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Estrogenic Activity, and Developmental Toxicity Studies of Pyrethroid Insecticides

  • Kim, Soon-Sun;Rhee, Gyu-Seek;Lee, Rhee-Da;Kwack, Seung-Jun;Lim, Kwon-Jo;Yhun, Hyo-Jung;Park, Kui-Lea
    • Proceedings of the Korea Society of Environmental Toocicology Conference
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    • 2003.10a
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    • pp.57-69
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    • 2003
  • It is well known that many pesticides possess hormonal activity, and affect the developments of wildlife and mammals including human. Currently, pyrethroid insecticides are in worldwide use to control in and outdoor pests, providing potential far environmental exposure. Hormonal activities of these pyrethroid insecticides, however, have been little studied, and the developmental effects of them were no reported. Therefore, we firstly examined the potential estrogenic activities of some pyrethroid insecticides (permethrin, cypermethrin, tetramethrin, deltamethrin, sumithrin, fenvalerate and bioallethrin) by immature rat uterotrophic assay, luciferase reporter gene assay and Calbindin-D$\sub$9k/ (CaBP-9k) gene expression assay. Uterine wet weights were increased by permethrin and the permethrin-induced weights were inhibited by ICI 182780 in the uterolrophic assay. On the other hand tetramethrin significantly reduced uterine and vaginal wet weights, and also inhibited the E2-induced weight increases at all doses tested. Cypermethrin and sumithrin had a tendency to increase uterine weights, although not statistically significant. Permethrin and cypermethrin dose-dependently increased the luciferase activity in reporter gene assay. Northern blot analysis showed that permethrin induced CaBP-9k mRNA expression whereas tetramethrin inhibted. Subsequent studies were conducted to investigate the possible developmental effects of four pyrethroid insecricides (permethrin, cypermethrin, sumithrin and teramethrin). Either diethlbestrol (DES) or 17${\beta}$ -estradiol (E2) was used as a reference control in this study. Pyrethroid insecticides were administered to Sprague Dawley rats via subcutaneous injection at 6 to 18 days of gestation or 1 to 5 days after birth. In utero treatment of permethrin (10mg/kg/day) in female rat resulted in significant increases in uterine and ovarian weights while significant decreases in serum E2 concentration, uterine and ovarian ER${\alpha}$ mRNA levels. Sumithrin and permethrin led to acceleration in vaginal opening of female rat, while delay in preputial separation of male after neonatal treatment. Anogenital distances of PND 18 were significantly reduced in sumthrin-treated, and permerhrin-treated male rats after neonatal treatment. All the pyrethroid insecticides tested caused significant increases in uterine weights on PND 18, while significant reductions in the first diestrus phase when neonataly treated. In addition, exposure to pyrethroids in neonatal period led to significant reduction in relative brain weight in female rat on PND 18, but its weight was recovered in diestrus phase. In summary, Our experimental data demonstrate the possibilities of developmental effects of pyrethroid insecticides via estrogenic or antiestrogenic activity.

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Research Study on Indoor Air Quality (IAQ) inside of the Subway Cabin in Seoul Metropolitan City (지하철 전동차 객실 내부 공기질 조사 연구)

  • Lee, Kyoung Bin;Kim, Jin Sik;Bae, Sung Joon;Kim, Shin Do
    • Journal of Korean Society for Atmospheric Environment
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    • v.30 no.2
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    • pp.175-187
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    • 2014
  • The subways play an important part in serious traffic problems. Almost seven million citizens a day are using subways as a means of traffic communication in the Seoul metropolitan city in 2012. However, the subway system is a semi-closed environment, so many serious problems occurred in subway stations and injured passengers' health. Platform screen doors (PSD) are expected to prevent negligent accident such as injury or death from falling and improve the air quality of the subway station. Installation of PSD at stations in Seoul metropolitan subway had been completed in December 2009. Consequently, the underground transportation system became a closed environment, so the air quality has improved the platforms, but it has deteriorated in the tunnels. Especially, the subway cabin has many doors, and the doors are frequently opened and closed. For this reason, the effect of door opening on subway cabin, dust flow inside the subway cabin. In this process, the maintenance work may influence the health of people who work underground, as well as that of subway users (passengers). In this study, we measured air quality inside and outside of the subway cabin line 2 in Seoul, Korea. This study focused on the investigation of Indoor Air Quality (IAQ) and measurement target pollutants are PM10, CO, $CO_2$, $NO_2$, $O_3$. It was found that levels of PM10, $CO_2$, and $NO_2$ inside subway cabin line 2 exceeded the Korea IAQ standard. Concentrations of PM10, $CO_2$, and $NO_2$ inside of the cabin are higher than outside of the cabin (Indoor Outdoor ratio is higher than 1.). Concentrations of CO, $O_3$ inside of the cabin are lower than outside of the cabin (Indoor Outdoor ratio is lower than 1.). There is a high correlation between $CO_2$ and passengers inside of the cabin and PM10 is only the weakest correlation with passengers. Therefore, it is important to find out the emission source of $NO_2$. The results of this study will be useful as fundamental data to study indoor air quality of a subway cabin.

Literature Review on Danggwisayeokgaohsuyusaenggang-tang (당귀사역가오수유생강탕의 문헌적 고찰)

  • Lee, Yong Hyun;Sun, Seung Ho;Jeong, Jong Jin;Park, Jeong Su;Go, Ho Yeon;Jung, Ki Yong;Cha, Yun Yeop;Song, Yun Kyung;Kim, Tae Hoon;Hong, Sung In;Choi, You Kyung;Ko, Seong Gyu;Lim, Eun Mee;Park, Jong Hyeong;Jeon, Chan Yong
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.28 no.1
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    • pp.1-8
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    • 2014
  • The purpose of this study is to review the literature on Danggwisayeokgaohsuyusaenggang-tang. The classic literature review was carried out using "http://www.theqi.com". The journal search was performed using MEDLINE, EMBASE, National Digital Science Links(NDSL), OASIS, Korean studies Information Service system(KISS), RISS, China National Knowledge Infrastructure(CNKI), Japan Science and Technology information Aggreator, Electronic(J-STAGE) from search engine's opening day to November 2013. Searching key words were the various combination of "Danggwisayeokgaohsuyusaenggang-tang", "Danggwisayeok", "Danggwi", "ohsuyu", "saenggang". The inclusion criteria was all kinds of journals except for review, essay, and experiment study. 40 classic literatures and 37 journals(1 chinese randomized controlled trial, 25 chinese case studies, 1 Korean case study, and 10 japanese case studies) were selected finally. The literatures and journals reported that Danggwisayeokgaohsuyusaenggang - tang was used to treat diverse types of diseases with coldness of hands and feet.

Analysis of Sports Medical Care Utilization during the 24th Seoul Olympic Games (서울올림픽대회 기간중 스포츠의료 이용에 관한 분석)

  • Yu, Seung-Hum;Sohn, Myong-Sei;Lee, Young-Doo;Park, Eun-Cheol;Kim, Chun-Bae
    • Journal of Preventive Medicine and Public Health
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    • v.22 no.1 s.25
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    • pp.136-145
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    • 1989
  • This study made a descriptive analysis of the cumulative amount and rate of sports medical care utilization during the 24th Seoul Olympic Games by the participating athletes, officials, etc. The sports medical care utilization was a component of the total medical care use and was basically caused by the prevention and treatment of sports injuries. The analytic data were derived from the Olympic Health Management Information System(OHMIS) of the SLOOC and the Korea Athlete Trainer Association(KATA). These were analyzed according to the quantity of physician visits and the utilization rate, which was the amount of utilization divided by the total number of participating persons. The results were as follows: Firstly, the sports medical care utilization by the persons participating in the Seoul Olympics amounted to 17.9% of the total medical care utilization. The venue medical services utilization accounted for 54.7% of the total physician visits, which was larger than the village medical center's utilization. The number of physician visits per hundred persons during the 2 week period in the venue clinic was 3.03 and that of the village medical center was 2.51, therefore, the total was 5.54. Secondly, athletes accounted for 82.3% and officials 12.2% in the sports medical care utilization by participants. These results were because athletes, who were directly related to the games, called extremely often on the physicians. The utilization rate of sports medical care by athletes was 34.29. Thirdly, the sports medical demand according to type of therapy could be ranked from high to low in the following order: sports massage, thermal therapy, and electrical stimulation treatment, etc. The department of physical therapy in the village medical center was used a great deal. Fourthly, the trend of daily sports medical care utilization by the athletes showed a bell shape centering around the opening day of the Seoul Olympic Games. The utilization rate of athletes was 2.3; however, that of officials was 0.6. Lastly, the sports medical demand was calculated according to the continents, and Central America, Africa and Middle-East Asia proved to have a higher rate of sports medical care utilization than the more powerful and industrialized continent or regions.

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A Study on the Direct connection Service Effectiveness in Gyeongbu(KTX) (경부선(KTX) 직결운행 도입 효과에 관한 연구)

  • Kim, Ik-Hui;Kim, Yeong-Jin
    • Journal of Korean Society of Transportation
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    • v.25 no.5
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    • pp.91-100
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    • 2007
  • This study suggests direct connection service which has advantage of high-speed operation of KTX and access convenience of general train, and Pre-feasibility studies on the direct connection service. And analyze transportation demand change by the method as follows; It is to analyze the demand change of before and after KTX operation by previous transport data of Gyeongbu line, and calculate the coefficient of utilization using triggering demand by opening the 2nd phase of Gyeongbu line (Dongdaegu${\sim}$Busan). Through Pre-feasibility analysis, reduction $70{\sim}100$ minutes of train travel time and total revenue will increase about $100 thousand per day. Also, there will be environment-friendly effects of decreasing $CO_2$ emissions. But, Direct connection service need to highly cost ; Buying and Operation cost of KTX train. Therefore, we will be get more correct result of Pre-feasibility study on direct connection service, if there are concrete on buying the KTX action plans.

Stomatal Movement and Related Environmental Factors to Stomate in the Wheat II. Effect of Nitrogen Application on the Stomatal Aperture of Wheat (소맥 엽신의 기공운동과 기공의 환경변이 II. 질소의 퇴비가 소맥엽신의 기공개도에 미치는 영향)

  • 남윤일;하용웅;김기준
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.29 no.3
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    • pp.267-274
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    • 1984
  • This experiment was carried out to investigate the stomatal aperture of wheat variety 'Chokwang' grown in the two different nitrogen level. Stomatal aperture was measured at the maximal tillering, shooting, booting, flowering and grain filling stages. Stomatal aperture in leaf blades gradually increased in accordance with the successive leaf growth. The maximal opening of stomata was observed at flowering stage and around noon in a day, but stomata closed around six o'clock in the afternoon. Stomata opened wider in the high nitrogen application than in the low nitrogen and their effects were the highest at the booting and flowering stage. Diurnal course at stomatal aperture of upper leaves was wider than that of lower leaves regardless of growth stages. Positive correlation (r=0.66$^{**}$) appeared between nitrogen content in leaf blades and stomatal aperture. The leaves of low position and the developing leaves showed smaller stomatal aperture than the full expanded top leaves irrespective of leaf stages. Water content of leaf, root weight and root activity were increased by the nitrogen application and thus considered as factors increase the stomatal aperture.ication and thus considered as factors increase the stomatal aperture.

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STRESS REDUCTION PROTOCOL FOR PROPER EXTRACTION OF ADVANCED INFECTED TEETH IN MEDICALLY COMPROMISED PATIENTS : REVIEW OF LITERATURE & REPORT OF CASES (전신질환자에서 과도한 감염치아 발치시 스트레스 감소법 : 문헌적 고찰 및 증례보고)

  • Yoo, Jae-Ha;Choi, Byung-Ho;Hong, Soon-Jae;Nam, Woong;Kim, Jong-Bae;Yoon, Jung-Hoon
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.26 no.1
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    • pp.85-92
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    • 2000
  • Common dental procedures(dental extraction & minor operation) are potentially stress-inducing in many patients, especially medically compromised patients. The body's response to dental stress involves the cardiovascular system(an increase in cardiovascular workload), the respiratory organ and the endocrine system(change in metabolism). To minimize the stress to the medical risk patient, the stress reduction protocol was established. The obtained contents were as follows: (1) Recognize the patient's degree of medical risk (2) Complete medical consultation before dental therapy (3) Schedule the patient's appointment in the morning (4) Monitor and record preoperative and postoperative vital signs (5) Use psychosedation during therapy (6) Use adequate pain control during therapy (7) Short length of appointment : do not exceed the patient's limits of tolerance (8) Follow up with postoperative pain/anxiety control (9) Telephone the higher medical risk patient later on the same day that treatment was given Though the stress reduction protocol above was applied to the dental extraction in medically compromised patients with the advanced infected teeth, the final responsibility for the complications(syncope, bleeding & infection, etc.) in a patient rests with the dentist who ultimately treats him. For the prevention of postextraction complications & poor prognosis, the authors treated the advanced infected teeth with the pulp extirpation, opening drainage through the canal and complete occlusal reduction. The final extraction and wound closure were then done after $1{\sim}2$ weeks. The final prognosis was comfortable without common complications.

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Co-treatment of Sewage Sludge and Cow Manure by Vermistabilization (Vermistabilization에 의한 하수 슬러지와 가축분뇨의 병합처리)

  • 손희정;김형석
    • Resources Recycling
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    • v.7 no.3
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    • pp.52-57
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    • 1998
  • The objective of this study was to investigate the effect of cow manure as additive material on the ripening of sewage s sludge for vermistabiJization. The changes of the waste properties by ripening for 50days were observed as a function of the v various mixture ratios of sewage sludge ‘and cow manure. The pH values of the mixture wastes decreased from 7.5-7.67 to 6_ 9~7.2 by the ripening for 50days, and the mixture ratio made dIfferent pH values. The initial value of oxidation-reduction p potential (Eh) of the mixture waste was a negative (-) value indicating an unfavorable condition for earthworm after, but the v values of Eh increased with the opening time. The Increase rate at Eh value was prop$\alpha$rtional to the mixture ratio of cow m manure. The value of alkalinity was also changed into the favorable range for earthworm after 50days except for non-use of 1 the cow manure When the mixture ratio of the cow manure increased from 10% to 30%, the growth of earthworms increased h from 63.7% to 88.3 % tor the survival rate, 265% to 321% for the liveweight increasing rate and 66.7_7% to 91% for hatching f rate of the cocoons. It can be concluded that the proper content of tbe cow manure in the sewage sludge to ensure effective v vermistabilization was over 20%, when the mixture was ripened during 50 days. The quantity of ingestion and 며ectian at 20%-30% was found to be O.15--i.L18g sludge and 0 1l--O.14g solid per capacity earthworm per day, respectively.

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Evaluation of Customer's Patronage Behaviors and Satisfaction Levels towards Service Quality Dimensions of University Residence Hall Foodservice (대학교 기숙사 급식소의 이용실태 조사 및 운영형태별 서비스 품질 영역에 대한 고객 만족도 평가)

  • Yang, Il-Sun;Weon, Chi-Hyun;Kang, Hye-Seung
    • Journal of the Korean Society of Food Culture
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    • v.15 no.2
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    • pp.79-94
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    • 2000
  • The purposes of this study were to : (a) analyze university students' perception and patronage behaviors to the service quality dimensions, and (b) assist university residence hall foodservices in formulating improved managerial strategies. Questionnaires were hand delivered and mailed to 1,210 university students residing in the residence hall and 13 foodservice managers. A total of 1,011 was usable; resulting in 83.6% response rate. The survey was conducted between October, 1998 and May, 1999. Statistical data analysis was completed using the SAS/Win 6.12 for Descriptive Analysis, $x^2-test$, T-test, ANOVA, and Stepwise Multiple Regression. Forty-seven percent of the respondents indicated that 'taste' was their first priority when choosing a menu. The reasons behind choosing residence hall foodservice were 'location', 'board plan', 'price', 'taste', 'opening hours', and 'menu variety'. The main reasons of dissatisfaction with the residence hall foodservice were 'board plan', 'taste', 'menu variety'. The overall satisfaction score was 2.99 out of 5. The satisfaction score of ${\ulcorner}convenience{\lrcorner}$, ${\ulcorner}food\;quality{\lrcorner}$ and ${\ulcorner}menu\;variety{\lrcorner}$were 3.25, 2.94 and 2.76, respectively. Generally, male students were more satisfied than females. Graduate students and students living in residence halls over six semesters were the most dissatisfied with the residence hall foodservice. Residence hall students were dissatisfied with the variables ${\ulcorner}menu\;variety{\lrcorner}$ and ${\ulcorner}facilities{\lrcorner}$in 'self-operated' operations, whereas ${\ulcorner}food\;quality{\lrcorner}$, ${\ulcorner}menu\;variety{\lrcorner}$ and ${\ulcorner}price{\lrcorner}$ in 'contracted' operations. Foodservice operations with 'less than 1,000 meals serving per day' was the highest satisfaction score(3.36) among other serving sizes. Meal price with 'less than 1,300 won' was most satisfied with students. When overall customer satisfaction and service quality dimensions were analyzed by Stepwise Multiple Regression ${\ulcorner}food\;quality{\lrcorner}$(p<.001), ${\ulcorner}price{\lrcorner}$(p<.001), ${\ulcorner}facilities{\lrcorner}$(p<.001), ${\ulcorner}convenience{\lrcorner}$(p<.001), ${\ulcorner}menu\;variety{\lrcorner}$(p<.001), ${\ulcorner}manager's\;attitude{\lrcorner}$(p<.0l), and ${\ulcorner}atmosphere{\lrcorner}$(p<.01), in decreasing order, significantly impacted on ${\ulcorner}overall\;customer\;satisfaction{\lrcorner}$.

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KTX Impact on the Inter-Regional Transportation System (고속철도 개통후 지역간 교통체계의 변화)

  • Lee, Jin-Seon;Kim, Gyeong-Tae
    • Journal of Korean Society of Transportation
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    • v.23 no.2
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    • pp.75-82
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    • 2005
  • To relieve congestion in the current system of intercity transportation, the Korea decided in 1990 to construct a high-speed railroad between Seoul and Busan and it is now in operation. This new mode of transportation significantly cut travel time between major cities and a trip from Seoul to the southeastern port of Busan. Since the KTX opening, average daily passenger numbers on both the Gyeongbu and Honam lines have increased about 1.3 fold over 2003 levels. As of December 2004, the KTX trains are carrying about 81,000 people a day. On KTX routes, the daily number of airline passengers dropped. Express long-distance bus traffic also dropped by 20% to 30%, while that on short-distance routes (100km or less) increased by about 20%. These figures clearly indicate that the Korean transportation network is becoming railroad-centric. However, the number of KTX passengers is fewer than anticipated possibly due to the Korean economic downturn and the operation of the KTX will leave many existing Saemaul and Mugunghwa train sets idle, which will be put into operation for areas, not covered by the KTX. When all the existing major lines have been electrified, more high-speed rail services will be phased in using direct connections to maximize operational efficiency. And also, the dual management by KTX and conventional rail will be regarded as the promotion of the benefit of the public.