• Journal of Pharmaceutical Investigation
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• 제25권3호
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• pp.249-264
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• 1995

Although liposome has many advantages as a pharmaceutical dosage form, its application in the industrial field has been limited because of some problems such as preparation method, reproducibility, scale-up, stability and sterilization etc. Liposomes prepared by microemulsification method had defined size, narrow size distribution, reproducibility and high entrapment efficiency. For enhancing the stability, the dry form of liposome was recommended. These types of liposome are proliposome and freeze-dried liposome. The liposome must have some properties for preparing of freeze-dried liposome; small size $(50{\sim}200\;nm)$, narrow size distribution and cryoprotectant. In this experiment, the liposomes containing 5-Fluorouracil(5-FU) and its prodrug(pentyl-5-FU-1-acetate; PFA, hexyl-5-FU-1-acetate; HFA) were made with soybean phosphatidylcholine, cholesterol, stearylamine(SA) and dicetyl phosphate(DCP) employing hydration method or microemulsification method using $Microfluidizer^{TM}$. Both or liposome types were MLV and MEL. After preparation, freeze drying and rehydration were performed. In the process of freezing, trehalose(Tr) was added as a cryoprotectant. Their evaluation methods were as follows; entrapment efficiency, mean particle size and size distribution, dissolution test, retain of entrapment efficiency and turbidity after freeze-drying. The results are summarized as belows. The entrapment efficiency of 5-FU was dependent on total lipid concentration and cholesterol content but that of PFA and HFA was decreased when cholesterol was added. When DCP and SA were added, entrapment efficiency was decreased. As the partition coefficient of drug was increased, entrapment efficiency was increased. Under the same condition, entrapment efficiency of MEL is similar to that of MLV. The mean particle size and size distribution of MEL were smaller than those of MLV. Dissolution rates of drug from both liposome types were comparatively similar. Dissolution rates of drugs with serum and liver homogenate were faster than without these material. After preparation of liposome, free drug was removed efficiency by Dowex 50W-X4. When liposome was freeze-dried and then rehydrated in the presence of Tr, characteristics of liposome were maintained well in MEL than MLV. Tr Was used successfully as a cryoprotectant in the process of freeze drying and the optimal ratio of Tr:Lipid was 4:1(g/g).

• 한국자동차공학회논문집
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• 제18권5호
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• pp.115-123
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• 2010

Cool-down performance after soaking is important because it affects passenger's thermal comfort. The cooling capacity of HVAC system determines initial cool down performance in most cases, the performance is also affected by location, and shape of panel vent, indoor seat arrangement. Therefore, optimal indoor designs are required in developing a new car. In this paper, initial cool down performance is predicted by CFD(computational fluid dynamics) analysis. Experimental time-averaging temperature data are used as inlet boundary condition. For more reliable analysis, real vehicle model and human FE model are used in grid generation procedure. Thermal and aerodynamic characteristics on re-circulation cool vent mode are investigated using CFX 12.0. Thermal comfort represented by PMV(predicted mean vote) is evaluated using acquired numerical data. Temperature and velocity fields show that flow in passenger's compartment after soaking is considerably unstable at the view point of thermodynamics. Volume-averaged temperature is decreased exponentially during overall cool down process. However, temperature monitored at different 16 spots in CFX-Solver shows local variation in head, chest, knee, foot. The cooling speed at the head and chest nearby panel vent are relatively faster than at the knee and foot. Horizontal temperature contour shows asymmetric distribution because of the location of exhaust vent. By evaluating the passenger's thermal comfort, slowest cooling region is found at the driver's seat.

• 대한물리의학회지
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• 제11권3호
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• pp.55-58
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• 2016

PURPOSE: This study was measured the differences in the flexor and extensor muscle activities of the elbow joints based on the tire pressure of wheelchairs during propulsion, investigating the optimal tire pressure for improving occupants' propulsion and avoiding related injury. METHODS: Ten healthy volunteers (10 men aged $23.1{\pm}1.9years$, weight: $67.9{\pm}3.4kg$, height: $175.1{\pm}2.7cm$) took part in the study. The mean values used in the statistical process were obtained from values measured while a subject sitting on a wheelchair propelled himself forward for 10 meters on a flat floor at maximum speed. The tire pressure of the wheelchairs was set at 100 psi, 50 psi, and 25 psi. All of the subjects performed wheelchair propulsion for each pressure. This study was measured the activation of the biceps brachii and triceps brachii muscles on the dominant side during wheelchair propulsion. The measured data was analyzed using one-way analysis of variance (ANOVA) via the statistical package for the social sciences (SPSS) version 12.0 for Windows to compare the muscle activity. RESULTS: The muscle activities of the biceps brachii and triceps brachii were significant differences between each pressure group. The post hoc test found statistically significant differences between 100 psi and 50 psi and 100 psi and 25 psi for the biceps brachii and triceps brachii muscles, respectively. CONCLUSION: The maintaining proper tire pressure in a wheelchair may help to prevent overuse syndrome in the occupant's elbow joints.

• Journal of Biosystems Engineering
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• 제33권5호
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• pp.317-325
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• 2008

The electrocardiogram (ECG) measurement system consists of I/O interface to input the ECG signals from two electrodes, FPGA (Field programmable gate arrays) module to process the signal conditioning, and real time module to control the system. The algorithms based on wavelet transform were developed to remove the noise of the ECG signals and to determine the QRS-waves. Triangular wave tests were conducted to determine the optimal factors of the wavelet filter by analyzing the SNRs (signal to noise ratios) and RMSEs (root mean square errors). The hybrid rule, soft method, and symlets of order 5 were selected as thresholding rule, thresholding method, and mother wavelet, respectively. The developed wavelet filter showed good performance to remove the noise of the triangular waves with 10.98 dB of SNR and 0.140 mV of RMSE. The ECG signals from a total of 6 subjects were measured at different measuring postures such as lying, sitting, and standing. The durations of QRS-waves, the amplitudes of R-waves, the intervals of RR-waves were analyzed by using the finite impulse response (FIR) filter and the developed wavelet filter. The wavelet filter showed good performance to determine the features of QRS-waves, but the FIR filter had some problems to detect the peaks of Q and S waves. The measuring postures affected accuracy and precision of the ECG signals. The noises of the ECG signals were increased due to the movement of the subject during measurement. The results showed that the wavelet filter was a useful tool to remove the noise of the ECG signals and to determine the features of the QRS-waves.

• Journal of Korean Neurosurgical Society
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• 제58권2호
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• pp.93-100
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• 2015

Objective : Optimal treatment decision and estimation of the prognosis in traumatic brain injury (TBI) is currently based on demographic and clinical predictors. But sometimes, there are limitations in these factors. In this study, we analyzed three central nervous system biomarkers in TBI patients, will discuss the roles and clinical applications of biomarkers in TBI. Methods : From July on 2013 to August on 2014, a total of 45 patients were included. The serum was obtained at the time of hospital admission, and biomarkers were extracted with centrifugal process. It was analyzed for the level of S-100 beta (S100B), glial fibrillary acidic protein (GFAP), and ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1). Results : This study included 33 males and 12 females with a mean age of 58.5 (19-84) years. TBI patients were classified into two groups. Group A was severe TBI with Glasgow Coma Scale (GCS) score 3-5 and Group B was mild TBI with GCS score 13-15. The median serum concentration of S100B, GFAP, and UCH-L1 in severe TBI were raised 5.1 fold, 5.5 fold, and 439.1 fold compared to mild injury, respectively. The serum levels of these markers correlated significantly with the injury severity and clinical outcome (p<0.001). Increased level of markers was strongly predicted poor outcomes. Conclusion : S100B, GFAP, and UCH-L1 serum level of were significantly increased in TBI according to severity and associated clinical outcomes. Biomarkers have potential utility as diagnostic, prognostic, and therapeutic adjuncts in the setting of TBI.

• 대한원격탐사학회지
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• 제30권2호
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• pp.219-226
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• 2014

분광혼합분석 결과로 얻어지는 각 물체의 점유비율을 활용하면 보다 세밀한 분류가 가능하다. 이는 복잡한 도심지역의 피복분류 뿐만 아니라 혼효림이 많은 한반도 임상분류에 적합한 분류기법이 될 수 있다. 효과적인 임상분류를 위해서는 무엇보다 적절한 endmember의 추출이 선행되어야 하는데, 기존에 주로 사용되었던 기하학적 방법(geometric endmember selection)은 분광특성이 유사한 산림지역에 적합하지 않다. 본 연구에서는 영상에서 직접 순수한 화소를 추출하는 기법 중의 하나인 IEA(Iterative Error Analysis)와 침엽수와 활엽수의 분광특성을 이용하여 실험지역을 대표할 수 있는 각각의 endmember를 자동으로 추출하였다. CASI(Compact Airborne Spectrographic Imager) 영상의 두 지역에 대하여 분광혼합분석을 이용한 분류를 수행한 결과, 분류 정확도는 각각 86%와 90%로, 제안한 기법이 실험대상지역을 대표하는 침엽수와 활엽수의 endmember를 적절하게 추출한 것으로 나타났다. 분광혼합분석 기법을 이용한 보다 효과적인 분류를 위해서 분류항목 외 기타물질을 endmember로 고려하는 연구가 필요할 것으로 보인다.

• 전자공학회논문지
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• 제50권7호
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• pp.216-224
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• 2013

영상분할에 사용되는 문턱치 처리 방법들 중 Otsu 방법은 클래스 내 분산(within-class variance)을 이용하여 최적의 문턱치를 자동으로 추정한다. 이때, Otsu 방법은 각 클래스(class)의 통계적 분포를 표현함에 있어 분산을 사용하며, 이러한 분산은 평균으로부터 해당 자료까지의 거리 제곱으로 표현된다. 그 결과, Otsu 방법의 최적 문턱치는 분산의 크기에 큰 영향을 받으며, 분산들 중 크기가 큰 쪽으로 편향되는 문제점을 보인다. 이에 본 논문은 분산을 표준편차로 변경함으로써 이러한 현상을 감소시켰으며, 보다 정확한 문턱치를 추정할 수 있었다. 본 논문은 기존의 클래스 분산(class variance)을 클래스 표준편차(class standard deviation)로 대체하였으며, 문턱치 선택 기준으로서 클래스 내 표준편차(within-class standard deviation)을 제안하였다. 타당성을 검증하기 위해 두 개의 정규분포 히스토그램(histogram) 및 음영이 있는 영상들에 대해 모의실험을 수행하였으며, 제안된 방법을 Otsu 방법 및 기존의 방법들과 비교하였다. 또한, 객관적 성능평가(Misclassification Error)를 통해 제안된 방법의 우수성을 확인하였다.

• 한국세라믹학회지
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• 제52권1호
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• pp.33-40
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• 2015

Onggi, described as a 'breathing' type of pottery' has significantly influenced the traditional food culture of Korea. It is known that Onggi is an optimal type of storage for fermented foods such as soy sauce, salted seafood, and Kimchi, as air or liquid can penetrate through the body of this material. These foods gain flavor due to the breeding of aerobic bacteria at the beginning of the fermentation process. In this study, Onggi materials from five regions, Gangjin, Yeoju, Ulsan, Yesan, and Jeju, were collected and analyzed to determine their chemical and physical properties before and after sintering. The differences in the raw materials of other mining regions are examined in terms of their chemical and mineralogical compositions, specific surface area, particle size, and particle distribution. Among them, the Gangjin raw material has the greatest mean particle size of $92.29{\mu}m$, as well as the widest particle size distribution. Differences in the levels of $SiO_2$ and $Fe_2O_3$ are shown among Onggi raw materials. However, the crystalline phases formed after sintering are identical, except for the Jeju samples. At all sintering temperatures tested here, Gangjin Onggi showed the greatest porosity, leading to complete air permeation through the body within 90 minutes. These results taken together indicate that air permeation is strongly related to the pore structures in the Onggi body. This is assumed to affect the fermentation behavior.

• 한국한의학연구원논문집
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• 제14권2호
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• pp.113-119
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• 2008

In pulse diagnosis, floating pulse and sinking pulse are frequently used for diagnosis about where disease is located and how much severe they are. However, in what mechanism floating pulse and sinking pulse arise is not known well. There are two point of views on substantial of floating pulse and sinking pulse. The first one is the floating and sinking degrees is the expression on the depth of pulsation. And, the second one is floating and sinking pulse is based on the response of pulsation to the indent pressure on radial artery. In this paper, we discussed these two opinions in the view point of tonometric measurement. The process for diagnosis on floating pulse and sinking pulse is similar to the tonometric measurement for non invasive blood pressure or intraocular pressure. We modelled the degrees of depth of pulsation with different indent pressures for initial pulsation feeling and different slopes of indent pressure lines. From this modelling, we can confirm the effect of pulsation depth on P-H curve, that is, in the model where lower pulsation is assumed, the shift of optimal indent pressure to the right was observed. The response of pulse pressure to the indent pressure was tried to be modelled with the degrees of mean blood pressure. Consequently, we tried to model the phenomenon of floating and sinking pulse for the first. And, from this modelling, we can get abundant understanding on how floating and sinking pulse can be caused. In the further study, we want to prove the suitability of this tonometric measurement based modelling with various studies including ultrasound measurement for the depth of pulsation in different EMI subjects.

• 융합신호처리학회논문지
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• 제14권1호
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• pp.27-32
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• 2013

영상처리로 물체를 검출 하는 경우, 타원 형태를 검출 하는 것은 많은 응용 분야에서 중요한 역할을 한다. 실제 영상에서 타원은 영상에 포함된 노이즈나 다른 물체에 가려 보이지 않거나 교차되어 타원 검출이 용이 하지 않다. 이에 본 논문에서는 영상에서 타원을 검출 하기 위하여 경계(edge)를 추출하고, 이미지 정보량을 줄이기 위하여 그룹화 과정을 수행하여 타원 검출의 속도를 향상시켰다. 또한 타원 검출을 위해 5 개의 타원 변수를 랜덤으로 선택한 후 최적의 타원 파라미터 선택을 위해 선형 최소자승 근사법을 적용하였다. 검출된 타원들을 검증하기 위하여 RANSAC 알고리즘을 적용하였다. 본 연구에서 제안한 알고리듬을 구현하여 실제 영상에 적용한 결과 75%의 정확도를 나타내었고, 타 연구와 비교 결과 타원검출 속도 면에서 탁월함을 확인하였다. 이러한 결과는 본 연구에서 제안한 알고리듬이 영상 내 타원을 검출 하기 위한 유효한 방법임을 확인 할 수 있었다.