.787). And Statistically significant difference was not observed after adjusting for age, gender and other variables. The OR was 1.399(95% confidence interval: 0.757-2.586). Conclusions: Depression in the adults was related to the number of remaining teeth. But there was no significant difference in the number of remaining teeth after adjusted for age, gender, and other factors.

• The Korean journal of internal medicine
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• 제33권6호
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• pp.1150-1159
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• 2018

Background/Aims: The aim of this study was to assess the association between the number of existing permanent teeth and chronic kidney disease (CKD) in a representative sample of the elderly Korean population. Methods: A total of 2,519 subjects who participated in the Korean National Health and Nutrition Examination Survey were cross-sectionally examined. The number of existing permanent teeth was evaluated by clinical oral examination. CKD was defined based on definition and classification by Kidney Disease: Improving Global Outcomes (KDIGO) 2012 guidelines. Multivariable logistic regression analyses were performed controlling for age, gender, income, education, tooth-brushing frequency, periodontitis, state of dentition, smoking, alcohol consumption, hypertension, obesity, diabetes mellitus, and hypercholesterolemia. Subgroup analyses by age and gender were also performed. Results: The number of teeth was significantly associated with CKD after controlling for all potential confounders (adjusted odds ratio [AOR], 1.67; 95% confidence interval [CI], 1.04 to 2.70 for lower number of teeth; AOR, 1.59; 95% CI, 1.14 to 2.23 for moderate number of teeth). In the subgroup analyses, the association was highlighted in females aged 75 years over (AOR, 2.55; 95% CI, 1.05 to 6.20 for lower number of teeth; AOR, 1.95; 95% CI, 1.01 to 3.80 for moderate number of teeth). Conclusions: Our findings suggest that the number of existing permanent teeth may be associated with CKD among Korean elderly.

• 대한본초학회지
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• 제33권3호
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• pp.45-53
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• 2018

Objectives : In cases of osteoarthritis, the hypofunction of the cartilage and joint leads to a limited range of joint motion, swelling, and pain, which is generally treated using pharmaceutical drugs (e.g., anti-inflammatory agents, cartilage protectants, and nonsteroidal anti-inflammatory drugs) or replacement arthroplasty. However, long-term drug treatment is associated with adverse effects on the gastrointestinal systems. The present study aimed to evaluate the ability of Giheolsotong-hwan to treat of osteoarthritis symptoms in the MIA-induced rat model based on histological analysis, and factors that are associated with inflammation and bone mineral metabolism. Methods : Giheolsotong-hwan was administered orally at doses of 200 mg/kg/day or 400 mg/kg/day for 2 weeks before direct injection of monosodium iodoacetate ($3mg/50{\mu}{\ell}$ of 0.9% saline) into the intra-articular space of the rats' right knee. The rats subsequently received the same doses of oral Giheolsotong-hwan for another 4 weeks. We evaluated the treatment effects based on serum biomarkers and histopathological analysis of the knee joints. Results : Compared to those in control rats, the Giheolsotong-hwan treatments significantly decreased the serum concentration of inflammation factors (i.e., $IL-1{\beta}$, IL-6, $TNF-{\alpha}$, $PGE_2$, and $LTB_4$), and bone degrade factors (i.e., MMP-9, CTX-II, and COMP). In addition, the Giheolsotong-hwan treatments significantly increased the concentration of glycosaminoglycans of bone defence factors, but no chage the TIMP-1. Furthermore, the Giheolsotong-hwan treatments effectively preserved the knee cartilage and proteoglycan. Conclusion : The results indicate that Giheolsotong-hwan treated osteoarthritis symptoms. Thus, Giheolsotong-hwan may be a novel oriental therapeutic option for the management of osteoarthritis.

• 한국치위생학회지
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• 제12권5호
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• pp.943-952
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• 2012

Objectives : The purpose of this study was to examine the impact of the systemic osteoporosis of Korean adults on their periodontal diseases and CPI index based on the data of their systemic osteoporosis. Methods : The third-year raw data of the 4th 2009 National Health & Nutrition Survey that turned out to be representative and reliable were utilized. The subjects in this study were 7,285 adults who were over the age of 19 and got both of health and dental checkups. As for data analysis, the statistical packages PASW 19.0 and SAS 9.0 were employed. Results : The most periodontal diseases were found in those who had osteoporosis in the entire parts, entire femur, femoral neck and spiral bone, but there was no significant relationship between periodontal diseases and osteoporosis. As for the connections between peridontal diseases and osteoporosis, the adults who had femoral neck osteoporosis had a 2.057-fold less bone mass than those who had a normal bone density in this part, and the former's periodontal diseases increased in proportion to that. There was consequently a statistically significant relationship between the two(p<0.05). Among the prevalence factors of osteoporosis, a lower entire femur bone mineral density led to a lower CPI index(p<0.01), and a lower femoral neck bone mineral density led to a higher CPI index(p<0.05). Thus, there was a significant relationship between osteoporosis and the oral health indicator. Conclusions : The above-mentioned findings confirmed that in terms of the relationship among the periodontal diseases, CPI index and osteoporosis of Korean adults, a higher risk of osteoporosis affected the increase of chronic periodontal diseases.

• 한국산학기술학회논문지
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• 제18권10호
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• pp.505-512
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• 2017

본 연구는 부산지역 병의원에 내원하는 성인을 대상으로 주관적 인식수준에 따른 삶의 질을 알아보고 영향요인을 분석하여 주관적 인식개선을 위한 방안마련과 함께 삶의 질 향상을 위한 기초자료로 삼고자 한다. 2015년 12월부터 약 9개월간 부산지역 병의원에 내원하는 성인들을 대상으로 설문조사를 실시하여 결과는 다음과 같다. 주관적 건강수준에서 여자가 3.16점으로 높았고, 연령은 높아질수록 낮았으며, 비 흡연자에서 3.17점으로 높았고, 주관적 구강건강수준은 연령이 높을수록 낮았고, 최종학력에서는 대졸이상이 3.04점으로 가장 높았으며, 흡연을 하지 않는 경우 2.87점으로 높았다. 증후증상 합은 여자가 1.41점으로, 연령이 낮을수록 증상의 인식이 없었다. 최종학력은 높을수록 월 소득은 많을수록, 비 흡연자에서 구강 내 증상 인식수준이 낮았다. 일반적 특성에 따른 삶의 질을 분석한 결과, OHIP-14는 최종학력이 높을수록, 전신질환 없는 경우 54.71점으로 높았으며, 단일문항 행복지수는 학력이 높을수록, 전신질환이 없는 경우 6.48점으로 높았다. 또한 5문항 행복지수는 학력이 높을수록, 전신질환이 없는 경우 3.82점으로 높았다. OHIP-14에 미치는 요인으로 증후증상 합이었으며, 행복지수, 주관적 구강건강상태순 등으로 영향을 미치는 것으로 나타났다. 행복지수에 가장 큰 영향력을 미치는 변인은 OHIP-14이었으며, 주관적 건강상태, 학력_고졸이하, 만성질환 유무 순 등으로 영향을 미치는 것으로 나타났다. 따라서 삶의 질 향상을 위해서는 주관적인 인식수준의 개선이 필요하며, 인식수준개선을 위한 다양한 보건교육프로그램과 함께 정확한 정보를 전달할 수 있는 장의 마련이 필요할 것으로 사료된다.

• Applied Microscopy
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• 제36권3호
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• pp.165-172
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• 2006

분비백혈구단백분해효소억제제 (SLPI)는 염증 부위에서 중성구 엘라스타제에 의한 손상 작용에 대해 조직을 보호하는 역할을 한다. SLPI의 새로운 기능에 대한 연구들은 단백질분해효소억제제 역할보다는 선천적 면역반응 작용에 주로 관여 할 것임을 보고하였다. 따라서 본 연구는 섬유모세포 세포주(NIH3T3)에서 박테리아성지질다당류(LPS)자극에 의한 SLPI의 기능을 확인하기 위하여 LPS처리에 따른 여러 성장 인자들과 비교하여 SLPI의 발현을 알아보았다. 역전사효소 중합반응(RT-PCR)과 면역학적 단백질 검출법 (Western blot)은 LPS 처리 후 SLPI와 몇몇 성장 인자들(VEGF, bFGF, PDGF)의 mRNA와 단백질의 검출을 위해 수행하였다. NIH3T3 세포주를 mL당 100ng의 LPS에 각각 30, 60, 90분, 24, 48시간 동안 노출시켰다. RT-PCR 결과 SLPI와 VEGF mRNA는 LPS처리와는 상관없이 강한 발현 양상을 보였다. bFGF mRNA는 대조군과 같이 약하게 발현하였고, PDGF mRNA는 LPS 노출 시간에 따라 점진적으로 증가하는 양상을 나타냈다. 그러나 세포질 용해액과 세포 배양액에서 SLPI단백질의 수준은 LPS처리에 의해 증가하였다. 또한 광학 현미경 관찰과 전자 현미경 관찰은 LPS가 NIH3T3세포주의 형태학적인 변화를 유발시킴을 증명하였다. 따라서 LPS는 NIH3T3세포에서 SLPI의 발현 증가를 조절하며, 분비된 SLPI는 세포분열과 이동을 자극할 것이라는 결론을 얻었다. SLPI가 세포분열과 세포이동에 어떻게 관여하는지는 아직까지 규명되지 않은 실정이므로-추후에 SLPI단백질이나 유전자 도입을 통하여 세포 이동에 관련된 실험이 진행되어야 할 것이다.