• 한국치위생학회지
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• 제19권3호
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• pp.387-397
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• 2019

Objectives: This study was conducted to examine the subjects' oral health status and changes in the oral environment after mouthwash with effervescent Vitamin C and its intake and to understand the impact on changes in the number of bacteria causing periodontal diseases in the oral cavity based on the oral health status and oral environmental condition. Methods: After obtaining approval from the Institutional Review Board of D-University, 45 people (24 in an experimental group and 21 in a control group) who participated in the oral health program were selected, among visitors of the Clinical Dental Hygienics Laboratory of D. University in B. Results: Based on the subjects' periodontal health status, the number of bacteria causing periodontal diseases in the oral cavity decreased in both experimental and control groups before and after the experiment. However, in the experimental group, it was significant when the Bleeding on Probing(BOP) level was below average, and Calculus index(CAL) was above average, in Aggregatibacter actinomycetemcomitans and the red complex. It was also significant when CAL was above average in the orange complex in the control group. Regarding bacterial changes in periodontal diseases based on the subjects' oral environmental condition, there was a significant change in the Adenosine Tri Phosphate (ATP : intraoral contaminants test) test in the oral cavity in A. actinomycetemcomitans and the red complex in the experimental group and in the O'Leary index in the control group. Further, there was a significant change in the orange complex in the ATP test in the experimental group. Conclusions: A comprehensive analysis of the results revealed that the oral health care program for dental hygiene decreased the number of bacteria causing periodontal diseases in the oral cavity in both experimental and control groups.

• Toxicological Research
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• 제25권3호
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• pp.140-146
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• 2009

This study was performed to evaluate the toxicity of cadmium selenide for a period of 28 days in Sprague-Dawley rats. Each of 10 healthy male and females rats per group received daily oral administration for 28-day period at dosage levels 30, 300 and 1,000 mg/kg of body weight. Mortality and clinical signs were checked, and body weight, water intake and food consumption were also recorded weekly. There were no dose-related changes in food consumption or urine volume. All animals survived to the end of study with no clinical signs or differences in body weight gain observed when compared with the control group. At the end of study, all animals including control group, were subjected to necropsy. Blood samples were collected for hematology tests including coagulation time and biochemistry analysis. Blood coagulation time and relative organ weight were unaffected by all received doses. White Blood Cell (WBC) counts significantly increased in the 300 mg/kg administered male animal group when compared to the control. Monocyte (MO) value were also increased significantly in both 300 and 1,000 mg/kg male animal group. However, Mean Corpuscular Volume (MCV) were significantly decreased compared with the control in the 1,000 mg/kg dose groups for male and female animals. Mean Corpuscular Hemoglobin (MCH) decreased significantly for female in the 300 and 1,000 mg/kg group compared to the control. Blood biochemical values of Inorganic phosphorus (IP) were significantly increased in both the 300 and 1,000 mg/kg dose groups in male animals when compared to the control. Creatinine (CRE) levels indicated significant increase in kidney function for the female, 30 mg/kg dose group when compared with control. There was a significant decrease in thymus absolute organ weight in the female, 1,000 mg/kg dose group when compared with control. Histopathological findings revealed no evidence of injury related to cadmium selenide except for one case of focal hepatic inflammation in the high dose (1,000 mg/kg) group. One case of lung inflammation was also seen in the control group. Basis on these result, the No Observable Adverse Effect Level (NOAEL) of cadmium selenide was determined to be more than 1,000 mg/kg/day for male and female rats under conditions in this study.

• 월간산업보건
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• 통권269호
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• pp.37-39
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• 2010

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제32권2호
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• pp.138-141
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• 2006

Introduction : In recent years, vascularized, i.e., living bone grafts, have been widely applied in the field of oral and maxillofacial surgery, as a method of treatment of congenital or acquired non-unions, and a large defects in mandible. The vascularized fibular graft has been especially used for this purpose because of its shape and mechanical strength. The postoperative hypertrophy of grafted fibula is of particular interest to us. Material and methods : This study was undertaken to determine the volume change(indirect methods) and radiographic appearance of a free vascularized fibular graft as it responds to the mechanical and physiologic features of its new environment. In order to elucidate the long term effect on fibular mass after mandibular reconstruction, change in various method of volume change was utilized as indirect measure of change in long-term. Results : The younger the patient, the more prominent and rapid the hypertrophy of the graft. the hypertrophy of the graft never exceeded the diameter of the recipient bone, except for callus enlargement after stress fracture of the grafted bone. Conclusion : Etiologic explanations for this phenomenon have not been clarified in the previeous literature. some of the factors implicated include a periosteal reaction or new bone formation, as seen at the onset of bone union after a fracture in a child, a reaction to the mechanical loading on the graft and a reaction to the circulatory changes resulting from the grafting procedure.

• 한국산학기술학회논문지
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• 제17권1호
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• pp.72-78
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• 2016

이 연구는 한국 노인의 구강건강상태와 치과보철물 필요도가 구강건강관련 삶의 질에 미치는 요인을 경험적으로 규명함으로써 향후 노인대상의 구강건강사업에 필요한 기초자료를 제공하고자 한다. 이 연구자료는 2010년 1월부터 12월까지 질병관리본부에서 시행한 '국민건강영양조사 제5기 1차 및 2차년도를 활용 구강검사까지 완료한 65세 이상 노인 2,389명 중 검사가 미흡한 노인 116명을 제외한 2,273명을 최종 연구대상으로 하였다. 수집된 자료는 SPSS 22.0 프로그램을 이용하여 전산통계 처리하였으며, 분석방법은 빈도분석, 다중회귀분석, 구조방정식 모형을 이용하였다. 주관적 구강건강상태에 영향을 미치는 요인은 나이가 적을수록, ST지수가 높을수록, FS-T 지수가 높을수록, T-Health 지수가 높을수록, 상악 크라운 요구도가 낮을수록, 상 하악 의치 요구도가 낮을수록 주관적 구강건강상태가 높은 것으로 나타났다. 씹기문제에 영향을 미치는 요인은 소득수준이 높을수록, T-Health 지수가 높을수록, 상악 크라운 요구도가 낮을수록, 상 하악 의치 요구도가 낮을수록 씹기 문제가 불편하지 않는 것으로 나타났다. 말하기 문제에 영향을 미치는 요인은 ST지수가 높을수록, T-Health 지수가 높을수록, 상악 임플란트 요구도가 낮을수록, 상악 의치 요구도가 낮을수록 말하기 문제가 불편하지 않는 것으로 나타났다. 이상의 결과를 토대로 구강건강상태와 치과보철물 필요도는 구강건강관련 삶의 질에 상당한 영향을 미치고 있음을 알 수 있었고, 향후 노인의 구강건강 관련 삶을 증진시키기 위해서는 노인을 위한 구강건강증진사업과 치과보철 사업이 필요가 요구된다.

• 디지털융복합연구
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• 제19권2호
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• pp.315-322
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• 2021

본 연구는 전신질환 노인을 대상으로 구강근기능과 구강환경을 조사하고 노인 구강건강 증진안을 제언하고자 하였다. 2019년 4-6월 동안 65세 이상 전신질환 노인 64명을 대상으로 구강근력, 구강건강관련 삶의 질, 구강세균에 대해 조사하고, PASW Statistics ver 18.0을 이용하여 분석하였다. 전신질환 유병은 1개 43.8%, 2개 40.6%, 기능치아수는 18.6개였다. 나이는 기능치아수(r=-.384, p<.01), 혀근력(r=-.104, p<.001)과 부적 상관관계가 있었고, 혀근력과 구순근력은(r=.279, p<.05)과 정적 상관관계가 있었으며, 연령과 총세균수는(r=-.336, p<.01) 부적 상관관계, 기능치아수와 총세균수는(r=.551, p<.001) 정적 상관관계 그리고 전신질환 수와 총세균수는(r=.327, p<.01) 정적 상관관계로 나타났다. 노인 전신질환자의 구강근기능과 구강환경의 문제점을 토대로 노인 구강건강 증진안을 제언하는데 의미가 있었고 초고령 시대를 앞두고 있는 지금 구강건강 관련 삶의 질을 증진시키기 위한 실제적인 정책안이 요구되었다.

• Toxicological Research
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• 제19권3호
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• pp.211-215
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• 2003

This study was carried out to investigate the acute oral toxicity of a crude extract derived from fruiting body of Phellinus gilvus (PGE) using male and female SD rats. Groups consisted of five male and female rats were treated with a single dose of the test substance intragastrically at 0, 500, 1,000, 2,000, and 5,000 mg/kgaj, respectively. Clinical signs, body weight change, and food and water consumption change were observed for 14 days after administration. No mortality or abnormal clinical signs in animals were shown during the observation period at the dose used in this study. Also there was no difference in net body weight gain, water and food consumption or gross pathological findings at terminal sacrifice among the groups of rat treated with different doses of the test substance. The results suggested that acute oral toxicity of PGE in rats is very low at the conditions employed in this study and $LD_{50}$ of PGE was estimated to be over 5,000 mg/$\textrm{m}{\ell}$ in both sexes of rats.

• 한국수산과학회지
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• 제41권6호
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• pp.440-445
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• 2008

Ciprofloxacin is the most commonly used fluoroquinolones for treating bacterial disease in olive flounder (Paralichthys olivaceus) farming, but its withdrawal time for industrial-scale farming has not been established. The depletion of ciprofloxacin was investigated in the olive flounder under field conditions. Fish were kept in an inland fish farm and fed a commercial diet containing 5 mg/kg of ciprofloxacin for 13 days. Seven fishes per sampling time were examined during and after the treatment. Ciprofloxacin and its major metabolite, enrofloxacin, were analyzed using HPLC with a fluorescence detector. The concentrations of ciprofloxacin and enrofloxacin in muscle increased during the medication period, and then decreased rapidly. The ciprofloxacin and enrofloxacin concentration in the olive flounder peaked on days 11 and 13, respectively, with maximum concentrations in muscle of 0.58 and 0.73 mg/kg. Residual ciprofloxacin and enrofloxacin were eliminated rapidly; 6 days after treatment, the respective levels in muscle were 0.04 and 0.10 mg/kg and neither was detected 15 days post treatment. The level of ciprofloxacin accumulation at the beginning of oral administration was variable according to the farming conditions, but the overall exhaustion time was similar. In conclusion, an adequate withdrawal period for enrofloxacin is 15 days in the case of oral ciprofloxacin administration.

• International Journal of Oral Biology
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• 제37권4호
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• pp.181-188
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• 2012

As the demand for large-scale analysis of gene expression using DNA arrays increases, the importance of the surface characterization of DNA arrays has emerged. We compared the efficiency of molecular biological applications on solid-phases with different surface polarities to identify the most optimal conditions. We employed thiol-gold reactions for DNA immobilization on solid surfaces. The surface polarity was controlled by creating a self-assembled monolayer (SAM) of mercaptohexanol or hepthanethiol, which create hydrophilic or hydrophobic surface properties, respectively. A hydrophilic environment was found to be much more favorable to solid-phase molecular biological manipulations. A SAM of mercaptoethanol had the highest affinity to DNA molecules in our experimetns and it showed greater efficiency in terms of DNA hybridization and polymerization. The optimal DNA concentration for immobilization was found to be 0.5 ${\mu}M$. The optimal reaction time for both thiolated DNA and matrix molecules was 10 min and for the polymerase reaction time was 150 min. Under these optimized conditions, molecular biology techniques including DNA hybridization, ligation, polymerization, PCR and multiplex PCR were shown to be feasible in solid-state conditions. We demonstrated from our present analysis the importance of surface polarity in solid-phase molecular biological applications. A hydrophilic SAM generated a far more favorable environment than hydrophobic SAM for solid-state molecular techniques. Our findings suggest that the conditions and methods identified here could be used for DNA-DNA hybridization applications such as DNA chips and for the further development of solid-phase genetic engineering applications that involve DNA-enzyme interactions.

• 대한치과의료관리학회지
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• 제11권1호
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• pp.78-88
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• 2023

This study aimed to analyze the correlation between working from home and sleep disorders among domestic workers using data from the 5th Working Environment Survey in 2017. Out of the total 30,108 wage workers, 818 employees work from home and 4,090 work in an office. A random sample of 1:5 pairs, considering gender and occupational group, was selected from these employees as the study subjects. The analysis included personal characteristics, occupational characteristics, work-from-home arrangements, and sleep disorders. Age, education, employment status, years in the workforce, weekly working hours, work-life balance, self-perceived health, depression, and anxiety were all adjusted as potential confounding variables. Conditional logistic regression analysis was conducted to examine the relationship between working from home (independent variable) and sleep disorder (dependent variable). This analysis aimed to analyze the correlation between working from home and sleep disorder. The analysis revealed that working from home was associated with sleep onset latency disorder OR=3.23 (95% CI=2.67~3.91), sleep maintenance disorder OR=3.67 (95% CI=3.02~4.45), and non-restorative sleep OR=3.01 (95% CI=2.46~3.67), which showed a statistically significant relationship with all three types of sleep disorders. Factors influencing the correlation between working from home and sleep disorders included work-life balance, social isolation, and anxiety.