• Mass Spectrometry Letters
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• 제8권3호
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• pp.53-58
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• 2017

Glycated hemoglobin ($HbA_{1c}$) has been commonly used to screen and diagnose for patients with diabetes mellitus. Here the accelerated procedure of microwave-assisted sample treatment from acid hydrolysis to enzyme digestion followed by isotope dilution liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS) was optimized and applied to measure $HbA_{1c}$ in an effort to speed up analysis time. First, two signature peptides of $HbA_{1c}$ and hemoglobin $A_0$ were certified with amino acid analysis by setting optimized acid hydrolysis conditions to $150^{\circ}C$, 1.5 h and $10{\mu}M$ sample concentration in 8 M hydrochloric acid. Consequently, the accurate certified peptides above were used as calibration standards to implement the proteolytic procedure with endoproteinase Glu-C at $37^{\circ}C$, 700 W for 6 h. Compared to the traditional method, the microwave heating not only shortened dramatically sample preparation time, but also afforded comparable recovery yields. The optimized protocol and analytical conditions in this study are suitable for a primary reference method of $HbA_{1c}$ quantification with full SI-traceability and other similar proteins in complex biological samples.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2008년도 춘계학술대회 논문집
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• pp.1166-1171
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• 2008

Through Korean high speed train development project "G7 Leading Technology Development Project" from 1996 to 2002, HSR-350X has been developed. It can run the maximum operating speed of 350 km/h. Based on this technology, KTX-2 which will be served commercially has been developed till 2007. This paper introduces the aerodynamic analysis of the High-Speed EMU and shows the results of optimized aerodynamic nose shape design techniques and clean pantograph panhead original techniques study. These are the important parts of developments for high speed train which maximum speed is 400 km/h. Especially for decrease of tunnel micro pressure waves, the optimized nose area distributions were derived and the characteristics of micro pressure wave were analyzed. The robust optimized pantograph panhead shapes investigated to improve the performance and decrease the vortex flow which is thought to be its noise source. These shapes are clean and robust to external disturbances like unsteady accelerated flow or side wind was derived. Finally aerodynamic performances was verified with PIV and smog visualization by wind tunnel test.

• 산업경영시스템학회지
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• 제43권3호
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• pp.61-67
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• 2020

The fourth industrial revolution encourages manufacturing industry to pursue a new paradigm shift to meet customers' diverse demands by managing the production process efficiently. However, it is not easy to manage efficiently a variety of tasks of all the processes including materials management, production management, process control, sales management, and inventory management. Especially, to set up an efficient production schedule and maintain appropriate inventory is crucial for tailored response to customers' needs. This paper deals with the optimized inventory policy in a steel company that produces granule products under supply contracts of three targeted on-time delivery rates. For efficient inventory management, products are classified into three groups A, B and C, and three differentiated production cycles and safety factors are assumed for the targeted on-time delivery rates of the groups. To derive the optimized inventory policy, we experimented eight cases of combined safety stock and data analysis methods in terms of key performance metrics such as mean inventory level and sold-out rate. Through simulation experiments based on real data we find that the proposed optimized inventory policy reduces inventory level by about 9%, and increases surplus production capacity rate, which is usually used for the production of products in Group C, from 43.4% to 46.3%, compared with the existing inventory policy.

• Structural Engineering and Mechanics
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• 제74권3호
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• pp.325-339
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• 2020

This study presents a practical application of topology optimization (TO) technique to seek the best form of perforated steel plate shear walls (PSPSW) in simple frames. For the numerical investigation, a finite element model is proposed based on the recent particular form of PSPSW that is called the ring-shaped steel plate shear wall. The TO is applied based on the sensitivity analysis to maximize the reaction forces as the objective function considering the fracture tendency. For this purpose, TO is conducted under a monotonic and cyclic loading considering the nonlinear behavior (material and geometry) and buckling. Also, the effect of plate thickness is studied on the TO results. The final material volume of the optimized plate is limited to the material volume of the ring-shaped plate. Finally, an optimized plate is introduced and its nonlinear behavior is investigated under a cyclic and monotonic loading. For a more comprehensive view, the results are compared to the ring-shaped and four usual forms of SPSWs. The material volume of the plate for all the models is the same. The results indicate the strength, load-carrying, and energy dissipation in the optimized plate are increased while the fracture tendency is reduced without changing the material volume.

• 한국기계가공학회지
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• 제21권4호
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• pp.100-106
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• 2022

Topology optimization is applied for the optimal design of various products to ensure weight reduction and productivity improvement. Reducing the weight of the mold while maintaining its rigidity can ensure shortening of the production cycle, stabilization of the mold temperature, and reduction of mold material costs. In this study, a topology optimization technique was applied to the optimal design of the injection mold, and a topology-optimized model of the mold was obtained. First, the injection mold for the square specimens was modeled. Subsequently, a structural analysis was performed by implementing a load condition generated during the injection molding process. Topology optimization was performed based on the structural analysis results, and the models of the initial and topology-optimized designs were manufactured at 1/4 magnification using a 3D printer. Consequently, compared with the existing model, the weight of the topology-optimized model decreased by 9.8%, and the manufacturing time decreased by 7.61%.

• Nuclear Engineering and Technology
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• 제55권1호
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• pp.330-338
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• 2023

In this study, impacts of an enhanced-moderation Fuel Assembly (FA) named Truly Optimized PWR (TOP) lattice, which is modified based on the standard 17 × 17 PWR FA, are investigated in a natural circulation Soluble-Boron-Free (SBF) Small Modular Reactor (SMR). Two different TOP lattice designs are considered for the analysis; one is with 1.26 cm pin pitch and 0.38 cm fuel pellet radius, and the other is with 1.40 cm pin pitch and 0.41 cm fuel pellet radius. The NuScale core design is utilized as the base model and assumed to be successfully converted to an SBF core. The analysis is performed following the primary coolant circulation loop, and the reactor is modelled as a single channel for thermal-hydraulic analyses. It is assumed that the ratio of the core pressure drop to the total system pressure drop is around 0.3. The results showed that the reactor power could be increased by 2.5% and 9.8% utilizing 1.26/0.38 cm and 1.40/0.41 cm TOP designs, respectively, under the identical coolant inlet and outlet temperatures as the constraints.

• Nuclear Engineering and Technology
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• 제55권11호
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• pp.4246-4251
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• 2023

The optimized design of a Neutron Activation Analysis (NAA) system, including Delayed Gamma NAA (DGNAA) and Prompt Gamma NAA (PGNAA), has been proposed in this research based on Mevex Linac with 5 MeV electron energy and 50 kW power as a neutron source. Based on the MCNPX 2.6 simulation, the optimized configuration contains; tungsten as an electron-photon converter, BeO as a photoneutron target, BeD₂ and plexiglass as moderators, and graphite as a reflector and collimator, as well as lead as a gamma shield. The obtained thermal neutron flux at the beam port is equal to 2.06 × 10⁹ (# /cm².s). In addition, using the optimized neutron beam, the detection limit has been calculated for some elements such as H-1, B-10, Na-23, Al-27, and Ti-48. The HPGe Coaxial detector has been used to measure gamma rays emitted by nuclides in the sample. By the results, the proposed system can be an appropriate solution to measure the concentration and toxicity of elements in different samples such as food, soil, and plant samples.

• Journal of Electrical Engineering and Technology
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• 제12권1호
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• pp.402-410
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• 2017

For many years, researchers in face description area have been representing and recognizing faces based on different methods that include subspace discriminant analysis, statistical learning and non-statistics based approach etc. But still automatic face recognition remains an interesting but challenging problem. This paper presents a novel and efficient face image representation method based on Optimized Local Ternary Pattern (OLTP) texture features. The face image is divided into several regions from which the OLTP texture feature distributions are extracted and concatenated into a feature vector that can act as face descriptor. The recognition is performed using nearest neighbor classification method with Chi-square distance as a similarity measure. Extensive experimental results on Yale B, ORL and AR face databases show that OLTP consistently performs much better than other well recognized texture models for face recognition.

• 한국정밀공학회지
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• 제25권9호
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• pp.38-44
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• 2008

Light guide plate is one of most important components which are composed of back light unit, affecting the quality and performance of LCD. Average brightness and uniformity are especially key factors for designing the light guide unit. These qualities are affected and controlled by the pattern being attached to the back of light guide unit. In order to obtain high brightness and uniformity the optimized pattern design is adopted for LGP. In this study, optimized molding condition for LGP with 0.4 mm thickness was obtained by using the Moldflow simulation software and the optimized pattern for better brightness uniformity was designed for the thickness of the 0.4 mm by trial and error method. The brightness was measured for the different LGP thicknesses and the residual stress analysis was performed for 0.4 mmthickness by the photoelasticity and the results are compared with 0.5 mm, 0.6 mm thickness.

• The Journal of the Acoustical Society of Korea
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• 제25권1E호
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• pp.8-13
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• 2006

In this paper, an Optimized Ambisonic Panning Algorithm (OAPA) which reduces sound localization error, is proposed. In the conventional Ambisonic Panning Algorithm (APA), sound localization is usually different from the panning angle, especially when listeners are not in an ideal listening position, because of low signal separation among other channels. To overcome this problem, an OAPA using window functions is proposed. A proper window function can be verified, comprising of higher harmonic components than 2M+1 and improved DPC and channel separation. Analysis results demonstrate that the proposed method results in higher signal separation among other channels and lower sound localization errors than the conventional APA.