• 한국지반공학회논문집
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• 제34권3호
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• pp.13-27
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• 2018

사석경사식 방파제의 안정성에 있어 파랑에 의한 사석마운드내의 침투흐름의 영향이 연구되었다. 침투흐름은 일반적으로 태풍시 방파제 주변 수위차에 의해 발생된다. 기존 사석마운드의 안정해석법은 정적해석으로 활동면 상의자중(콘크리트블록, 사석, 필터, 보호층)에 의한 수직력과 콘크리트 블록에 작용하는 파압에 의한 수평력(Goda 식으로 산정)의 힘의 평형조건으로 결정된다. 그러나 이 정적방법은 사석마운드 내의 파랑에 의한 침투흐름을 고려할 수 없다. 이런 침투흐름은 사석마운드의 안정성을 감소시킬 수 있다. 본 연구에서는 침투 작용시 사석경사식 방파제의 안정성에 대해 CFD 프로그램(OpenFOAM)과 한계평형해석법(GeoStudio)을 이용하여 검토하였다. 수치해석결과 침투로 인해 사석경사식 방파제의 안정성이 감소하는 것으로 나타났다. 또한 수치해석 결과는 사석마운드의 안정성이 시간에 따라 변하는 것을 보여주었다. 특히 파가 방파제를 월류하고 침투류에 의해 상치콘크리트 측면과 하부에 강한 양압력과 사석마운드 내부에 간극수압이 크게 발생하는 시점에 가장 불안정 상태를 보이는 것으로 나타났다. 따라서 동적 파랑에 의한 침투류의 영향을 고려한 동적해석도 정적해석과 함께 검토할 필요가 있다.

• International Journal of Computer Science & Network Security
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• 제21권6호
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• pp.252-257
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• 2021

The application of the principle of trigeneration allows to simultaneously provide electricity to power electronic devices, as well as heat and cold to create the necessary microclimate of the premises and increase efficiency compared to separate cooling and heating systems. The use of Peltier thermoelectric modules (TEM) as part of trigenerative systems allows for smooth and precise control of the temperature regime, high manufacturability and reliability due to the absence of moving parts, resistance to shock and vibration, and small weight and size parameters of the system. One of the promising areas of improvement of trigenerative systems is their modeling and optimization based on the automatic control theory. A block diagram and functional model of an energy-saving trigenerative climate control system based on Peltier modules are developed, and the transfer functions of an open and closed system are obtained. The simulation of the transient characteristics of the system with varying parameters of the components is performed. The directions for improving the quality of transients in the climate control system are determined, as well as the prospects of the proposed methodology for modeling and analyzing control systems operating in substantially nonlinear modes.

• 한국전산유체공학회지
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• 제21권2호
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• pp.99-105
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• 2016

The present study has been carried out to analyze the flow characteristics with geometric shape and control conditions in subsea by-pass valve. The function of by-pass valve is to prevent reverse flow. In this study, the static analysis has been perform for analyzing fluid flow in open state. In order to consider the turbulent effect, the standard ${\kappa}-{\varepsilon}$ model was used. A variety of parametric studies, such as by-pass valve type or size, volume flow rate, leakage hole size, leakage hole position, block type, block shape, were performed. The pressure difference across the valve in the model broadened the flow channel cross-sectional area was greater than the base model for the same operating conditions. As the pipe diameter in the block decreases the pressure difference is greatly increased. The pressure difference according to block shape such as edge type and round was almost negligible. For the same Reynolds number the pressure difference was little changed according to the size of the valve.

• 대한토목학회논문집
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• 제32권3C호
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• pp.121-127
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• 2012

본 논문은 터널건설로 인해 발생된 인접지반에서의 지반변위가 프레임구조물에 미치는 영향을 터널 시공조건(지반손실)을 달리하면서 조사한 것이다. 터널굴착에 의해 발생된 지반변위에 노출된 4층 오픈 프레임구조물과 블록으로 채워진 프레임구조물이 서로 다른 시공조건(지반손실)에 노출될 때 발생되는 구조물 거동을 수치해석을 통해 조사하였다. 오픈 프레임구조물은 탄성구조물로서 모델링 한 반면, 블록으로 채워진 프레임구조물은 소요전단 및 인장강도 이상의 응력이 발생할 때 구조물에 실제크랙이 발생할 수 있도록 모델링하였다. 터널굴착유발 지반변위에 노출된 두 서로 다른 프레임구조물의 거동 및 손상정도를 터널 시공조건에 따라 조사하였으며, 발생된 구조물의 거동 및 손상정도는 구조물에 발생한 변형, 크랙크기 및 분포를 고려하여 서로 비교하였다. 뿐만 아니라, 다양한 시공조건(지반손실)의 변화에 의해 구조물에 유발될 수 있는 손상정도의 크기를 손상도 예측기준(Son and Cording, 2005)을 사용하여 제시하였다. 이러한 결과들은 향후 터널굴착으로 인해 유발되는 인접 프레임구조물의 손상을 제어하고 최소화하는데 필요한 정보를 제공할 것이다.

• The Korean Journal of Physiology and Pharmacology
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• 제27권1호
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• pp.95-103
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• 2023

Rosiglitazone is a thiazolidinedione-class antidiabetic drug that reduces blood glucose and glycated hemoglobin levels. We here investigated the interaction of rosiglitazone with Kv3.1 expressed in Chinese hamster ovary cells using the wholecell patch-clamp technique. Rosiglitazone rapidly and reversibly inhibited Kv3.1 currents in a concentration-dependent manner (IC₅₀ = 29.8 µM) and accelerated the decay of Kv3.1 currents without modifying the activation kinetics. The rosiglitazonemediated inhibition of Kv3.1 channels increased steeply in a sigmoidal pattern over the voltage range of -20 to +30 mV, whereas it was voltage-independent in the voltage range above +30 mV, where the channels were fully activated. The deactivation of Kv3.1 current, measured along with tail currents, was also slowed by the drug. In addition, the steady-state inactivation curve of Kv3.1 by rosiglitazone shifts to a negative potential without significant change in the slope value. All the results with the use dependence of the rosiglitazone-mediated blockade suggest that rosiglitazone acts on Kv3.1 channels as an open channel blocker.

• The Korean Journal of Physiology and Pharmacology
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• 제22권1호
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• pp.71-80
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• 2018

In patients with epilepsy, depression is a common comorbidity but difficult to be treated because many antidepressants cause pro-convulsive effects. Thus, it is important to identify the risk of seizures associated with antidepressants. To determine whether paroxetine, a very potent selective serotonin reuptake inhibitor (SSRI), interacts with ion channels that modulate neuronal excitability, we examined the effects of paroxetine on Kv3.1 potassium channels, which contribute to high-frequency firing of interneurons, using the whole-cell patch-clamp technique. Kv3.1 channels were cloned from rat neurons and expressed in Chinese hamster ovary cells. Paroxetine reversibly reduced the amplitude of Kv3.1 current, with an $IC_{50}$ value of $9.43{\mu}M$ and a Hill coefficient of 1.43, and also accelerated the decay of Kv3.1 current. The paroxetine-induced inhibition of Kv3.1 channels was voltage-dependent even when the channels were fully open. The binding ($k_{+1}$) and unbinding ($k_{-1}$) rate constants for the paroxetine effect were $4.5{\mu}M^{-1}s^{-1}$ and $35.8s^{-1}$, respectively, yielding a calculated $K_D$ value of $7.9{\mu}M$. The analyses of Kv3.1 tail current indicated that paroxetine did not affect ion selectivity and slowed its deactivation time course, resulting in a tail crossover phenomenon. Paroxetine inhibited Kv3.1 channels in a use-dependent manner. Taken together, these results suggest that paroxetine blocks the open state of Kv3.1 channels. Given the role of Kv3.1 in fast spiking of interneurons, our data imply that the blockade of Kv3.1 by paroxetine might elevate epileptic activity of neural networks by interfering with repetitive firing of inhibitory neurons.

• 한국통신학회논문지
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• 제10권4호
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• pp.184-192
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• 1985

三項出力歸還 制御器의 파라미터調整을 컴퓨터模擬實驗에 의해 時間領域解析과 最適値를 活用할 수 있게 하였다. 正常狀態應答, 外亂無視, 過渡應答遂行을 效率的으로 選擇될 수 있는 PID制御器의 設計를 汎用例에 의하여 考察하였다. 이에 의해 sensor base system構成圖를 또한 提示한다.

• 농촌계획
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• 제18권1호
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• pp.17-28
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• 2012

Functional mismatch and thought and plan-less material use of recently built boundary barriers in rural areas should greatly degrade their amenity value as one of linear villagescapes, but, their present state-of-art basically necessary for problem-solving had never surveyed up to now. From this point of view, this study tried to investigate present stock quantities and qualities of boundary barriers in rural areas by sample studies on 21 case villages(7 types ${\times}$ 3 cases) and comparative analysis between the planned or improved and nots. Wall type was absolutely dominated in the structural terms, of which more than half was used cement block as building material and, therefore, grey-colored. More than half of total barrier length were fully shielded, while relatively partially shielded in the mountainous villages in open space and 'Cultural villages' with closed housing structures. Free standing style of barriers was shown along over two thirds of their total length, although not more than half in planned reclaimed villages. Especially, because of one-sided wall type structure, mismatched over-shieldness and poorer maintenance condition of the boundary barriers in peri-urban villages, there should be provided with very intensive improvement efforts for amenity barriers.

• The Korean Journal of Physiology and Pharmacology
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• 제21권2호
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• pp.169-177
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• 2017

Lamotrigine is an antiepileptic drug widely used to treat epileptic seizures. Using whole-cell voltage clamp recordings in combination with a fast drug application approach, we investigated the effects of lamotrigine on 5-hydroxytryptamine $(5-HT)_3$ receptors in NCB-20 neuroblastoma cells. Co-application of lamotrigine ($1{\sim}300{\mu}M$) resulted in a concentration-dependent reduction in peak amplitude of currents induced by $3{\mu}m$ of 5-HT for an $IC_{50}$ value of $28.2{\pm}3.6{\mu}M$ with a Hill coefficient of $1.2{\pm}0.1$. These peak amplitude decreases were accompanied by the rise slope reduction. In addition, $5-HT_3$-mediated currents evoked by 1 mM dopamine, a partial $5-HT_3$ receptor agonist, were inhibited by lamotrigine co-application. The $EC_{50}$ of 5-HT for $5-HT_3$ receptor currents were shifted to the right by co-application of lamotrigine without a significant change of maximal effect. Currents activated by 5-HT and lamotrigine co-application in the presence of 1 min pretreatment of lamotrigine were similar to those activated by 5-HT and lamotrigine co-application alone. Moreover, subsequent application of lamotrigine in the presence of 5-HT and 5-hydroxyindole, known to attenuate $5-HT_3$ receptor desensitization, inhibited $5-HT_3$ receptor currents in a concentration-dependent manner. The deactivation of $5-HT_3$ receptor was delayed by washing with an external solution containing lamotrigine. Lamotrigine accelerated the desensitization process of $5-HT_3$ receptors. There was no voltage-dependency in the inhibitory effects of lamotrigine on the $5-HT_3$ receptor currents. These results indicate that lamotrigine inhibits $5-HT_3$-activated currents in a competitive manner by binding to the open state of the channels and blocking channel activation or accelerating receptor desensitization.

• 정보과학회 컴퓨팅의 실제 논문지
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• 제22권6호
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• pp.296-301
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• 2016

객체 기반 스토리지 솔루션은 비정형 데이터를 효과적으로 처리할 뿐만 아니라 보안, 확장성에서 기존 블록 스토리지보다 장점을 갖고 있다. 그러나 전력관리 관점에서, 객체 기반 스토리지가 기록하는 많은 수의 사본들은 여러 서버들을 유휴상태에서 불필요한 전력을 소모하게 하는 문제가 있다. 이 문제를 해결하기 위해서는 작업량에 따라 유휴상태 서버들의 전원모드를 변화시키는 전력관리기법의 적용이 필요하다. 본 논문에서는 프락시 서버에서 보내는 작업량 정보를 기반으로 스토리지 서버의 전력 상태를 동적으로 전환하는 전력관리 기법을 제안한다. 실험 결과, 제안한 전력관리 기법은 오픈스택 기반 스위프트 객체 스토리지에서 전체 전력 소모량을 12% 감소시키는 것으로 나타났다.