• Asian Pacific Journal of Cancer Prevention
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• 제15권14호
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• pp.5721-5727
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• 2014

Objectives: To evaluate the performance of clustering methods used in the prognostic assessment of categorical clinical data for hepatocellular carcinoma (HCC) patients in China, and establish a predictable prognostic nomogram for clinical decisions. Materials and Methods: A total of 332 newly diagnosed HCC patients treated with hepatic resection during 2006-2009 were enrolled. Patients were regularly followed up at outpatient clinics. Clustering methods including the Average linkage, k-modes, fuzzy k-modes, PAM, CLARA, protocluster, and ROCK were compared by Monte Carlo simulation, and the optimal method was applied to investigate the clustering pattern of the indices including platelet count, platelet/lymphocyte ratio (PLR) and serum aspartate aminotransferase activity/platelet count ratio index (APRI). Then the clustering variable, age group, tumor size, number of tumor and vascular invasion were studied in a multivariable Cox regression model. A prognostic nomogram was constructed for clinical decisions. Results: The ROCK was best in both the overlapping and non-overlapping cases performed to assess the prognostic value of platelet-based indices. Patients with categorical platelet-based indices significantly split across two clusters, and those with high values, had a high risk of HCC recurrence (hazard ratio [HR] 1.42, 95% CI 1.09-1.86; p<0.01). Tumor size, number of tumor and blood vessel invasion were also associated with high risk of HCC recurrence (all p< 0.01). The nomogram well predicted HCC patient survival at 3 and 5 years. Conclusions: A cluster of platelet-based indices combined with other clinical covariates could be used for prognosis evaluation in HCC.

• 한국가스학회지
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• 제18권4호
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• pp.63-67
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• 2014

Fischer-Tropsch 합성은 주로 긴 carbon 사슬을 가지고 있는 높은 점도의 왁스를 product로 생산한다. 촉매 고정층 반응기를 이용하여 Fischer-Tropsch 합성을 수행할 경우, 왁스는 촉매입자의 표면에서 생산되어 촉매입자 표면에 흡착되어 있다. 이런 왁스의 hold-up 현상이 반응기 전체의 압력강하는 증가시키고 내부 흐름을 막는 문제를 일으킨다. 따라서 반응기 내부에 왁스가 hold-up되는 현상에 대한 모델링을 통해 왁스 hold-up 현상을 최소화 할 수 있는 반응기 및 촉매 입자의 크기를 결정하는 설계 과정이 필요하다. 본 연구에서는 왁스가 hold-up된 촉매 입자와 기체 흐름 사이의 대류 물질 전달 실험 모델을 이용하여 반응기 구조 및 운전 조건을 고려할 수 있는 반응기 내부 왁스 hold-up 모델을 개발하였다. 개발된 모델은 실험 데이터를 제공한 Knochen의 연구 결과와 비교하여 모델의 우수성을 검증하였다. 이 모델을 이용하여 반응기의 길이와 단면이 반응기 내부 왁스 hold-up 현상에 어떻게 영향을 미칠 수 있는지 분석해 보았다.

• Fisheries and Aquatic Sciences
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• 제20권11호
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• pp.30.1-30.10
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• 2017

Small-scale fish farmers in developing countries are faced with challenges owing to their limited information on aquaculture management. Nile tilapia farmers in Teso North Sub-County recorded lower yields than expected in 2009 despite having been provided with required inputs. Water quality was suspected to be the key factor responsible for the low yields. This study sought to assess the effects of earthen pond water physico-chemical parameters on the growth of Nile tilapia in six earthen fish ponds under semi-intensive culture system in Teso North Sub-County. The study was longitudinal in nature with pond water and fish being the units of analysis. Systematic sampling was used to select five ponds while a control pond was purposively selected based on its previously high harvest. Four ponds were fed by surface flow and two by underground water. Each pond was fertilized and stocked with 900 fry of averagely 1.4 g and 4.4 cm. Physico-chemical parameters were measured in-situ using a multi-parameter probe. Sixty fish samples were randomly obtained from each pond fortnightly for four months using a 10 mm mesh size and measured, weighed and returned into the pond. Mean range of physico-chemical parameters were: dissolved oxygen (DO) 4.86-10.53 mg/l, temperature $24-26^{\circ}C$, pH 6.1-8.3, conductivity $35-87{\mu}S/cm$ and ammonia 0.01-0.3 mg/l. Temperature (p = 0.012) and conductivity (p = 0.0001) levels varied significantly between ponds. Overall Specific Growth Rate ranged between 1.8% (0.1692 g/day) and 3.8% (1.9 g/day). Ammonia, DO and pH in the ponds were within the optimal levels for growth of tilapia, while temperature and conductivity were below optimal levels. As temperature and DO increased, growth rate of tilapia increased. However, increase in conductivity, pH and ammonia decreased fish growth rate. Temperature and DO ranging between 27 and $30^{\circ}C$ and 5-23 mg/l, respectively, and SGR of 3.8%/day and above are recommended for higher productivity.

• Animal cells and systems
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• 제4권4호
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• pp.329-336
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• 2000

Life table experiments were performed in order to examine the effects of food quality on Moina macrocopa fed with four kinds of algal foods, Botryococcus sp., Scenedesmus subspicatus, Selenastrum capricornutum, and Chlorella sp., at $20^{\circ}C$ . The temperature effects on M. macrocopa were also assessed, feeding Chlorella at $17^{\circ}C$,$20^{\circ}C$,$25^{\circ}C$, and a combination of $28^{\circ}C$ (light) and $25^{\circ}C$ (dark). The cartilaginous Botryococcs cells were Inappropriate food for Moina. Among the foods tested, Chlorella was the food of the best quality in all accounts of life history traits. Moina grown on Chlorella showed higher net reproductive rate ($R_0$), longer mean and maximum longevities, earlier mean age at maturity, longer mean carapace length at maturity, larger mean clutch size, and shorter mean time interval between clutch productions than those grown on Selenastrum and Scenedesmus. An optimal temperature for Moina was $20^{\circ}C$ . When Moina were grown on Chlorella at $20^{\circ}C$, they showed the highest r, the highest $R_0$, the shortest T, the longest mean longevity, the earliest mean age at maturity, the longest mean carapace length at maturity, and the largest mean clutch size. The results of life table experiments showed that the individual and population growth patterns were much more affected by low temperature $17^{\circ}C$, than by high temperature ($\geq 20^{\circ}C$). In the optimal condition, the r value was very high, 5.1 in $d^{-1}$. In conclusion, the food quality and the temperature are the most important factors to govern the size and continuity of Moina population, by which the individual growth rates and reproductivity of members in the population can be controlled to survive in their environment such as small and temporary water bodies in nature.

• 설비공학논문집
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• 제29권11호
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• pp.592-604
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• 2017

A chiller, having a thermal storage system, can contribute to load-leveling and can reduce the cost of electricity by using electricity at night. In this study, the control experiments and simulations are conducted using both conventional and advanced methods for the building cooling system. Advanced approaches, such as the "region control method", divide the control region into five zones according to the size of the building load, and determines the cooling capacities of the chiller and thermal storage. On the other hand, the "dynamic programming method" obtains the optimal cooling capacities of the chiller and thermal storage by selecting the minimum-cost path by carrying out repetitive calculations. The "thermal storage priority method" shows an inferior chiller performance owing to the low-part load operation, whereas the chiller priority method leads to a high electric cost owing to the low utilization of thermal storage and electricity at night. It has been proven that the advanced control methods have advantages over the conventional methods in terms of electricity consumption, as well as cost-effectiveness. According to the simulation results during the winter season, the electric cost when using the dynamic programming method was 6.5% and 8.9% lower than that of the chiller priority and the thermal storage priority methods, respectively. It is therefore concluded that the cost of electricity utilizing the region control method is comparable to that of the dynamic programming method.

• 대한치과보철학회지
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• 제56권1호
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• pp.50-55
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• 2018

무치악 환자에서 악간관계의 부조화는 자주 관찰되며, 의치에서 인공치의 교합접촉 시 안정의 결여는 환자의 불편감과 점막 외상, 나아가서는 근육과 신경의 변화나 감정적 장애를 일으킬 수 있다. 따라서 기능 시 의치에 가해지는 교합력을 고려하여 적절한 교합을 설정하는 것이 성공적인 의치 치료에 중요한 요소라고 할 수 있다. 본 증례에서는 하악 전돌로 인한 상하악 악궁간의 심한 부조화를 가진 완전무치악 환자를 양악총의치로 수복하였다. 비정상적인 악간 관계를 보상하기 위해 구치부 교차교합으로 인공치를 배열함으로써 의치의 안정과 유지를 확보하였고, 환자 또한 기능적, 심미적으로 만족하였다.

• 한국자동차공학회논문집
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• 제11권1호
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• pp.42-48
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• 2003

LPG has been a broad concern of pro-environmental alternative fuel for vehicles. Recently, the new Liquid Phase LPG Injection(LPLI) system extends the limit of power of LPG engine and gives a chance to substitute LPG engine for diesel engine of heavy duty vehicles that are the main resources of air pollution in urban area. Large bore size of heavy duty LPG engine derives a serious knock problem. To find an optimal MBT conditions, it is necessary to know how the flame develops in the combustion chamber and find where the knock positions are. In this study. the ion-probe head gasket was used to estimate the knock position. Inverse operation of the ion-probe signal provides the flame developing characteristics. The further the position is from the spark plug, the later the flame arrives and the more times knock occurs. The main factor that effects knock position is inferred a flor situation of mixed gas in the combustion chamber.

• 디지털융복합연구
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• 제12권6호
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• pp.125-134
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• 2014

공급사슬관리(Supply Chain Management)는 기업의 규모가 커지고 관리하는 제품의 수가 다양해지면서 그 중요성이 증대되고 있는 실정이다. 제조 기업의 공급사슬관리 최적화를 위해서는 다양한 변수를 고려하여 생산계획과 분배계획을 효율적으로 수립하여야 하며 각 개별의 단계를 통합적 관접에서 고려하여야 한다. 본 논문은 첫째, 고객의 수요가 다기간이며 확정된 수요정보가 생산자 단계의 생산능력 범위 내에서 변동함에 있어서 공급사슬관리의 최적화된 운영방안에 대해서 제시하였다. 둘째, 공급사슬관리에 있어서 생산계획과 분배계획 수립에 있어 재고비용과 수요불충분비용을 고려하여 최적화된 수요대응방안을 도출하도록 하였다. 본 논문은 기존의 그 유용성이 입증된 유전자 알고리즘(Genetic Algorithm)을 응용 적용하였으며 확정된 수요정보의 기간 및 변동성에 대응하기 위해 두 가지 방안으로 나누어 공급사슬관리의 최적화된 운영방안에 대해 제시하는데 그 의의가 있다.

• 한국식품조리과학회지
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• 제22권4호통권94호
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• pp.419-427
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• 2006

The purpose of this study is to promote the substitution of rice flour for wheat flour in making bread and thus the consumption of rice by examining the effect of particle size of rice flour on leavening rice bread. For this purpose, several experiments were carried out. With regard to particle size distribution, 59.45% of wheat flour had passed 200 mesh and 3 kinds of rice flour milled to penetrate into 20, 35, and 45 mesh (S1, S2 and S3) had passed 21.88%, 33.1% and 36.38% of those for 200 mesh, respectively. To leaven the rice flour dough to bread, 25% of vital gluten was needed. To determine the optimal water quantity for rice bread dough, the hardness of wheat and rice flour dough was measured by rheometer. The appropriate water quantity for S1, S2 and S3 was set at 285 ml , 295 ml and 335${\sim}$340m1, respectively. The loaf volume index of the wheat flour bread was 6.24, while that of and rice flour bread S1, S2 and S3 was 5.38, 5.50 and 5.75, respectively. These results indicated that the loaf volume index of rice flour bread is lower than that of wheat flour bread, but that the volume of rice flour bread was increased with fuel particle size of rice flour. Scanning electron microscopy (SEM), image of the wheat bread tissue at a magnification of 35 times showed long, large, oval-shaped, air cells and thin cell membrane, as well as small air cells, whereas the images of rice flour showed angular, circular, air cells and rough and thick cell membrane. The size and number of air cells in the rice bread were larger in S2 and S3 with fuel particle flours than in S1. In particular, the bread made with S3 contained many air cells that were as large as those in the wheat bread were. In addition, when the inner cell wall was magnified 1500 times, almost no small air cell was observed in C and S3, whereas many fine air cells were observed in the cell wall of S1 and S2.

• 디지털융복합연구
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• 제19권1호
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• pp.167-176
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• 2021

인천항의 성장을 지속시키고 항만배후단지와 연계된 발전을 추구하기 위해서는 자유무역지역의 지정이 시급히 필요하다. 본 연구는 인천항 자유무역지역 최적 후보지에 대한 입지평가와 정책적 시사점을 도출하는 것을 목적으로 하였으며, 요인 우선순위를 그룹별로 도출하여 비교했다. 본 연구에서는 언어학적 척도를 정량화하고 평가할 수 있는 CFPR(Consistent Fuzzy Preference Relation) 분석기법을 이용하였다. 인천항 자유무역지역의 입지를 평가한 결과, 인천신항 배후부지, 아암물류 2단지, 북항 배후단지, 경인항 배후단지 등 4개 후보지역 중 인천신항 배후부지가 가장 높은 점수를 받았다. 인천신항 배후부지는 정성적·정량적인 요인으로 구성된 총 8개의 평가요인 중 정성적인 요인 4개 모두에서 1위, 정량적 요인 1개 등 종합점수 1위로 인천항 자유무역지역 지정 최적 후보지로 평가되었다. 또한 그룹별 요인 중요도 비교에서는 그룹 1에서는 입주 기업 유치 가능성이 가장 높으며, 그룹 2는 단지 규모, 그리고 그룹 3에서도 입주 기업 유치 가능성이 가장 높은 중요도를 나타냈다. 본 연구는 자유무역지역 입지선정과 평가에 중요한 요인을 제시하였다는 시사점을 갖는다. 향후 연구에서는 연구 대상 확대 또는 각 집단의 이해관계를 반영한 요인선정등 세분화된 실증연구가 필요하다.