• Journal of the Korean Geotechnical Society
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• v.34 no.3
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• pp.13-27
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• 2018

To study how stable the rubble mound breakwaters are, one can look to the research of wave induced seepage flow through the pores of the rubble mound. Seepage flow is generally generated by the difference between the water level around the breakwater during a typhoon. The existing stability analysis method of the rubble mound is the static analysis which simply considers the force equilibrium taking into account the horizontal force acting on the concrete block induced by a wave (calculated by Goda equation) and the vertical force induced by the weight inclusive of the concrete block, quarry run, filter, and armor layer above the slipping plane. However, this static method does not consider the wave-induced seepage flow in the rubble mound. Such seepage may decrease the stability of the rubble mound. The stability of a rubble mound breakwater under the action of seepage was studied based on the results of CFD software (OpenFOAM) and Limit Equilibrium Method (GeoStudio). The numerical analysis result showed that the seepage flow decreased the stability of the rubble mound breakwaters. The results of the numerical analyses also revealed the stability of the rubble mound was varied with time. Especially, the most critical state happened at the condition of overtopping the concrete block, acting strong uplift pressure raising along side and underneath the concrete block, and generating high pore pressure inside rubble mound due to seepage flow. Therefore, it may be necessary to conduct a dynamic analysis considering the effect of wave-induce seepage flow together with the static analysis.

• International Journal of Computer Science & Network Security
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• v.21 no.6
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• pp.252-257
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• 2021

The application of the principle of trigeneration allows to simultaneously provide electricity to power electronic devices, as well as heat and cold to create the necessary microclimate of the premises and increase efficiency compared to separate cooling and heating systems. The use of Peltier thermoelectric modules (TEM) as part of trigenerative systems allows for smooth and precise control of the temperature regime, high manufacturability and reliability due to the absence of moving parts, resistance to shock and vibration, and small weight and size parameters of the system. One of the promising areas of improvement of trigenerative systems is their modeling and optimization based on the automatic control theory. A block diagram and functional model of an energy-saving trigenerative climate control system based on Peltier modules are developed, and the transfer functions of an open and closed system are obtained. The simulation of the transient characteristics of the system with varying parameters of the components is performed. The directions for improving the quality of transients in the climate control system are determined, as well as the prospects of the proposed methodology for modeling and analyzing control systems operating in substantially nonlinear modes.

• Journal of computational fluids engineering
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• v.21 no.2
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• pp.99-105
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• 2016

The present study has been carried out to analyze the flow characteristics with geometric shape and control conditions in subsea by-pass valve. The function of by-pass valve is to prevent reverse flow. In this study, the static analysis has been perform for analyzing fluid flow in open state. In order to consider the turbulent effect, the standard ${\kappa}-{\varepsilon}$ model was used. A variety of parametric studies, such as by-pass valve type or size, volume flow rate, leakage hole size, leakage hole position, block type, block shape, were performed. The pressure difference across the valve in the model broadened the flow channel cross-sectional area was greater than the base model for the same operating conditions. As the pipe diameter in the block decreases the pressure difference is greatly increased. The pressure difference according to block shape such as edge type and round was almost negligible. For the same Reynolds number the pressure difference was little changed according to the size of the valve.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.32 no.3C
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• pp.121-127
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• 2012

This paper investigates the response of frame structures with the consideration of tunnel construction (ground loss) conditions. The response of four-story open frame structure and block-infilled frame structures, which are subjected to tunnelling-induced ground movements, has been investigated in different construction (ground loss) conditions using numerical analysis. The open frame structure has been modelled as an elastic structure, while the block-infilled frame structure has been modelled to have real cracks when the shear and tensile stress exceed the maximum shear and tensile strength. The response of the two different frame structures has been investigated in terms of construction (ground loss) conditions considering the magnitude of deformations and cracks in structures. In addition, the damage levels, which are possibly induced in the structures, has been provided in terms of construction (ground loss) conditions using the state of strain damage estimation criterion (Son and Cording, 2005). The results of this study will provide a background for better understandings for controlling and minimizing building damage on nearby frame structures due to tunnelling-induced ground movements.

• The Korean Journal of Physiology and Pharmacology
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• v.27 no.1
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• pp.95-103
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• 2023

Rosiglitazone is a thiazolidinedione-class antidiabetic drug that reduces blood glucose and glycated hemoglobin levels. We here investigated the interaction of rosiglitazone with Kv3.1 expressed in Chinese hamster ovary cells using the wholecell patch-clamp technique. Rosiglitazone rapidly and reversibly inhibited Kv3.1 currents in a concentration-dependent manner (IC₅₀ = 29.8 µM) and accelerated the decay of Kv3.1 currents without modifying the activation kinetics. The rosiglitazonemediated inhibition of Kv3.1 channels increased steeply in a sigmoidal pattern over the voltage range of -20 to +30 mV, whereas it was voltage-independent in the voltage range above +30 mV, where the channels were fully activated. The deactivation of Kv3.1 current, measured along with tail currents, was also slowed by the drug. In addition, the steady-state inactivation curve of Kv3.1 by rosiglitazone shifts to a negative potential without significant change in the slope value. All the results with the use dependence of the rosiglitazone-mediated blockade suggest that rosiglitazone acts on Kv3.1 channels as an open channel blocker.

• The Korean Journal of Physiology and Pharmacology
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• v.22 no.1
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• pp.71-80
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• 2018

In patients with epilepsy, depression is a common comorbidity but difficult to be treated because many antidepressants cause pro-convulsive effects. Thus, it is important to identify the risk of seizures associated with antidepressants. To determine whether paroxetine, a very potent selective serotonin reuptake inhibitor (SSRI), interacts with ion channels that modulate neuronal excitability, we examined the effects of paroxetine on Kv3.1 potassium channels, which contribute to high-frequency firing of interneurons, using the whole-cell patch-clamp technique. Kv3.1 channels were cloned from rat neurons and expressed in Chinese hamster ovary cells. Paroxetine reversibly reduced the amplitude of Kv3.1 current, with an $IC_{50}$ value of $9.43{\mu}M$ and a Hill coefficient of 1.43, and also accelerated the decay of Kv3.1 current. The paroxetine-induced inhibition of Kv3.1 channels was voltage-dependent even when the channels were fully open. The binding ($k_{+1}$) and unbinding ($k_{-1}$) rate constants for the paroxetine effect were $4.5{\mu}M^{-1}s^{-1}$ and $35.8s^{-1}$, respectively, yielding a calculated $K_D$ value of $7.9{\mu}M$. The analyses of Kv3.1 tail current indicated that paroxetine did not affect ion selectivity and slowed its deactivation time course, resulting in a tail crossover phenomenon. Paroxetine inhibited Kv3.1 channels in a use-dependent manner. Taken together, these results suggest that paroxetine blocks the open state of Kv3.1 channels. Given the role of Kv3.1 in fast spiking of interneurons, our data imply that the blockade of Kv3.1 by paroxetine might elevate epileptic activity of neural networks by interfering with repetitive firing of inhibitory neurons.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.10 no.4
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• pp.184-192
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• 1985

The parameter regulation of proportional-plus-intergral-plus-derivative output feedback controllers is presented in the practical compter simulation and the time-domain analysis. Particularly, the restriction of parameter regulation for PID controller utilization is investigated as a result of simulation method. It is finally noted that one may resort to the design of controllers, as investigated, for rapid steady-state response, disturbance rejection, and transient response performance (over 3rd-order process) without computing the open-loop transfer functionmatrix. in consequence is presented the block diagram of sensor base system for PID output feedback controllers.

• Journal of Korean Society of Rural Planning
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• v.18 no.1
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• pp.17-28
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• 2012

Functional mismatch and thought and plan-less material use of recently built boundary barriers in rural areas should greatly degrade their amenity value as one of linear villagescapes, but, their present state-of-art basically necessary for problem-solving had never surveyed up to now. From this point of view, this study tried to investigate present stock quantities and qualities of boundary barriers in rural areas by sample studies on 21 case villages(7 types ${\times}$ 3 cases) and comparative analysis between the planned or improved and nots. Wall type was absolutely dominated in the structural terms, of which more than half was used cement block as building material and, therefore, grey-colored. More than half of total barrier length were fully shielded, while relatively partially shielded in the mountainous villages in open space and 'Cultural villages' with closed housing structures. Free standing style of barriers was shown along over two thirds of their total length, although not more than half in planned reclaimed villages. Especially, because of one-sided wall type structure, mismatched over-shieldness and poorer maintenance condition of the boundary barriers in peri-urban villages, there should be provided with very intensive improvement efforts for amenity barriers.

• The Korean Journal of Physiology and Pharmacology
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• v.21 no.2
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• pp.169-177
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• 2017

Lamotrigine is an antiepileptic drug widely used to treat epileptic seizures. Using whole-cell voltage clamp recordings in combination with a fast drug application approach, we investigated the effects of lamotrigine on 5-hydroxytryptamine $(5-HT)_3$ receptors in NCB-20 neuroblastoma cells. Co-application of lamotrigine ($1{\sim}300{\mu}M$) resulted in a concentration-dependent reduction in peak amplitude of currents induced by $3{\mu}m$ of 5-HT for an $IC_{50}$ value of $28.2{\pm}3.6{\mu}M$ with a Hill coefficient of $1.2{\pm}0.1$. These peak amplitude decreases were accompanied by the rise slope reduction. In addition, $5-HT_3$-mediated currents evoked by 1 mM dopamine, a partial $5-HT_3$ receptor agonist, were inhibited by lamotrigine co-application. The $EC_{50}$ of 5-HT for $5-HT_3$ receptor currents were shifted to the right by co-application of lamotrigine without a significant change of maximal effect. Currents activated by 5-HT and lamotrigine co-application in the presence of 1 min pretreatment of lamotrigine were similar to those activated by 5-HT and lamotrigine co-application alone. Moreover, subsequent application of lamotrigine in the presence of 5-HT and 5-hydroxyindole, known to attenuate $5-HT_3$ receptor desensitization, inhibited $5-HT_3$ receptor currents in a concentration-dependent manner. The deactivation of $5-HT_3$ receptor was delayed by washing with an external solution containing lamotrigine. Lamotrigine accelerated the desensitization process of $5-HT_3$ receptors. There was no voltage-dependency in the inhibitory effects of lamotrigine on the $5-HT_3$ receptor currents. These results indicate that lamotrigine inhibits $5-HT_3$-activated currents in a competitive manner by binding to the open state of the channels and blocking channel activation or accelerating receptor desensitization.

• KIISE Transactions on Computing Practices
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• v.22 no.6
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• pp.296-301
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• 2016

Object-based storage is an efficient storage solution that can handle unstructured data and shows better security and scalability than traditional block-based storage. However, in terms of power management, Object-based storage writes multiple copies in storage cluster, hence many servers consume unnecessary power in idle state. In order to resolve this problem, it is necessary to apply power management strategy by adjusting power mode of servers in idle state according to their workloads. In this paper, we proposed a new dynamic power management (DPM) method to transform power mode of storage servers dynamically according to workload information sent from proxy server. The experimental result shows that the proposed power management technic reduces total power consumption by 12% in the OpenStack based Swift object storage.