• Biomolecules & Therapeutics
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• v.32 no.5
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• pp.627-634
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• 2024

Sesquiterpene lactones, a class of natural compounds abundant in the Asteraceae family, have gained attention owing to their diverse biological activities, and particularly their anti-proliferative effects on human cancer cells. In this study, we systematically investigated the structure-activity relationship of ten sesquiterpene lactones with the aim of elucidating the structural determinants for the STAT3 inhibition governing their anti-proliferative effects. Our findings revealed a significant correlation between the STAT3 inhibitory activity and the anti-proliferative effects of sesquiterpene lactones in MDA-MB-231 breast cancer cell lines. Among the compounds tested, alantolactone and isoalantolactone emerged as the most potent STAT3 inhibitors, highlighting their potential as candidates for anticancer drug development. Through protein-ligand docking studies, we revealed the structural basis of STAT3 inhibition by sesquiterpene lactones, emphasizing the critical role of hydrogen-bonding interactions with key residues, including Arg609, Ser611, Glu612, and Ser613, in the SH2 domain of STAT3. Furthermore, our conformational analysis revealed the decisive role of the torsion angle within the geometry-optimized structures of sesquiterpene lactones in their STAT3 inhibitory activity (R=0.80, p<0.01). These findings not only provide preclinical evidence for sesquiterpene lactones as promising phytomedicines against diseases associated with abnormal STAT3 activation, but also highlight the importance of stereochemical aspects in their activity.

• Korean Journal of Optics and Photonics
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• v.20 no.2
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• pp.128-133
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• 2009

In this paper, an optical touch panel device is newly proposed, with operating principle based on the optical coupling between a pointing pen having a built-in light source and perpendicularly crossed optical waveguide arrays. In order to enable an external light to couple into a waveguide core, the auxiliary pyramidal structures are introduced into all intersecting points located periodically along optical waveguides. The shape is optimized for minimizing the unwanted propagation loss due to the same structure by a ray tracing method. For the optical waveguide with the size of $50{\times}50{\mu}m^2$, the bottom width, height, and slope angle of the optimized pyramidal structure are $50{\mu}m$, $22.5{\mu}m$, and $42^{\circ}$, respectively. The optical coupling efficiency of about 97.8% and the average propagation loss of 0.3 dB/mm were achieved for the optimized touch panel. Finally, it is found from the tolerance analysis that tilting of the pen up to ${\pm}12^{\circ}$ can be allowed.

• Korean Journal of Optics and Photonics
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• v.24 no.5
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• pp.213-216
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• 2013

This paper presents a combination of linear Fresnel lenses optimized for ${\times}25$ solar concentration. The combined lens consists of $5{\times}5$ linear Fresnel lenses. Each Fresnel lens is of $10{\times}10$ mm and optimized to tilt the incoming light onto a solar cell of the same size. All of the optimized Fresnel segments have the same pattern height of 35 ${\mu}m$, draft angle of $4^{\circ}$, and edge groove round of 1 ${\mu}m$ but with different facet angles varying from $14.1^{\circ}$ to $31.2^{\circ}$. The solar concentrating efficiency of the combination is shown to be over 80% and more robust than a conventional single ${\times}25$ circular Fresnel lens in terms of pointing misalignment and manufacturing errors. A sensitivity analysis finds that the edge groove round should be kept as small as machining allows since the concentrating efficiency drops ~5% per 1 ${\mu}m$ increase of the edge groove.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.25 no.4B
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• pp.788-795
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• 2000

Scattered look-ahead pipelining method can be efficiently used for high sample rate or low-power applications of digital recursive filters. Although the pipelined filters are guaranteed to be stable by this method, these filters suffer from large round off noise when the poles are crowed within some critical regions. To avoid this problem, a low-noise implementation technique was proposed using constrained Remez exchange algorithm. By the constrained filter design approach, the desired filter spectrum is satisfied while some of the pole angles are constrained to avoid pole crowding within critical regions. In the proposed approach, to obtain improved spectrum characteristics or better round off noise properties, the radius of the angle-constrained pole is optimized depending on the direction of the pole movement.

• Proceedings of the KIEE Conference
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• 2004.07c
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• pp.1945-1947
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• 2004

"CRT" which had dominated the market of display until 2000 is not appropriate for information indicating media due to several limitations. Thus, TFT-LCD, PDP, OLED, etc are growing in display industry instead of CRT because they meet demands of information indicating media. OLED display which responses within 1ms fits any picture manifestation medias because it uses self radiance OLED for picture clement that has no obstacles in showing the angle of vision. OLED's characteristic of action is very sensitive to thickness of electrode so that this has been an important issue. This study tried to find the most suitable thickness of electrode using ITO, Mo, and AL. Using the results of IVL measurements, analyzed equality of electrode board. As a result, found the thickness of electrode that has high electrical efficiency and optimized it.

• Fashion & Textile Research Journal
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• v.14 no.4
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• pp.635-640
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• 2012

In this study, thermoplastic urethane (TPU) coating yarns were prepared at various extruding temperatures. The fine structure and mechanical properties of resultant TPU coating yarns examined by the wide angle X-ray diffractometer (WAXD), differential scanning calorimetry (DSC), dynamic mechanical thermal analysis (DMTA), and tensile test. TPU coating yarns (prepared at extruding temperatures at $175^{\circ}C$) were confirmed as a stable fine structure that obtained excellent tensile strength and flexibility. The C samples prepared by optimized conditions made by TPU woven floor mat. The structure of the woven mat is $4{\times}4$ basket weave and have laminated with the EVA foam to obtained final TPU woven floor mat products. The resultant TPU woven floor mat was obtained to 1.5MN of tensile strength, 22% of the elongation, and 0.2MN of tear strength. The weight loss abrasion and the resilience by the ball rebound of the TPU-woven floor mat was prior to those of the PVC subsequently, we were able to develop a woven floor mat with TPU coating yarn and produce an eco-friendly high valuable woven floor mat using an interior product.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.9 no.2
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• pp.41-50
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• 2010

In this paper, a multi-band antenna with novel structure for mobile communications is designed and fabricated. The proposed antenna has the Multi-band antenna characteristics by two common-grounded slots with different size and angle. In order to reduce size and to enhance the gain of the antenna, a reflector is consisted of chokes on the three sides. It is optimized by using the CST Microwave Studio commercial software based on the FIA(Finite Integration Algorithm) and PBA(Perfect Boundary Approximation), and then the fabricating and measuring is practiced. As a result of measurement, the reflection coefficient is less than -11 dB(VSWR < 1.8) and the gain of antenna is more than 6dBi at 824~894MHz and 1885-2500MHz.

• International Journal of Aeronautical and Space Sciences
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• v.17 no.3
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• pp.332-340
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• 2016

A design optimization is performed for the double-bolted joint in cylindrical composite structures by using a simplified analytical method. This method uses failure criteria for the major failure modes of the bolted composite joint. For the double-bolted joint with a zigzag arrangement, it is necessary to consider an interaction effect between the bolt arrays. This paper proposes another failure mode which is determined by angle and distance between two bolts in different arrays and define a failure criterion for the failure mode. The optimal design for the double-bolted joint is carried out by considering the interactive net-tension failure mode. The genetic algorithm (GA) is adopted to determine the optimized parameters; bolt spacing, edge distance, and stacking sequence of the composite laminate. A purpose of the design optimization is to maximize the burst pressure of the cylindrical structures by ensuring structural integrity. Also, a progressive failure analysis (PFA) is performed to verify the results of the optimal design for the double-bolted joint. In PFA, Hashin 3D failure criterion is used to determine the ply that would fail. A stiffness reduction model is then used to reduce the stiffness of the failed ply for the corresponding failure mode.

• Proceedings of the Korean Society For Composite Materials Conference
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• 2000.04a
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• pp.154-157
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• 2000

Distributed piezoelectric sensor and actuator system has been designed for the active vibration control of shell structure. PVDF is used for the materials of sensor/actuator. To prevent the adverse effect of spillover, distributed modal sensor/actuator system is established. Although shell structure is three-dimensional structure, the PVDF sensor/actuator system can be treated as two-dimensional Finite element programs are developed to consider curved structures having PVDF modal sensor/actuator. The nine-node Mindlin shell element with five nodal degree of freedoms is used for finite element discretization. The electrode patterns and lamination angle of PVDF sensor/actuator are optimized to design the modal sensor/actuator system Genetic algorithm is used for optimization. Sensor is designed to minimize the observation spillover, and actuator is designed to minimize the system energy of the control modes under a given initial condition. Modal sensor/actuator for the first and second modes of singly curved cantilevered shell structure are designed using mentioned methods. Discrete LQG method is used as a control law. Experimental demonstrations of the active vibration control with designed sensor/actuator system have been performed successfully.

• Journal of electromagnetic engineering and science
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• v.8 no.2
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• pp.70-75
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• 2008

In this paper, the EM wave absorber was designed and fabricated for countermeasure against EMI from a ceiling of a tollgate in ETC system. We fabricated several samples in different composition ratios of MnZn-ferrite, Carbon, and CPE(Chlorinated Polyethylene). Absorption abilities were simulated in accordance with different thicknesses of the prepared absorbers and changed complex relative permittivity and permeability according to composition ratio. The optimized mixing ratio of MnZn-ferrite, Carbon, and CPE was found as 40:15:45 wt.% by experiments and simulation. Then the EM wave absorber was fabricated and tested using the simulated data. As a result, the developed EM wave absorber has the thickness of 3.3 mm and absorption ability was more than 20 dB in the case of normal incidence and more than 11 dB for the incident angle from 15 to 45 degrees at 5.8 GHz. Therefore, it was confirmed that the newly developed absorber can be used for ETC system.